Douglas Cyr

University of North Carolina at Chapel Hill

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 38 papers. Top paper: “Type I Hsp40s/ DnaJs aggregates exhibit features reminiscent of amyloidogenic structures”.

Type I Hsp40s/ DnaJs aggregates exhibit features reminiscent of amyloidogenic structures

FEBS Journal(2024)10.1111/febs.17215

N/A

0.183DataRank · unranked

2 citations

Leonardo A. Linhares, Annelize Zambon Barbosa Aragão, Jemmyson Romário de Jesus, Ana Paula Wasilewska‐Sampaio, Fernanda G. De Felice +5 more

CHIP activates HSF1 and confers protection against apoptosis and cellular stress

UNC Libraries(2020)10.17615/aaye-3j55

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0DataRank · unranked

14 citations

Qian Dai, Yaxu Wu, Holly McDonough, Hui Hua Li, Ryan Whaley +7 more

Assembly and Misassembly of Cystic Fibrosis Transmembrane Conductance Regulator: Folding Defects Caused by Deletion of F508 Occur Before and After the Calnexin-dependent Association of Membrane Spanning Domain (MSD) 1 and MSD2

UNC Libraries(2020)10.17615/abxe-z065

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0DataRank · unranked

1 citations

Douglas Cyr, Meredith F.N. Rosser, Diane E. Grove, Liling Chen

Mechanisms for Rescue of Correctable Folding Defects in CFTR F508

UNC Libraries(2020)10.17615/9pcz-n932

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0DataRank · unranked

1 citations

Meredith F.N. Rosser, Yu Ren Hong, Anjaparavanda P. Naren, Diane E. Grove, Douglas Cyr

Amyloid deposits: Protection against toxic protein species?

UNC Libraries(2020)10.17615/wnww-ja53

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0DataRank · unranked

1 citations

Sebastian Treusch, Douglas Cyr, Susan Lindquist

VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1

UNC Libraries(2020)10.17615/5pzy-8d07

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0DataRank · unranked

1 citations

Scott A. Houck, Douglas Cyr, Fredrick Van Goor, Oxana De La Rosa, Beth J. Hoffman +3 more

DNAJB12 and Hsp70 Facilitate the Conformation Specific Degradation of Arrested N1303K-CFTR Intermediates by ER Associated-Autophagy

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.28.358580

N/A

0DataRank · unranked

0 citations

Andrew S. Kennedy, Scott A. Houck, Andrei A. Aleksandrov, Nancy L. Quinney, Deborah M. Cholon +5 more

Distinct Roles for the AAA ATPases NSF and p97 in the Secretory Pathway

UNC Libraries(2020)10.17615/0q09-a855

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0DataRank · unranked

0 citations

Phyllis I. Hanson, Meredith F.N. Rosser, Seema Dalal, Douglas Cyr

The Type II Hsp40 Sis1 Cooperates with Hsp70 and the E3 Ligase Ubr1 to Promote Degradation of Terminally Misfolded Cytosolic Protein

UNC Libraries(2020)10.17615/11fy-1111

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0DataRank · unranked

0 citations

Hong Yu Ren, Katie J. Wolfe, Daniel W. Summers, Douglas Cyr

Restoration of R117H CFTR folding and function in human airway cells through combination treatment with VX-809 and VX-770

UNC Libraries(2020)10.17615/pgag-s631

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0DataRank · unranked

0 citations

Deborah M. Cholon, Jhuma Das, Pattarawut Sopha, Nikolay V. Dokholyan, Imron G. Chaudhry +6 more

The Type I Hsp40 Ydj1 Utilizes a Farnesyl Moiety and Zinc Finger-like Region to Suppress Prion Toxicity

UNC Libraries(2020)10.17615/dbxg-xw61

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0DataRank · unranked

0 citations

Peter M. Douglas, Hong Yu Ren, Daniel W. Summers, Douglas Cyr

Polypeptide transfer from Hsp40 to Hsp70 molecular chaperones

UNC Libraries(2020)10.17615/w185-8169

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0DataRank · unranked

0 citations

Daniel W. Summers, Douglas Cyr, Peter M. Douglas, Cathy Isaura Ramos

Endoplasmic reticulum stress–induced degradation of DNAJB12 stimulates BOK accumulation and primes cancer cells for apoptosis

