Lindsey I. James

University of North Carolina at Chapel Hill

Also affiliated with University of North Carolina Health Care, Segeberger Kliniken, UNC Lineberger Comprehensive Cancer Center

Biochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 41 papers. Top paper: “Discovery of an H3K36me3-Derived Peptidomimetic Ligand with Enhanced Affinity for Plant Homeodomain Finger Protein 1 (PHF1)”.

Discovery of an H3K36me3-Derived Peptidomimetic Ligand with Enhanced Affinity for Plant Homeodomain Finger Protein 1 (PHF1)

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c00430

N/A

0.608DataRank · unranked

20 citations

Jiuyang Liu, Jacqueline L. Norris‐Drouin, Stephanie H. Cholensky, Samantha Ottavi, Stephen V. Frye +3 more

Structural basis of paralog-specific KDM2A/B nucleosome recognition

Nature Chemical Biology(2023)10.1038/s41589-023-01256-y

N/A

0.500DataRank · unranked

27 citations

Aleksandra Skrajna, Caroline A. Foley, Anh Nguyen, Gabrielle R. Budziszewski, Dalal N. Azzam +12 more

A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells

Cell Reports(2025)10.1016/j.celrep.2024.115192

N/A

0.383DataRank · unranked

11 citations

James Nolan, David M Reck, Craig Monger, Samantha Rustichelli, Eric Conway +16 more

Discovery of CHD1 Antagonists for PTEN-Deficient Prostate Cancer

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.4c01172

N/A

0.367DataRank · unranked

9 citations

Amanda L. Graboski, Fengling Li, Jacqueline L. Norris‐Drouin, William G. Walton, C.H. Arrowsmith +4 more

Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells

Nature Communications(2025)10.1038/s41467-025-57005-3

N/A

0.330DataRank · unranked

8 citations

Devan J. Shell, Madhushika Silva, Yu Deng, Fengling Li, Magdalena M. Szewczyk +21 more

Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.11.25.398586

N/A

0.269DataRank · unranked

5 citations

Yanli Liu, Magdalena M. Szewczyk, Naimee Mehta, Fengling Li, David McLeod +14 more

Pharmacological targeting of a PWWP domain demonstrates cooperative control of NSD2 localization

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.03.05.433782

N/A

0.208DataRank · unranked

3 citations

Ronan P. Hanley, Renato Ferreira de Freitas, Abdellah Allali‐Hassani, Mengqi Zhou, Naimee Mehta +29 more

REPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERIC MODULATOR

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.02.23.432388

N/A

0.208DataRank · unranked

3 citations

Daniel Bsteh, Yibo Si, Bryce Hart, Tyler Weaver, Carina Pribitzer +22 more

An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering

Nature Communications(2023)10.1038/s41467-023-41821-6

N/A

0.165DataRank · unranked

2 citations

Maria Victoria Botuyan, Pascal Drané, Qi Hu, Benoît Bragantini, James R. Thompson +8 more

Epigenomic characterization of latent HIV infection identifies latency regulating transcription factors

PLoS Pathogens(2021)10.1371/journal.ppat.1009346

N/A

0DataRank · unranked

56 citations

Samuel D. Burgos, Jackson J. Peterson, Sara R. Selitsky, Anne‐Marie W. Turner, Lindsey I. James +6 more

A Peptidomimetic Ligand Targeting the Chromodomain of MPP8 Reveals HRP2’s Association with the HUSH Complex

ACS Chemical Biology(2021)10.1021/acschembio.1c00429

N/A

0DataRank · unranked

21 citations

Sarah E. Clinkscales, Kimberly D. Barnash, Gabrielle R. Budziszewski, Justin M. Rectenwald, Anna M. Chiarella +8 more

Discovery of Potent Peptidomimetic Antagonists for Heterochromatin Protein 1 Family Proteins

ACS Omega(2021)10.1021/acsomega.1c05381

N/A

0DataRank · unranked

10 citations

Sarah N. Dishman, Jarod M. Waybright, Isabelle A. Engelberg, Justin M. Rectenwald, Jacqueline L. Norris‐Drouin +5 more

Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2

Journal of the American Chemical Society(2023)10.1021/jacs.3c01421

N/A

0DataRank · unranked

64 citations

David Y. Nie, John R. Tabor, Fengling Li, Amin Sobh, Chenxi Xu +14 more

PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components

ACS Chemical Biology(2023)10.1021/acschembio.2c00804

N/A

0DataRank · unranked

49 citations

Caroline A. Foley, Han Wee Ong, Justin M. Rectenwald, Ronan P. Hanley, Jacqueline L. Norris‐Drouin +8 more

SETDB1 Triple Tudor Domain Ligand, ( R , R )-59, Promotes Methylation of Akt1 in Cells

ACS Chemical Biology(2023)10.1021/acschembio.3c00280

N/A

0DataRank · unranked

15 citations

Yu Deng, Fengling Li, Devan J. Shell, Jacqueline L. Norris‐Drouin, Michael A. Stashko +7 more

MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing

Frontiers in Oncology(2023)10.3389/fonc.2023.1099550

N/A

0DataRank · unranked

6 citations

Aminah Wali, Kyle V. Butler, Yan Xiong, Joseph P. Foster, Shelsa S. Marcel +11 more

Recruitment of FBXO22 for Targeted Degradation of NSD2

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.11.01.564830

N/A

0DataRank · unranked

4 citations

John R. Tabor, Jianping Li, Maria Kutera, Jonathan St‐Germain, Ronan P. Hanley +22 more

MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing

UNC Libraries(2023)10.17615/jb05-mz95

N/A

0DataRank · unranked

0 citations

Jian Jin, Stephen V. Frye, Shelsa S. Marcel, Amber L. Mosely, Kyle V. Butler +11 more

An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.20.534960

N/A

0DataRank · unranked

0 citations

Maria Victoria Botuyan, Pascal Drané, Qi Hu, Benoît Bragantini, James Thompson +8 more

SETDB1 Triple Tudor Domain Ligand, ( R,R )-59, Promotes Methylation of Akt1 in Cells

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.10.539986

N/A

0DataRank · unranked

0 citations

Yu Deng, Fengling Li, Devan J. Shell, Jacqueline L. Norris‐Drouin, Michael A. Stashko +7 more

Recruitment of FBXO22 for targeted degradation of NSD2

Nature Chemical Biology(2024)10.1038/s41589-024-01660-y

N/A

0DataRank · unranked

59 citations

John R. Tabor, Jianping Li, Maria Kutera, Jonathan St‐Germain, Ronan P. Hanley +24 more

Advanced piperazine-containing inhibitors target microbial β-glucuronidases linked to gut toxicity

RSC Chemical Biology(2024)10.1039/d4cb00058g

N/A

0DataRank · unranked

6 citations

Joshua B. Simpson, Samuel J. Pellock, Naimee Mehta, Benjamin C. Creekmore, Yamuna Ariyarathna +13 more

Potent and Selective SETDB1 Covalent Negative Allosteric Modulator Reduces Methyltransferase Activity in Cells

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.09.27.615363

N/A

0DataRank · unranked

2 citations

Devan J. Shell, Madhushika Silva, Yu Deng, Fengling Li, Magdalena M. Szewczyk +21 more

Targeting Regorafenib-Induced Toxicity through Inhibition of Gut Microbial β-Glucuronidases

Figshare(2024)10.17615/3qds-f928

N/A

0DataRank · unranked

0 citations

Lauren Lim, Matthew R. Redinbo, Samantha M. Ervin, Aadra P. Bhatt, Lindsey I. James +3 more

Structural basis of paralog-specific KDM2A/B nucleosome recognition

UNC Libraries(2024)10.17615/n5q3-1z22

N/A

0DataRank · unranked

0 citations

Dmitri Kireev, Caroline A. Foley, Gabrielle R. Budziszewski, Lindsey I. James, Eyla C. Arteaga +12 more

Evaluation of EED Inhibitors as a Class of PRC2-Targeted Small Molecules for HIV Latency Reversal

Figshare(2024)10.17615/bsgz-rc06

N/A

0DataRank · unranked

0 citations

Katherine S. James, Daniel Winecoff, Frances Potjewyd, Lindsey I. James, Nancie M. Archin +6 more

Epigenomic characterization of latent HIV infection identifies latency regulating transcription factors

UNC Libraries(2024)10.17615/z3nx-z674

N/A

0DataRank · unranked

0 citations

Alisha R. Coffey, Joel S. Parker, Samuel D. Burgos, Anne‐Marie W. Turner, Edward P. Browne +6 more

