James Spencer

Pohang University of Science and Technology

Also affiliated with University of Bristol, Cellular Research (United States), Pohang Accelerator Laboratory

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 13 papers. Top paper: “Allosteric communication in class A β-lactamases occurs via cooperative coupling of loop dynamics”.

Allosteric communication in class A β-lactamases occurs via cooperative coupling of loop dynamics

eLife(2021)10.7554/elife.66567

N/A

1.8DataRank · unranked

82 citations

Shen Qu, A. Sofia F. Oliveira, Edgar Olehnovics, Andrew R Mack, María F. Mojica +8 more

Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Nature Chemistry(2021)10.1038/s41557-021-00831-x

N/A

0DataRank · unranked

84 citations

Tharindi Panduwawala, Jon Hansen, Joanne F. M. Hewitt, Edgars Liepinsh, Pavel A. Donets +56 more

An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography

Nature Communications(2021)10.1038/s41467-021-24757-7

N/A

0DataRank · unranked

78 citations

Philipp S. Simon, Pierre Aller, Philip Hinchliffe, Ramzi Massad, Gabriel Leen +31 more

Faropenem reacts with serine and metallo-β-lactamases to give multiple products

European Journal of Medicinal Chemistry(2021)10.1016/j.ejmech.2021.113257

N/A

0DataRank · unranked

26 citations

Philip Hinchliffe, Tika R. Malla, Catherine L. Tooke, Jürgen Brem, Karina Calvopiña +8 more

2-Mercaptomethyl-thiazolidines use conserved aromatic–S interactions to achieve broad-range inhibition of metallo-β-lactamases

Chemical Science(2021)10.1039/d0sc05172a

N/A

0DataRank · unranked

38 citations

V. Rodríguez Martínez, Philip Hinchliffe, María F. Mojica, Valerie Castillo, Diego M. Moreno +9 more

2-Mercaptomethyl Thiazolidines (MMTZs) Inhibit All Metallo-β-Lactamase Classes by Maintaining a Conserved Binding Mode

ACS Infectious Diseases(2021)10.1021/acsinfecdis.1c00194

N/A

0DataRank · unranked

21 citations

Diego M. Moreno, María-Agustina Rossi, María F. Mojica, V. Rodríguez Martínez, Valentina Villamil +8 more

A multiscale approach to predict the binding mode of metallo beta‐lactamase inhibitors

Proteins Structure Function and Bioinformatics(2021)10.1002/prot.26227

N/A

0DataRank · unranked

14 citations

James Spencer, Philip Hinchliffe, Alessandro Pedretti, Franco Vairoletti, Graciela Mahler +2 more

Allosteric communication in Class A β-lactamases occurs via Cooperative Coupling of Loop Dynamics

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2020.12.30.424904

N/A

0DataRank · unranked

0 citations

Shen Qu, Ana Sofia F Oliveria, Edgar Olehnovics, Andrew R Mack, María F. Mojica +8 more

Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition

mBio(2022)10.1128/mbio.01793-21

N/A

0DataRank · unranked

17 citations

Catherine L. Tooke, Christopher R. Bethel, Benlian Wang, Christopher J. Arthur, Kate J. Heesom +6 more

Association of a Perioperative Multicomponent Fall Prevention Intervention With Falls and Quality of Life After Elective Inpatient Surgical Procedures

JAMA Network Open(2022)10.1001/jamanetworkopen.2022.1938

N/A

0DataRank · unranked

11 citations

Christopher R. King, Divya Mehta, Emily Somerville, Alex Kronzer, Arbi Ben Abdallah +41 more

Interactions of hydrolyzed β-lactams with the L1 metallo-β-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.104606

N/A

0DataRank · unranked

10 citations

Karina Calvopiña, Patrick Rabe, María F. Mojica, Christopher J. Schofield, Gary I. Dmitrienko +4 more

Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl–enzyme conformational dynamics to extend antibiotic resistance

Journal of Biological Chemistry(2020)10.1074/jbc.ra120.016461

N/A

0DataRank · unranked

49 citations

Philip Hinchliffe, Robert A. Bonomo, Christopher J. Schofield, Adrian J. Mulholland, James Spencer +1 more

Rational Design of Benzobisheterocycle Metallo-β-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.3c02209

N/A

0DataRank · unranked

7 citations

María-Agustina Rossi, María F. Mojica, Philip Hinchliffe, V. Rodríguez Martínez, Valerie Castillo +9 more