UNC Libraries(2020)10.17615/8nf9-qe71

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0DataRank · unranked

0 citations

Douglas Cyr, Pattarawut Sopha, Diane E. Grove, Hong Yu Ren

Stress-dependent Daxx-CHIP Interaction Suppresses the p53 Apoptotic Program

UNC Libraries(2020)10.17615/xvvb-ch05

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0DataRank · unranked

0 citations

Andrea L. Portbury, Douglas Cyr, Shu Bing Qian, Eleanor Hilliard, Holly McDonough +3 more

Exchangeable Chaperone Modules Contribute to Specification of Type I and Type II Hsp40 Cellular Function

UNC Libraries(2020)10.17615/yjcw-rc31

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0DataRank · unranked

0 citations

Soojin Lee, Douglas Cyr, Chun Yang Fan, Hong Yu Ren

Conserved Central Domains Control the Quaternary Structure of Type I and Type II Hsp40 Molecular Chaperones

UNC Libraries(2020)10.17615/0s1s-z921

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0DataRank · unranked

0 citations

Cathy Isaura Ramos, Cristiano L. P. Oliveira, Í. Torriani, Douglas Cyr, Chung-Yang Fan

The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTR F508

UNC Libraries(2020)10.17615/bry3-d491

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0DataRank · unranked

0 citations

Chun Yang Fan, Hong Yu Ren, Diane E. Grove, Douglas Cyr

The Hsp70/90 cochaperone, Sti1, suppresses proteotoxicity by regulating spatial quality control of amyloid-like proteins

UNC Libraries(2020)10.17615/szj4-g321

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0DataRank · unranked

0 citations

Hong Yu Rena, Douglas Cyr, Katie J. Wolfe, Philipp Trepte

Prion propagation by Hsp40 molecular chaperones

UNC Libraries(2020)10.17615/2mev-h320

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0DataRank · unranked

0 citations

Douglas Cyr, Daniel W. Summers, Peter M. Douglas

Reciprocal Efficiency of RNQ1 and Polyglutamine Detoxification in the Cytosol and Nucleus

UNC Libraries(2020)10.17615/vv59-gn91

N/A

0DataRank · unranked

0 citations

Peter M. Douglas, Daniel W. Summers, Douglas Cyr, Hong Yu Ren

Ubr1 and Ubr2 Function in a Quality Control Pathway for Degradation of Unfolded Cytosolic Proteins

UNC Libraries(2020)10.17615/1cbr-wg66

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0DataRank · unranked

0 citations

Rasheda Sultana, A. Mandal, Katie J. Mayo, Hong Yu Ren, Douglas Cyr +5 more

Molecular chaperones antagonize proteotoxicity by differentially modulating protein aggregation pathways

UNC Libraries(2020)10.17615/2jvs-vd92

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0DataRank · unranked

0 citations

Peter M. Douglas, Douglas Cyr, Daniel W. Summers

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations

UNC Libraries(2020)10.17615/cqba-1865

N/A

0DataRank · unranked

0 citations

Garry R. Cutting, Zhiwei Cai, Scott A. Houck, Veit, Gudio, David N. Sheppard +13 more

Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth

UNC Libraries(2020)10.17615/jx2b-sf27

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0DataRank · unranked

0 citations

Zhaokang Cheng, Joan M. Taylor, Christopher P. Mack, Douglas Cyr, Qiang Zhu +2 more

CHIP protects against cardiac pressure overload through regulation of AMPK

UNC Libraries(2020)10.17615/fmrs-8q20

N/A

0DataRank · unranked

0 citations

Pamela Lockyer, Chunlian Zhang, Carrie E. Rubel, Cam Patterson, Douglas Cyr +1 more

Quality Control Autophagy Degrades Soluble ERAD-Resistant Conformers of the Misfolded Membrane Protein GnRHR

UNC Libraries(2020)10.17615/2szj-9x86

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0DataRank · unranked

0 citations

Jo Ann Janovick, Douglas Cyr, Scott A. Houck, Michael P. Conlin, Jaclyn N. Bonner +3 more

Use of yeast as a system to study amyloid toxicity

UNC Libraries(2020)10.17615/vxak-ff80

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0DataRank · unranked

0 citations

Daniel W. Summers, Douglas Cyr

CHIP Is a U-box-dependent E3 Ubiquitin Ligase: IDENTIFICATION OF Hsc70 AS A TARGET FOR UBIQUITYLATION

UNC Libraries(2021)10.17615/cmep-zs62

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0DataRank · unranked

30 citations

Yaxu Wu, Douglas Cyr, Carol A. Ballinger, Cam Patterson, Jörg Höhfeld +2 more

Chaperone-dependent Regulation of Endothelial Nitric-oxide Synthase Intracellular Trafficking by the Co-chaperone/Ubiquitin Ligase CHIP

UNC Libraries(2021)10.17615/75r0-gb68

N/A

0DataRank · unranked

4 citations

William C. Sessa, Douglas Cyr, Cam Patterson, Jihong Jiang, Roger W. Babbitt

Regulation of the Cytoplasmic Quality Control Protein Degradation Pathway by BAG2

UNC Libraries(2021)10.17615/qrs7-yt69

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0DataRank · unranked

4 citations

David Huang, Hui Hua Li, Cam Patterson, Qian Dai, Shu Bing Qian +6 more

The Type I Hsp40 Zinc Finger-like Region Is Required for Hsp70 to Capture Non-native Polypeptides from Ydj1

UNC Libraries(2021)10.17615/wapj-et40

N/A

0DataRank · unranked

0 citations

Avrom J. Caplan, Chun Yang Fan, Paul Lee, Hong Yu Ren, Douglas Cyr

Chaperone Functions of the E3 Ubiquitin Ligase CHIP

UNC Libraries(2021)10.17615/1rth-0n05

N/A

0DataRank · unranked

0 citations

Cam Patterson, Meredith F.N. Rosser, Erin Washburn, Paul J. Muchowski, Douglas Cyr

Regulation of Hsp70 function by a eukaryotic DnaJ homolog

UNC Libraries(2021)10.17615/419e-2w83

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0DataRank · unranked

0 citations

Douglas Cyr, LU Xiang-yang, Michael G Douglas

Human Hsp70 and Hsp40 Chaperone Proteins Facilitate Human Papillomavirus-11 E1 Protein Binding to the Origin and Stimulate Cell-free DNA Replication

UNC Libraries(2021)10.17615/vzaw-r289

N/A

0DataRank · unranked

0 citations

Thomas R. Broker, Jen Sing Liu, Jack D. Griffith, Alexander M. Makhov, Louise T. Chow +2 more

J-domain protein chaperone circuits in proteostasis and disease

Trends in Cell Biology(2022)10.1016/j.tcb.2022.05.004

N/A

0DataRank · unranked

64 citations

Duccio Malinverni, Douglas Cyr, Paolo De Los Rios, Nadinath B. Nillegoda, Ruobing Zhang

DNAJB12 and Hsp70 Mediate Triage of Misfolded Membrane Proteins for Proteasomal versus Lysosomal Degradation

Autophagy Reports(2022)10.1080/27694127.2022.2139335

N/A

0DataRank · unranked

6 citations

Douglas Cyr, Andrew S. Kennedy

CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70

UNC Libraries(2020)10.17615/9h26-yj25

N/A

0DataRank · unranked

13 citations

Frank Boellmann, Holly McDonough, Cam Patterson, Douglas Cyr, Shu‐Bing Qian

DNAJB12 and Hsp70 triage arrested intermediates of N1303K-CFTR for endoplasmic reticulum-associated autophagy

UNC Libraries(2024)10.17615/h22d-zx50

N/A

0DataRank · unranked

0 citations

Andrew S. Kennedy, Suzanne Houck, Nancy L. Quinney, Hong Yu Ren, Scott H. Randell +6 more