🏆 Finalist — NIH Data Sharing Index (“S-Index”) Challenge

James E. Bradner

Amgen (United States)

ORCID: 0000-0003-1422-5318

Also affiliated with Boston Biomedical (United States)

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 5%percentile
0.446Author DataRank

Indexed papers

7in pilot corpus
datarank_citation_only_1hop_v6· scope data_onlyMethodology
Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 7 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Top data-sharing exemplar

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

High-throughput approaches to uncover synergistic drug combinations in leukemia

SLAS DISCOVERY(2023)10.1016/j.slasd.2023.04.004
Top 42%
0.446DataRank
Top 42%9 citations

Meng Wang, Michele Ceribelli, Aleksandra M. Michalowska, Stefan Golas, Erin Beck +13 more

Papers

Driven by 14 papers — median percentile 58. Top paper: “PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET Bromodomains”.

PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET Bromodomains

Cancer Research(2013)10.1158/0008-5472.can-12-3292
N/A
0.828DataRank · unranked
249 citations

David Da Costa, Angeliki Thanasopoulou, Panagis Filippakopoulos, Paul V. Fish, Martin Philpott +12 more

Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins

Cell Reports(2021)10.1016/j.celrep.2020.108532
N/A
0.716DataRank · unranked
117 citations

Geoffrey M. Matthews, Sara Gandolfi, Ricardo De Matos Simoes, Dennis L. Buckley, Joseline Raja +34 more

Discovery of histone deacetylase 8 selective inhibitors

Bioorganic & Medicinal Chemistry Letters(2011)10.1016/j.bmcl.2011.01.134
N/A
0.678DataRank · unranked
91 citations

Tuoping Luo, Edward F. Greenberg, James E. Bradner, Stuart L. Schreiber, Weiping Tang

Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias

Nature Cancer(2023)10.1038/s43018-023-00550-x
N/A
0.568DataRank · unranked
43 citations

Ryosuke Shirasaki, Sondra L. Downey-Kopyscinski, Geoffrey M. Matthews, Benjamin G. Barwick, Vikas A. Gupta +36 more

BET bromodomain proteins regulate transcriptional reprogramming in genetic dilated cardiomyopathy

JCI Insight(2020)10.1172/jci.insight.138687
N/A
0.550DataRank · unranked
38 citations

Hiroko Wakimoto, Zhe Jiao, Joshua M. Gorham, Steven R. DePalma, Madeleine E. Lemieux +10 more

High-throughput approaches to uncover synergistic drug combinations in leukemia

SLAS DISCOVERY(2023)10.1016/j.slasd.2023.04.004
Top 42%
0.446DataRank
Top 42%9 citations

Meng Wang, Michele Ceribelli, Aleksandra M. Michalowska, Stefan Golas, Erin Beck +13 more

Selective targeting of MYC mRNA by stabilized antisense oligonucleotides

Oncogene(2021)10.1038/s41388-021-02053-4
N/A
0.442DataRank · unranked
18 citations

Haichuan Wang, Raj Bandaru, Matthew A. Lawlor, Chenyue Lu, Linda T. Nieman +8 more

The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53

Neoplasia(2021)10.1016/j.neo.2021.05.003
N/A
0.416DataRank · unranked
15 citations

Oscar Sias‐Garcia, Nicole Nasholm, Xiaoyu Hu, Amanda Balboni Iniguez, Matthew D. Hall +12 more

Supplementary Table S1 from The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects

10.1158/1078-0432.22459374.v1
N/A
0DataRank · unranked
0 citations

Pei Y. Liu, Bernard Atmadibrata, James E. Bradner, Glenn M. Marshall, Richard B. Lock +2 more

Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer

UNC Libraries(2020)10.17615/c0ws-ey78
N/A
0DataRank · unranked
7 citations

Julián Carretero, Roderick T. Bronson, James E. Bradner, Charles Y. Lin, Myles Brown +26 more

Supplementary Figure S2 from The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects

10.1158/1078-0432.22459389
N/A
0DataRank · unranked
0 citations

Pei Y. Liu, Bernard Atmadibrata, James E. Bradner, Glenn M. Marshall, Richard B. Lock +2 more

Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma

Journal of Clinical Investigation(2020)10.1172/jci134132
N/A
0DataRank · unranked
71 citations

Tong Liang, Yann Jamin, Susanne Walz, Colin Kwok, Anne Hakkert +38 more

Targeting oncoproteins with a positive selection assay for protein degraders

Science Advances(2021)10.1126/sciadv.abd6263
N/A
0DataRank · unranked
47 citations

Leslie Duplaquet, Benjamin L. Lampson, Adam C. Wang, Amin H. Sabet, Mette Ishoey +21 more

Supplementary Figure S4 from The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects

10.1158/1078-0432.22459383
N/A
0DataRank · unranked
0 citations

Pei Y. Liu, Bernard Atmadibrata, James E. Bradner, Glenn M. Marshall, Richard B. Lock +2 more