Andrew G. Stephen

Biochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 35 papers. Top paper: “Machine learning–driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins”.

Machine learning–driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2113297119

N/A

0.675DataRank · unranked

89 citations

Chris Neale, Timothy S. Carpenter, Rebika Shrestha, César A. López, Timothy H. Tran +37 more

Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome

Nature Structural & Molecular Biology(2022)10.1038/s41594-022-00841-4

N/A

0.601DataRank · unranked

54 citations

Patrick Alexander, Kelly Snead, Nicole Hartig, Matthew Drew, Simon Messing +8 more

Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110331

N/A

0.540DataRank · unranked

15 citations

Albert H. Chan, Dana Rabara, Monalisa Swain, Erik K. Larsen, Marcin Dyba +11 more

RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome–associated cardiac hypertrophy

Science Advances(2023)10.1126/sciadv.adf4766

N/A

0.489DataRank · unranked

25 citations

Morgan E. Wagner, Richard Van, Monalisa Swain, Stephanie Mo, John Columbus +10 more

Direct Modulators of K-Ras–Membrane Interactions

ACS Chemical Biology(2023)10.1021/acschembio.3c00413

N/A

0.483DataRank · unranked

24 citations

Rebika Shrestha, Que N. Van, César A. López, Neha Arora, Marco Tonelli +8 more

Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31P NMR

Journal of Biological Chemistry(2024)10.1016/j.jbc.2024.105650

N/A

0.464DataRank · unranked

21 citations

Jun Pei, Yue Yang, Marcin Dyba, Brian D. Smith, Dana Rabara +11 more

Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity

Cancer Research(2023)10.1158/0008-5472.can-22-3210

N/A

0.416DataRank · unranked

15 citations

Timothy H. Tran, Bethany Hunt, Rebecca Agnor, Christian W. Johnson, Bing Shui +6 more

Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.10.22.618529

N/A

0.391DataRank · unranked

9 citations

Julien Dilly, Shengwu Liu, Eejung Kim, Yuemin Bian, Srisathiyanarayanan Dharmaiah +24 more

Revealing KRas4b topology on the membrane surface

Biochemical and Biophysical Research Communications(2023)10.1016/j.bbrc.2023.08.035

N/A

0.292DataRank · unranked

6 citations

Mark A. McLean, Andrew G. Stephen, Stephen G. Sligar, Shweta Shree

Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2410766122

N/A

0.292DataRank · unranked

6 citations

Yue Yang, Alok K. Sharma, David M. Turner, Caroline J. DeHart, Hazem Abdelkarim +29 more

Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.05.10.491335

N/A

0.241DataRank · unranked

4 citations

Patrick Alexander, Kelly Snead, Nicole Hartig, Matthew Drew, Simon Messing +8 more

Measurement of KRAS-GTPase Activity

Methods in Molecular Biology(2024)10.1007/978-1-0716-3822-4_7

N/A

0.208DataRank · unranked

3 citations

Andrew G. Stephen, Dana Rabara

An In Vitro BRAF Activation Assay Elucidates Molecular Mechanisms Driving Disassembly of the Autoinhibited BRAF State

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.19.671159

N/A

0.104DataRank · unranked

1 citations

David Durrant, Matthew Drew, Suzanne I. Sandin, Juliana A. Martinez Fiesco, Xiaohua Zhang +21 more

Allosteric regulation of switch-II controls K-Ras oncogenicity

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.20.508702

N/A

0.104DataRank · unranked

1 citations

Timothy H. Tran, Bethany Hunt, Rebecca Agnor, Christian W. Johnson, Timothy J. Waybright +5 more

Ras-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.02.514888

N/A

0DataRank · unranked

1 citations

Morgan E. Wagner, Richard Van, Monalisa Swain, Madeline R. Allison, Alice Cheng +7 more

Exploring CRD mobility during RAS/RAF engagement at the membrane

Biophysical Journal(2022)10.1016/j.bpj.2022.06.035

N/A

0DataRank · unranked

28 citations

César A. López, Chris Neale, Que N. Van, Timothy S. Carpenter, Francesco Di Natale +25 more

RASopathy mutations provide functional insight into the BRAF cysteine-rich domain and reveal the importance of autoinhibition in BRAF regulation

Molecular Cell(2022)10.1016/j.molcel.2022.10.016

N/A

0DataRank · unranked

44 citations

Elizabeth M. Terrell, Christine Insinna, Constance Agamasu, Morgan E. Wagner, Daniel A. Ritt +4 more

RASopathy Mutations Provide Functional Insight into the BRAF Cysteine-rich Domain and Demonstrate the Importance of Autoinhibition in BRAF Regulation

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.10.01.462773

N/A

0DataRank · unranked

1 citations

Elizabeth M. Terrell, Christine Insinna, Constance Agamasu, Morgan E. Wagner, Daniel A. Ritt +4 more

GAP positions catalytic H-Ras residue Q61 for GTP hydrolysis in molecular dynamics simulations, complicating chemical rescue of Ras deactivation

