Philip J. Kranzusch

Also affiliated with Dana-Farber Cancer Institute, Dana-Farber/Harvard Cancer Center, Weizmann Institute of Science

Immunology and MicrobiologyEnvironmental ScienceBiochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 43 papers. Top paper: “STING cyclic dinucleotide sensing originated in bacteria”.

STING cyclic dinucleotide sensing originated in bacteria

Nature(2020)10.1038/s41586-020-2719-5

N/A

0.898DataRank · unranked

397 citations

Apurva A. Govande, Adi Millman, Alexander F. A. Keszei, B. Lowey, Gal Ofir +4 more

Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity

Molecular Cell(2020)10.1016/j.molcel.2019.12.010

N/A

0.805DataRank · unranked

213 citations

Qiaozhen Ye, Erica A. Birkholz, Kyle R. Berg, Lucas Patel, Ian T. Mathews +10 more

cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing

Molecular Cell(2021)10.1016/j.molcel.2021.01.024

N/A

0.798DataRank · unranked

204 citations

Lisa Mohr, John Maciejowski, Philip J. Kranzusch, Wen Zhou

Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity

Nature(2022)10.1038/s41586-022-04716-y

N/A

0.791DataRank · unranked

194 citations

Tanita Wein, Allen Lu, Benjamin R. Morehouse, Julia A. Schnabel, Azita Leavitt +4 more

Viruses inhibit TIR gcADPR signalling to overcome bacterial defence

Nature(2022)10.1038/s41586-022-05375-9

N/A

0.767DataRank · unranked

165 citations

Erez Yirmiya, Gil Amitai, Allen Lu, Jeremy Garb, Ehud Herbst +7 more

Animal and bacterial viruses share conserved mechanisms of immune evasion

Cell(2024)10.1016/j.cell.2024.07.057

N/A

0.550DataRank · unranked

38 citations

Jason Nomburg, Jennifer A. Doudna, Philip J. Kranzusch, Samuel J. Hobbs

A large-scale type I CBASS antiphage screen identifies the phage prohead protease as a key determinant of immune activation and evasion

Cell Host & Microbe(2024)10.1016/j.chom.2024.05.021

N/A

0.483DataRank · unranked

24 citations

Samuel J. Hobbs, Jasmine M. Garcia, H. Toyoda, Jingjing Gao, Sichen Shao +3 more

Structural homology screens reveal host-derived poxvirus protein families impacting inflammasome activity

Cell Reports(2023)10.1016/j.celrep.2023.112878

N/A

0.464DataRank · unranked

21 citations

Alex G. Johnson, Meghan Quinlan, Philip J. Kranzusch, Nels C. Elde, Ian N. Boys

Mechanisms of HSV-1 helicase-primase inhibition and replication fork complex assembly

Cell(2025)10.1016/j.cell.2025.11.041

N/A

0.269DataRank · unranked

5 citations

Pradeep Sathyanarayana, Cong Liu, Joel M. J. Tan, Pan pan Yang, Biswajit Das +10 more

Three functionally distinct classes of cGAS proteins in nature revealed by self-DNA-induced interferon responses

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.03.09.483681

N/A

0.241DataRank · unranked

4 citations

Wen Zhou, Apurva A. Govande, Dustin C. Hancks, Philip J. Kranzusch, Jonathan C. Kagan +1 more

Editorial overview: Evolution of antiviral defense

Current Opinion in Microbiology(2023)10.1016/j.mib.2023.102352

N/A

0.165DataRank · unranked

2 citations

Philip J. Kranzusch

The virus-induced cyclic dinucleotide 2′3′-c-di-GMP mediates STING-dependent antiviral immunity in Drosophila

Immunity(2023)10.1016/j.immuni.2023.08.006

N/A

0DataRank · unranked

62 citations

Lihua Li, Kailey M. Slavik, Jingxian Huang, Ting Yin, Xianlong Ai +15 more

Species-specific self-DNA detection mechanisms by mammalian cyclic GMP-AMP synthases

Science Immunology(2023)10.1126/sciimmunol.abp9765

N/A

0DataRank · unranked

18 citations

Stephanie N. Kennedy, Kristin M. Bahleda, Kailey M. Slavik, Wen Zhou, Apurva A. Govande +4 more

Bacterial SEAL domains undergo autoproteolysis and function in regulated intramembrane proteolysis

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2310862120

N/A

0DataRank · unranked

12 citations

Cameron Habib, Samuel J. Hobbs, Philip J. Kranzusch, David Z. Rudner, Anna P. Brogan

Viral sponges sequester nucleotide signals to inactivate immunity

Trends in Microbiology(2023)10.1016/j.tim.2023.04.004

N/A

0DataRank · unranked

2 citations

Philip J. Kranzusch, Desmond Richmond-Buccola

CARD-like domains mediate anti-phage defense in bacterial gasdermin systems

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.28.542683

N/A

0DataRank · unranked

25 citations

Alex G. Johnson, Adi Millman, Katharina Lange, Erez Yirmiya, Romi Hadary +6 more

Structural basis of Gabija anti-phage defense and viral immune evasion

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.01.538945

N/A

0DataRank · unranked

10 citations

Alex G. Johnson, Sarah E. Mooney, Azita Leavitt, Megan L. Mayer, Erez Yirmiya +4 more

cGLRs are a diverse family of pattern recognition receptors in animal innate immunity

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.22.529553

N/A

0DataRank · unranked

9 citations

Kailey M. Slavik, Benjamin R. Morehouse, Carina C. de Oliveira Mann, Kepler Mears, Jingjing Liu +4 more

Structure and assembly of a bacterial gasdermin pore

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.20.537723

N/A

0DataRank · unranked

7 citations

Megan L. Mayer, Stefan L. Schaefer, Nora K. McNamara-Bordewick, Gerhard Hummer, Philip J. Kranzusch +1 more

Convergent mutations in phage virion assembly proteins enable evasion of Type I CBASS immunity

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.21.541620

N/A

0DataRank · unranked

4 citations

Samuel J. Hobbs, Jasmine M. Garcia, H. Toyoda, Jingjing Gao, Sichen Shao +3 more

Structural homology screens reveal poxvirus-encoded proteins impacting inflammasome-mediated defenses

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.26.529821

N/A

0DataRank · unranked

2 citations

Alex G. Johnson, Meghan Quinlan, Philip J. Kranzusch, Nels C. Elde, Ian N. Boys

Nucleotide Immune Signaling in CBASS, Pycsar, Thoeris, and CRISPR Antiphage Defense

Annual Review of Microbiology(2024)10.1146/annurev-micro-041222-024843

N/A

0DataRank · unranked

59 citations

Philip J. Kranzusch, Samuel J. Hobbs

Structure and assembly of a bacterial gasdermin pore

Nature(2024)10.1038/s41586-024-07216-3

N/A

0DataRank · unranked

41 citations

Megan L. Mayer, Stefan L. Schaefer, Nora K. McNamara-Bordewick, Gerhard Hummer, Philip J. Kranzusch +1 more

Tracing the evolutionary origins of antiviral immunity

PLoS Biology(2024)10.1371/journal.pbio.3002481

N/A

0DataRank · unranked

5 citations

Philip J. Kranzusch, James B. Eaglesham

A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.12.30.630793

N/A

0DataRank · unranked

6 citations

H. Toyoda, Samuel J. Hobbs, Desmond Richmond-Buccola, Tanita Wein, Nils Burger +4 more

Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.04.22.590513

N/A

0DataRank · unranked

2 citations

Lydia M. Arnold, Jordan A. Powers, D McCann, Ana B. Rowe, Devin E. Christensen +8 more

CARD domains mediate anti-phage defence in bacterial gasdermin systems

Nature(2025)10.1038/s41586-024-08498-3

N/A

0DataRank · unranked

31 citations

Adi Millman, Kathrin Lange, Erez Yirmiya, Romi Hadary, Jeremy Garb +8 more

Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS immune sensing

PLoS Pathogens(2025)10.1371/journal.ppat.1012206

N/A

0DataRank · unranked

12 citations

Lydia M. Arnold, Jordan A. Powers, D McCann, Ana B. Rowe, Devin E. Christensen +8 more

A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense

Molecular Cell(2025)10.1016/j.molcel.2025.07.016

N/A

0DataRank · unranked

12 citations

Hunter C. Toyoda, Samuel J. Hobbs, Romi Hadary, Desmond Richmond-Buccola, Tanita Wein +6 more

Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity

Science(2025)10.1126/science.adx6053

N/A

0DataRank · unranked

4 citations

Patrick Pfaff, Joao A. Paulo, Steven P. Gygi, Kevan M. Shokat, Philip J. Kranzusch +1 more

Activating and inhibiting nucleotide signals coordinate bacterial anti-phage defense

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.07.09.663793

N/A

0DataRank · unranked

1 citations

Samantha G. Fernandez, Douglas R. Wassarman, Marlen Lüders, Frank Schwede, Philip J. Kranzusch +1 more

A choanoflagellate cGLR-STING pathway reveals evolutionary links between bacterial and animal immunity

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.09.04.674280

N/A

0DataRank · unranked

0 citations

H. Toyoda, Samantha G. Fernandez, Bianca Tiwari, Collin McNairy, Arielle Woznica +2 more

Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.09.30.678621

N/A

0DataRank · unranked

0 citations

Aidan B. Hill, Richard Han, Jasmine M. Garcia, Hugo Bisio, Chantal Abergel +3 more

CBASS Immunity Uses CARF-Related Effectors to Sense 3′–5′- and 2′–5′-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection

Cell(2020)10.1016/j.cell.2020.05.019

N/A

0DataRank · unranked

252 citations

Aaron T. Whiteley, Alexander F. A. Keszei, Benjamin R. Morehouse, Ian T. Mathews, Sadie P. Antine +10 more

A novel STING1 variant causes a recessive form of STING-associated vasculopathy with onset in infancy (SAVI)

Journal of Allergy and Clinical Immunology(2020)10.1016/j.jaci.2020.06.032

N/A

0DataRank · unranked

81 citations

Roberta Berard, A. A. Rasheed, Buthaina Al‐Adba, Philip J. Kranzusch, Maggie Henderlight +9 more

Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host–pathogen conflict

eLife(2020)10.7554/elife.59753

N/A

0DataRank · unranked

63 citations

Kacie L McCarty, Philip J. Kranzusch, James B. Eaglesham

cGAS-like receptors sense RNA and control 3′2′-cGAMP signalling in Drosophila

Nature(2021)10.1038/s41586-021-03743-5

N/A

0DataRank · unranked

192 citations

Benjamin R. Morehouse, Adelyn E. Ragucci, Wen Zhou, Xianlong Ai, Yuqiang Chen +10 more

Cryo-EM structure of an active bacterial TIR–STING filament complex

Nature(2022)10.1038/s41586-022-04999-1

N/A

0DataRank · unranked

126 citations

Matthew C. J. Yip, Alexander F. A. Keszei, Nora K. McNamara-Bordewick, Sichen Shao, Philip J. Kranzusch +1 more

Structural basis of human TREX1 DNA degradation and autoimmune disease

Nature Communications(2022)10.1038/s41467-022-32055-z

N/A

0DataRank · unranked

53 citations

Desmond Richmond-Buccola, Qiannan Wang, Philip J. Kranzusch, Wen Zhou

Viruses inhibit TIR gcADPR signaling to overcome bacterial defense

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.05.03.490397

N/A

0DataRank · unranked

12 citations

Erez Yirmiya, Gil Amitai, Allen Lu, Jeremy Garb, Benjamin R. Morehouse +4 more

Structural basis of Gabija anti-phage defence and viral immune evasion

Nature(2023)10.1038/s41586-023-06855-2

N/A

0DataRank · unranked

119 citations

Alex G. Johnson, Sarah E. Mooney, Azita Leavitt, Megan L. Mayer, Erez Yirmiya +4 more

cGLRs are a diverse family of pattern recognition receptors in innate immunity

Cell(2023)10.1016/j.cell.2023.05.038

N/A

0DataRank · unranked

108 citations

Kailey M. Slavik, Hunter C. Toyoda, Benjamin R. Morehouse, Carina C. de Oliveira Mann, Anamaria Elek +11 more

CBASS to cGAS-STING: The Origins and Mechanisms of Nucleotide Second Messenger Immune Signaling

Annual Review of Virology(2023)10.1146/annurev-virology-111821-115636

N/A

0DataRank · unranked

76 citations

Philip J. Kranzusch, Kailey M. Slavik