Carl H. June

Hospital of the University of Pennsylvania

Also affiliated with California University of Pennsylvania, Parker Institute for Cancer Immunotherapy, University of Pennsylvania

MedicineImmunology and MicrobiologyBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

5in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 5 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

Supplementary Table 1 from Phase I Trial of Adoptive Cell Transfer with Mixed-Profile Type-I/Type-II Allogeneic T Cells for Metastatic Breast Cancer

(2023)10.1158/1078-0432.22443327

Top 100%

0DataRank

Top 100%0 citations

Miriam E. Mossoba, Seth M. Steinberg, Vicki Fellowes, Xiaoyi Yan, Frances T. Hakim +14 more

Papers

Driven by 81 papers — median percentile 0. Top paper: “Decade-long leukaemia remissions with persistence of CD4+ CAR T cells”.

Decade-long leukaemia remissions with persistence of CD4+ CAR T cells

Nature(2022)10.1038/s41586-021-04390-6

N/A

10.2DataRank · unranked

929 citations

Gregory M. Chen, Meng Wang, David L. Porter, Changya Chen, McKensie Collins +29 more

Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells

Cell(2023)10.1016/j.cell.2023.08.041

N/A

3.4DataRank · unranked

190 citations

Nadav Brandes, Raymund Bueno, Marena Trinidad, Thomas Mazumder, Bingfei Yu +18 more

CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication

Journal of Clinical Investigation(2021)10.1172/jci144486

N/A

2.6DataRank · unranked

98 citations

Julie K. Jadlowsky, Pamela A. Shaw, Lifeng Tian, Erin Esparza, Andrea Brennan +21 more

Cytokine-mediated CAR T therapy resistance in AML

Nature Medicine(2024)10.1038/s41591-024-03271-5

N/A

2.2DataRank · unranked

90 citations

Leonel Torres, Olga Shestova, Maksim Shestov, Patrick Mellors, Han R Fisher +24 more

Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma

Cancer Research Communications(2023)10.1158/2767-9764.crc-22-0486

N/A

2.2DataRank · unranked

95 citations

Alexander C. Huang, Xiaowei Xu, Robert Orlowski, Ravi K. Amaravadi, Lynn M. Schuchter +20 more

Monitoring Therapeutic Response to Anti-FAP CAR T Cells Using [18F]AlF-FAPI-74

Clinical Cancer Research(2022)10.1158/1078-0432.ccr-22-1379

N/A

1.7DataRank · unranked

48 citations

Estela Noguera-Ortega, Zebin Xiao, Leslie Todd, John Scholler, Decheng Song +10 more

Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies

Cell(2020)10.1016/j.cell.2020.08.022

N/A

0.922DataRank · unranked

465 citations

Denis Migliorini, Eric Perkey, Kathryn E. Yost, Aparna Bhaduri, Puneet Bagga +16 more

Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer

Science Translational Medicine(2018)10.1126/scitranslmed.aao5931

N/A

0.917DataRank · unranked

450 citations

Sara Bobisse, Eran Ophir, Sandra Tuyaerts, Annalisa Roberti, Raphaël Genolet +25 more

An NK-like CAR T cell transition in CAR T cell dysfunction

Cell(2021)10.1016/j.cell.2021.11.016

N/A

0.902DataRank · unranked

409 citations

M. Ángela Aznar, Shunichiro Kuramitsu, Parisa Samareh, Sangya Agarwal, Greg Donahue +25 more

Nanomaterials for T-cell cancer immunotherapy

Nature Nanotechnology(2021)10.1038/s41565-020-00822-y

N/A

0.862DataRank · unranked

312 citations

Neil C. Sheppard, Margaret M. Billingsley, Carl H. June, Michael J. Mitchell, Ningqiang Gong

Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors

Nature Communications(2023)10.1038/s41467-023-40850-5

N/A

0.816DataRank · unranked

229 citations

Leslie Todd, Li Huang, Estela Noguera-Ortega, Zhen Lu, Lili Huang +12 more

Bispecific and split CAR T cells targeting CD13 and TIM3 eradicate acute myeloid leukemia

Blood(2020)10.1182/blood.2019002779

N/A

0.801DataRank · unranked

207 citations

Zijie Feng, Jian Ma, Sunbin Ling, Yan Cao, Buddha Gurung +7 more

A phase I trial of cyclosporine for hospitalized patients with COVID-19

JCI Insight(2022)10.1172/jci.insight.155682

N/A

0.766DataRank · unranked

24 citations

Julia Han Noll, Pablo Tebas, Joseph A. Fraietta, Ian Frank, Amy Marshall +18 more

Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.22.533709

N/A

0.762DataRank · unranked

16 citations

Nadav Brandes, Raymund Bueno, Marena Trinidad, Thomas Mazumder, Bingfei Yu +17 more

Changes in Bone Marrow Tumor and Immune Cells Correlate with Durability of Remissions Following BCMA CAR T Therapy in Myeloma

Blood Cancer Discovery(2022)10.1158/2643-3230.bcd-22-0018

N/A

0.709DataRank · unranked

112 citations

Adam D. Cohen, Akhilesh Kaushal, Alfred L. Garfall, Renee Julia Manalo, Allison R. Carr +8 more

Immunotherapy for Glioblastoma: Adoptive T-cell Strategies

Clinical Cancer Research(2019)10.1158/1078-0432.ccr-18-1625

N/A

0.702DataRank · unranked

107 citations

Marcela V. Maus, Carl H. June, John H. Sampson, Bryan D. Choi

A rational mouse model to detect on-target, off-tumor CAR T cell toxicity

JCI Insight(2020)10.1172/jci.insight.136012

N/A

0.700DataRank · unranked

105 citations

Caroline Sands, Tong Da, John Scholler, Kathleen Graham, Elizabeth L. Buza +4 more

Case Report: Prolonged Survival Following EGFRvIII CAR T Cell Treatment for Recurrent Glioblastoma

Frontiers in Oncology(2021)10.3389/fonc.2021.669071

N/A

0.648DataRank · unranked

74 citations

Fraser Henderson, MacLean P. Nasrallah, Suyash Mohan, Sumei Wang, Simon F. Lacey +10 more

Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy

Advanced Materials(2024)10.1002/adma.202313226

N/A

0.648DataRank · unranked

74 citations

Marshall S. Padilla, Ningqiang Gong, Margaret M. Billingsley, Xuexiang Han, Maria Merolle +12 more

Comprehensive Serum Proteome Profiling of Cytokine Release Syndrome and Immune Effector Cell–Associated Neurotoxicity Syndrome Patients with B-Cell ALL Receiving CAR T19

Clinical Cancer Research(2022)10.1158/1078-0432.ccr-22-0822

N/A

0.633DataRank · unranked

67 citations

Rawan Shraim, Regina M. Myers, Edward M. Behrens, Scott Canna, Hamid Bassiri +21 more

CD38 as a pan-hematologic target for chimeric antigen receptor T cells

Blood Advances(2023)10.1182/bloodadvances.2022007059

N/A

0.624DataRank · unranked

63 citations

Caroline Diorio, John Chukinas, Kimberly Veliz, Olga Shestova, Feng Shen +10 more

Dual Targeting of Mesothelin and CD19 with Chimeric Antigen Receptor-Modified T Cells in Patients with Metastatic Pancreatic Cancer

Molecular Therapy(2020)10.1016/j.ymthe.2020.07.017

N/A

0.606DataRank · unranked

56 citations

Alexander C. Jordan, Evan Tooker, Simon F. Lacey, Renee B. Chang, Yan Li +11 more

