Xin Chen

Also affiliated with Shaanxi Provincial People's Hospital, Wangjing Hospital of China Academy of Chinese Medical Sciences, China Academy of Chinese Medical Sciences, Shanxi Provincial People’s Hospital, Hubei University of Technology

Biochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 69 papers. Top paper: “A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis”.

A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis

Nature Communications(2021)10.1038/s41467-021-27452-9

N/A

8.8DataRank · unranked

342 citations

Yalan Deng, Yang Zhao, Ying Mei, Yilei Zhang, Xiaoguang Liu +20 more

Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors

Proceedings of the National Academy of Sciences(2003)10.1073/pnas.2235735100

N/A

0.971DataRank · unranked

648 citations

Xin Chen, Jonathan S. Draper, Jessica E. Antosiewicz, Chris H. Chon, Sunita B. Jones +5 more

Variation in Gene Expression Patterns in Human Gastric Cancers

Molecular Biology of the Cell(2003)10.1091/mbc.e02-12-0833

N/A

0.865DataRank · unranked

318 citations

Suet Y. Leung, Siu T. Yuen, Kent-Man Chu, Jiafu Ji, Rui Li +11 more

HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma

Cancer Research(2024)10.1158/0008-5472.can-24-0456

N/A

0.218DataRank · unranked

3 citations

Adriana Pitea, Gwendolyn M. Jang, Zhong Xu, Huat Chye Lim, Alex L. Choi +22 more

Inhibition of GSK3 and TSC2 Mediates the Oncogenic Activity of AKT in Hepatocellular Carcinoma

Cancer Research(2025)10.1158/0008-5472.can-25-1615

N/A

0.208DataRank · unranked

3 citations

Yi Zhou, Weiting Liao, Eleonora Cossu, Matthias Evert, Shu Zhang +19 more

Figure S3 from HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma

Figshare(2025)10.1158/0008-5472.28428325

N/A

0DataRank · unranked

0 citations

Adriana Pitea, Gwendolyn M. Jang, Zhong Xu, Huat Chye Lim, Alex L. Choi +22 more

Figure S3 from HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma

Figshare(2025)10.1158/0008-5472.28431540

N/A

0DataRank · unranked

0 citations

Adriana Pitea, Gwendolyn M. Jang, Zhong Xu, Huat Chye Lim, Alex L. Choi +22 more

Supplementary text from HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma

(2025)10.1158/0008-5472.28428316

N/A

0DataRank · unranked

0 citations

Adriana Pitea, Gwendolyn M. Jang, Zhong Xu, Huat Chye Lim, Alex L. Choi +22 more

HBV rewires liver cancer signaling by altering PP2A complexes

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.15.532845

N/A

0DataRank · unranked

0 citations

Rigney E. Turnham, Manon Eckhardt, Gwendolyn M. Jang, Zhong Xu, Alex Choi +23 more

Data from HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma

(2025)10.1158/0008-5472.c.7676185

N/A

0DataRank · unranked

0 citations

Adriana Pitea, Gwendolyn M. Jang, Zhong Xu, Huat Chye Lim, Alex L. Choi +22 more

Figure S1 from HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma

Figshare(2025)10.1158/0008-5472.28428331

N/A

0DataRank · unranked

0 citations

Adriana Pitea, Gwendolyn M. Jang, Zhong Xu, Huat Chye Lim, Alex L. Choi +22 more

Figure S4 from HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma

Figshare(2025)10.1158/0008-5472.28428322

N/A

0DataRank · unranked

0 citations

Adriana Pitea, Gwendolyn M. Jang, Zhong Xu, Huat Chye Lim, Alex L. Choi +22 more

Figure S4 from HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma

(2025)10.1158/0008-5472.28431537

N/A

0DataRank · unranked

0 citations

Adriana Pitea, Gwendolyn M. Jang, Zhong Xu, Huat Chye Lim, Alex L. Choi +22 more

Identifying strategies to target the metabolic flexibility of tumours

Nature Metabolism(2020)10.1038/s42255-020-0195-8

N/A

0DataRank · unranked

147 citations

Wei Lin, Paul C. Driscoll, Nathalie Legrave, Laura Novellasdemunt, Chencheng Xie +11 more

Role of the Mammalian Target of Rapamycin Pathway in Liver Cancer: From Molecular Genetics to Targeted Therapies

