Craig M. Crews

ORCID: 0000-0002-8456-2005

Also affiliated with Cellular Research (United States), Institut de Biologie Moléculaire et Cellulaire

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 28 papers. Top paper: “Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery”.

Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

Cell(2020)10.1016/j.cell.2019.11.031

N/A

1.0DataRank · unranked

981 citations

Craig M. Crews, George M. Burslem

PROTACs: An Emerging Therapeutic Modality in Precision Medicine

Cell chemical biology(2020)10.1016/j.chembiol.2020.07.020

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0DataRank · unranked

489 citations

Craig M. Crews, Dhanusha A. Nalawansha

Mechanistic basis and efficacy of targeting the β-catenin–TCF7L2–JMJD6–c-Myc axis to overcome resistance to BET inhibitors

Blood(2020)10.1182/blood.2019002922

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0DataRank · unranked

73 citations

Warren Fiskus, Christopher P. Mill, Dimuthu Perera, Taghi Manshouri, Bernardo H Lara +18 more

Scaffold hopping enables direct access to more potent PROTACs with in vivo activity

Chemical Communications(2020)10.1039/d0cc02201b

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0DataRank · unranked

33 citations

Daniel P. Bondeson, Craig M. Crews, George M. Burslem

Targeted Degradation of Oncogenic KRASG12C by VHL-recruiting PROTACs

ChemRxiv(2020)10.26434/chemrxiv.12091176.v1

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0DataRank · unranked

15 citations

Ling Chu, Dhanusha A. Nalawansha, Ke Li, Craig M. Crews, Michael J. Bond

Mutant-selective Degradation by BRAF-targeting PROTACs

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.08.10.245159

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0DataRank · unranked

14 citations

Saul Jaime‐Figueroa, Zhan Yao, Yijun Gao, John Hines, Kusal T. G. Samarasinghe +4 more

Targeted Degradation of Oncogenic KRASG12C by VHL-recruiting PROTACs

ChemRxiv(2020)10.26434/chemrxiv.12091176

N/A

0DataRank · unranked

11 citations

Ling Chu, Dhanusha A. Nalawansha, Ke Li, Craig M. Crews, Michael J. Bond

Targeted Degradation of Transcription Factors by TRAFTACs: Transcription Factor Targeting Chimeras

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.12.336529

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0DataRank · unranked

9 citations

Saul Jaime‐Figueroa, Katherine Dai, Zhenyi Hu, Craig M. Crews, Kusal T. G. Samarasinghe

Targeted protein degradation: A promise for undruggable proteins

Cell chemical biology(2021)10.1016/j.chembiol.2021.04.011

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0DataRank · unranked

272 citations

Craig M. Crews, Kusal T. G. Samarasinghe

Major advances in targeted protein degradation: PROTACs, LYTACs, and MADTACs

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100647

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0DataRank · unranked

259 citations

Craig M. Crews, Shanique Alabi

Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation

RSC Chemical Biology(2021)10.1039/d1cb00011j

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0DataRank · unranked

219 citations

Craig M. Crews, Michael J. Bond

Recent Developments in PROTAC‐Mediated Protein Degradation: From Bench to Clinic

ChemBioChem(2021)10.1002/cbic.202100270

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0DataRank · unranked

213 citations

Craig M. Crews, Zhenyi Hu

Mutant-selective degradation by BRAF-targeting PROTACs

Nature Communications(2021)10.1038/s41467-021-21159-7

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0DataRank · unranked

138 citations

Saul Jaime‐Figueroa, Zhan Yao, Yijun Gao, John Hines, Kusal T. G. Samarasinghe +4 more

Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs)

ACS Chemical Biology(2021)10.1021/acschembio.1c00693

N/A

0DataRank · unranked

127 citations

Zhenyi Hu, Elvira An, Ifunanya Okeke, Sijin Zheng, Xuanmeng Luo +4 more

BET proteolysis targeted chimera-based therapy of novel models of Richter Transformation-diffuse large B-cell lymphoma

Leukemia(2021)10.1038/s41375-021-01181-w

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0DataRank · unranked

29 citations

Christopher P. Mill, Dimuthu Perera, Christine Birdwell, Qing Deng, Haopeng Yang +13 more

OligoTRAFTACs: A Generalizable Method for Transcription Factor Degradation

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.12.20.473482

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0DataRank · unranked

3 citations

Elvira An, Miriam A. Genuth, Ling Chu, Scott A. Holley, Craig M. Crews +1 more

PROTAC targeted protein degraders: the past is prologue

Nature Reviews Drug Discovery(2022)10.1038/s41573-021-00371-6

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0DataRank · unranked

3111 citations

David R. Langley, Craig M. Crews, Miklós Békés

PROTACs: past, present and future

Chemical Society Reviews(2022)10.1039/d2cs00193d

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0DataRank · unranked

746 citations

Craig M. Crews, Ke Li

OligoTRAFTACs: A generalizable method for transcription factor degradation

RSC Chemical Biology(2022)10.1039/d2cb00138a

N/A

0DataRank · unranked

50 citations

Elvira An, Miriam A. Genuth, Ling Chu, Scott A. Holley, Craig M. Crews +1 more

Hijacking Methyl Reader Proteins for Nuclear-Specific Protein Degradation

Journal of the American Chemical Society(2022)10.1021/jacs.2c00874

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0DataRank · unranked

36 citations

Ke Li, John Hines, Craig M. Crews, Dhanusha A. Nalawansha

Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC

ACS Chemical Biology(2022)10.1021/acschembio.2c00145

N/A

0DataRank · unranked

15 citations

Michael J. Bond, Andreas P. Pintado-Urbanc, Mehana Daftary, Mackenzie W. Krone, Todd Douglas +6 more

Hijacking Methyl Reader Proteins for Nuclear-Specific Protein Degradation

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.01.24.477424

N/A

0DataRank · unranked

0 citations

Ke Li, John Hines, Craig M. Crews, Dhanusha A. Nalawansha

Targeted Dephosphorylation of Tau by Phosphorylation Targeting Chimeras (PhosTACs) as a Therapeutic Modality

Journal of the American Chemical Society(2023)10.1021/jacs.2c11706

N/A

0DataRank · unranked

85 citations

Po‐Han Chen, Wenxue Li, Todd Douglas, John Hines, Yansheng Liu +2 more

Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.01.01.522436

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0DataRank · unranked

33 citations

Chris D. Forbes, Rebecca Stronk, Jonathan P. Rappi, Kyle J. Eastman, Samuel W. Gerritz +27 more

Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies

Cell chemical biology(2024)10.1016/j.chembiol.2024.07.005

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0DataRank · unranked

70 citations

Chris D. Forbes, Rebecca Stronk, Jonathan P. Rappi, Kyle J. Eastman, Nilesh Zaware +30 more

Next steps for targeted protein degradation

Cell chemical biology(2024)10.1016/j.chembiol.2024.10.004

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0DataRank · unranked

34 citations

Craig M. Crews, Mackenzie W. Krone

Development of Ligands and Degraders Targeting MAGE-A3

Journal of the American Chemical Society(2024)10.1021/jacs.4c05393

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0DataRank · unranked

14 citations

Mackenzie W. Krone, Arseniy Butrin, Michael J. Bond, Brian M. Linhares, Craig M. Crews +1 more

Development of a Small Molecule Downmodulator for the Transcription Factor Brachyury

Angewandte Chemie International Edition(2024)10.1002/anie.202316496

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0DataRank · unranked

5 citations

Adrian M. Bebenek, Pengju Nie, Saul Jaime‐Figueroa, Arseniy Butrin, Danielle Castro +4 more