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A β-lactamase inhibitory protein mutant displays high potency and a broad inhibition profile due to an altered binding mode with β-lactamases

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110850Source: DataRank Database

A β-lactamase inhibitory protein mutant displays high potency and a broad inhibition profile due to an altered binding mode with β-lactamases is a research paper published in Journal of Biological Chemistry (2025). On theSindex it has a DataRank of 0.

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Enrichment:Funding (6 grants)Impact (FWCI 0.00)OA: goldTopics (36)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Shuo Lu ORCID,Dignite Ngango,Banumathi Sankaran ORCID,B. V. Venkataram Prasad ORCID,Timothy Palzkill ORCID

Live enrichment

PubMed:41135675 PMC:PMC12666564 OpenAlex:https://openalex.org/W4415460149

US Department of Energy Office of Science

Grant: DE-AC02-05CH11231

National Institute of Allergy and Infectious Diseases

Grant: AI32956

National Institute of General Medical Sciences

Grant: P30 GM124169-01

NIAID NIH HHS

Grant: R01 AI032956

NIGMS NIH HHS

Grant: P30 GM124169

National Institutes of Health

FWCI

0.00

Citation Percentile

0.2%

goldLicense: http://creativecommons.org/licenses/by-nc-nd/4.0/

journalhttps://doi.org/10.1016/j.jbc.2025.110850

publisherhttps://doi.org/10.1016/j.jbc.2025.110850

publisherhttps://api.elsevier.com/content/article/PII:S0021925825027024?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925825027024?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41135675

Fields of Study

Antibiotic Resistance in BacteriaEnzyme Structure and FunctionBacterial Genetics and Biotechnologybeta-Lactamasesbeta-Lactamase InhibitorsBacterial ProteinsProtein BindingCrystallography, X-RayMutationEscherichia coliAmino Acid Substitution

MeSH Terms

Bacterial Proteinsbeta-LactamasesEscherichia coliMutationProtein BindingCrystallography, X-RayAmino Acid Substitutionbeta-Lactamase Inhibitors

Keywords

MutantActive siteBinding siteEnzymePlasma protein bindingMutationInhibitor proteinInhibitory postsynaptic potentialProtein structureAntibioticsProtein conformationEnzyme kineticsX-ray crystallographyAntibiotic Resistanceenzyme inhibitorBeta-lactamaseProtein–protein Interaction

A β-lactamase inhibitory protein mutant displays high potency and a broad inhibition profile due to an altered binding mode with β-lactamases

FAIR Checklist

Authors (6)

Funding (6 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)