Timothy Spicer

Also affiliated with The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology

Biochemistry, Genetics and Molecular BiologyNeuroscienceMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 50 papers. Top paper: “Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming”.

Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming

Nature Chemical Biology(2020)10.1038/s41589-020-0584-z

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0DataRank · unranked

185 citations

Aparajita Madhavan, Lauren Čech, Bryan O. Seguinot, Ryan J Paxman, Emery Smith +8 more

SYNGAP1Controls the Maturation of Dendrites, Synaptic Function, and Network Activity in Developing Human Neurons

Journal of Neuroscience(2020)10.1523/jneurosci.1367-20.2020

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0DataRank · unranked

78 citations

Vineet Arora, Ridhima Vij, Murat Kılınç, Łukasz Bijoch, Camilo Rojas +10 more

High-Throughput Screening for Drugs That Inhibit Papain-Like Protease in SARS-CoV-2

SLAS DISCOVERY(2020)10.1177/2472555220963667

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52 citations

Meredith E. Davis-Gardner, Rubén D. Garcia-Ordoñez, Tu-Trinh H. Nguyen, Mitchell Hull, Emily Chen +7 more

Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening

SLAS DISCOVERY(2020)10.1177/2472555220945283

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16 citations

Michael V. Airola, Yong‐Mi Choi, Nicolas Coant, Justin M. Snider, Chris Cariello +10 more

An unbiased high‐throughput drug screen reveals a potential therapeutic vulnerability in the most lethal molecular subtype of pancreatic cancer

Molecular Oncology(2020)10.1002/1878-0261.12743

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16 citations

Yuka Otsuka, BanuPriya Sridharan, Melissa Woo, Cindy V. Leiton, Sruthi Babu +10 more

Rescue of mutant gonadotropin-releasing hormone receptor function independent of cognate receptor activity

Scientific Reports(2020)10.1038/s41598-020-67473-w

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0DataRank · unranked

9 citations

Jo Ann Janovick, Thomas D. Bannister, Justin Shumate, Vadivel Ganapathy, Louis Scampavia +2 more

Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment

Science Advances(2020)10.1126/sciadv.aaz8031

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0DataRank · unranked

36 citations

Chiang-Min Cheng, Jun Qin, Mafei Xu, Chung‐Yang Kao, Jingjing Shi +12 more

Identification of Compounds That Promote Readthrough of Premature Termination Codons in the CFTR

SLAS DISCOVERY(2020)10.1177/2472555220962001

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8 citations

Danijela Dukovski, Justin Shumate, Louis Scampavia, John P. Miller, Timothy Spicer +1 more

Drug Discovery Targeting COVID-19

SLAS DISCOVERY(2020)10.1177/2472555220970966

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2 citations

Timothy Spicer

Prioritizing targeted therapies in an evidence-based manner, integrating biological context and functional precision medicine.

Journal of Clinical Oncology(2020)10.1200/jco.2020.38.15_suppl.e14065

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2 citations

Krithika Bhuvaneshwar, Virneliz Fernández-Vega, Jayaram Kancherla, Shruti Rao, Subha Madhavan +6 more

Human SYNGAP1 Regulates the Development of Neuronal Activity by Controlling Dendritic and Synaptic Maturation

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.06.01.127613

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2 citations

Vineet Arora, Ridhima Vij, Murat Kılınç, Łukasz Bijoch, Camilo Rojas +10 more

Discovery and Optimization of Selective Inhibitors of Meprin α (Part I)

Preprints.org(2020)10.20944/preprints202012.0354.v1

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1 citations

Juan J. Díez, Chao Wang, Christoph Becker‐Pauly, Gregg B. Fields, Thomas D. Bannister +4 more

Development and pilot screen of novel high content assay for down regulators of expression of heterogenous nuclear ribonuclear protein H2

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.05.326116

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0DataRank · unranked

0 citations

Sumitha Rajendrarao, Shadi A. Baajour, Praathibha Sripadhan, Timothy Spicer, Louis Scampavia +2 more

Discovery and Optimization of Selective Inhibitors of Meprin α (Part II)

Preprints.org(2020)10.20944/preprints202012.0383.v1

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0 citations

Juan J. Díez, HaJeung Park, Christoph Becker‐Pauly, Gregg B. Fields, Timothy Spicer +4 more

Receptor antagonism/agonism can be uncoupled from pharmacoperone activity

UNC Libraries(2020)10.17615/452n-cs70

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0 citations

Emery Smith, Timothy Spicer, Jo Ann Janovick, Terry Kenakin, P. Michael Conn +2 more

Identification of novel modulators of a schistosome transient receptor potential channel targeted by praziquantel

PLoS neglected tropical diseases(2021)10.1371/journal.pntd.0009898

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25 citations

Emery Smith, Claudia M. Rohr, Nawal A. Yahya, Sang-Kyu Park, Louis Scampavia +3 more

Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay

Bioorganic & Medicinal Chemistry(2021)10.1016/j.bmc.2021.116246

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8 citations

Jonathan R. Hart, BanuPriya Sridharan, Scott J. Novick, Lewis D. Turner, Bin Zhou +11 more

Identification of Potential Modulators of the RGS7/Gβ5/R7BP Complex

SLAS DISCOVERY(2021)10.1177/24725552211020679

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1 citations

Virneliz Fernández-Vega, Brian S. Muntean, Dipak N. Patil, Justin Shumate, Thomas D. Bannister +4 more

Development and Pilot Screen of Novel High Content Assay for Down Regulators of Expression of Heterogenous Nuclear Ribonuclear Protein H2

Cellular Physiology and Biochemistry(2021)10.33594/000000372

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0DataRank · unranked

0 citations

Sumitha Rajendrarao, Shadi A. Baajour, Praathibha Sripadhan, Timothy Spicer, Louis Scampavia +2 more

LPCAT3 Inhibitors Remodel the Polyunsaturated Phospholipid Content of Human Cells and Protect from Ferroptosis

ACS Chemical Biology(2022)10.1021/acschembio.2c00317

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151 citations

Taka-Aki Ichu, Natalia Milosevich, Bruno Melillo, Michael A. Schafroth, Yuka Otsuka +4 more

Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 M pro /3CL pro in Living Cells

mBio(2022)10.1128/mbio.00784-22

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39 citations

Morgan A. Esler, Yuka Otsuka, Jordan T. Becker, Sofia N. Moraes, Constance B. Anderson +12 more

Identification of potent small molecule inhibitors of SARS-CoV-2 entry

SLAS DISCOVERY(2022)10.1016/j.slasd.2021.10.012

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32 citations

Huihui Mou, Yuka Otsuka, Joseph Jablonski, Robert S. Adcock, Lalit Batra +19 more

Lead identification using 3D models of pancreatic cancer

SLAS DISCOVERY(2022)10.1016/j.slasd.2022.03.002

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32 citations

Shurong Hou, Dennis Plenker, Hervé Tiriac, Pierre Baillargeon, Justin Shumate +6 more

High throughput screening for compounds to the orphan nuclear receptor NR2F6

SLAS DISCOVERY(2022)10.1016/j.slasd.2022.03.005

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13 citations

Sean Campbell, Adrianna N. Wilson, Justin Shumate, Pierre Baillargeon, Louis Scampavia +4 more

Screening for modulators of autism spectrum disorder using induced human neurons

SLAS DISCOVERY(2022)10.1016/j.slasd.2022.01.004

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10 citations

Ana Kostić, Pierre Baillargeon, Virneliz Fernández-Vega, Mitzy Ríos de Anda, Kelty Fletcher +5 more

A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy

Cell Research(2023)10.1038/s41422-022-00744-5

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21 citations

Kaige Chen, Jun Dai, Peng Xu, Wei Sun, Wanlin Liu +24 more

Elemene sensitizes pancreatic cancer cells to bortezomib by enhancing proteasome inhibition via molecular patch mechanism

Signal Transduction and Targeted Therapy(2023)10.1038/s41392-023-01373-z

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17 citations

Zhenzhen Li, Xiaoling Chen, Wenxin Wang, Ting Duan, Louis Scampavia +5 more

High throughput screening for drugs that inhibit 3C-like protease in SARS-CoV-2

SLAS DISCOVERY(2023)10.1016/j.slasd.2023.01.001

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14 citations

Meredith E. Davis-Gardner, Rubén D. Garcia-Ordoñez, Tu-Trinh Nguyen, Mitchell Hull, Emily Chen +8 more

Protocol for 3D screening of lung cancer spheroids using natural products

SLAS DISCOVERY(2023)10.1016/j.slasd.2023.01.005

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13 citations

Dong Yang, Luis Ortiz Jordán, Fei Ye, Louis P. Conway, Li Yun Chen +7 more

In Vitro and In Vivo Drug-Response Profiling Using Patient-Derived High-Grade Glioma

Cancers(2023)10.3390/cancers15133289

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11 citations

Virneliz Fernández-Vega, Jantzen Sperry, Jonathan Nakashima, Long Do, W. Andrews +10 more

A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer

Cell Death and Disease(2023)10.1038/s41419-023-06145-9

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7 citations

Suyakarn Archasappawat, Keely Ji, Jocelyn Pena, Virneliz Fernández-Vega, Ritika Gangaraju +8 more

High throughput assay for compounds that boost BDNF expression in neurons

SLAS DISCOVERY(2023)10.1016/j.slasd.2023.02.005

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5 citations

Haifei Xu, Justin Shumate, Louis Scampavia, Timothy Spicer, Baoji Xu +1 more

Neutral ceramidase-active site inhibitor chemotypes and binding modes

Bioorganic Chemistry(2023)10.1016/j.bioorg.2023.106747

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3 citations

John D. Bickel, Ronald J. Rahaim, Yuka Otsuka, Yong‐Mi Choi, Ruijuan Xu +14 more

Target-based discovery of a broad spectrum flukicide

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.09.22.559026

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6 citations

Sang-Kyu Park, Svenja Gramberg, Lisa Bauer, Claudia M. Rohr, Evgeny G. Chulkov +6 more