Hepatology(2020)10.1002/hep.31310

N/A

0DataRank · unranked

123 citations

Panagiotis Paliogiannis, Diego F. Calvisi, Xin Chen, Xinjun Lu

Cabozantinib-based combination therapy for the treatment of hepatocellular carcinoma

Gut(2020)10.1136/gutjnl-2020-320716

N/A

0DataRank · unranked

107 citations

Xinhua Song, Pan Wang, Yi Zhou, Xinjun Lu, Jingxiao Wang +10 more

Distinct and Overlapping Roles of Hippo Effectors YAP and TAZ During Human and Mouse Hepatocarcinogenesis

Cellular and Molecular Gastroenterology and Hepatology(2020)10.1016/j.jcmgh.2020.11.008

N/A

0DataRank · unranked

76 citations

Jingxiao Wang, Shanshan Zhang, Jiaoyuan Jia, Xianqiong Liu, Jie Zhang +12 more

The Hippo Effector Transcriptional Coactivator with PDZ-Binding Motif Cooperates with Oncogenic β-Catenin to Induce Hepatoblastoma Development in Mice and Humans

American Journal Of Pathology(2020)10.1016/j.ajpath.2020.03.011

N/A

0DataRank · unranked

53 citations

Jie Zhang, Katja Evert, Xiaolei Li, Liu Pin, András Kiss +12 more

mTORC2 Signaling Is Necessary for Timely Liver Regeneration after Partial Hepatectomy

American Journal Of Pathology(2020)10.1016/j.ajpath.2019.12.010

N/A

0DataRank · unranked

18 citations

Haichuan Wang, Jingxiao Wang, Deviana Burhan, Runze Shang, Pan Wang +14 more

Novel genomic targets of valosin-containing protein in protecting pathological cardiac hypertrophy

Scientific Reports(2020)10.1038/s41598-020-75128-z

N/A

0DataRank · unranked

12 citations

Xin Chen, Jing Xi, Ben Ma, Christiana Leimena, Shaunrick Stoll +4 more

Mammalian Target of Rapamycin Complex 2 Signaling Is Required for Liver Regeneration in a Cholestatic Liver Injury Murine Model

American Journal Of Pathology(2020)10.1016/j.ajpath.2020.03.010

N/A

0DataRank · unranked

9 citations

Meng Xu, Liu Pin, Bin-yong Liang, Manning Qian, Haichuan Wang +8 more

WNT regulates programmed muscle remodeling through PLC-β and calcineurin in C. elegans males

Development(2020)10.1242/dev.181305

N/A

0DataRank · unranked

8 citations

Xin Chen, L. René García, Brigitte LeBoeuf

Asymmetric inheritance of epigenetic states in asymmetrically dividing stem cells

Current Opinion in Cell Biology(2020)10.1016/j.ceb.2020.08.003

N/A

0DataRank · unranked

39 citations

Chinmayi Chandrasekhara, Xin Chen, Emily Zion

Overexpression of Mothers Against Decapentaplegic Homolog 7 Activates the Yes‐Associated Protein/NOTCH Cascade and Promotes Liver Carcinogenesis in Mice and Humans

Hepatology(2020)10.1002/hep.31692

N/A

0DataRank · unranked

39 citations

Xinhua Song, Haotian Liao, Pan Wang, Yi Zhang, Li Che +15 more

Oncogene-dependent function of BRG1 in hepatocarcinogenesis

Cell Death and Disease(2020)10.1038/s41419-020-2289-3

N/A

0DataRank · unranked

33 citations

Xinhua Song, Dan Cao, Kairong Cui, Jingxiao Wang, Kirsten Utpatel +8 more

Inhibition of Lapatinib-Induced Kinome Reprogramming in ERBB2-Positive Breast Cancer by Targeting BET Family Bromodomains

UNC Libraries(2020)10.17615/vnt3-7a98

N/A

0DataRank · unranked

3 citations

Jon S. Zawistowski, Lisa A. Carey, Rachel A. Reuther, Kazuhiro Nakamura, Steven P. Angus +15 more

CDK9 is dispensable for YAP‐driven hepatoblastoma development

Pediatric Blood & Cancer(2020)10.1002/pbc.28221

N/A

0DataRank · unranked

4 citations

András Kiss, Zsuzsa Schaff, Katja Evert, Yi Zhang, Sheng Zhong +5 more

Identifying strategies to target the metabolic flexibility of tumours

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.01.06.896571

N/A

0DataRank · unranked

15 citations

Wei Lin, Paul C. Driscoll, Nathalie Legrave, Laura Novellasdemunt Vilaseca, Chencheng Xie +11 more

Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations

Cancer Cell(2021)10.1016/j.ccell.2021.03.012

N/A

0DataRank · unranked

407 citations

Ajay Nair, Francesco Brundu, Aashreya Ravichandra, Sonakshi Bhattacharjee, Michitaka Matsuda +32 more

Focal adhesion kinase (FAK) promotes cholangiocarcinoma development and progression via YAP activation

Journal of Hepatology(2021)10.1016/j.jhep.2021.05.018

N/A

0DataRank · unranked

111 citations

Hongwei Xu, Pan Wang, Jingxiao Wang, Silvia Affò, Haichuan Wang +13 more

TAZ is indispensable for c-MYC-induced hepatocarcinogenesis

Journal of Hepatology(2021)10.1016/j.jhep.2021.08.021

N/A

0DataRank · unranked

95 citations

Shanshan Zhang, Yi Zhang, Jiaoyuan Jia, Jingxiao Wang, Xianqiong Liu +11 more

YAP Accelerates Notch-Driven Cholangiocarcinogenesis via mTORC1 in Mice

American Journal Of Pathology(2021)10.1016/j.ajpath.2021.05.017

N/A

0DataRank · unranked

59 citations

Baogang Peng, Ge Chen, Giovanni Mario Pes, Silvia Ribback, Cindy Ament +10 more

TBX3 functions as a tumor suppressor downstream of activated CTNNB1 mutants during hepatocarcinogenesis

Journal of Hepatology(2021)10.1016/j.jhep.2021.01.044

N/A

0DataRank · unranked

58 citations

Yi Zhou, Manning Qian, Meng Xu, Jingxiao Wang, Yi Zhang +13 more

Loss of Apc Cooperates with Activated Oncogenes to Induce Liver Tumor Formation in Mice

American Journal Of Pathology(2021)10.1016/j.ajpath.2021.01.010

N/A

0DataRank · unranked

42 citations

Bin-yong Liang, Xinhua Song, Haichuan Wang, Matthias Evert, Yi Zhou +4 more

Identification of the atypical cadherin FAT1 as a novel glypican-3 interacting protein in liver cancer cells

Scientific Reports(2021)10.1038/s41598-020-79524-3

N/A

0DataRank · unranked

40 citations

Yifan Zhang, Wangli Zhang, Xin Chen, Tong Xu, Sheng Hu +5 more

Distinct functions of transforming growth factor-β signaling in c-MYC driven hepatocellular carcinoma initiation and progression

Cell Death and Disease(2021)10.1038/s41419-021-03488-z

N/A

0DataRank · unranked

33 citations

Pan Wang, Meng Xu, Xinhua Song, Hong Wu, Matthias Evert +4 more

Alpelisib combination treatment as novel targeted therapy against hepatocellular carcinoma

Cell Death and Disease(2021)10.1038/s41419-021-04206-5

N/A

0DataRank · unranked

28 citations

Kefei Chen, Runze Shang, Xinyan Chen, Yi Zhang, Xinhua Song +6 more

Selective targeting of MYC mRNA by stabilized antisense oligonucleotides

Oncogene(2021)10.1038/s41388-021-02053-4

N/A

0DataRank · unranked

17 citations

Haichuan Wang, Raj Bandaru, Matthew A. Lawlor, Chenyue Lu, Linda T. Nieman +8 more

Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development

Communications Biology(2021)10.1038/s42003-021-02286-9

N/A

0DataRank · unranked

16 citations

Gloria Scattolin, Patrizia Romani, Cindy Ament, Silvia Ribback, Xin Chen +4 more

Combination Therapy of Hepatocellular Carcinoma by GPC3-Targeted Bispecific Antibody and Irinotecan is Potent in Suppressing Tumor Growth in Mice

Molecular Cancer Therapeutics(2021)10.1158/1535-7163.mct-20-1025

N/A

0DataRank · unranked

14 citations

Yanmin Chen, Rong Liang, Lanxin Xiang, Jingwen Li, Yuankui Zhu +10 more

β-Catenin signaling in hepatocellular carcinoma

Journal of Clinical Investigation(2022)10.1172/jci154515

N/A

0DataRank · unranked

290 citations

Zhong Xu, Yi Zhang, Matthias Evert, Diego F. Calvisi, Xin Chen +1 more

Therapeutic efficacy of FASN inhibition in preclinical models of HCC

Hepatology(2022)10.1002/hep.32359

N/A

0DataRank · unranked

126 citations

Yi Zhou, Hongwei Xu, Xue Wang, Yi Zhang, Runze Shang +9 more

Glutamine synthetase limits β-catenin–mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1

