James E. Bear

University of North Carolina at Chapel Hill

Also affiliated with University of North Carolina Health Care

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 59 papers. Top paper: “Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing”.

Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing

PLoS Computational Biology(2020)10.1371/journal.pcbi.1007708

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8 citations

Anisur Rahman, Krithika Mohan, Timothy C. Elston, James E. Bear, Jason M. Haugh +1 more

Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation

JCI Insight(2020)10.1172/jci.insight.131382

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31 citations

Alexandra C. Doolittle, Kimheak Sao, Jeremy D. Rotty, James E. Bear, Veronica Ulici +5 more

Arp2/3 Is Critical for Lamellipodia and Response to Extracellular Matrix Cues but Is Dispensable for Chemotaxis

UNC Libraries(2020)10.17615/c2jn-w351

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4 citations

Elizabeth M. Haynes, Shawn M. Gomez, Jack D. Griffith, Congying Wu, Sreeja B. Asokan +3 more

The Sac1 Phosphoinositide Phosphatase Regulates Golgi Membrane Morphology and Mitotic Spindle Organization in Mammals

UNC Libraries(2020)10.17615/nh26-c133

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4 citations

Emily K. Tribble, Elizabeth Morin‐Kensicki, Vytas A. Bankaitis, James E. Bear, Andrea C. Uetrecht +2 more

Quantitative analysis of B-lymphocyte migration directed by CXCL13

UNC Libraries(2020)10.17615/p7n8-w358

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3 citations

Sreeja B. Asokan, James E. Bear, Jason M. Haugh, Xia-Ji Liu

Simultaneous Multi-Species Tracking in Live Cells with Quantum Dot Conjugates

UNC Libraries(2020)10.17615/0gr0-8m84

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1 citations

James E. Bear, Eva C. Arnspang, Mathias P. Clausen, B. Christoffer Lagerholm, Byron Ballou

Mena INV mediates synergistic cross-talk between signaling pathways driving chemotaxis and haptotaxis

UNC Libraries(2020)10.17615/qhpn-5r74

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1 citations

Shannon K. Hughes, Tatsiana Kosciuk, Alisha Lussiez, Frank B. Gertler, Joëlle Klazen +5 more

An optogenetic switch for the Set2 methyltransferase provides evidence for transcription-dependent and -independent dynamics of H3K36 methylation

Genome Research(2020)10.1101/gr.264283.120

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17 citations

Austin J. Hepperla, Gregory R. Keele, Hashem A. Meriesh, Hayretin Yumerefendi, David Restrepo +6 more

Coronin 1B Coordinates Arp2/3 Complex and Cofilin Activities at the Leading Edge

UNC Libraries(2020)10.17615/j96q-nt77

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Andrea C. Uetrecht, Dorothy A. Schafer, Thomas W. Marshall, James E. Bear, Liang Cai

Coronin 1B Antagonizes Cortactin and Remodels Arp2/3-Containing Actin Branches in Lamellipodia

UNC Libraries(2020)10.17615/ke52-hg69

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Alexander M. Makhov, Liang Cai, James E. Bear, Dorothy A. Schafer

Ankyrin-B is a PI3P effector that promotes polarized α5β1-integrin recycling via recruiting RabGAP1L to early endosomes

UNC Libraries(2020)10.17615/6j9n-fa80

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0 citations

Samantha King, Fangfei Qu, Vann Bennett, Rebecca Brooks, Damaris N. Lorenzo +1 more

Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin

UNC Libraries(2020)10.17615/bg8e-ds15

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David W. Roadcap, James E. Bear, Keefe T. Chan, Nicholas Holoweckyj

Control of Protein Activity and Cell Fate Specification via Light-Mediated Nuclear Translocation

UNC Libraries(2020)10.17615/6qr8-w815

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Brian Kuhlman, Daniel J. Dickinson, James E. Bear, Klaus M. Hahn, Seth P. Zimmerman +3 more

N-glycosylation controls the function of junctional adhesion molecule-A

UNC Libraries(2020)10.17615/x98t-3t38

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James E. Bear, Erika S. Wittchen, David W. Scott, Keith Burridge, Caitlin E. Tolbert +1 more

