Christophe Morisseau

Also affiliated with Comprehensive Blood & Cancer Center, Sylvester Comprehensive Cancer Center, U-M Rogel Cancer Center, UC Davis Comprehensive Cancer Center, University of California, Davis

Biochemistry, Genetics and Molecular BiologyMedicinePharmacology, Toxicology and PharmaceuticsChemistry

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 47 papers. Top paper: “Microbial biotherapeutic metabolite alleviates liver injury by restoring hepatic lipid metabolism through PPARα across the gut-liver axis”.

Microbial biotherapeutic metabolite alleviates liver injury by restoring hepatic lipid metabolism through PPARα across the gut-liver axis

mBio(2025)10.1128/mbio.01718-25

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0.439DataRank · unranked

12 citations

Weicang Wang, Ikaika Christian Loque, Chara J. Walters-Laird, Christophe Morisseau, Xiaoyue Xiao +6 more

Development of potent inhibitors of the human microsomal epoxide hydrolase

European Journal of Medicinal Chemistry(2020)10.1016/j.ejmech.2020.112206

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10 citations

Nalin Singh, Sophie Négrel, Yue Zhang, Damien Magis, Capucine Roux +7 more

Soluble Epoxide Hydrolase Inhibition by t-TUCB Promotes Brown Adipogenesis and Reduces Serum Triglycerides in Diet-Induced Obesity

International Journal of Molecular Sciences(2020)10.3390/ijms21197039

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12 citations

Yang Yang, Xinyun Xu, Katherine Graham, Kelsey Hildreth, Sue In Choi +8 more

Soluble epoxide hydrolase inhibitor, TPPU, increases regulatory T cells pathway in an arthritis model

The FASEB Journal(2020)10.1096/fj.202000415r

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44 citations

Juliana Trindade Clemente‐Napimoga, Henrique Ballassini Abdalla, Sergio Marcolino Rosa, Carlos Ueira‐Vieira, Christophe Morisseau +5 more

Preparation and evaluation of soluble epoxide hydrolase inhibitors with improved physical properties and potencies for treating diabetic neuropathic pain

Bioorganic & Medicinal Chemistry(2020)10.1016/j.bmc.2020.115735

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31 citations

Jen C. Ng, Jun Yang, Sung‐Hee Hwang, Christophe Morisseau, Karen Wagner +2 more

Relative Importance of Soluble and Microsomal Epoxide Hydrolases for the Hydrolysis of Epoxy-Fatty Acids in Human Tissues

International Journal of Molecular Sciences(2021)10.3390/ijms22094993

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36 citations

Sean D. Kodani, Shizuo G. Kamita, Jun Yang, Kin Sing Stephen Lee, Bruce D. Hammock +1 more

Adrenic Acid-Derived Epoxy Fatty Acids Are Naturally Occurring Lipids and Their Methyl Ester Prodrug Reduces Endoplasmic Reticulum Stress and Inflammatory Pain

ACS Omega(2021)10.1021/acsomega.1c00241

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30 citations

Bogdan Barnych, Karen Wagner, Debin Wan, Christophe Morisseau, Bruce D. Hammock +1 more

EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence

eLife(2021)10.7554/elife.68445

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29 citations

Christophe Morisseau, Wendy K. Chung, Jamila Zammouri, Martine Auclair, Geneviève Baujat +12 more

Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors

Bioorganic & Medicinal Chemistry(2021)10.1016/j.bmc.2021.116507

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25 citations

Sean D. Kodani, Leah Valencia, P. K. Hudson, Stephanie Sanchez, Taylor Quintana +5 more

Discovery of memantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopolysaccharide-induced sepsis

European Journal of Medicinal Chemistry(2021)10.1016/j.ejmech.2021.113678

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21 citations

Wenjiao Sun, Christophe Morisseau, Bruce D. Hammock, Xuefei Bao, Qiu Liu +8 more

Differential Effects of 17,18-EEQ and 19,20-EDP Combined with Soluble Epoxide Hydrolase Inhibitor t-TUCB on Diet-Induced Obesity in Mice

International Journal of Molecular Sciences(2021)10.3390/ijms22158267

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14 citations

Xinyun Xu, Haoying Wu, Jun Yang, Jiangang Chen, Christophe Morisseau +4 more

Genetic deficiency or pharmacological inhibition of soluble epoxide hydrolase ameliorates high fat diet-induced pancreatic β-cell dysfunction and loss

