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Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy

Nucleic Acids Research(2025)10.1093/nar/gkaf479Source: DataRank Database

Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy is a research paper published in Nucleic Acids Research (2025). On theSindex it has a DataRank of 0. It has been cited 15 times.

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Open Access15 citations

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Linked data & code

geo bioproject refseq

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (6 grants)Impact (FWCI 6.69)OA: goldTopics (43)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (25)

Samuel Hildebrand ORCID,Hannah J. MacMillan,Kathryn Monopoli ORCID,Julianna Buchwald ORCID,Jacquelyn Sousa ORCID

Live enrichment

PubMed:40548938 PMC:PMC12205987 OpenAlex:https://openalex.org/W4411623005

National Institutes of Health

Grant: 1F31LM013111-01A1

Defining the Rules for Designing Fully Chemically Modified siRNAs to Treat Genetically Linked Central Nervous System Disorders

National Institutes of Health

Grant: R35 GM131839

National Institutes of Health

Grant: S10 OD020012

NLM NIH HHS

Grant: F31 LM013111

National Institutes of Health

Grant: 5R35GM131839-05

Chemical engineering of therapeutic RNAs for extrahepatic delivery

National Institutes of Health

Grant: 1S10OD020012-01

Mid-Scale RNA Synthesis, Purification and Quality Control System

FWCI

6.69

Citation Percentile

1.0%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttps://academic.oup.com/nar/article-pdf/53/12/gkaf479/63551220/gkaf479.pdf

publisherhttps://academic.oup.com/nar/article-pdf/53/12/gkaf479/63551220/gkaf479.pdf

journalhttps://doi.org/10.1093/nar/gkaf479

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40548938

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12205987

Fields of Study

RNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesMicroRNA in disease regulationRNA, Small InterferingRNA, MessengerHumanstau ProteinsAmyloid Precursor Protein SecretasesAspartic Acid Endopeptidasesalpha-SynucleinRNA InterferenceGenes, Reporter

MeSH Terms

HumansRNA, MessengerAspartic Acid Endopeptidasestau ProteinsGenes, ReporterRNA InterferenceRNA, Small Interferingalpha-SynucleinAmyloid Precursor Protein Secretases

Keywords

Small interfering RNABiologyGene silencingContext (archaeology)Messenger RNAPolyadenylationRNA interferenceComputational biologyMolecular biologyRNACell biologyGeneGeneticsChemical Biology and Nucleic Acid ChemistryGenes, Reporteralpha-SynucleinHumansAspartic Acid Endopeptidasestau ProteinsRNA, MessengerRNA, Small InterferingAmyloid Precursor Protein Secretases

Sustainable Development Goals

SDG 0: Good health and well-being

Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy

FAIR Checklist

Authors (25)

Funding (6 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)