Journal of Clinical Investigation(2022)10.1172/jci161408

N/A

0DataRank · unranked

67 citations

Jianliang Shen, Junrong Yan, Alex J. Bott, Sara Maimouni, Heineken Queen +12 more

β-Catenin Sustains and Is Required for YES-associated Protein Oncogenic Activity in Cholangiocarcinoma

Gastroenterology(2022)10.1053/j.gastro.2022.04.028

N/A

0DataRank · unranked

49 citations

Hongwei Xu, Guofei Cui, Bin-yong Liang, Xi Chen, Xiangzheng Chen +20 more

The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease

Journal of Experimental & Clinical Cancer Research(2022)10.1186/s13046-022-02394-2

N/A

0DataRank · unranked

42 citations

Shanshan Zhang, Silvia Ribback, Sara Steinmann, Marcella Sini, Cindy Ament +17 more

Differential requirement of Hippo cascade during CTNNB1 or AXIN1 mutation‐driven hepatocarcinogenesis

Hepatology(2022)10.1002/hep.32693

N/A

0DataRank · unranked

29 citations

Haichuan Wang, Yu Qiao, Xue Wang, Manning Qian, Xinhua Song +13 more

Computational analysis to define efficacy & molecular mechanisms of 7, 4’- Dihydroxyflavone on eosinophilic esophagitis: Ex-vivo validation in human esophagus biopsies

Frontiers in Immunology(2022)10.3389/fimmu.2022.1015437

N/A

0DataRank · unranked

8 citations

Zhenzhen Wang, Xin Chen, David Dunkin, Nan Yang, Gary Soffer +3 more

[ 18 F]-(2S,4R)4-Fluoroglutamine PET Imaging of Glutamine Metabolism in Murine Models of Hepatocellular Carcinoma (HCC)

Molecular Imaging(2022)10.1155/2022/5185951

N/A

0DataRank · unranked

3 citations

Miranda C. Craig, Stephanie T. Murphy, Jinjin Feng, Xin Chen, Mariia Yuneva +1 more

miR-22 gene therapy treats HCC by promoting anti-tumor immunity and enhancing metabolism

Molecular Therapy(2023)10.1016/j.ymthe.2023.04.019

N/A

0DataRank · unranked

45 citations

Tahereh Setayesh, Farzam Vaziri, Xuesong Wu, Samuel Hwang, Xin Chen +2 more

Combination of AFP vaccine and immune checkpoint inhibitors slows hepatocellular carcinoma progression in preclinical models

Journal of Clinical Investigation(2023)10.1172/jci163291

N/A

0DataRank · unranked

40 citations

Shanshan Deng, Jiejie Xu, Benjamin L. Green, Honghua Zhang, Guofei Cui +13 more

Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis

Cell Death and Disease(2023)10.1038/s41419-023-05958-y

N/A

0DataRank · unranked

22 citations

Guofei Cui, Hongwei Xu, Joanne Chun, Doris Yang, Zheng Zhang +8 more

Targeting stroma and tumor, silencing galectin 1 treats orthotopic mouse hepatocellular carcinoma

Acta Pharmaceutica Sinica B(2023)10.1016/j.apsb.2023.10.010

N/A

0DataRank · unranked

13 citations

Ying Hu, Farzam Vaziri, Xin Chen, Jinping Lai, Dongguang Wei +2 more

Preclinical and clinical studies of immunotherapy for the treatment of cholangiocarcinoma

JHEP Reports(2023)10.1016/j.jhepr.2023.100723

N/A

0DataRank · unranked

10 citations

Benjamin L. Green, Changqing Xie, Chao Liu, Xin Chen, Xinjun Lu

Syngeneic murine models with distinct immune microenvironments represent subsets of human intrahepatic cholangiocarcinoma

Journal of Hepatology(2024)10.1016/j.jhep.2024.02.008

N/A

0DataRank · unranked

27 citations

Binbin Li, Jingchun Yang, Emilien Loeuillard, Hannah E. Stumpf, Hendrien Kuipers +11 more

Preclinical Models of Hepatocellular Carcinoma: Current Utility, Limitations, and Challenges

Biomedicines(2024)10.3390/biomedicines12071624

N/A

0DataRank · unranked

23 citations

Weiting Liao, Giovanni Deiana, Davide Rizzo, Xin Chen, Diego F. Calvisi +1 more

SLC13A3 is a major effector downstream of activated β-catenin in liver cancer pathogenesis