Free Radical Biology and Medicine(2021)10.1016/j.freeradbiomed.2021.05.029

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7 citations

Ming-Fo Hsu, Ahmed Bettaieb, Bryan Chu, Naoki Matsumoto, Christophe Morisseau +5 more

Activity of sEH and Oxidant Status during Systemic Bovine Coliform Mastitis

Antioxidants(2021)10.3390/antiox10050812

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10 citations

Matthew J. Kuhn, Angel Abuelo, Christophe Morisseau, Bruce D. Hammock, Lorraine M. Sordillo +1 more

New Alkoxy- Analogues of Epoxyeicosatrienoic Acids Attenuate Cisplatin Nephrotoxicity In Vitro via Reduction of Mitochondrial Dysfunction, Oxidative Stress, Mitogen-Activated Protein Kinase Signaling, and Caspase Activation

Chemical Research in Toxicology(2021)10.1021/acs.chemrestox.1c00347

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6 citations

Anders Vik, Daniel B. Lybrand, Christophe Morisseau, Bruce D. Hammock, Nalin Singh

Species Differences in Metabolism of Soluble Epoxide Hydrolase Inhibitor, EC1728, Highlight the Importance of Clinically Relevant Screening Mechanisms in Drug Development

Molecules(2021)10.3390/molecules26165034

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6 citations

Jun Yang, Alonso Guedes, Christophe Morisseau, R Moruno García, Heather K. Knych +6 more

Adenosine A 2A Receptor and Vascular Response: Role of Soluble Epoxide Hydrolase, Adenosine A 1 Receptor and Angiotensin‐II

The FASEB Journal(2021)10.1096/fasebj.2021.35.s1.02369

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1 citations

Ahmed Hanif, Catherine Ledent, Stephen L. Tilley, Christophe Morisseau, Hana A. Itani +1 more

CRISPR/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury

Journal of Advanced Research(2022)10.1016/j.jare.2022.03.004

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21 citations

Thomas Duflot, Séverine Ménoret, Hind Messaoudi, Zoubir Djerada, Déborah Groussard +39 more

The Role of Hydrolases in Biology and Xenobiotics Metabolism

International Journal of Molecular Sciences(2022)10.3390/ijms23094870

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19 citations

Christophe Morisseau

Structure-activity relationship studies of benzothiazole-phenyl analogs as multi-target ligands to alleviate pain without affecting normal behavior

Prostaglandins & Other Lipid Mediators(2022)10.1016/j.prostaglandins.2022.106702

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17 citations

Xiaohui Weng, Aleksei Solomatov, Christopher R. Chin, Alyssa Fernandez, P. K. Hudson +5 more

Aflatoxin B1 exposure disrupts the intestinal immune function via a soluble epoxide hydrolase-mediated manner

Ecotoxicology and Environmental Safety(2022)10.1016/j.ecoenv.2022.114417

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16 citations

Yuxin Wang, Jun Yang, Karen Wagner, Sung Hee Hwang, Jeff Cheng +7 more

Improved ELISA for linoleate-derived diols in human plasma utilizing a polyHRP-based secondary tracer

Analytical Methods(2022)10.1039/d2ay00272h

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5 citations

Dongyang Li, Cindy B. McReynolds, Christophe Morisseau, Bruce D. Hammock, Nalin Singh

Soluble Epoxide Hydrolase Is Associated with Postprandial Anxiety Decrease in Healthy Adult Women

International Journal of Molecular Sciences(2022)10.3390/ijms231911798

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3 citations

Christophe Morisseau, Dongyang Li, Jun Yang, Eileen Lam, D. Blake Woodside +3 more

PROTAC-mediated selective degradation of cytosolic soluble epoxide hydrolase enhances ER-stress reduction

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.01.20.477134

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0 citations

Christophe Morisseau, Akihiro Takamura, Debin Wan, Dongyang Li, Simone Sidoli +5 more

Mix-and-Read Nanobody-Based Sandwich Homogeneous Split-Luciferase Assay for the Rapid Detection of Human Soluble Epoxide Hydrolase

