Shyam K. Sharan

Also affiliated with Frederick National Laboratory for Cancer Research, National Cancer Institute, Cancer Genetics (United States), Center for Cancer Research

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 32 papers. Top paper: “Spatiotemporal modulation of growth factors directs the generation of multilineage mouse embryonic stem cell-derived mammary organoids”.

Spatiotemporal modulation of growth factors directs the generation of multilineage mouse embryonic stem cell-derived mammary organoids

Developmental Cell(2023)10.1016/j.devcel.2023.12.003

N/A

0.563DataRank · unranked

16 citations

Sarthak Sahoo, Teresa Sullivan, T. Norene O’Sullivan, Sevilay Turan, Mary Albaugh +8 more

Calibration of Pathogenicity Due to Variant-Induced Leaky Splicing Defects by Using BRCA2 Exon 3 as a Model System

Cancer Research(2020)10.1158/0008-5472.can-20-0895

N/A

0.515DataRank · unranked

30 citations

Sandrine M. Caputo, Teresa Sullivan, Julie Rondeaux, Sophie Krieger, Virginie Caux‐Moncoutier +33 more

Saturation genome editing of 11 codons and exon 13 of BRCA2 coupled with chemotherapeutic drug response accurately determines pathogenicity of variants

PLoS Genetics(2023)10.1371/journal.pgen.1010940

N/A

0.464DataRank · unranked

21 citations

Teresa Sullivan, Alexander Y. Mitrophanov, Mélissa Galloux, Darryl Nousome, Eileen Southon +10 more

A novel mouse model of PMS2 founder mutation that causes mismatch repair defect due to aberrant splicing

Cell Death and Disease(2021)10.1038/s41419-021-04130-8

N/A

0.385DataRank · unranked

12 citations

Martin Couillard, Luca Cavallone, Sandra Burkett, Stacey Stauffer, Betty K. Martin +14 more

Rare germline variants in PALB2 and BRCA2 in familial and sporadic chordoma

Human Mutation(2022)10.1002/humu.24427

N/A

0.330DataRank · unranked

8 citations

Kajal Biswas, Tzeh Keong Foo, Thiago T. Gomes, Maximilian Riedel‐Topper, Eileen Southon +24 more

Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.16.533020

N/A

0.104DataRank · unranked

1 citations

Ramona N. Moro, Suhas S. Kharat, Prosun Das, A Chaudhuri, Shyam K. Sharan +2 more

Coiled-Coil Domain: Uncoiling Tumor Suppression by BRCA1

Cancer Research(2021)10.1158/0008-5472.can-21-3480

N/A

0.104DataRank · unranked

1 citations

Sounak Sahu, Shyam K. Sharan, Arun Prakash Mishra

RAD52 S346X variant reduces breast cancer risk in BRCA2 mutation carriers

Molecular Oncology(2020)10.1002/1878-0261.12679

N/A

0DataRank · unranked

8 citations

Shyam K. Sharan, Kajal Biswas

Exploring role of 5hmC as potential marker of chemoresistance

Molecular & Cellular Oncology(2020)10.1080/23723556.2020.1827904

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0DataRank · unranked

5 citations

Shyam K. Sharan, Suhas S. Kharat

Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCα and TSC2-mTOR downregulation

Communications Biology(2021)10.1038/s42003-021-01864-1

N/A

0DataRank · unranked

41 citations

Yotam Blech‐Hermoni, Kalpana Subedi, Jessica Mpamugo, Charissa Obeng-Nyarko, Rachel Ohman +7 more

WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells

Nature Communications(2021)10.1038/s41467-021-26811-w

N/A

0DataRank · unranked

51 citations

Kajal Biswas, Joshua A. Sommers, Haley Thompson, Sanket Awate, Claudia M. Nicolae +6 more

The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation

Nature Communications(2021)10.1038/s41467-021-23809-2

N/A

0DataRank · unranked

40 citations

Kai Ni, Yafeng He, Jianke Ren, Chongkui Sun, Yie Liu +7 more

Genotype-cancer association in patients with Fanconi anemia due to pathogenic variants in FANCD1 (BRCA2) or FANCN (PALB2)

Cancer Genetics(2021)10.1016/j.cancergen.2021.10.001

N/A

0DataRank · unranked

31 citations

Kajal Biswas, Neelam Giri, Shyam K. Sharan, Blanche P. Alter, Lisa J. McReynolds

Distinct Biomarker Profiles and TCR Sequence Diversity Characterize the Response to PD-L1 Blockade in a Mouse Melanoma Model

Molecular Cancer Research(2021)10.1158/1541-7786.mcr-20-0881

N/A

0DataRank · unranked

3 citations

Devon Atkinson, Alan Kulaga, Abdalla Abdelmaksoud, Michelle Gumprecht, Nathan Pate +11 more

Growth factor dependency in mammary organoids regulates ductal morphogenesis during organ regeneration

Scientific Reports(2022)10.1038/s41598-022-11224-6

N/A

0DataRank · unranked

23 citations

Mary Albaugh, Betty K. Martin, Nimit L. Patel, Lisa Riffle, Susan Mackem +3 more

BRCA2-DSS1 interaction is dispensable for RAD51 recruitment at replication-induced and meiotic DNA double strand breaks

Nature Communications(2022)10.1038/s41467-022-29409-y

N/A

0DataRank · unranked

24 citations

Suzanne A. Hartford, Sounak Sahu, Kimberly D. Klarmann, Rajani Kant Chittela, Kajal Biswas +11 more

Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15

Nature Communications(2023)10.1038/s41467-023-41801-w

N/A

0DataRank · unranked

27 citations

Uddipta Biswas, Suhas S. Kharat, Filip D Duzanic, Prosun Das, Maria Stavrou +6 more

Protocol for the saturation and multiplexing of genetic variants using CRISPR-Cas9

STAR Protocols(2023)10.1016/j.xpro.2023.102702

N/A

0DataRank · unranked

5 citations

Teresa Sullivan, Eileen Southon, Dylan Caylor, Josephine Geh, Shyam K. Sharan +1 more

Characterization of BRCA2 R3052Q variant in mice supports its functional impact as a low-risk variant

Cell Death and Disease(2023)10.1038/s41419-023-06289-8

N/A

0DataRank · unranked

3 citations

Suzanne A. Hartford, Rajani Kant Chittela, Sounak Sahu, Suhas S. Kharat, Lucia Alvaro-Aranda +11 more

Sequencing-based functional assays for classification of BRCA2 variants in mouse ESCs

Cell Reports Methods(2023)10.1016/j.crmeth.2023.100628

N/A

0DataRank · unranked

2 citations

Alexander Y. Mitrophanov, Sounak Sahu, Teresa Sullivan, Eileen Southon, Darryl Nousome +13 more

AVENGERS: Analysis of Variant Effects using Next Generation sequencing to Enhance BRCA2 Stratification

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.14.571713

N/A

0DataRank · unranked

3 citations

Mélissa Galloux, Eileen Southon, Dylan Caylor, Teresa Sullivan, Matteo Arnaudi +5 more

Data from Degradation of BRCA2 in Alkyltransferase-Mediated DNA Repair and Its Clinical Implications

(2023)10.1158/0008-5472.c.6498177.v1

N/A

0DataRank · unranked

0 citations

Srividya Swaminathan, Sergey G. Kuznetsov, Sreenivas Kanugula, Kajal Biswas, Suhwan Chang +6 more

Mismatch repair protein MLH1 suppresses replicative stress in BRCA2-deficient breast tumors

Journal of Clinical Investigation(2024)10.1172/jci173718

N/A

0DataRank · unranked

11 citations

Xiaoju Hu, Vaishnavi Peddibhotla, Kuppusamy Balamurugan, Alexander Y. Mitrophanov, Lois McKennett +12 more

Treatment with novel topoisomerase inhibitors in Ewing sarcoma models reveals heterogeneity of tumor response

Frontiers in Cell and Developmental Biology(2024)10.3389/fcell.2024.1462840

N/A

0DataRank · unranked

0 citations

Ludmila Szabova, Victor J. Collins, Melanie B. Gordon, Kristine Johnson, Deborah B. Householder +15 more

Multimodel preclinical platform predicts clinical response of melanoma to immunotherapy

Nature Medicine(2020)10.1038/s41591-020-0818-3

N/A

0DataRank · unranked

118 citations

Howard H. Yang, Romina E. Araya, Rajaâ El Meskini, Helen Michael, Suman K. Vodnala +20 more

5hmC enhances PARP trapping and restores PARP inhibitor sensitivity in chemoresistant BRCA1/2-deficient cells

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110393

N/A

0DataRank · unranked

3 citations

Arun Prakash Mishra, Satheesh Kumar Sengodan, Dillon Dierman, Stephen D. Fox, Walter Chazin +2 more

Degradation of 5hmC-marked stalled replication forks by APE1 causes genomic instability

Science Signaling(2020)10.1126/scisignal.aba8091

N/A

0DataRank · unranked

65 citations

Xia Ding, Divya Swaminathan, Akshey Suresh, Manish Singh, Satheesh Kumar Sengodan +10 more

Translating Embryogenesis to Generate Organoids: Novel Approaches to Personalized Medicine

iScience(2020)10.1016/j.isci.2020.101485

N/A

0DataRank · unranked

51 citations

Shyam K. Sharan, Sounak Sahu

Epidemiological and ES cell‐based functional evaluation of BRCA2 variants identified in families with breast cancer

Human Mutation(2020)10.1002/humu.24154

N/A

0DataRank · unranked

8 citations

Eswary Thirthagiri, Chan‐Eng Chong, Stacey Stauffer, Susan Reid, Eileen Southon +19 more

Functional evaluation of five BRCA2 unclassified variants identified in a Sri Lankan cohort with inherited cancer syndromes using a mouse embryonic stem cell-based assay

Breast Cancer Research(2020)10.1186/s13058-020-01272-z

N/A

0DataRank · unranked

8 citations

Kajal Biswas, Teresa Sullivan, Stacey Stauffer, Linda Cleveland, Eileen Southon +3 more

Bypass of premature stop codons and generation of functional BRCA2 by exon skipping

Journal of Human Genetics(2020)10.1038/s10038-020-0768-0

N/A

0DataRank · unranked

8 citations

Kajal Biswas, Shyam K. Sharan, Stacey Stauffer

A computational model for classification of BRCA2 variants using mouse embryonic stem cell-based functional assays

npj Genomic Medicine(2020)10.1038/s41525-020-00158-5

N/A

0DataRank · unranked

30 citations

Gary Lipton, Stacey Stauffer, Teresa Sullivan, Linda Cleveland, Eileen Southon +5 more