Golgi polarity does not correlate with speed or persistence of freely migrating fibroblasts

UNC Libraries(2020)10.17615/rvw0-4c72

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James E. Bear, Andrea C. Uetrecht

F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling

UNC Libraries(2020)10.17615/5naw-p626

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0 citations

Heath E. Johnson, Samantha J. King, Jason M. Haugh, James E. Bear, Sreeja B. Asokan +1 more

Metastasis in an orthotopic murine model of melanoma is independent of RAS/RAF mutation

UNC Libraries(2020)10.17615/54pk-ad77

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0 citations

Gabriela I. Rozenberg, Norman E. Sharpless, Kimberly B. Monahan, Chad Torrice, James E. Bear

Altered T-cell entry and egress in the absence of Coronin 1A attenuates murine acute graft versus host disease: Cellular immune response

UNC Libraries(2020)10.17615/ztmk-p459

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James E. Bear, Niko Föger, Nicholas Taylor, LeShara M Fulton, Albert S. Baldwin +4 more

Tuning the Binding Affinities and Reversion Kinetics of a Light Inducible Dimer Allows Control of Transmembrane Protein Localization

INDIGO (University of Illinois at Chicago)(2020)10.17615/sy9k-m240

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James E. Bear, Brian Kuhlman, Ryan A. Hallett, Matthew J. Kennedy, Ashley M. Bourke +1 more

Subtumoral analysis of PRINT nanoparticle distribution reveals targeting variation based on cellular and particle properties

UNC Libraries(2020)10.17615/snq3-ca26

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0 citations

Matthew C. Parrott, Ian J. Davis, Tao Bo, James E. Bear, Hailey E. Brighton +5 more

GMF controls branched actin content and lamellipodial retraction in fibroblasts

UNC Libraries(2020)10.17615/wdde-ym85

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0 citations

Elizabeth M. Haynes, Heath E. Johnson, Samantha J. King, James E. Bear, Jason M. Haugh +1 more

Plexin-B2 Negatively Regulates Macrophage Motility, Rac, and Cdc42 Activation

Carolina Digital Repository (University of North Carolina at Chapel Hill)(2020)10.17615/kgpy-vx72

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0 citations

Eda K. Holl, Haitao Wen, Elizabeth H. Guthrie, Brian P. O’Connor, Jenny P.-Y. Ting +7 more

Unraveling the enigma: progress towards understanding the coronin family of actin regulators

UNC Libraries(2020)10.17615/vjs5-p886

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0 citations

Keefe T. Chan, Sarah J. Creed, James E. Bear

Self-sorting of nonmuscle myosins IIA and IIB polarizes the cytoskeleton and modulates cell motility

UNC Libraries(2020)10.17615/xkvr-cf86

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0 citations

Tatyana Svitkina, James E. Bear, Shefali Talwar, Sreeja B. Asokan, Maria S. Shutova +1 more

The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility

UNC Libraries(2020)10.17615/d3gc-5f69

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0 citations

James E. Bear, Victoria L. Bautch, Thomas W. Marshall, Channing J. Der, Kent L. Rossman +3 more

LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues

Carolina Digital Repository (University of North Carolina at Chapel Hill)(2020)10.17615/nr0g-cg74

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Evan S. Dubose, Tao Bo, Shawn M. Gomez, James E. Bear, Wenjin Liu +7 more

Mesenchymal Chemotaxis Requires Selective Inactivation of Myosin II at the Leading Edge via a Noncanonical PLCγ/PKCα Pathway

UNC Libraries(2020)10.17615/m06r-1438

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James E. Bear, Samantha King, Irina P. Lebedeva, Jeremy D. Rotty, Heath E. Johnson +3 more

Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins

UNC Libraries(2020)10.17615/34fj-dp19

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0 citations

Gurkan Guntas, Tishan Williams, Ryan A. Hallett, James E. Bear, Hayretin Yumerefendi +2 more

Nanoparticle clearance is governed by Th1/Th2 immunity and strain background

UNC Libraries(2020)10.17615/7vth-5e13

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Jillian L. Perry, Joseph M. DeSimone, James E. Bear, Mary E. Napier, Gregory R. Robbins +6 more