The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion

Nature Communications(2024)10.1038/s41467-024-47692-9

N/A

0.598DataRank · unranked

53 citations

Lijun Sun, Sofia Castelli, Amanda Finck, Charles-Antoine Assenmacher, Regina M. Young +3 more

Tumor-Derived Small Extracellular Vesicles Inhibit the Efficacy of CAR T Cells against Solid Tumors

Cancer Research(2023)10.1158/0008-5472.can-22-2220

N/A

0.598DataRank · unranked

53 citations

Zebin Xiao, Zhiyuan Qin, Jingbo Yang, Yi Wen, Ziyan Yu +9 more

The Safety of Bridging Radiation with Anti-BCMA CAR T-Cell Therapy for Multiple Myeloma

Clinical Cancer Research(2021)10.1158/1078-0432.ccr-21-0308

N/A

0.561DataRank · unranked

41 citations

Adam D. Cohen, Simon F. Lacey, Megan M. Davis, Alfred L. Garfall, J. Joseph Melenhorst +11 more

Solid tumour CAR-T cells engineered with fusion proteins targeting PD-L1 for localized IL-12 delivery

Nature Biomedical Engineering(2025)10.1038/s41551-025-01509-2

N/A

0.546DataRank · unranked

37 citations

Lea Christian, Reginaldo Cruz Alves Rosa, Yuwei Ren, Alyssa J. Buckley, Eric Hee Jun Lee +15 more

Costimulation of γδTCR and TLR7/8 promotes Vδ2 T-cell antitumor activity by modulating mTOR pathway and APC function

Journal for ImmunoTherapy of Cancer(2021)10.1136/jitc-2021-003339

N/A

0.524DataRank · unranked

32 citations

Hui Chen, Shujing Liu, Jie Zhang, Hezhe Lu, Rajasekharan Somasundaram +19 more

Phase I trial of autologous cMET-directed CAR-t cells administered intravenously in patients with melanoma & breast carcinoma.

Journal of Clinical Oncology(2020)10.1200/jco.2020.38.15_suppl.10035

N/A

0.470DataRank · unranked

22 citations

Alexander C. Huang, Xiaowei Xu, Paul J. Zhang, Robert Orlowski, Tina Matlawski +15 more

Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager

Nature Biomedical Engineering(2024)10.1038/s41551-023-01147-6

N/A

0.470DataRank · unranked

22 citations

Xuexiang Han, Lulu Xue, Margaret M. Billingsley, Xisha Huang, Rakan El‐Mayta +5 more

Clinical and molecular dissection of CAR T cell resistance in pancreatic cancer

Cell Reports Medicine(2025)10.1016/j.xcrm.2025.102301

N/A

0.429DataRank · unranked

14 citations

Charly R. Good, Julie S. Barber-Rotenberg, Sangya Agarwal, Wesley V. Wilson, Alex Watts +27 more

CAR T-cell Therapy Meets Clonal Hematopoiesis

Blood Cancer Discovery(2022)10.1158/2643-3230.bcd-22-0067

N/A

0.416DataRank · unranked

15 citations

Carl H. June, Uğur Uslu

IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing antitumor efficacy

Immunity(2025)10.1016/j.immuni.2025.10.021

N/A

0.385DataRank · unranked

12 citations

Wesley V. Wilson, Uğur Uslu, Amanda Finck, Philipp C. Rommel, Charles-Antoine Assenmacher +6 more

The next innovations in chimeric antigen receptor T cell immunotherapies for cancer

Cytotherapy(2025)10.1016/j.jcyt.2025.05.010

N/A

0.373DataRank · unranked

11 citations

Julia Malachowski, Isabella Hodson, Daniel Zhu, Carl H. June, Bruce L. Levine +1 more

B‐cell maturation antigen chimeric antigen receptor T‐cell re‐expansion in a patient with myeloma following salvage programmed cell death protein 1 inhibitor‐based combination therapy