Computational Biology and Chemistry(2023)10.1016/j.compbiolchem.2023.107835

N/A

0DataRank · unranked

5 citations

Timothy J. Waybright, Andrew G. Stephen, Chris Neale, Lara A. Patel

Unveiling the Dynamics of KRAS4b on Lipid Model Membranes

The Journal of Membrane Biology(2021)10.1007/s00232-021-00176-z

N/A

0DataRank · unranked

11 citations

Animesh Agarwal, Que N. Van, Andrew G. Stephen, S. Gnanakaran, César A. López

Supplementary Figure 1 from Echinomycin, a Small-Molecule Inhibitor of Hypoxia-Inducible Factor-1 DNA-Binding Activity

(2023)10.1158/0008-5472.22365320

N/A

0DataRank · unranked

0 citations

Eun‐Jung Park, Andrew G. Stephen, Maura Calvani, John H. Cardellina, Anne Monks +4 more

Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket

Cell(2024)10.1016/j.cell.2024.08.017

N/A

0DataRank · unranked

56 citations

Victoria Bowcut, Micah C. Fernando, Yue Yang, Lawrence Zhu, Meredith L. Jenkins +12 more

Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties

Science Advances(2024)10.1126/sciadv.adj4137

N/A

0DataRank · unranked

38 citations

Timothy H. Tran, Megan Rigby, Ming Yi, Srisathiyanarayanan Dharmaiah, Timothy J. Waybright +12 more

Membrane-bound KRAS approximates an entropic ensemble of configurations

Biophysical Journal(2021)10.1016/j.bpj.2021.08.008

N/A

0DataRank · unranked

8 citations

Que N. Van, Frantz Jean-François, Andrew G. Stephen, Mathias Lösche, Frank Heinrich

Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane

Communications Biology(2024)10.1038/s42003-024-05916-0

N/A

0DataRank · unranked

13 citations

Timothy S. Carpenter, Que N. Van, Constance Agamasu, Marco Tonelli, Fikret Aydin +15 more

KRas4b–Calmodulin Interaction with Membrane Surfaces: Role of Headgroup, Acyl Chain, and Electrostatics

Biochemistry(2024)10.1021/acs.biochem.4c00116

N/A

0DataRank · unranked

4 citations

Mark A. McLean, Andrew G. Stephen, Stephen G. Sligar, Shweta Shree

Development of a High-throughput NanoBRET Screening Platform to Identify Modulators of the RAS/RAF Interaction

Molecular Cancer Therapeutics(2021)10.1158/1535-7163.mct-21-0175

N/A

0DataRank · unranked

30 citations

Emily A. Smith, Ekaterina I. Goncharova, Nirmala Sharma, Patrick Alexander, Andrew G. Stephen +3 more

Two hearts beat as one: the debate over RAS dimers continues

Trends in Biochemical Sciences(2024)10.1016/j.tibs.2024.09.005

N/A

0DataRank · unranked

0 citations

Andrew G. Stephen

KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

Nature Communications(2021)10.1038/s41467-021-21422-x

N/A

0DataRank · unranked

253 citations

Albert H. Chan, Lucy C. Young, Lakshman Bindu, Chris Neale, Simon Messing +9 more

Anionic Lipids Impact RAS-Binding Site Accessibility and Membrane Binding Affinity of CRAF RBD-CRD

Biophysical Journal(2020)10.1016/j.bpj.2020.06.021

N/A

0DataRank · unranked

19 citations

César A. López, Constance Agamasu, Jeevapani J. Hettige, Simon Messing, Angel E. Garcı́a +3 more

An in vitro BRAF activation assay elucidates molecular mechanisms driving disassembly of the autoinhibited BRAF state

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2508169122

N/A

0DataRank · unranked

6 citations

David Durrant, Matthew Drew, Suzanne I. Sandin, Juliana A. Martinez Fiesco, Xiao‐Hua Zhang +21 more

Dynamics and lipid membrane coupling of the RAS-RAF complex revealed via multiscale simulations

Biophysical Journal(2025)10.1016/j.bpj.2025.08.020

N/A

0DataRank · unranked

2 citations

Fikret Aydin, Chris Neale, Que N. Van, Xiaohua Zhang, Harsh Bhatia +35 more

Tolypocladamides A–G: Cytotoxic Peptaibols from Tolypocladium inflatum

Journal of Natural Products(2022)10.1021/acs.jnatprod.2c00240

N/A

0DataRank · unranked

11 citations

Dongdong Wang, Chang‐Kwon Kim, Emily A. Smith, David Durrant, Patrick Alexander +7 more

Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.2006504117

N/A

0DataRank · unranked

58 citations

César A. López, Marco Tonelli, Troy Taylor, Ben Niu, Christopher B. Stanley +24 more

A cancer-associated K-RAS mutant that preferentially binds GDP displays gain-of-function and atypical signaling

Research Square(2022)10.21203/rs.3.rs-1521657/v1

N/A

0DataRank · unranked

1 citations

Tatu Pantsar, Alex G. Papageorge1, Brajendra K. Tripathi, Beatriz Sánchez‐Solana, Marian E. Durkin +8 more