Catherine Z. Chen

Also affiliated with National Center for Advancing Translational Sciences

MedicineComputer Science

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 46 papers. Top paper: “RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery”.

RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery

SLAS DISCOVERY(2020)10.1177/2472555220942123

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191 citations

Catherine Z. Chen, Kirill Gorshkov, Miao Xu, Donald C. Lo, Wei Zheng +1 more

Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium

Cell stem cell(2020)10.1016/j.stem.2020.09.016

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458 citations

Sarshan R. Pather, Wei‐Kai Huang, Feng Zhang, Samuel Zheng Hao Wong, Haowen Zhou +12 more

Synergistic and Antagonistic Drug Combinations against SARS-CoV-2

Molecular Therapy(2020)10.1016/j.ymthe.2020.12.016

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126 citations

Lu Chen, Richard T. Eastman, Zina Itkin, Paul Shinn, Catherine Z. Chen +8 more

Drug Discovery Strategies for SARS-CoV-2

Journal of Pharmacology and Experimental Therapeutics(2020)10.1124/jpet.120.000123

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107 citations

Kirill Gorshkov, Catherine Z. Chen, Wei Zheng, Zeenat A. Shyr

The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules

ACS Infectious Diseases(2020)10.1021/acsinfecdis.0c00349

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93 citations

Catherine Z. Chen, Robert Bostwick, Lynn Rasmussen, Bruce Nguyen Tran, Yu-Shan Cheng +21 more

Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.07.28.225151

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30 citations

Sarshan R. Pather, Wei‐Kai Huang, Samuel Zheng Hao Wong, Haowen Zhou, Feng Zhang +11 more

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.08.18.255877

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30 citations

Paul Shinn, Zina Itkin, Richard T. Eastman, Robert Bostwick, Lynn Rasmussen +14 more

Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-throughput Screening

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.07.17.207019

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27 citations

Miao Xu, Catherine Z. Chen, Hui Guo, Min Shen, Xin Hu +5 more

Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS-S and MERS-S pseudotyped particles

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.07.10.197988

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20 citations

Miao Xu, Manisha Pradhan, Kirill Gorshkov, Jennifer D. Petersen, Marco R. Straus +10 more

Massive-scale biological activity-based modeling identifies novel antiviral leads against SARS-CoV-2

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.07.27.223578

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15 citations

Miao Xu, Hu Zhu, Catherine Z. Chen, Emily M. Lee, Shihua He +11 more

Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.07.14.202549

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13 citations

Catherine Z. Chen, Manju Swaroop, Miao Xu, Lihui Wang, Juhyung Lee +12 more

Discovery of TMPRSS2 inhibitors from virtual screening

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.12.28.424413

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8 citations

Jonathan H. Shrimp, Hui Guo, Miao Xu, Catherine Z. Chen, Wei Zhu +7 more

Development of a high-throughput homogeneous AlphaLISA drug screening assay for the detection of SARS-CoV-2 Nucleocapsid

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.08.20.258129

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3 citations

Catherine Z. Chen, Juan Carlos de la Torre, Luis Martínez‐Sobrido, Thomas M. Moran, Wei Zheng +1 more

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

Frontiers in Pharmacology(2021)10.3389/fphar.2020.592737

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95 citations

Paul Shinn, Zina Itkin, Richard T. Eastman, Robert Bostwick, Lynn Rasmussen +14 more

Biological activity-based modeling identifies antiviral leads against SARS-CoV-2

Nature Biotechnology(2021)10.1038/s41587-021-00839-1

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53 citations

Miao Xu, Hu Zhu, Catherine Z. Chen, Wei Zhu, Emily M. Lee +15 more

Rottlerin inhibits La Crosse virus-induced encephalitis in mice and blocks release of replicating virus from the Golgi body in neurons

Nature Microbiology(2021)10.1038/s41564-021-00968-y

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35 citations

Clayton W. Winkler, Jacqueline M. Leung, Tyson A. Woods, Catherine Z. Chen, Vinod Nair +8 more

Mining of high throughput screening database reveals AP-1 and autophagy pathways as potential targets for COVID-19 therapeutics

Scientific Reports(2021)10.1038/s41598-021-86110-8

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31 citations

Catherine Z. Chen, Srilatha Sakamuru, Jinghua Zhao, Deborah K. Ngan, Anton Simeonov +5 more

Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection

Bioorganic & Medicinal Chemistry Letters(2021)10.1016/j.bmcl.2021.127906

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24 citations

Miao Xu, Xin Hu, Emily M. Lee, Xiao Lü, Ruili Huang +19 more

Hybrid In Silico Approach Reveals Novel Inhibitors of Multiple SARS-CoV-2 Variants

ACS Pharmacology & Translational Science(2021)10.1021/acsptsci.1c00176

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16 citations

Daniel C. Talley, Bolormaa Baljinnyam, Jun Choe, Quinlin Hanson, Wei Zhu +10 more

Identification of SARS-CoV-2 viral entry inhibitors using machine learning and cell-based pseudotyped particle assay

Bioorganic & Medicinal Chemistry(2021)10.1016/j.bmc.2021.116119

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12 citations

Yuhong Wang, Catherine Z. Chen, Miao Xu, Hui Guo, Misha Itkin +3 more

Generation of an induced pluripotent stem cell line (TRNDi031-A) from a patient with Alagille syndrome type 1 carrying a heterozygous p. C312X (c. 936 T > A) mutation in JAGGED-1

Stem Cell Research(2021)10.1016/j.scr.2021.102447

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4 citations

Manisha Pradhan, Yu‐Shan Cheng, Kirill Gorshkov, Atena Farkhondeh, Catherine Z. Chen +6 more

Generation of an induced pluripotent stem cell line (TRNDi030-A) from a patient with Farber disease carrying a homozygous p. Y36C (c. 107 A>G) mutation in ASAH1

Stem Cell Research(2021)10.1016/j.scr.2021.102387

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2 citations

Charles D. Yeh, Jeanette Beers, Chengyu Liu, Yu‐Shan Cheng, Kirill Gorshkov +4 more

Camel nanobodies broadly neutralize SARS-CoV-2 variants

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.10.27.465996

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12 citations

Hyung Joon Kwon, Raúl E. Cachau, Catherine Z. Chen, Kevin John Butay, Zhijian Duan +13 more

A high throughput screening assay for inhibitors of SARS-CoV-2 pseudotyped particle entry

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.10.04.463106

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6 citations

Manisha Pradhan, Kirill Gorshkov, Jennifer D. Petersen, Min Shen, Hui Guo +11 more

A SARS-CoV-2 nucleocapsid protein TR-FRET assay amenable to high-throughput screening

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.07.03.450938

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2 citations

Desarey Morales Vasquez, Kevin Chiem, Chengjin Ye, Bruce Nguyen Tran, Juan Carlos de la Torre +5 more

A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.10.22.465476

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1 citations

Juliana da Fonseca Rezende e Mello, Bryan D. Fleming, Alex Renn, Catherine Z. Chen, Xin Hu +26 more

A Graph Convolutional Network-based screening strategy for rapid identification of SARS-CoV-2 cell-entry inhibitors

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.12.08.471787

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1 citations

Miao Xu, Qi Zhang, Catherine Z. Chen, Hui Guo, Yihong Ye +3 more

Dromedary camel nanobodies broadly neutralize SARS-CoV-2 variants

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2201433119

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37 citations

Hyung Joon Kwon, Raúl E. Cachau, Catherine Z. Chen, Kevin John Butay, Zhijian Duan +13 more

Therapeutic Strategies For Tay-Sachs Disease

Frontiers in Pharmacology(2022)10.3389/fphar.2022.906647

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32 citations

Wei Zheng, Catherine Z. Chen, Jaqueline A. Picache

Preclinical Pharmacokinetics and In Vitro Properties of GS-441524, a Potential Oral Drug Candidate for COVID-19 Treatment

Frontiers in Pharmacology(2022)10.3389/fphar.2022.918083

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30 citations

Natalie R. Hagen, Elias Carvalho Padilha, Mengbi Yang, Pranav Shah, Catherine Z. Chen +6 more

A high throughput screening assay for inhibitors of SARS-CoV-2 pseudotyped particle entry

SLAS DISCOVERY(2022)10.1016/j.slasd.2021.12.005

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26 citations

Manisha Pradhan, Kirill Gorshkov, Jennifer D. Petersen, Min Shen, Hui Guo +11 more

Efficient Identification of Anti-SARS-CoV-2 Compounds Using Chemical Structure- and Biological Activity-Based Modeling

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.1c01372

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26 citations

Miao Xu, Wei Zhu, Catherine Z. Chen, Qi Zhang, Wei Zheng +2 more

Mitoxantrone modulates a heparan sulfate-spike complex to inhibit SARS-CoV-2 infection