British Journal of Haematology(2021)10.1111/bjh.17397

N/A

0.373DataRank · unranked

11 citations

Lifeng Tian, Alfred L. Garfall, J. Joseph Melenhorst, Simon F. Lacey, Edward A. Stadtmauer +10 more

ZFP36 disruption is insufficient to enhance the function of mesothelin-targeting human CAR-T cells

Scientific Reports(2024)10.1038/s41598-024-53769-8

N/A

0.292DataRank · unranked

6 citations

Tifara Boyce, Aakash Mehta, Jordan Reff, John Scholler, Neil C. Sheppard +2 more

Induction of a CD8 T cell intrinsic DNA damage and repair response is associated with clinical response to PD-1 blockade in uterine cancer

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.04.16.488552

N/A

0.269DataRank · unranked

5 citations

Sasikanth Manne, Nils Wellhausen, Derek A. Oldridge, Allison R. Greenplate, Lakshmi Chilukuri +10 more

Decade-long remissions of leukemia sustained by the persistence of activated CD4 + CAR T-cells

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.05.07.443194

N/A

0.165DataRank · unranked

2 citations

Gregory M. Chen, Meng Wang, David L. Porter, Peng Gao, Shovik Bandyopadhyay +23 more

DR5 CAR-T cells target melanoma and suppress MDSCs with minimal toxicity

Molecular Therapy(2025)10.1016/j.ymthe.2025.12.025

N/A

0.104DataRank · unranked

1 citations

Shujing Liu, Prithvi Sinha, Fang Liu, Xiaogang Zhang, Yeye Guo +19 more

Decade-long remissions of leukemia sustained by the persistence of activated CD4+ CAR T-cells

Research Square(2021)10.21203/rs.3.rs-505891/v1

N/A

0.104DataRank · unranked

1 citations

Gregory Chen, Meng Wang, David L. Porter, Peng Gao, Shovik Bandyopadhyay +23 more

Modulation of the gut microbiota engages antigen cross-presentation to enhance antitumor effects of CAR T cell immunotherapy

Molecular Therapy(2023)10.1016/j.ymthe.2023.01.012

N/A

0DataRank · unranked

59 citations

Silvia Beghi, Marco Ruella, Kalpana Parvathaneni, Silvano Salaris, Νεκτάριος Κωστόπουλος +23 more

Next-Generation CAR T-cell Therapies

Cancer Discovery(2022)10.1158/2159-8290.cd-21-1683

N/A

0DataRank · unranked

174 citations

Nils W. Engel, Uğur Uslu, Nils Wellhausen, Carl H. June, Regina M. Young

Sequential Exposure to IL21 and IL15 During Human Natural Killer Cell Expansion Optimizes Yield and Function

Cancer Immunology Research(2023)10.1158/2326-6066.cir-23-0151

N/A

0DataRank · unranked

29 citations

Siddhant Kadu, Yansen Xiao, Omar Johnson, Andre Kelly, Roddy S. O’Connor +10 more

Exploiting the CD200-CD200R immune checkpoint axis in multiple myeloma to enhance CAR T-cell therapy

Blood(2023)10.1182/blood.2022018658

N/A

0DataRank · unranked

22 citations

Wei Liu, Siddhant Kadu, Omar Johnson, Zainul S. Hasanali, Andre Kelly +15 more

Data from Targeting HER-2/neu in Early Breast Cancer Development Using Dendritic Cells with Staged Interleukin-12 Burst Secretion

(2023)10.1158/0008-5472.c.6496416

N/A

0DataRank · unranked

0 citations

Gary K. Koski, Ursula Koldovsky, Shuwen Xu, Peter A. Cohen, Rosemarie Mick +16 more

Supplementary Table 1 from Phase I Trial of Adoptive Cell Transfer with Mixed-Profile Type-I/Type-II Allogeneic T Cells for Metastatic Breast Cancer

