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Allosteric communication in class A β-lactamases occurs via cooperative coupling of loop dynamics

eLife(2021)10.7554/elife.66567Source: DataRank Database

Allosteric communication in class A β-lactamases occurs via cooperative coupling of loop dynamics is a research paper published in eLife (2021). On theSindex it has a DataRank of 1.8. It has been cited 82 times, with 46 citing works in its 1-hop citation network.

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1.8DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access82 citations · 46 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

figshare10.6084/m9.figshare.13583384

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (32 grants)Impact (FWCI 4.41)OA: goldTopics (56)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 38%Citation Network 62%

Base Score Contribution

0.663

From this paper's citation signal

Citation Network Contribution

1.1

From 40 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 46 citers.

Molecular mechanisms responsible KPC-135-mediated resistance to ceftazidime-avibactam in ST11-K47 hypervirulent Klebsiella pneumoniae
Emerging Microbes & Infections202430 citations40 referencesContributes 0.086
Design and engineering of allosteric communications in proteins
Current Opinion in Structural Biology202243 citations52 referencesContributes 0.073
Computing allostery: from the understanding of biomolecular regulation and the discovery of cryptic sites to molecular design
Current Opinion in Structural Biology202324 citations47 referencesContributes 0.068
Inhibition of Class A β-Lactamase (TEM-1) by Narrow Fractions of Humic Substances
ACS Omega202116 citations46 referencesContributes 0.062
Activation mechanism of Drosophila cryptochrome through an allosteric switch
Science Advances202124 citations57 referencesContributes 0.056

Authors (13)

Shen Qu ORCID,A. Sofia F. Oliveira ORCID,Edgar Olehnovics,Andrew R Mack ORCID,María F. Mojica ORCID

Live enrichment

PubMed:33755013 PMC:PMC8060031 OpenAlex:https://openalex.org/W3138090372

AstraZeneca

Grant: Case Studentship

National Institute of General Medical Sciences

Grant: GM105978

National Institutes of Health

Grant: RO1AI063517

Engineering and Physical Sciences Research Council

Grant: EP/M022609/1

CCP-BioSim: Biomolecular Simulation at the Life Sciences Interface

Engineering and Physical Sciences Research Council

Grant: EP/N024117/1

Nicotinic Ligand Development to Target Smoking Cessation and Gain a Molecular Level Understanding of Partial Agonism

Biotechnology and Biological Sciences Research Council

Grant: BB/L01386X/1

BrisSynBio: Bristol Centre for Synthetic Biology

Medical Research Council

Grant: MR/T016035/1

Carbapenem Antibiotic Resistance in Enterobacteriaceae: Understanding Interactions of KPC Carbapenemases with Substrates and Inhibitors

National Institute of Allergy and Infectious Diseases

Grant: R01AI100560

National Institute of Allergy and Infectious Diseases

Grant: R01AI063517

National Institute of Allergy and Infectious Diseases

Grant: R01AI072219

Biotechnology and Biological Sciences Research Council

Grant: BB/K016601/1

Engineering and Physical Sciences Research Council

Grant: EP/G007705/1

Engineering and Physical Sciences Research Council

Grant: EP/R029407/1

Biotechnology and Biological Sciences Research Council

Grant: BB/T017066/1

Biotechnology and Biological Sciences Research Council

Grant: BB/L018756/1

Engineering and Physical Sciences Research Council

Grant: EP/J010588/1

Engineering and Physical Sciences Research Council

Grant: EP/R029407/2

BLRD VA

Grant: I01 BX001974

NIGMS NIH HHS

Grant: R01 GM105978

Engineering and Physical Sciences Research Council

Grant: EP/G042853/1

Engineering and Physical Sciences Research Council

Grant: EP/L000253/1

Engineering and Physical Sciences Research Council

Grant: EP/M027546/1

Engineering and Physical Sciences Research Council

Grant: GR/R86119/01

Engineering and Physical Sciences Research Council

Grant: EP/E022197/1

Engineering and Physical Sciences Research Council

Grant: EP/G002843/1

Engineering and Physical Sciences Research Council

Grant: EP/I030395/1

Engineering and Physical Sciences Research Council

Grant: EP/M015378/1

National Institutes of Health

Grant: 5R01GM105978-02

Conformational sub-states in enzyme catalysis: Applications to ribonuclease

National Institutes of Health

Grant: 5R01AI072219-12

Understanding B-Lactam Resistance in Acinetobacter baumannii

National Institutes of Health

Grant: 5R01AI063517-13

Challenges in beta-Lactamase Mediated Resistance

National Institutes of Health

Grant: 5I01BX001974-11

The Continuing Challenge of Carbapenemases in K. pneumoniae: KPC-2 & NDM-1

National Institutes of Health

Grant: 5R01AI100560-04

A Mechanism-Based Approach to Metallo-beta-Lactamase Inhibition

FWCI

4.41

Citation Percentile

1.0%

Influential Citations

Citation Trend

2021

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.7554/elife.66567

GREENhttps://www.biorxiv.org/content/biorxiv/early/2021/01/01/2020.12.30.424904.full.pdf

publisherhttps://doi.org/10.7554/elife.66567

publisherhttps://cdn.elifesciences.org/articles/66567/elife-66567-v3.pdf

publisherhttps://cdn.elifesciences.org/articles/66567/elife-66567-v3.xml

Fields of Study

Antibiotic Resistance in BacteriaEvolution and Genetic DynamicsVibrio bacteria research studiesMedicineBiologyChemistry0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

beta-LactamasesProtein ConformationAmino Acid SubstitutionDrug Resistance, BacterialMolecular Dynamics Simulation

Keywords

Allosteric regulationAllosteric enzymeNon-equilibrium thermodynamicsComputational biologyProtein dynamicsBiologyCoupling (piping)Mechanism (biology)Signal transductionBiophysicsEnzymeChemistryProtein structureGeneticsBiochemistryPhysicsMaterials scienceMedicineStructural BiologyKPC-2Β-lactamaseTem-1Molecular Biophysics570/dk/atira/pure/core/keywords/brissynbio; name=BrisSynBioQH301-705.5Protein ConformationScience/dk/atira/pure/core/keywords/biodesign_SRIMolecular Dynamics Simulationname=BrisSynBiobeta-LactamasesDrug Resistance, BacterialBiology (General)QRAmino Acid Substitution/dk/atira/pure/core/keywords/faculty_of_enigneering/school_of_chemistry/physical_theoretical; name=Physical & Theoretical/dk/atira/pure/core/keywords/brissynbiosynthetic biologyname=Bristol BioDesign Institute/dk/atira/pure/core/keywords/biodesign_SRI; name=Bristol BioDesign Institute

Sustainable Development Goals

SDG 8: 8. Economic growth