Bruce M. Spiegelman

Also affiliated with Dana-Farber Cancer Institute, Dana-Farber/Harvard Cancer Center

MedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 33 papers. Top paper: “PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes”.

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Nature Genetics(2003)10.1038/ng1180

N/A

1.4DataRank · unranked

10534 citations

Cecilia M. Lindgren, Karl-Fredrik Eriksson, Aravind Subramanian, Smita Sihag, Joseph Lehar +19 more

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Science(1993)10.1126/science.7678183

N/A

1.3DataRank · unranked

7426 citations

Narinder S. Shargill, Bruce M. Spiegelman, Gökhan S. Hotamışlıgil, Gökhan S. Hotamisligil

Deletion of FNDC5/irisin modifies murine osteocyte function in a sex-specific manner

eLife(2023)10.7554/elife.92263

N/A

0.470DataRank · unranked

11 citations

Fabrizio Pin, Matthew Prideaux, Gang Peng, Joshua R. Huot, Hyeonwoo Kim +4 more

A Plasma Protein Network Regulates PM20D1 and N-Acyl Amino Acid Bioactivity

Cell chemical biology(2020)10.1016/j.chembiol.2020.04.009

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0DataRank · unranked

17 citations

Mark P. Jedrychowski, Wei Wei, Daniel Fernández, Curt R. Fischer, Steven M. Banik +3 more

Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.2001387117

N/A

0DataRank · unranked

39 citations

Gina Z. Lu, John Szpyt, Marco Mariotti, Ryan Garrity, Joao A. Paulo +9 more

Obesity-linked PPARγ S273 phosphorylation promotes insulin resistance through Growth Differentiation Factor 3

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.01.13.904953

N/A

0DataRank · unranked

3 citations

Deepti Ramachandran, Hyun Cheol Roh, Joanna R. DiSpirito, Thiago Belchior, Peter‐James H. Zushin +17 more

Irisin Directly Stimulates Osteoclastogenesis and Bone Resorption In Vitro and In Vivo

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.09.085977

N/A

0DataRank · unranked

1 citations

Phuong Le, Yosta Vegting, Hyeonwoo Kim, Roland Baron, Bruce M. Spiegelman +2 more

Exercise hormone irisin is a critical regulator of cognitive function

Nature Metabolism(2021)10.1038/s42255-021-00438-z

N/A

0DataRank · unranked

394 citations

Sophia Valaris, Michael Young, Erin B. Haley, Renhao Luo, Sabrina F. Bond +17 more

Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis

Cell Metabolism(2021)10.1016/j.cmet.2021.07.010

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0DataRank · unranked

136 citations

Meng Zhao, Laëtitia Voilquin, Yunshin Jung, Mari Aikio, Tanushi Sahai +15 more

Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation

Cell Metabolism(2021)10.1016/j.cmet.2021.11.003

N/A

0DataRank · unranked

58 citations

Cathal Harmon, Mark P. Jedrychowski, Haopeng Xiao, Anja V. Gruszczyk, Gary A. Bradshaw +11 more

Architecture of the outbred brown fat proteome defines regulators of metabolic physiology

Cell(2022)10.1016/j.cell.2022.10.003

N/A

0DataRank · unranked

39 citations

Luiz H. M. Bozi, Yizhi Sun, Christopher L. Riley, Vivek M. Philip, Mandy Chen +41 more

Antagonistic regulation of Drosophila mitochondrial uncoupling protein UCP4b by cold and BMP signaling

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.01.27.477603

N/A

0DataRank · unranked

3 citations

Wei Song, Phillip A. Dumesic, Bruce M. Spiegelman, Norbert Perrimon, Nirmalya Chatterjee

Role of Mitochondrial TNAP in Thermogenesis and Obesity

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.0r355

N/A

0DataRank · unranked

0 citations

Bruce M. Spiegelman, Yizhi Sun

Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling

Neuron(2023)10.1016/j.neuron.2023.08.012

N/A

0DataRank · unranked

115 citations

Hyeonwoo Kim, Mark P. Jedrychowski, Grisilda Bakiasi, Joseph Park, Jane M. Kruskop +9 more

Regulatory T cells shield muscle mitochondria from interferon-γ–mediated damage to promote the beneficial effects of exercise

Science Immunology(2023)10.1126/sciimmunol.adi5377

N/A

0DataRank · unranked

74 citations

Yizhi Sun, Birgitta Ryback, Amber L. Mueller, Bruce M. Spiegelman, Christophe Benoıst +2 more

Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues

Cell Metabolism(2023)10.1016/j.cmet.2022.12.014

N/A

0DataRank · unranked

72 citations

Mark P. Jedrychowski, Jonathan G. Van Vranken, Hans‐Georg Sprenger, Sarah E. Wilensky, Phillip A. Dumesic +11 more

Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α

Molecular Cell(2023)10.1016/j.molcel.2023.05.008

N/A

0DataRank · unranked

64 citations

Thomas E. Wales, Haixia Zhou, Sorin-Valeriu Draga-Coletă, Christoph Gorgulla, Katherine Blackmore +17 more

REPTOR and CREBRF encode key regulators of muscle energy metabolism

Nature Communications(2023)10.1038/s41467-023-40595-1

N/A

0DataRank · unranked

25 citations

Phillip A. Dumesic, Yanhui Hu, Elizabeth Filine, Patrick Jouandin, Richard Binari +8 more

Irisin Enhances Mitochondrial Function in Osteoclast Progenitors during Differentiation

Biomedicines(2023)10.3390/biomedicines11123311

N/A

0DataRank · unranked

7 citations

Tsunagu Ichikawa, Paige Giffault, Lynda F. Bonewald, Bruce M. Spiegelman, Clifford J. Rosen +1 more

Reviewer #2 (Public Review): Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner

(2023)10.7554/elife.92263.1.sa1

N/A

0DataRank · unranked

0 citations

Fabrizio Pin, Matthew Prideaux, Gang Peng, Joshua R. Huot, Hyeonwoo Kim +4 more

Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner

(2023)10.7554/elife.92263.1

N/A

0DataRank · unranked

0 citations

Fabrizio Pin, Matthew Prideaux, Gang Peng, Joshua R. Huot, Hyeonwoo Kim +4 more

Author Response: Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner

(2023)10.7554/elife.92263.1.sa4

N/A

0DataRank · unranked

0 citations

Fabrizio Pin, Matthew Prideaux, Gang Peng, Joshua R. Huot, Hyeonwoo Kim +4 more

Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle

Cell Metabolism(2024)10.1016/j.cmet.2024.07.002

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0DataRank · unranked

33 citations

Yizhi Sun, Amanda L. Smythers, Louisa Grauvogel, Phillip A. Dumesic, Margo P. Emont +13 more

Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition

Molecular Metabolism(2024)10.1016/j.molmet.2024.101912

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0DataRank · unranked

25 citations

Paulo R. Jannig, Igor Červenka, Marta Murgia, Melanie J. Mittenbühler, Ekaterina Chernogubova +17 more

Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.04.10.588849

N/A

0DataRank · unranked

6 citations

Melanie J. Mittenbühler, Yizhi Sun, Jonathan G. Van Vranken, Sebastian Schindler, Abhilash Jayaraj +21 more

Correction: Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo

eLife(2024)10.7554/elife.104341

N/A

0DataRank · unranked

1 citations

Phuong Le, Yosta Vegting, Hyeonwoo Kim, Christiane D. Wrann, Mary Bouxsein +5 more

Proteomic profiling of extracellular fluids to identify secreted proteins from muscle and fat tissues

Methods in cell biology(2024)10.1016/bs.mcb.2024.08.004

N/A

0DataRank · unranked

0 citations

Amanda L. Smythers, Bruce M. Spiegelman, Melanie J. Mittenbühler

Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST

Cell Metabolism(2025)10.1016/j.cmet.2025.01.024

N/A

0DataRank · unranked

45 citations

Melanie J. Mittenbühler, Yizhi Sun, Jonathan G. Van Vranken, Sebastian Schindler, Abhilash Jayaraj +23 more

A consensus guide to preclinical indirect calorimetry experiments

Nature Metabolism(2025)10.1038/s42255-025-01360-4

N/A

0DataRank · unranked

22 citations

David B. Allison, Thierry Alquier, Md Ansarullah, Steven N. Austad, Johan Auwerx +74 more

RBM43 controls PGC1α translation and a PGC1α-STING signaling axis

Cell Metabolism(2025)10.1016/j.cmet.2025.01.013

N/A

0DataRank · unranked

17 citations

Sarah E. Wilensky, Symanthika Bose, Jonathan G. Van Vranken, Steven P. Gygi, Bruce M. Spiegelman +1 more

Cardiac adaptation to endurance exercise training requires suppression of GDF15 via PGC-1α

Nature Cardiovascular Research(2025)10.1038/s44161-025-00712-3

N/A

0DataRank · unranked

5 citations

Haobo Li, Tevis Vitale, James Rhee, Saketh Challa, Claire Castro +31 more

CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling

Cell(2020)10.1016/j.cell.2020.06.021

N/A

0DataRank · unranked

298 citations

Kosaku Shinoda, Hyeonwoo Kim, Diana Alba, W. Reid Bolus, Qiang Wang +18 more

Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3

Cell Metabolism(2020)10.1016/j.cmet.2020.08.016

N/A

0DataRank · unranked

96 citations

Deepti Ramachandran, Hyun Cheol Roh, Joanna R. DiSpirito, Thiago Belchior, Peter‐James H. Zushin +17 more