Aik Choon Tan

Also affiliated with Singapore General Hospital, Huntsman Cancer Institute, International Society for Computational Biology, Canisius-Wilhelmina Ziekenhuis

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 62 papers. Top paper: “Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial”.

Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial

Nature Medicine(2023)10.1038/s41591-023-02275-x

N/A

1.7DataRank · unranked

77 citations

Conor Steuer, Asari Ekpenyong, Ashley A. McCook‐Veal, Kelly R. Magliocca, Mihir R. Patel +18 more

Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: The Multi-Targeting Drug DREAM Challenge

PLoS Computational Biology(2021)10.1371/journal.pcbi.1009302

N/A

0.911DataRank · unranked

16 citations

Minji Jeon, Robert J. Allaway, Jaewoo Kang, Donghyeon Park, Jinhyuk Lee +17 more

Improved prognosis and evidence of enhanced immunogenicity in tumor and circulation of high-risk melanoma patients with unknown primary

Journal for ImmunoTherapy of Cancer(2022)10.1136/jitc-2021-004310

N/A

0.762DataRank · unranked

19 citations

Sandra J. Lee, Aik Choon Tan, Issam M. El Naqa, F. Stephen Hodi, Lisa H. Butterfield +9 more

Deep Learning of Histopathology Images at the Single Cell Level

Frontiers in Artificial Intelligence(2021)10.3389/frai.2021.754641

N/A

0.617DataRank · unranked

60 citations

John H. Lockhart, Mengyu Xie, Ritu Chaudhary, Robbert J.C. Slebos, Elsa R. Flores +3 more

Enhanced immune activation within the tumor microenvironment and circulation of female high-risk melanoma patients and improved survival with adjuvant CTLA4 blockade compared to males

Journal of Translational Medicine(2022)10.1186/s12967-022-03450-3

N/A

0.614DataRank · unranked

12 citations

Sandra J. Lee, Aik Choon Tan, Issam M. El Naqa, F. Stephen Hodi, Lisa H. Butterfield +10 more

BiNGS!SL-seq: A Bioinformatics Pipeline for the Analysis and Interpretation of Deep Sequencing Genome-Wide Synthetic Lethal Screen

Methods in Molecular Biology(2012)10.1007/978-1-61779-400-1_26

N/A

0.515DataRank · unranked

30 citations

Aik Choon Tan, Jihye Kim

First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer

Molecular Cancer Therapeutics(2020)10.1158/1535-7163.mct-20-0106

N/A

0.510DataRank · unranked

29 citations

Qiong Zhou, Hector Esquer, Laura A. Pike, Travis P. Broneske, Sébastien Rinaldetti +10 more

A real-world cohort study of immune-related adverse events in patients receiving immune checkpoint inhibitors

npj Precision Oncology(2025)10.1038/s41698-025-01123-0

N/A

0.509DataRank · unranked

16 citations

Yi Guo, Aik Choon Tan, Lili Zhao, Xu Shi, Yong Chen +7 more

Inhibiting Translation Elongation with SVC112 Suppresses Cancer Stem Cells and Inhibits Growth in Head and Neck Squamous Carcinoma

Cancer Research(2020)10.1158/0008-5472.can-19-3232

N/A

0.470DataRank · unranked

22 citations

Nathan Gomes, Bettina Miller, Brian C. Jackson, Phuong N. Le, J. Jason Morton +13 more

Systematic evaluation of the predictive gene expression signatures of immune checkpoint inhibitors in metastatic melanoma

Molecular Carcinogenesis(2022)10.1002/mc.23442

N/A

0.470DataRank · unranked

22 citations

Mengyu Xie, