David Eisenberg

Also affiliated with UCLA Health, Abterra Biosciences (United States), Institute of Molecular Medicine

Biochemistry, Genetics and Molecular BiologyMaterials ScienceMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 44 papers. Top paper: “The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure”.

The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.1917914117

N/A

4.3DataRank · unranked

183 citations

Binsen Li, Chuanqi Sun, Weijia Fan, Kang Zhou, Michael P. Hughes +4 more

Half a century of amyloids: past, present and future

Chemical Society Reviews(2020)10.1039/c9cs00199a

N/A

0.956DataRank · unranked

584 citations

Ruhong Zhou, Louise C. Serpell, Roland Riek, Tuomas P. J. Knowles, Hilal A. Lashuel +10 more

The expanding amyloid family: Structure, stability, function, and pathogenesis

Cell(2021)10.1016/j.cell.2021.08.013

N/A

0.928DataRank · unranked

486 citations

Michael P. Hughes, José A. Rodríguez, Roland Riek, David Eisenberg, M.R. Sawaya

Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils

Nature Structural & Molecular Biology(2020)10.1038/s41594-020-0435-3

N/A

0.752DataRank · unranked

149 citations

David R. Boyer, M.R. Sawaya, P. Ge, David Eisenberg, Qin Cao

Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core

Nature Structural & Molecular Biology(2020)10.1038/s41594-020-0403-y

N/A

0.689DataRank · unranked

98 citations

M.R. Sawaya, P. Ge, Marcus Gallagher-Jones, Connor Short, Ronquiajah Bowman +5 more

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.06.16.545386

N/A

0.561DataRank · unranked

41 citations

Nabeela Ariqat, Justin McKetney, Gita Rohanitazangi, C Bravo, Rudra Bose +22 more

Atomic view of an amyloid dodecamer exhibiting selective cellular toxic vulnerability in acute brain slices

Protein Science(2021)10.1002/pro.4268

N/A

0.416DataRank · unranked

15 citations

M.R. Sawaya, Debalina Acharyya, Jinchao Lou, Emery M. Edington, Michael D. Best +4 more

How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer’s disease brain by a strain-relief mechanism

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.03.25.586668

N/A

0.208DataRank · unranked

3 citations

P. Ge, M.R. Sawaya, Joshua L. Dolinsky, Yuan Yang, Yi Xiao Jiang +11 more

The SARS-CoV-2 nucleocapsid protein preferentially binds long and structured RNAs

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.12.25.474155

N/A

0.104DataRank · unranked

1 citations

Einav Tayeb-Fligelman, Sarah L. Griner, Łukasz Salwiński, Jeannette T. Bowler, Romany Abskharon +6 more

Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.03.05.434000

N/A

0DataRank · unranked

24 citations

Xinyi Cheng, Christen E. Tai, Jeannette T. Bowler, Sarah L. Griner, M.R. Sawaya +19 more

Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro

Nature Communications(2022)10.1038/s41467-022-32951-4

N/A

0DataRank · unranked

187 citations

Kevin A. Murray, David R. Boyer, P. Ge, M.R. Sawaya, Carolyn J. Hu +9 more

Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43

Nature(2022)10.1038/s41586-022-04670-9

N/A

0DataRank · unranked

180 citations

Qin Cao, M.R. Sawaya, Romany Abskharon, P. Ge, Michael DeTure +6 more

Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2119952119

N/A

0DataRank · unranked

98 citations

M.R. Sawaya, David R. Boyer, Qin Cao, Binh A. Nguyen, Duilio Cascio +2 more

Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies

Nature Structural & Molecular Biology(2022)10.1038/s41594-022-00774-y

N/A

0DataRank · unranked

43 citations

Michael P. Hughes, Carolyn J. Hu, M.R. Sawaya, Łukasz Salwiński, Hope Pan +4 more

Extended β-Strands Contribute to Reversible Amyloid Formation

ACS Nano(2022)10.1021/acsnano.1c08043

N/A

0DataRank · unranked

30 citations

Declan Evans, Michael P. Hughes, M.R. Sawaya, Carolyn J. Hu, K. N. Houk +2 more

The rippled β-sheet layer configuration—a novel supramolecular architecture based on predictions by Pauling and Corey

