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cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing

Molecular Cell(2021)10.1016/j.molcel.2021.01.024Source: DataRank Database

cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing is a research paper published in Molecular Cell (2021). On theSindex it has a DataRank of 0. It has been cited 201 times.

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Open Access201 citations

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Enrichment:Funding (16 grants)OA: bronzeTopics (32)IDs (PubMed, PMC)Annotations (1)SDGs (1)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (4)

Lisa Mohr ORCID,John Maciejowski ORCID,Philip J. Kranzusch ORCID,Wen Zhou ORCID

Live enrichment

PubMed:33606975 PMC:PMC7899126

NCI NIH HHS

Grant: R00 CA212290

NCI NIH HHS

Grant: P30 CA008748

National Institutes of Health

Grant: 2P30CA008748-43

MOUSE GENETICS

National Institutes of Health

Grant: 3P30GM124165-03S1

NE-CAT: A Resource for Advanced Macromolecular Crystallography

National Institutes of Health

Grant: 1S10OD021527-01

Pixel Array Detector for Macromolecular Crystallography

National Institutes of Health

Grant: 5R00CA212290-04

The origins of chromosome rearrangement in the cancer genome

Cancer Research Institute

Charles A. King Trust

National Institutes of Health

Parker Institute for Cancer Immunotherapy

Concern Foundation

Charles H. Hood Foundation

V Foundation for Cancer Research

National Cancer Institute

Geoffrey Beene Cancer Research Center

Richard and Susan Smith Family Foundation

bronzeLicense: Elsevier Non-Commercial

publisherhttp://www.cell.com/article/S1097276521000447/pdf

publisherhttps://api.elsevier.com/content/article/PII:S1097276521000447?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1097276521000447?httpAccept=text/plain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7899126

https://doi.org/10.1016/j.molcel.2021.01.024

Fields of Study

0301 basic medicine03 medical and health sciences

MeSH Terms

Cell Line, TumorCytosolHumansAutoimmune Diseases of the Nervous SystemNervous System MalformationsExodeoxyribonucleasesNucleotidyltransferasesPhosphoproteinsDNAMutationCatalysisHEK293 CellsCyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase

Keywords

Phase separationinnate immunityTrex1CgasDNACyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseNervous System MalformationsPhosphoproteinsNucleotidyltransferasesCatalysisAutoimmune Diseases of the Nervous SystemCytosolExodeoxyribonucleasesHEK293 CellsCell Line, TumorMutationHumans

Sustainable Development Goals

SDG 3: 3. Good health