High throughput screening for SARS-CoV-2 helicase inhibitors

SLAS DISCOVERY(2024)10.1016/j.slasd.2024.100180

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15 citations

Eunjung Kim, Austin Krueger, Justin Shumate, Chao Wang, Bilel Bdiri +7 more

Target-based discovery of a broad-spectrum flukicide

Nature Structural & Molecular Biology(2024)10.1038/s41594-024-01298-3

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13 citations

Sang-Kyu Park, Svenja Gramberg, Lisa Bauer, Claudia M. Rohr, Evgeny G. Chulkov +6 more

Protocol for high throughput 3D drug screening of patient derived melanoma and renal cell carcinoma

SLAS DISCOVERY(2024)10.1016/j.slasd.2024.01.002

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7 citations

Virneliz Fernández Vega, Justin Shumate, A. Mihaljević Peleš, Jordan Zeiger, Louis Scampavia +2 more

A high-throughput cell-based screening method for Zika virus protease inhibitor discovery

SLAS DISCOVERY(2024)10.1016/j.slasd.2024.100164

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6 citations

Yuka Otsuka, Simon Lattmann, Khac Huy Ngo, Chong Wai Liew, CongBao Kang +5 more

SARS-CoV-2 Mpro inhibitor identification using a cellular gain-of-signal assay for high-throughput screening

SLAS DISCOVERY(2024)10.1016/j.slasd.2024.100181

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6 citations

Jyoti Vishwakarma, Seyed Arad Moghadasi, Yuka Otsuka, Justin Shumate, Ashley Cuell +14 more

Simultaneous screening for selective SARS-CoV-2, Lassa, and Machupo virus entry inhibitors

SLAS DISCOVERY(2024)10.1016/j.slasd.2024.100178

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5 citations

Lizhou Zhang, Huihui Mou, Justin Shumate, Claire E. Kitzmiller, Louis Scampavia +5 more

Protocol for kinetic mode potassium channel assays on common plate readers and microscopes

SLAS DISCOVERY(2024)10.1016/j.slasd.2024.100148

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2 citations

Louise Dickson, Philip Pickford, Anna Rowland, Justin Shumate, Katherine Pérez +4 more

Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.3c01763

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3 citations

Kanamata Reddy, Virneliz Fernández Vega, Raja Dey, Katherine A. Hicks, Sumitha Rajendra Rao +8 more

Homeostatic scaling of dynorphin signaling by a non-canonical opioid receptor

Nature Communications(2025)10.1038/s41467-025-62133-x

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4 citations

Nathan D. Winters, Shubhi Pandey, Colten K. Lankford, Hannah M. Stoveken, Emery Smith +6 more

High throughput screening for SARS-CoV-2 inhibitors targeting 5 helix bundle

SLAS DISCOVERY(2025)10.1016/j.slasd.2025.100262

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2 citations

Qibin Geng, Justin Shumate, Yuka Otsuka, Louis Scampavia, Thomas D. Bannister +2 more

Hyperphosphorylated tau-based Alzheimer’s Disease drug discovery: Identification of inhibitors of tau aggregation and cytotoxicity

SLAS DISCOVERY(2025)10.1016/j.slasd.2025.100235

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4 citations

Virneliz Fernández-Vega, Kuang‐Wei Wang, Luis M. Ortiz Jordan, Justin Shumate, Louis Scampavia +5 more

High-throughput in vivo screening platform for rapid discovery of adult mosquitocides: Design, validation and automation for scalable vector control

Pesticide Biochemistry and Physiology(2025)10.1016/j.pestbp.2025.106619

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1 citations

Justin Shumate, Jocelyn Peña, Timothy Spicer, Louis Scampavia, Troy D. Anderson +2 more

A high throughput assay for phosphoribosylformylglycinamidine synthase

SLAS DISCOVERY(2025)10.1016/j.slasd.2025.100212

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2 citations

Yuka Otsuka, Louis Scampavia, Timothy Spicer, Jarrod B. French, Nandini Sharma

Discovery of a potent anti-Zika virus benzamide series targeting the viral protein NS4B

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.10.09.681361

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1 citations

Yuka Otsuka, Eunjung Kim, Sultan Ullah, Nicole Kennedy, Khac Huy Ngo +15 more

SLAS special issue editorial 2025: Outcomes from antiviral drug discovery for pathogens of pandemic concern

SLAS DISCOVERY(2025)10.1016/j.slasd.2025.100231

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0 citations

Louis Scampavia, Timothy Spicer

Cell based high-throughput screening for small molecule inhibitors of ATE1

SLAS DISCOVERY(2025)10.1016/j.slasd.2025.100263

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0 citations

Evan Ambrose, Devang M. Patel, Hassan Al‐Ali, Louis Scampavia, Fangliang Zhang +2 more