(2023)10.1158/1078-0432.22443327

Top 100%

0DataRank

Top 100%0 citations

Miriam E. Mossoba, Seth M. Steinberg, Vicki Fellowes, Xiaoyi Yan, Frances T. Hakim +14 more

Data from Phase I Trial of Adoptive Cell Transfer with Mixed-Profile Type-I/Type-II Allogeneic T Cells for Metastatic Breast Cancer

(2023)10.1158/1078-0432.c.6519780.v1

N/A

0DataRank · unranked

0 citations

Miriam E. Mossoba, Seth M. Steinberg, Vicki Fellowes, Xiaoyi Yan, Frances T. Hakim +14 more

Supplementary Table 1 from Phase I Trial of Adoptive Cell Transfer with Mixed-Profile Type-I/Type-II Allogeneic T Cells for Metastatic Breast Cancer

INDIGO (University of Illinois at Chicago)(2023)10.1158/1078-0432.22443327.v1

Top 100%

0DataRank

Top 100%0 citations

Miriam E. Mossoba, Seth M. Steinberg, Vicki Fellowes, Xiaoyi Yan, Frances T. Hakim +14 more

Data from Rapid Immune Recovery and Graft-versus-Host Disease–like Engraftment Syndrome following Adoptive Transfer of Costimulated Autologous T Cells

(2023)10.1158/1078-0432.c.6517645.v1

N/A

0DataRank · unranked

0 citations

Edward A. Stadtmauer, Nicole A. Aqui, Dan T. Vogl, Anne Chew, Hong‐Bin Fang +20 more

Data from Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T cells Administered Intravenously in Patients with Melanoma & Breast Carcinoma

(2023)10.1158/2767-9764.c.6547846.v1

N/A

0DataRank · unranked

0 citations

Alexander C. Huang, Xiaowei Xu, Robert Orlowski, Ravi K. Amaravadi, Lynn M. Schuchter +20 more

Data from Identification of Chimeric Antigen Receptors That Mediate Constitutive or Inducible Proliferation of T Cells

(2023)10.1158/2326-6066.c.6548833.v1

N/A

0DataRank · unranked

0 citations

Ji‐Hyun Lee, Maria C. Basil, Carmine Carpenito, Shinichiro Motohashi, John Scholler +14 more

Data from Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma

(2023)10.1158/2767-9764.c.6547846.v2

N/A

0DataRank · unranked

0 citations

Alexander C. Huang, Xiaowei Xu, Robert Orlowski, Ravi K. Amaravadi, Lynn M. Schuchter +20 more

CAR T cell combination therapies to treat cancer

Cancer Cell(2024)10.1016/j.ccell.2024.07.002

N/A

0DataRank · unranked

112 citations

Sofia Castelli, Carl H. June, Uğur Uslu

Better living through chemistry: CRISPR/Cas engineered T cells for cancer immunotherapy

Current Opinion in Immunology(2021)10.1016/j.coi.2021.10.008

N/A

0DataRank · unranked

23 citations

Sangya Agarwal, Philipp C. Rommel, Saar Gill, Carl H. June, Nils Wellhausen

CD19-targeted chimeric antigen receptor T-cell therapy for CNS relapsed or refractory acute lymphocytic leukaemia: a post-hoc analysis of pooled data from five clinical trials

The Lancet Haematology(2021)10.1016/s2352-3026(21)00238-6

N/A

0DataRank · unranked

121 citations

Haley Newman, Yimei Li, Hongyan Liu, Regina M. Myers, Amanda DiNofia +11 more

Pretreatment with IL-15 and IL-18 rescues natural killer cells from granzyme B-mediated apoptosis after cryopreservation