Profilin-1 Serves as a Gatekeeper for Actin Assembly by Arp2/3-Dependent and -Independent Pathways

UNC Libraries(2020)10.17615/2zfj-pd48

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Congying Wu, Jeremy D. Rotty, Heath E. Johnson, Cristian Suarez, Jason M. Haugh +4 more

Lamellipodia are crucial for haptotactic sensing and response

UNC Libraries(2020)10.17615/wy7s-wc23

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0 citations

Norman E. Sharpless, Alicia C. Tagliatela, James E. Bear, Seth P. Zimmerman, Jason M. Haugh +11 more

Light-induced nuclear export reveals rapid dynamics of epigenetic modifications

UNC Libraries(2020)10.17615/myp5-ws09

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James E. Bear, Klaus M. Hahn, Andrew M. Lerner, Seth P. Zimmerman, Brian D. Strahl +2 more

Loss of Arp2/3 induces an NF-κB–dependent, nonautonomous effect on chemotactic signaling

UNC Libraries(2020)10.17615/n796-qd81

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0 citations

James E. Bear, Gary L. Johnson, Jeremy M. Simon, Sreeja B. Asokan, Norman E. Sharpless +4 more

Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet

UNC Libraries(2020)10.17615/jgtb-q145

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0 citations

James E. Bear, Jason M. Haugh

Coronin 1B Regulates S1P-Induced Human Lung Endothelial Cell Chemotaxis: Role of PLD2, Protein Kinase C and Rac1 Signal Transduction

UNC Libraries(2020)10.17615/sj5b-ce31

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0 citations

Long Huang, Viswanathan Natarajan, Donghong He, James E. Bear, David L. Ebenezer +7 more

Tortuous Microvessels Contribute to Wound Healing via Sprouting AngiogenesisHighlights

UNC Libraries(2020)10.17615/8bjp-z006

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0 citations

Victoria L. Bautch, Zhixian Yu, Diana C. Chong, Hailey E. Brighton, James E. Bear

Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression

UNC Libraries(2020)10.17615/5ptk-cs32

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0 citations

Kari B. Wisinski, Jeff Wyckoff, Oliver Jonas, Liliane C. Broye, Maaike Cima +14 more

Modeling cell protrusion predicts how myosin II and actin turnover affect adhesion-based signaling

Biophysical Journal(2021)10.1016/j.bpj.2021.11.2889

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17 citations

Mitchell T. Butler, James E. Bear, Jason M. Haugh, Ankit Chandra

Phosphorylation of Coronin 1B by Protein Kinase C Regulates Interaction with Arp2/3 and Cell Motility

UNC Libraries(2021)10.17615/ry4b-w686

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0 citations

Michael D. Schaller, James E. Bear, Nicholas Holoweckyj, Liang Cai

Ena/VASP: towards resolving a pointed controversy at the barbed end

UNC Libraries(2021)10.17615/jm1s-5w39

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0 citations

James E. Bear, Frank B. Gertler

F-actin binding is essential for coronin 1B function in vivo

Carolina Digital Repository (University of North Carolina at Chapel Hill)(2021)10.17615/ajbs-8d33

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0 citations

Liang Cai, James E. Bear, Alexander M. Makhov

Coro1B and Coro1C regulate lamellipodia dynamics and cell motility by tuning branched actin turnover

The Journal of Cell Biology(2022)10.1083/jcb.202111126

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33 citations

Mitchell T. Butler, Max A. Hockenberry, Bhagawat C. Subramanian, Priscila F. Siesser, David M. Graham +3 more

A kinetic model of phospholipase C-γ1 linking structure-based insights to dynamics of enzyme autoinhibition and activation

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.101886

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9 citations

James E. Bear, Jason M. Haugh, Jamie L. Nosbisch

Zyxin and non-muscle myosin are required for single fibroblast durotaxis, but Rho-kinase activity and the Arp2/3 complex are dispensable

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.06.03.494725

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1 citations

Bhagawat C. Subramanian, Max A. Hockenberry, Zayna T. King, Mitchell T. Butler, Wesley R. Legant +2 more

Viral Airway Injury Promotes Cell Engraftment in an In Vitro Model of Cystic Fibrosis Cell Therapy