Nature Communications(2024)10.1038/s41467-024-51860-2

N/A

0DataRank · unranked

21 citations

Xue Wang, Lifeng Han, Chunze Zhang, Chenxi Wang, Kong De +11 more

TSC/mTORC1 mediates mTORC2/AKT1 signaling in c-MYC–induced murine hepatocarcinogenesis via centromere protein M

Journal of Clinical Investigation(2024)10.1172/jci174415

N/A

0DataRank · unranked

12 citations

Shu Zhang, Guoteng Qiu, Xue Wang, Andrew Yonemura, Hongwei Xu +15 more

HSPA9/mortalin inhibition disrupts erythroid maturation through a TP53-dependent mechanism in human CD34+ hematopoietic progenitor cells

Cell Stress and Chaperones(2024)10.1016/j.cstres.2024.03.006

N/A

0DataRank · unranked

6 citations

Morgan Dunmire, Jaebok Choi, Gábor Szalai, Anissa Johnson, Wei Lei +6 more

MAD2L1 supports MYC-driven liver carcinogenesis in mice and predicts poor prognosis in human hepatocarcinoma

Toxicological Sciences(2024)10.1093/toxsci/kfae126

N/A

0DataRank · unranked

3 citations

Ya Zhang, Jiahao Xue, Matthias Evert, Diego F. Calvisi, Xin Chen +2 more

Overexpression of TBX3 suppresses tumorigenesis in experimental and human cholangiocarcinoma

Cell Death and Disease(2024)10.1038/s41419-024-06839-8

N/A

0DataRank · unranked

2 citations

Xinjun Lu, Xue Wang, Binyong Liang, Hongwei Xu, Doris Yang +12 more

An Intrinsically Disordered RNA Binding Protein Modulates mRNA Translation and Storage

Journal of Molecular Biology(2024)10.1016/j.jmb.2024.168884

N/A

0DataRank · unranked

1 citations

Mashiat N. Chowdhury, Hong Jin, Xin Chen

Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers

Research Square(2024)10.21203/rs.3.rs-5494074/v1

N/A

0DataRank · unranked

0 citations

Brandon M. Lehrich, Evan R. Delgado, Tyler M. Yasaka, Silvia Liu, Catherine Cao +29 more

Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers

Nature Communications(2025)10.1038/s41467-025-60457-2

N/A

0DataRank · unranked

31 citations

Evan R. Delgado, Tyler M. Yasaka, Silvia Liu, Catherine Cao, Y. Liu +30 more

Figure S2 from HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma

Figshare(2025)10.1158/0008-5472.28428328

N/A

0DataRank · unranked

0 citations

Adriana Pitea, Gwendolyn M. Jang, Zhong Xu, Huat Chye Lim, Alex L. Choi +22 more

Targeting mTORC2-dependent AKT/FOXO1/RNF125 signaling exploits a therapeutic vulnerability in c-MET–activated and β-catenin–mutated hepatocellular carcinoma

Hepatology(2025)10.1097/hep.0000000000001637

N/A

0DataRank · unranked

2 citations

Yi Zhou, Shu Zhang, Christine Farrar, Xuemei Xie, Jian Li +18 more

Towards trustworthy AI in Industry 5.0: Ante-hoc interpretability with deep learning

Computers & Industrial Engineering(2026)10.1016/j.cie.2026.111805

N/A

0DataRank · unranked

0 citations

Lucheng Chen, Tengliang Zhu, Xuyang Su, Yuanfa Dong, Long Wen +7 more

Supplementary text from HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma

(2025)10.1158/0008-5472.28431528

N/A

0DataRank · unranked

0 citations

Adriana Pitea, Gwendolyn M. Jang, Zhong Xu, Huat Chye Lim, Alex L. Choi +22 more

Figure S1 from HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma

Figshare(2025)10.1158/0008-5472.28431549

N/A

0DataRank · unranked

0 citations

Adriana Pitea, Gwendolyn M. Jang, Zhong Xu, Huat Chye Lim, Alex L. Choi +22 more

Supplementary Tables 1-8 from HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma

Figshare(2025)10.1158/0008-5472.28428319

N/A

0DataRank · unranked

0 citations

Adriana Pitea, Gwendolyn M. Jang, Zhong Xu, Huat Chye Lim, Alex L. Choi +22 more