Samuel Hildebrand

University of Massachusetts Chan Medical School

Biochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 16 papers. Top paper: “An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis”.

An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis

Molecular Therapy(2021)10.1016/j.ymthe.2021.11.007

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0DataRank · unranked

46 citations

Nicole Wetoska, Mark Kelly, Dimas Echeverria, Kyounghee Min, Lawrence M. Lifshitz +13 more

Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity

Nucleic Acids Research(2021)10.1093/nar/gkab1126

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0DataRank · unranked

20 citations

Samuel Hildebrand, Sarah M. Davis, Rachael Miller, Faith Conroy, Ellen Sapp +10 more

PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs

Molecular Therapy — Nucleic Acids(2022)10.1016/j.omtn.2022.06.005

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0DataRank · unranked

27 citations

Emily G. Knox, Samuel Hildebrand, James W. Gilbert, Dimas Echeverria, Zachary Kennedy +9 more

Formamide significantly enhances the efficiency of chemical adenylation of RNA sequencing ligation adaptors

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.16.516815

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0DataRank · unranked

0 citations

Adam K. Hedger, Jonathan K. Watts, Anastasia Khvorova, Samuel Hildebrand

Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin

Nature Communications(2023)10.1038/s41467-023-42714-4

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0DataRank · unranked

50 citations

Hassan H. Fakih, Mohammad Zain UI Abideen, Samuel Hildebrand, Khashayar Afshari, Katherine Y. Gross +31 more

Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2219523120

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0DataRank · unranked

48 citations

Minwook Shin, Ching‐Wen Chang, Daniel O’Reilly, Annabelle Biscans, Ken Yamada +41 more

Formamide significantly enhances the efficiency of chemical adenylation of RNA sequencing ligation adaptors

RNA(2023)10.1261/rna.079521.122

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0DataRank · unranked

1 citations

Adam K. Hedger, Ken Yamada, Jonathan K. Watts, Anastasia Khvorova, Samuel Hildebrand

Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.26.542506

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0DataRank · unranked

7 citations

Vignesh Hariharan, Jillian Caiazzi, Rachael Miller, Chantal Furguson, Ellen Sapp +18 more

Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo

Research Square(2023)10.21203/rs.3.rs-2987323/v1

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0DataRank · unranked

4 citations

Jillian Caiazzi, Rachael Miller, Chantal Ferguson, Ellen Sapp, Hassan Fakih +18 more

Silencing Apoe with divalent‐siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease

Alzheimer s & Dementia(2024)10.1002/alz.13703

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0DataRank · unranked

33 citations

Samuel Hildebrand, Bruno M.D.C. Godinho, Julianna Buchwald, Dimas Echeverria, Andrew H. Coles +10 more

A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system

Nucleic Acids Research(2024)10.1093/nar/gkae368

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0DataRank · unranked

26 citations

Qi Tang, Samuel Hildebrand, Ashley Summers, Ellen Sapp, Dimas Echeverria +11 more

Phosphatidylcholine head group chemistry alters the extrahepatic accumulation of lipid-conjugated siRNA

Molecular Therapy — Nucleic Acids(2024)10.1016/j.omtn.2024.102230

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0DataRank · unranked

5 citations

Takahiro Nakamura, Minwook Shin, Qi Tang, Vyankat A. Sontakke, Jillian Caiazzi +4 more

Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy

Nucleic Acids Research(2025)10.1093/nar/gkaf479

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0DataRank · unranked

15 citations

Samuel Hildebrand, Hannah J. MacMillan, Kathryn Monopoli, Julianna Buchwald, Jacquelyn Sousa +20 more

Potent and durable gene modulation in heart and muscle with chemically defined lipophilic siRNAs

Nucleic Acids Research(2025)10.1093/nar/gkaf1374

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0DataRank · unranked

1 citations

Clemens Lochmann, Rosemary Gagnon, Ashley Summers, Jillian Caiazzi, Julianna Buchwald +15 more

Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington’s disease pathogenesis in mice

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.06.24.661398

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0DataRank · unranked

7 citations

Ashley Summers, Christian Landles, Jonathan Greene, Samuel Hildebrand, Emily G. Knox +21 more

Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality for one year in an MECP2 duplication mouse model

Research Square(2025)10.21203/rs.3.rs-6465542/v1

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0DataRank · unranked

0 citations

Ashley Summers, Amy E. Clipperton‐Allen, Jillian Caiazzi, Samuel Hildebrand, Daniel O’Reilly +11 more