Chemical Science(2022)10.1039/d2sc02531k

N/A

0DataRank · unranked

16 citations

M.R. Sawaya, Niko Vlahakis, Timothy C. Johnstone, David R. Boyer, José A. Rodríguez +3 more

Bioinformatic identification of previously unrecognized amyloidogenic proteins

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.101920

N/A

0DataRank · unranked

12 citations

Kevin A. Murray, Łukasz Salwiński, Michael P. Hughes, Romany Abskharon, David Eisenberg +1 more

Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.01.28.478258

N/A

0DataRank · unranked

11 citations

M.R. Sawaya, David R. Boyer, Qin Cao, Binh A. Nguyen, Duilio Cascio +2 more

Structural polymorphism of amyloid fibrils in cardiac transthyretin amyloidosis revealed by cryo-electron microscopy

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.06.21.496949

N/A

0DataRank · unranked

8 citations

Shumaila Afrin, Virender Singh, Yasmin Ahmed, Rose Pedretti, María del Carmen Fernández‐Ramírez +12 more

Amyloid fibrils in frontotemporal lobar degeneration with TDP-43 inclusions are composed of TMEM106B, rather than TDP-43

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.01.31.478523

N/A

0DataRank · unranked

1 citations

Qin Cao, M.R. Sawaya, Romany Abskharon, P. Ge, Michael DeTure +6 more

Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2217835120

N/A

0DataRank · unranked

48 citations

Carolyn J. Hu, Hope Pan, Jiahui Lu, Romany Abskharon, Jeannette T. Bowler +9 more

Racemic Peptides from Amyloid β and Amylin Form Rippled β-Sheets Rather Than Pleated β-Sheets

Journal of the American Chemical Society(2023)10.1021/jacs.3c11712

N/A

0DataRank · unranked

16 citations

M.R. Sawaya, Maria Sajimon, Niko Vlahakis, José A. Rodríguez, David Eisenberg +2 more

Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils

Nature Communications(2023)10.1038/s41467-023-37865-3

N/A

0DataRank · unranked

27 citations

Jeannette T. Bowler, Christen E. Tai, M.R. Sawaya, Yi Xiao Jiang, Gustavo Garcia +23 more

Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.105531

N/A

0DataRank · unranked

5 citations

P. Ge, M.R. Sawaya, Michael P. Hughes, David R. Boyer, Qin Cao +5 more

Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method

PNAS Nexus(2023)10.1093/pnasnexus/pgad402

N/A

0DataRank · unranked

4 citations

Romany Abskharon, David R. Boyer, P. Ge, M.R. Sawaya, David Eisenberg +1 more

Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy

Nature Communications(2024)10.1038/s41467-024-44820-3

N/A

0DataRank · unranked

62 citations

Virender Singh, Shumaila Afrin, Anna Yakubovska, Lanie Wang, Yasmin Ahmed +13 more

How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer’s disease brain by a strain-relief mechanism

Research Square(2024)10.21203/rs.3.rs-4152095/v1

N/A

0DataRank · unranked

3 citations

Ke Hou, P. Ge, M.R. Sawaya, Joshua L. Dolinsky, Yuan Yang +11 more

How short peptides disassemble tau fibrils in Alzheimer’s disease

Nature(2025)10.1038/s41586-025-09244-z

N/A

0DataRank · unranked

17 citations

P. Ge, M.R. Sawaya, Liisa Lutter, Joshua L. Dolinsky, Yuan Yang +12 more

Formation of rippled β-sheets from mixed chirality linear and cyclic peptides—new structural motifs based on the pauling-corey rippled β-sheet

Chemical Science(2025)10.1039/d4sc08079c

N/A

0DataRank · unranked

8 citations

M.R. Sawaya, Hyeonju Lee, Maria Sajimon, Hyungjun Kim, William A. Goddard +3 more

To What Extent is Anfinsen’s Thermodynamic Hypothesis Consistent With the Formation and Polymorphism of Amyloid Fibrils?

Journal of Molecular Biology(2025)10.1016/j.jmb.2025.169364

N/A

0DataRank · unranked

8 citations

David Eisenberg, Yi Xiao Jiang

Liganded magnetic nanoparticles for magnetic resonance imaging of α-synuclein

npj Parkinson s Disease(2025)10.1038/s41531-025-00918-z

N/A

0DataRank · unranked

2 citations

Melinda Balbirnie, Ke Hou, Naomi S. Sta Maria, Shruti Sahay, Paul Denver +20 more

A Shared Amyloid Architecture in Cardiac Fibrils from Three Neuropathy-Associated ATTR Variants

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.05.667944

N/A

0DataRank · unranked

2 citations

Shumaila Afrin, Binh A. Nguyen, Virender Singh, Maja Pękała, Preeti Singh +8 more

A structure-guided antibody detects SOD1 oligomers in diverse ALS genotypes

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.05.05.652290

N/A

0DataRank · unranked

1 citations

H. Rieder, Destaye M. Moore, Négar Khanlou, Bennett G. Novitch, Mark Geisberg +2 more

Leveraging structure-informed machine learning for fast steric zipper propensity prediction across whole proteomes

PLoS Computational Biology(2025)10.1371/journal.pcbi.1013395

N/A

0DataRank · unranked

0 citations

Songrong Qu, Thomas Holton, E. Bharani Shankar, P. G. Stanley, David Eisenberg +3 more

How Sup35 monomer conformation and amyloid fibril polymorphism determine yeast strain phenotypes

Research Square(2025)10.21203/rs.3.rs-7945345/v1

N/A

0DataRank · unranked

0 citations

Takashi Nomura, David R. Boyer, Yusuke Komi, P. Ge, Rodrigo A. Maillard +7 more

CNS-11g reduces α-synuclein pathology and restores motor function in a Parkinson’s model

Research Square(2025)10.21203/rs.3.rs-7935366/v1

N/A

0DataRank · unranked

0 citations

Kapil Manglani, Xiaohong Zuo, Cansheng Zhu, Mychica Jones, Alex Bombino +7 more

CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid

Nature Communications(2020)10.1038/s41467-020-17905-y

N/A

0DataRank · unranked

116 citations

Qin Cao, Michael P. Hughes, M.R. Sawaya, David R. Boyer, Duilio Cascio +2 more

Inhibition of synucleinopathic seeding by rationally designed inhibitors

eLife(2020)10.7554/elife.46775

N/A

0DataRank · unranked

79 citations

Shruti Sahay, Kevin A. Murray, Sophie Morgan, E.L. Guenther, Lin Jiang +5 more

Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease

Journal of Biological Chemistry(2020)10.1074/jbc.ra120.013638

N/A

0DataRank · unranked

36 citations

Paul M. Seidler, M.R. Sawaya, Duilio Cascio, Tianxiao Yang, Stephan Philipp +11 more

Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.25.114967

N/A

0DataRank · unranked

3 citations

David R. Boyer, M.R. Sawaya, P. Ge, David Eisenberg, Qin Cao

The cryoEM structure of the fibril-forming low-complexity domain of hnRNPA2 reveals distinct differences from pathogenic amyloid and shows how mutation converts it to the pathogenic form

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.24.113621

N/A

0DataRank · unranked

1 citations

Qin Cao, Michael P. Hughes, M.R. Sawaya, David R. Boyer, Duilio Cascio +2 more

Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores

Nature Structural & Molecular Biology(2021)10.1038/s41594-021-00646-x

N/A

0DataRank · unranked

90 citations

David R. Boyer, M.R. Sawaya, Romany Abskharon, Lorena Saelices, Binh A. Nguyen +5 more

Prevalence and species distribution of the low-complexity, amyloid-like, reversible, kinked segment structural motif in amyloid-like fibrils

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.101194

N/A

0DataRank · unranked

47 citations

Lukasz Goldschmidt, David Eisenberg, Michael P. Hughes

Catalytic Synthesis of PEGylated EGCG Conjugates that Disaggregate Alzheimer’s Tau

Synthesis(2021)10.1055/a-1509-5904

N/A

0DataRank · unranked

4 citations

Patrick G. Harran, Anton El Khoury, Paul M. Seidler, David Eisenberg