Nature Communications(2024)10.1038/s41467-024-47574-0

N/A

0DataRank · unranked

42 citations

Deeksha Muthumani, Oscar A. Aguilar, Oz Pomp, Omar Johnson, Amanda Finck +8 more

Off-the-shelf CAR-T cells could prove paradigm shifting for autoimmune diseases

Cell(2024)10.1016/j.cell.2024.07.056

N/A

0DataRank · unranked

27 citations

Carl H. June, Daniel Baker

Proton radiation boosts the efficacy of mesothelin-targeting chimeric antigen receptor T cell therapy in pancreatic cancer

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2403002121

N/A

0DataRank · unranked

19 citations

Uğur Uslu, Ioannis I. Verginadis, Michele M. Kim, Seyyedeh Azar Oliaei Motlagh, Eric S. Diffenderfer +8 more

The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function

Cell(2021)10.1016/j.cell.2021.08.004

N/A

0DataRank · unranked

184 citations

Daniel Y. Lee, Jacqueline S. Eacret, Darwin Ye, Carl H. June, Andy J. Minn +1 more

CAR T-cell Resistance to Oncogenic Transformation

Blood Cancer Discovery(2024)10.1158/2643-3230.bcd-23-0273

N/A

0DataRank · unranked

3 citations

Carl H. June, Marco Ruella

Stem Loop Mediated Transgene Modulation in Human T Cells

ACS Synthetic Biology(2024)10.1021/acssynbio.4c00152

N/A

0DataRank · unranked

1 citations

Carly M. Harro, Aabir Sanyal, Philipp C. Rommel, Neil C. Sheppard, Carl H. June +1 more

A Cure for HIV Infection: “Not in My Lifetime” or “Just Around the Corner”?

UNC Libraries(2024)10.17615/sxzh-4d66

N/A

0DataRank · unranked

0 citations

Pablo Tebas, Carl H. June, Michael M. Lederman, Hans‐Peter Kiem, John W. Mellors +10 more

From concept to cure: The evolution of CAR-T cell therapy

Molecular Therapy(2025)10.1016/j.ymthe.2025.03.005

N/A

0DataRank · unranked

136 citations

Mito Tariveranmoshabad, Siddhant Kadu, Nour Shobaki, Carl H. June, Kisha K. Patel

Autologous CD4 T Lymphocytes Modified with a Tat-Dependent, Virus-Specific Endoribonuclease Gene in HIV-Infected Individuals

Molecular Therapy(2020)10.1016/j.ymthe.2020.11.007

N/A

0DataRank · unranked

6 citations

Julie K. Jadlowsky, Simon F. Lacey, Joseph A. Fraietta, Gabriela Plesa, Hideto Chono +11 more

Harnessing CAR T-cell Insights to Develop Treatments for Hyperinflammatory Responses in Patients with COVID-19

Cancer Discovery(2020)10.1158/2159-8290.cd-20-0473

N/A

0DataRank · unranked

31 citations

Carl H. June, Sangya Agarwal

Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design

Molecular Therapy — Methods & Clinical Development(2020)10.1016/j.omtm.2020.07.008

N/A

0DataRank · unranked

64 citations

Francisco J. Martinez-Becerra, Аlyssa M. Master, Sarah A. Richman, David Heo, John Leferovich +10 more

Multiplex engineering using microRNA-mediated gene silencing in CAR T cells

Frontiers in Immunology(2025)10.3389/fimmu.2025.1647433

N/A

0DataRank · unranked

4 citations

John Scholler, Audrey Roussel-Gervais, A. Šakić, Sten Ilmjärv, Decheng Song +15 more

Checkpoint antibody receptor modified ARMed CAR T circumvents the suppressive immunome in GBM

Frontiers in Immunology(2025)10.3389/fimmu.2025.1579925

N/A

0DataRank · unranked

2 citations

Alina C. Boesteanu, Yibo Yin, Reiss Reid, Laura Roccograndi, Nadia Dahmane +5 more

Engineering a Juxtamembrane-Targeting CAR T-Cell Against Mesothelin: A Novel Binder Resilient to Shed Antigen in Ovarian and Pancreatic Cancer

