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Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease

Journal of Biological Chemistry(2020)10.1074/jbc.ra120.013638Source: DataRank Database

Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease is a research paper published in Journal of Biological Chemistry (2020). On theSindex it has a DataRank of 0. It has been cited 36 times.

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Open Access36 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (21 grants)Impact (FWCI 2.61)OA: hybridTopics (69)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (16)

Paul M. Seidler ORCID,M.R. Sawaya ORCID,Duilio Cascio ORCID,Tianxiao Yang ORCID,Stephan Philipp ORCID

Live enrichment

PubMed:32493775 PMC:PMC7397112 OpenAlex:https://openalex.org/W3031459901

HHS | NIH | National Institute on Aging

Grant: 1R01 AG029430

HHS | NIH | National Institute on Aging

Grant: RF1 AG054022

HHS | NIH | National Institute on Aging

Grant: RF1AG056507

HHS | NIH | National Institute on Aging

Grant: PHS P30-AG010133

HHS | NIH | National Institute of Neurological Disorders and Stroke

Grant: 1F32 NS095661

BrightFocus Foundation

Grant: A2016588F

HHS | NIH | National Institute of General Medical Sciences

Grant: P30 GM124165

DOE | LDRD | Argonne National Laboratory

Grant: S10 RR029205

NIA NIH HHS

Grant: R01 AG070895

NIA NIH HHS

Grant: R01 AG029430

NIA NIH HHS

Grant: R56 AG061847

NINDS NIH HHS

Grant: F32 NS095661

NIA NIH HHS

Grant: P30 AG010133

National Institutes of Health

Grant: 3P30GM124165-03S1

NE-CAT: A Resource for Advanced Macromolecular Crystallography

National Institutes of Health

Grant: 3RF1AG056507-01A1S1

Conformational polymorphisms of amyloid in AD and immunological biomarkers and therapeutics

National Institutes of Health

Grant: 1S10RR029205-01

Pixel Array Detector for X-ray Crystallography

National Institutes of Health

Grant: 1RF1AG054022-01

Structure and Inhibition of Amyloid in Alzheimer's Disease

National Institutes of Health

Grant: 5R01AG029430-08

Structural Biology of Amyloid Disease

National Institutes of Health

Grant: 5P30AG010133-08

CORE-- EDUCATION AND INFORMATION TRANSFER

Howard Hughes Medical Institute

FWCI

2.61

Citation Percentile

0.9%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttp://www.jbc.org/article/S0021925817501052/pdf

publisherhttp://www.jbc.org/article/S0021925817501052/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925817501052?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925817501052?httpAccept=text/plain

publisherhttps://syndication.highwire.org/content/doi/10.1074/jbc.RA120.013638

Fields of Study

Alzheimer's disease research and treatmentsPrion Diseases and Protein MisfoldingProtein Structure and Dynamics0301 basic medicine0303 health sciences03 medical and health sciencesAlzheimer DiseaseCrystallography, X-RayHumansProtein MultimerizationSingle-Chain Antibodiestau Proteins

MeSH Terms

Alzheimer DiseaseHumanstau ProteinsCrystallography, X-RayProtein MultimerizationSingle-Chain Antibodies

Keywords

AntibodySeedingPathologicalChemistryBiophysicsDiseaseBiochemistryCrystallographyBiologyMedicineImmunologyPathologyAmyloidInhibitorAntibody engineeringProtein crystallizationAlzheimer diseasePrionNeurodegenerative diseaseFibrilOligomerizationTauProtein aggregationNeurodegenerationprotein structureTauopathyAgingNeurodegenerativeAlzheimer's DiseaseCrystallography, X-RayMedical and Health Sciences2.1 Biological and endogenous factorsAetiologyBiological Sciences5.1 PharmaceuticalsNeurologicalDevelopment of treatments and therapeutic interventions570Biochemistry & Molecular Biology610tau ProteinsAcquired Cognitive ImpairmentHumansNeurosciencesAlzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)Brain DisordersChemical SciencesX-RayDementiaProtein MultimerizationSingle-Chain Antibodies

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease

FAIR Checklist

Authors (16)

Funding (21 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)