Scientific Reports(2022)10.1038/s41598-022-10293-x

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24 citations

Peter Radvák, Juhyung Lee, Yue Xu, Vivian Cao-Dao, Miao Xu +5 more

A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike

PLoS ONE(2022)10.1371/journal.pone.0272364

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18 citations

Juliana da Fonseca Rezende e Mello, Bryan D. Fleming, Alex Renn, Catherine Z. Chen, Xin Hu +27 more

Graph Convolutional Network-Based Screening Strategy for Rapid Identification of SARS-CoV-2 Cell-Entry Inhibitors

Journal of Chemical Information and Modeling(2022)10.1021/acs.jcim.2c00222

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8 citations

Miao Xu, Qi Zhang, Catherine Z. Chen, Hui Guo, Yihong Ye +3 more

Suite of TMPRSS2 Assays for Screening Drug Repurposing Candidates as Potential Treatments of COVID-19

ACS Infectious Diseases(2022)10.1021/acsinfecdis.2c00172

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8 citations

John Janiszewski, Catherine Z. Chen, Miao Xu, Kelli M. Wilson, Stephen C. Kales +12 more

In vitro effect of a non-immunosuppressive FKBP ligand, FK1706, on SARS-CoV-2 replication in combination with antivirals

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.02.03.479080

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3 citations

Tracy L. Hartman, Michelle Mendenhall, Catherine Z. Chen, William E. Fitzsimmons

Preclinical Pharmacokinetics and In Vitro Properties of GS-441524, A Potential Oral Drug Candidate for COVID-19 Treatment

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.02.07.478848

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2 citations

Natalie R. Hagen, Elias Carvalho Padilha, Mengbi Yang, Pranav Shah, Catherine Z. Chen +6 more

A Protocol for Culture and Characterization of Human Induced Pluripotent Stem Cells After Induction

Current Protocols(2023)10.1002/cpz1.866

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15 citations

Miao Xu, Guibin Chen, Jeanette Beers, Catherine Z. Chen, Chengyu Liu +3 more

Heparan sulfate promotes ACE2 super-cluster assembly to enhance SARS-CoV-2-associated syncytium formation

Research Square(2023)10.21203/rs.3.rs-2693563/v1

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0 citations

Wei‐Chun Tang, Eduardo Stancanelli, Eun-Kyung Jung, Zulfeqhar A. Syed, Vijayakanth Pagadala +13 more

Identification of Potent ADCK3 Inhibitors through Structure-Based Virtual Screening

Journal of Chemical Information and Modeling(2024)10.1021/acs.jcim.4c00530

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2 citations

Mitali A. Tambe, Catherine Z. Chen, Wenwei Huang, Gregory J. Tawa, Tal Hirschhorn +4 more

Establishment of human post-vaccination SARS-CoV-2 standard reference sera

Journal of Immunological Methods(2024)10.1016/j.jim.2024.113698

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3 citations

Louis N. Katz, Patricia Winokur, Ashok Chaudhary, Barbara Digmann, Rebecca Bradford +13 more

Generation of induced pluripotent stem cell lines TRNDi037-A and TRNDi038-A from two patients with Alagille syndrome carrying heterozygous JAG1 mutations

Stem Cell Research(2024)10.1016/j.scr.2024.103634

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0DataRank · unranked

0 citations

Guibin Chen, Ivan Pavlinov, Xiuli Huang, Kaari L. Linask, Chengyu Liu +9 more

Reversal gene expression assessment for drug repurposing, a case study of glioblastoma

Journal of Translational Medicine(2025)10.1186/s12967-024-06046-1

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9 citations

Zeenat A. Shyr, Kathleen McDaniel, Yuhong Fang, Dingyin Tao, Catherine Z. Chen +3 more

Leveraging viral genome sequences and machine learning models for identification of potentially selective antiviral agents

Communications Chemistry(2025)10.1038/s42004-025-01583-2

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3 citations

Miao Xu, Qi Zhang, Catherine Z. Chen, Wei Zheng, Ruili Huang +1 more

Reactivation of Human X-Linked Gene and Stable X-Chromosome Inactivation Observed in Generation and Differentiation of iPSCs from a Female Patient with HNRNPH2 Mutation

Cells(2025)10.3390/cells14191486

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1 citations

Alexander Rodríguez‐López, Darawalee Wangsa, Richa Madan Lomash, Xiuli Huang, Catherine Z. Chen +7 more