Combined noncanonical NF-κB agonism and targeted BET bromodomain inhibition reverse HIV latency ex vivo

UNC Libraries(2024)10.17615/7mta-7638

N/A

0DataRank · unranked

0 citations

Rab K. Prinjha, Simon Ghofrani, Cameron Sutton, David M. Irlbeck, JoAnn Kuruc +26 more

Advanced piperazine-containing inhibitors target microbial β-glucuronidases linked to gut toxicity

UNC Libraries(2024)10.17615/6109-6p53

N/A

0DataRank · unranked

0 citations

Amanda L. Graboski, Josh J. Sekela, Benjamin C. Creekmore, Samuel J. Pellock, Aadra P. Bhatt +13 more

Potent and Selective SETDB1 Covalent Negative Allosteric Modulator Reduces Methyltransferase Activity in Cells

Research Square(2024)10.21203/rs.3.rs-5039962/v1

N/A

0DataRank · unranked

0 citations

Mélanie Uguen, Devan J. Shell, Madhushika Silva, Yu Deng, Fengling Li +21 more

Exploring the Ligandability of 53BP1 Through Fragment-Based Approaches

ChemRxiv(2024)10.26434/chemrxiv-2024-lng9q

N/A

0DataRank · unranked

0 citations

Menachem J. Gunzburg, Caroline A. Foley, Hong Zeng, A. Dong, Peter J. Brown +9 more

An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1

Figshare(2020)10.17615/q3bp-3c89

N/A

0DataRank · unranked

3 citations

Feng Liu, Masoud Vedadi, Kyle D. Konze, C.H. Arrowsmith, Gang Greg Wang +18 more

Dynamic activation of rAAV transgene expression by a small molecule that recruits endogenous transcriptional machinery

Nucleic Acids Research(2025)10.1093/nar/gkaf345

N/A

0DataRank · unranked

4 citations

Savannah Muron, Hae Rim Lee, Madison L Routh, Austin J. Hepperla, Deena M Scoville +7 more

Epigenomic characterization of latent HIV infection identifies latency regulating transcription factors

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.07.24.220012

N/A

0DataRank · unranked

2 citations

S. Burgos, Jackson J. Peterson, Sara R. Selitsky, Anne‐Marie W. Turner, Lindsey I. James +4 more

Small-Molecule Ligands of Methyl-Lysine Binding Proteins: Optimization of Selectivity for L3MBTL3

UNC Libraries(2020)10.17615/g8fd-vy49

N/A

0DataRank · unranked

0 citations

William P. Janzen, Liubov Krichevsky, Jacqueline L. Norris, Victoria Korboukh, Dmitri Kireev +4 more

The structure–activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface

UNC Libraries(2020)10.17615/6838-7x37

N/A

0DataRank · unranked

0 citations

Aiping Dong, C.H. Arrowsmith, Brandi M. Baughman, Jacqueline L. Norris, Dmitri Kireev +6 more

Structure–Activity Relationships and Kinetic Studies of Peptidic Antagonists of CBX Chromodomains

INDIGO (University of Illinois at Chicago)(2020)10.17615/4qgg-qe95

N/A

0DataRank · unranked

0 citations

Stephen V. Frye, Nancy Cheng, Jacqueline L. Norris‐Drouin, Jacob I. Stuckey, Catherine Simpson +6 more

Chemical probes for methyl lysine reader domains

UNC Libraries(2020)10.17615/8mtz-3r76

N/A

0DataRank · unranked

0 citations

Stephen V. Frye, Lindsey I. James

Design, synthesis, and protein methyltransferase activity of a unique set of constrained amine containing compounds

UNC Libraries(2020)10.17615/d3je-1864

N/A

0DataRank · unranked

0 citations

Kimberly D. Barnash, Stephen V. Frye, Xin Che, Hao Zhou, Peng Li +4 more

Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain

UNC Libraries(2020)10.17615/17wc-xm97

N/A

0DataRank · unranked

0 citations

Christopher J. MacNevin, Stephen V. Frye, William P. Janzen, Dalia Barsyte-Lovejoy, Xi‐Ping Huang +19 more

A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization

Nature Chemical Biology(2021)10.1038/s41589-021-00898-0

N/A

0DataRank · unranked

109 citations

Ronan P. Hanley, Renato Ferreira de Freitas, Abdellah Allali‐Hassani, Mengqi Zhou, Naimee Mehta +35 more