Analytical Chemistry(2023)10.1021/acs.analchem.3c00079

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15 citations

Mark R. McCoy, Huiyi Yang, Mingxia Lin, Xiping Cui, Suqing Zhao +4 more

Novel inhibition of AKR1C3 and androgen receptor axis by PTUPB synergizes enzalutamide treatment in advanced prostate cancer

Oncogene(2023)10.1038/s41388-022-02566-6

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21 citations

Pengfei Xu, Shu Ning, Logan J. Wasielewski, Hans Adomat, Sung Hee Hwang +9 more

Soluble Epoxide Hydrolase Contributes to Cell Senescence and ER Stress in Aging Mice Colon

International Journal of Molecular Sciences(2023)10.3390/ijms24054570

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16 citations

Karen Wagner, Yuxin Wang, Nalin Singh, Jun Yang, Qiyi He +3 more

Aflatoxin B1 Increases Soluble Epoxide Hydrolase in the Brain and Induces Neuroinflammation and Dopaminergic Neurotoxicity

International Journal of Molecular Sciences(2023)10.3390/ijms24129938

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16 citations

Yuxin Wang, Karen Wagner, Ruth D. Lee, Sung Hee Hwang, Christophe Morisseau +3 more

Soluble epoxide hydrolase-targeting PROTAC activates AMPK and inhibits endoplasmic reticulum stress

Biomedicine & Pharmacotherapy(2023)10.1016/j.biopha.2023.115667

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15 citations

Emma Barroso, Andreea L. Turcu, Francesc Estrany, Dáire Smith, Javier Jurado-Aguilar +9 more

PROTAC-Mediated Selective Degradation of Cytosolic Soluble Epoxide Hydrolase Enhances ER Stress Reduction

ACS Chemical Biology(2023)10.1021/acschembio.3c00017

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12 citations

Christophe Morisseau, Akihiro Takamura, Debin Wan, Dongyang Li, Simone Sidoli +5 more

Neuroprotective effect of herbal extracts inhibiting soluble epoxide hydrolase (sEH) and cyclooxygenase (COX) against chemotherapy-induced cognitive impairment in mice

Biochemical and Biophysical Research Communications(2023)10.1016/j.bbrc.2023.05.008

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7 citations

Richa Mehta, Sumanta Goswami, Bruce D. Hammock, Christophe Morisseau, Sung Hee Hwang +5 more

The Generation of a Nanobody-Based ELISA for Human Microsomal Epoxide Hydrolase

International Journal of Molecular Sciences(2023)10.3390/ijms241914698

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5 citations

Mark R. McCoy, Qi Meng, Christophe Morisseau, Huiyi Yang, Chengpeng Xu +5 more

Effects of Individual Circulating FFAs on Plasma and Hepatic FFA Epoxides, Diols, and Epoxide-Diol Ratios as Indices of Soluble Epoxide Hydrolase Activity

International Journal of Molecular Sciences(2023)10.3390/ijms241310760

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2 citations

Jun Yang, Christophe Morisseau, Qiyi He, Bruce D. Hammock, Jang H. Youn +1 more

Data from Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo

(2023)10.1158/1535-7163.c.6532113

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0 citations

See‐Hyoung Park, Christophe Morisseau, Sung Hee Hwang, Bruce D. Hammock, Robert H. Weiss +1 more

Quinolinyl-based multitarget-directed ligands with soluble epoxide hydrolase and fatty acid amide hydrolase inhibitory activities: Synthetic studies and pharmacological evaluations

Heliyon(2024)10.1016/j.heliyon.2024.e32262

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14 citations

Leah Duong, Faye Yun, Anesa Mesic, Cassandra Yuan, Daniel F. Carr +7 more

Microglial pro-inflammatory mechanisms induced by monomeric C-reactive protein are counteracted by soluble epoxide hydrolase inhibitors

International Immunopharmacology(2025)10.1016/j.intimp.2025.114644

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7 citations

Kristijan Vuraić, Yi Yuan, Sandra Codony, Haydeé Valdés-Quiroz, Carmen Casal +11 more

Preclinical Evaluation of Soluble Epoxide Hydrolase Inhibitor AMHDU against Neuropathic Pain

