Timothy Palzkill

Biochemistry, Genetics and Molecular BiologyMedicineMaterials Science

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 28 papers. Top paper: “A drug-resistant β-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency”.

A drug-resistant β-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency

Journal of Biological Chemistry(2020)10.1074/jbc.ra120.016103

N/A

0.918DataRank · unranked

21 citations

Shuo Lu, Liya Hu, Allison Judge, Banumathi Sankaran, B. V. Venkataram Prasad +2 more

Network of epistatic interactions in an enzyme active site revealed by large-scale deep mutational scanning

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2313513121

N/A

0.538DataRank · unranked

35 citations

Banumathi Sankaran, Liya Hu, Murugesan Palaniappan, André Birgy, B. V. Venkataram Prasad +2 more

Conformational flexibility is a critical factor in designing broad-spectrum human norovirus protease inhibitors

Journal of Virology(2025)10.1128/jvi.01757-24

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0.165DataRank · unranked

2 citations

Boyang Zhao, Neetu Neetu, Banumathi Sankaran, Ketki Patil, Sasirekha Ramani +5 more

Modulating the rate of fibrin formation and clot structure attenuates microvascular thrombosis in systemic inflammation

Blood Advances(2020)10.1182/bloodadvances.2020001500

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0DataRank · unranked

26 citations

Marina Martinez-Vargas, Nitin S. Sekhar, Fong Lam, Cameron A. Brown, Timothy Palzkill +7 more

DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 M pro inhibitors

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2111172118

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0DataRank · unranked

60 citations

Shuo Lu, Melek N. Ucisik, Kurt M. Bohren, Ying‐Chu Chen, Huang-Chi Du +18 more

Mechanistic Basis of OXA-48-like β-Lactamases’ Hydrolysis of Carbapenems

ACS Infectious Diseases(2021)10.1021/acsinfecdis.0c00798

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0DataRank · unranked

43 citations

Liya Hu, Banumathi Sankaran, Feng Wang, Peng Tao, B. V. Venkataram Prasad +2 more

Local interactions with the Glu166 base and the conformation of an active site loop play key roles in carbapenem hydrolysis by the KPC-2 β-lactamase

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100799

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0DataRank · unranked

23 citations

Shrenik Mehta, Banumathi Sankaran, Liya Hu, B. V. Venkataram Prasad, Timothy Palzkill +1 more

QM/MM modeling of class A β-lactamases reveals distinct acylation pathways for ampicillin and cefalexin

Organic & Biomolecular Chemistry(2021)10.1039/d1ob01593a

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0DataRank · unranked

7 citations

Francesco Trozzi, Timothy Palzkill, Peng Tao, Zilin Song

Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48

ACS Infectious Diseases(2021)10.1021/acsinfecdis.1c00501

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0DataRank · unranked

6 citations

Justin L. Anglin, Liya Hu, Lingfei Wang, Banumathi Sankaran, Jin Wang +4 more

An active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M β-lactamase drug-resistance enzymes

Nature Communications(2022)10.1038/s41467-022-34564-3

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0DataRank · unranked

21 citations

Liya Hu, Hanfeng Lin, Allison Judge, Paola Rivera, Murugesan Palaniappan +5 more

Unveiling the structural features that regulate carbapenem deacylation in KPC-2 through QM/MM and interpretable machine learning

Physical Chemistry Chemical Physics(2022)10.1039/d2cp03724f

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0DataRank · unranked

7 citations

Zilin Song, Hao Tian, Timothy Palzkill, Peng Tao, Chao Yin

Slow Protein Dynamics Elicits New Enzymatic Functions by Means of Epistatic Interactions

Molecular Biology and Evolution(2022)10.1093/molbev/msac194

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0DataRank · unranked

12 citations

Timothy Palzkill, Fábio C. L. Almeida, Alejandro J. Vila, María-Agustina Rossi

Consensus on β-Lactamase Nomenclature

Antimicrobial Agents and Chemotherapy(2022)10.1128/aac.00333-22

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0DataRank · unranked

32 citations

Robert A. Bonomo, Karen Bush, Alessandra Carattoli, Michael Feldgarden, Daniel H. Haft +9 more

Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.06.07.494873

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0DataRank · unranked

8 citations

Tugba Ozturk, Carter N. Abbott, Christina Nnabuife, Jennifer M. Colquhoun, Sarah W. Satola +4 more

Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.105493

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0DataRank · unranked

21 citations

Hanfeng Lin, Liya Hu, Neetu Neetu, Banumathi Sankaran, Jin Wang +3 more

Structural biology of MCR-1-mediated resistance to polymyxin antibiotics

Current Opinion in Structural Biology(2023)10.1016/j.sbi.2023.102647

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0DataRank · unranked

17 citations

Timothy Palzkill, Isabel C. Materon

Mapping the determinants of catalysis and substrate specificity of the antibiotic resistance enzyme CTX-M β-lactamase

Communications Biology(2023)10.1038/s42003-023-04422-z

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0DataRank · unranked

21 citations

Liya Hu, Banumathi Sankaran, Justin Van Riper, B. V. Venkataram Prasad, Timothy Palzkill +1 more

DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors

Communications Chemistry(2023)10.1038/s42004-023-00961-y

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0DataRank · unranked

17 citations

Srinivas Chamakuri, Shuo Lu, Melek N. Ucisik, Peng‐Jen Chen, Kurt M. Bohren +19 more

Mapping human norovirus antigens during infection reveals the breadth of the humoral immune response

npj Vaccines(2023)10.1038/s41541-023-00683-1

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0DataRank · unranked

10 citations

Wanzhi Huang, Frederick H. Neill, Mary K. Estes, Robert L. Atmar, Timothy Palzkill +1 more

Exploiting the Carboxylate-Binding Pocket of β-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c01834

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0DataRank · unranked

8 citations

Jiayi Fan, Srinivas Chamakuri, Murugesan Palaniappan, Kiran Sharma, Xuan Qin +10 more

Mutagenesis and structural analysis reveal the CTX-M β-lactamase active site is optimized for cephalosporin catalysis and drug resistance

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.104630

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0DataRank · unranked

6 citations

Miranda M. Montoya, Liya Hu, Neetu Neetu, Banumathi Sankaran, B. V. Venkataram Prasad +2 more

The mechanism of ceftazidime and cefiderocol hydrolysis by D179Y variants of KPC carbapenemases is similar and involves the formation of a long-lived covalent intermediate

Antimicrobial Agents and Chemotherapy(2024)10.1128/aac.01108-23

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0DataRank · unranked

24 citations

Christina Nnabuife, Timothy Palzkill, André Birgy

Conformational flexibility is a critical factor in designing broad-spectrum human norovirus protease inhibitors

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.09.16.613336

N/A

0DataRank · unranked

1 citations

Boyang Zhao, Neetu Neetu, Banumathi Sankaran, Ketki Patil, Sasirekha Ramani +5 more

Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline

Nature Communications(2025)10.1038/s41467-025-60828-9

N/A

0DataRank · unranked

12 citations

Tugba Ozturk, Carter N. Abbott, Christina Nnabuife, Jennifer M. Colquhoun, Sarah W. Satola +4 more

KPC-2 β-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate

Journal of Biological Chemistry(2020)10.1074/jbc.ra120.015050

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0DataRank · unranked

40 citations

I. Furey, O.A. Pemberton, David M. Boragine, Yu Chen, Timothy Palzkill +1 more

A β-lactamase inhibitory protein mutant displays high potency and a broad inhibition profile due to an altered binding mode with β-lactamases

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110850

N/A

0DataRank · unranked

0 citations

Shuo Lu, Dignite Ngango, Banumathi Sankaran, B. V. Venkataram Prasad, Timothy Palzkill +1 more

Streptococcus pyogenes genes that promote pharyngitis in primates

JCI Insight(2020)10.1172/jci.insight.137686

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0DataRank · unranked

21 citations

Randall J. Olsen, Stephen B. Beres, Matthew Ojeda Saavedra, Samantha L. Kubiak, Concepcion Cantu +8 more

The vimentin rod domain blocks P-selectin-P-selectin glycoprotein ligand 1 interactions to attenuate leukocyte adhesion to inflamed endothelium

PLoS ONE(2020)10.1371/journal.pone.0240164

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0DataRank · unranked

14 citations

Cameron A. Brown, Christian Valladolid, Dabel Cynthia Emebo, Timothy Palzkill, Miguel A. Crúz +1 more