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.14.516213

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0 citations

Teresa Mascenik, Sidra C. Major, Catherine A. Lewis, James E. Bear, Raymond J. Pickles +2 more

G-actin diffusion is insufficient to achieve F-actin assembly in fast-treadmilling protrusions

Biophysical Journal(2023)10.1016/j.bpj.2023.08.022

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3 citations

Mitchell T. Butler, James E. Bear, Jason M. Haugh, Ravikanth Appalabhotla

The actin binding protein profilin 1 is critical for mitochondria function

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.08.07.552354

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8 citations

Bruno A. Cisterna, Kristen Skruber, Samah Ahmadieh, Halli L. Lindamood, Josefine A. Vitriol +10 more

Local Monomer Levels and Established Filaments Potentiate Non-Muscle Myosin 2 Assembly

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.26.538303

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3 citations

Hiral Patel, Huini Wu, Kem A. Sochacki, Matthew Akamatsu, Jeremy D. Rotty +6 more

The actin binding protein profilin 1 localizes inside mitochondria and is critical for their function

EMBO Reports(2024)10.1038/s44319-024-00209-3

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13 citations

Bruno A. Cisterna, Kristen Skruber, Samah Ahmadieh, Tatiana M. Liu, Josefine A. Vitriol +11 more

Local monomer levels and established filaments potentiate non-muscle myosin 2 assembly

The Journal of Cell Biology(2024)10.1083/jcb.202305023

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19 citations

Hiral Patel, Huini Wu, Kem A. Sochacki, Shreya Chandrasekar, Matthew Akamatsu +7 more

Prolonged depletion of profilin 1 or F-actin causes an adaptive response in microtubules

The Journal of Cell Biology(2024)10.1083/jcb.202309097

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8 citations

Kristen Skruber, Makenzie L. Jane, Caleb I. Camesi, Ivan D. Nguyen, Tatiana M. Liu +8 more

An optogenetic switch for the Set2 methyltransferase provides evidence for transcription-dependent and -independent dynamics of H3K36 methylation

UNC Libraries(2024)10.17615/qpkr-t108

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0 citations

Austin J. Hepperla, Seth P. Zimmerman, Gregory R. Keele, Ian J. Davis, Brian Kuhlman +6 more

Measurement of cellular traction forces during confined migration

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2509535122

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5 citations

Andrew J. Ulmer, Johann L. Rapp, Harrison H. Truscott, Frank A. Leibfarth, James E. Bear +2 more

When two worlds collide: actin dynamics on endomembranes regulates membrane trafficking

Current Opinion in Cell Biology(2025)10.1016/j.ceb.2025.102596

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4 citations

James E. Bear, Michelle F. Marchan

Coro1A and TRIM67 collaborate in netrin-dependent neuronal morphogenesis

The Journal of Cell Biology(2025)10.1083/jcb.202503068

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1 citations

Elliot B. Evans, Kimberly Lukasik, Ellen C. O’Shaughnessy, Aneri Shah, Chih-Hsuan Hsu +4 more

Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction

UNC Libraries(2025)10.17615/qd12-gc03

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0 citations

Tomas Andersen, Martial Balland, Brenton D. Hoffman, Keith Burridge, David M. Graham +5 more

Optogenetic control of PLC-γ1 activity directs cell motility

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.10.09.681531

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0 citations

Priscila F. Siesser, Harrison H. Truscott, Nicole Hajicek, John Sondek, James E. Bear +2 more

Small Molecule Activators of the Mitochondrial Protease ClpP Induce Senescence in Triple-Negative Breast Cancer Cells and Sensitize Cells to the Bcl-2 Inhibitor Venetoclax

Research Square(2025)10.21203/rs.3.rs-7682325/v1

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0 citations

Sabrina Daglish, Owen G Canterbury, Paul R. Graves, Sarah Carter, Sydney Beese +18 more

Viral airway injury promotes cell engraftment in an in vitro model of cystic fibrosis cell therapy

UNC Libraries(2025)10.17615/m22s-sf03

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0 citations

Raymond J. Pickles, Sidra C. Major, Emily C. Bulik‐Sullivan, Finn Hawkins, Rhianna E. Lee +7 more