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.02.668276

N/A

0DataRank · unranked

1 citations

Ai Lin Song, Mansi Deshmukh, Decheng Song, Carl H. June, Don L. Siegel +1 more

LOXHD1 is an oncofusion-regulated antigen of ewing sarcoma

Scientific Reports(2025)10.1038/s41598-025-96877-9

N/A

0DataRank · unranked

0 citations

Pouya Faridi, Chong Xu, Adham S. Bear, Reyaz ur Rasool, Grace Huang +12 more

DR5 CAR-T cells target solid tumors and suppress MDSCs with minimal toxicity

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.06.09.658618

N/A

0DataRank · unranked

0 citations

Shujing Liu, Prithvi Sinha, Fang Liu, Xiaogang Zhang, Yeye Guo +20 more

Viral vector-free generation of orthogonal IL-2–responsive CAR T cells through gene editing of IL-2 and its receptor

Blood Immunology & Cellular Therapy(2025)10.1016/j.bict.2025.100019

N/A

0DataRank · unranked

0 citations

Yihao Wu, Jee‐Eun Yang, Kevin N. Zhou, Eric Nigel Ebenezer Anand Manoharan, Tyra Wentz +16 more

Ping-pong dual CAR T cells: antigen-specific peripheral expansion of dual-targeted CAR T cells boosts antitumor immunity against solid tumors 2126

The Journal of Immunology(2025)10.1093/jimmun/vkaf283.088

N/A

0DataRank · unranked

0 citations

Ziming Wang, Angela Aznar Gomez, Sofia Castelli, Nils Wellhausen, Donna Gonzales +3 more

IL-9 signaling enhances CAR T cell antitumor efficacy in solid tumors by promoting memory phenotypes and reducing dysfunction under antigen stress 2144

The Journal of Immunology(2025)10.1093/jimmun/vkaf283.106

N/A

0DataRank · unranked

0 citations

Wesley V. Wilson, Uğur Uslu, Amanda Finck, Charles-Antoine Assenmacher, Sebastian J Atoche +4 more

4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling

Science Signaling(2020)10.1126/scisignal.aay8248

N/A

0DataRank · unranked

222 citations

Roddy S. O’Connor, Michael J. May, Carl H. June, Steven Μ. Albelda, Michael C. Milone +1 more

Cancer immunotherapy comes of age and looks for maturity

Nature Communications(2020)10.1038/s41467-020-17140-5

N/A

0DataRank · unranked

148 citations

Saar Gill, Carl H. June, Amanda Finck

Deletion of the inhibitory co-receptor CTLA-4 enhances and invigorates chimeric antigen receptor T cells

Immunity(2023)10.1016/j.immuni.2023.09.001

N/A

0DataRank · unranked

171 citations

M. Ángela Aznar, Andrew J. Rech, Charly R. Good, Shunichiro Kuramitsu, Tong Da +15 more

Single residue in CD28-costimulated CAR-T cells limits long-term persistence and antitumor durability

Journal of Clinical Investigation(2020)10.1172/jci133215

N/A

0DataRank · unranked

197 citations

Aviv Madar, Victoria Casado‐Medrano, Carolyn E. Shaw, Anna Wing, Fang Liu +4 more

Ionizable Lipid Nanoparticles with Integrated Immune Checkpoint Inhibition for mRNA CAR T Cell Engineering

Advanced Healthcare Materials(2023)10.1002/adhm.202301515

N/A

0DataRank · unranked

95 citations

Kelsey L. Swingle, Ryann A. Joseph, David Mai, Ningqiang Gong, Margaret M. Billingsley +6 more

Combined disruption of T cell inflammatory regulators Regnase-1 and Roquin-1 enhances antitumor activity of engineered human T cells

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2218632120

N/A

0DataRank · unranked

81 citations

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N/A

0DataRank · unranked

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N/A

0DataRank · unranked

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