🏆 Finalist — NIH Data Sharing Index (“S-Index”) Challenge

Shyaron Poudel

St. Jude Children's Research Hospital

ORCID: 0000-0002-4819-0929
Pharmacology, Toxicology and PharmaceuticsBiochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile
0Author DataRank

Indexed papers

0in pilot corpus
datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 10 papers. Top paper: “Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and Beyond”.

Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and Beyond

Drug Metabolism and Disposition(2022)10.1124/dmd.122.000858
N/A
0.553DataRank · unranked
39 citations

Andrew D. Huber, Taosheng Chen, Shyaron Poudel

A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR

Nucleic Acids Research(2023)10.1093/nar/gkad1175
N/A
0.352DataRank · unranked
7 citations

Shyaron Poudel, Jing Wu, Darcie J. Miller, Wenwei Lin, Lei Yang +7 more

Subtle changes in ligand-receptor interactions dramatically alter transcriptional outcomes of pregnane X receptor modulators

Structure(2025)10.1016/j.str.2025.09.011
N/A
0.165DataRank · unranked
2 citations

Efren Garcia-Maldonado, Wenwei Lin, Shyaron Poudel, Jing Wu, Darcie J. Miller +2 more

Structure-guided approach to modulate small molecule binding to the promiscuous pregnane X receptor

Journal of Pharmacology and Experimental Therapeutics(2023)10.1124/jpet.122.524030
N/A
0DataRank · unranked
0 citations

Wenwei Lin, Shyaron Poudel, Yongtao Li, J. Seetharaman, Darcie J. Miller +2 more

Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR

Nature Communications(2024)10.1038/s41467-024-48472-1
N/A
0DataRank · unranked
20 citations

Andrew D. Huber, Sergio C. Chai, Stanley Nithianantham, Yongtao Li, Jing Wu +5 more

PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network

Structure(2024)10.1016/j.str.2024.09.016
N/A
0DataRank · unranked
10 citations

Wenwei Lin, Shyaron Poudel, Darcie J. Miller, Taosheng Chen, Andrew D. Huber

First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy Efficacy

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.4c01926
N/A
0DataRank · unranked
10 citations

Kwan‐Young Jung, Yongtao Li, Wenwei Lin, Jing Wu, Shyaron Poudel +5 more

PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors

Nature Communications(2025)10.1038/s41467-025-64773-5
N/A
0DataRank · unranked
1 citations

Wenwei Lin, Kwan‐Young Jung, Shyaron Poudel, Guangwei Yang, Jing Wu +15 more

Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2217804120
N/A
0DataRank · unranked
18 citations

Andrew D. Huber, Shyaron Poudel, Yongtao Li, J. Seetharaman, Darcie J. Miller +2 more

Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand

Structure(2023)10.1016/j.str.2023.08.020
N/A
0DataRank · unranked
14 citations

Shyaron Poudel, Yongtao Li, Wenwei Lin, Jing Wu, Darcie J. Miller +2 more