International Journal of Molecular Sciences(2024)10.3390/ijms25168841

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5 citations

Natalya V. Eliseeva, Kristina I. Adzhienko, Viktoria Bagmetova, Д. В. Данилов, Cynthia B. McReynolds +4 more

4-Phenyl-thiazole-based dual inhibitors of fatty acid amide hydrolase and soluble epoxide hydrolase do not alleviate orofacial inflammatory pain in female rats

BBA Advances(2024)10.1016/j.bbadva.2024.100119

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7 citations

Christopher R. Chin, Tiffany Chacon, Monijeh Khoja Herawi, Michael Gonzalez, Ryan M. West +5 more

Effects of sEH inhibition on the eicosanoid and cytokine storms in SARS‐CoV ‐2‐infected mice

The FASEB Journal(2024)10.1096/fj.202302202rr

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5 citations

Artiom Gruzdev, Joan P. Graves, Fred B. Lih, Christophe Morisseau, James M. Ward +4 more

In Vivo -Active Soluble Epoxide Hydrolase-Targeting PROTACs with Improved Potency and Stability

ACS Medicinal Chemistry Letters(2024)10.1021/acsmedchemlett.4c00357

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5 citations

Christophe Morisseau, Presley Dowker-Key, Gabrielle Benitez, Jennifer T. Aguilan, Emiko Nagai +6 more

Inhibition of Soluble Epoxide Hydrolase Ameliorates Cerebral Blood Flow Autoregulation and Cognition in Alzheimer’s Disease and Diabetes-Related Dementia Rat Models

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.08.30.610540

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3 citations

Jane J. Border, Huawei Zhang, Andrew Gregory, Shan Bai, Xing Fang +21 more

Structure-activity relationship studies and pharmacological evaluation of 4-phenylthiazoles as dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors

Bioorganic & Medicinal Chemistry(2025)10.1016/j.bmc.2025.118112

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9 citations

Amanda Tsang, Manuel Berumen, Adriana Rodríguez, Faye Yun, Anesa Mesic +11 more

Polynitrogen-containing compounds as multi-target sEH/FAAH inhibitors: Structure-activity relationship and pharmacological studies

Bioorganic & Medicinal Chemistry(2025)10.1016/j.bmc.2025.118495

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2 citations

Cassandra Yuan, Manuel Berumen, Leah Duong, Karen Rocío Plata-Gómez, Shelby Seely +13 more

Dimethoxybenzohomoadamantane-based soluble epoxide hydrolase inhibitors: in vivo efficacy in a murine model of chemotherapy-induced neuropathic pain

Journal of Enzyme Inhibition and Medicinal Chemistry(2025)10.1080/14756366.2025.2574990

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0DataRank · unranked

1 citations

Beatrice Jora, Miriam Santos-Caballero, Qiongju Qiu, Carla Calvó‐Tusell, Celia Escriche +21 more

Synthesis and evaluation of isoquinolinyl and pyridinyl-based dual inhibitors of fatty acid amide hydrolase and soluble epoxide hydrolase to alleviate orofacial hyperalgesia in the rat

Biochemistry and Biophysics Reports(2025)10.1016/j.bbrep.2025.102009

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1 citations

Siena Gunari, Gabrielle Gorostiza, Madison Mercado, Lucy Pavana, Leah Duong +9 more

Dual Inhibition of sEH and COX-2 Improved Cognition in Alzheimer’s Disease via Enhanced Myogenic Response and Cerebral Artery Distensibility

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.21.669945

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2 citations

Andrew Gregory, Chengyun Tang, Sung Hee Hwang, Jane J. Border, Jing Xu +20 more

Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer's Disease

Neurotherapeutics(2020)10.1007/s13311-020-00854-1

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88 citations

Sandra Codony, Eugènia Pujol, Jun Yang, Rosana Leiva, Carmen Escolano +13 more

Effects of 17,18-Epoxyeicosatetraenoic Acid and 19,20-Epoxydocosapentaenoic Acid Combined with Soluble Epoxide Hydrolase Inhibitor t-TUCB on Brown Adipogenesis and Mitochondrial Respiration

Nutrients(2025)10.3390/nu17060936

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0 citations

Haoying Wu, Xinyun Xu, Christophe Morisseau, Kin Sing Stephen Lee, Bruce D. Hammock +3 more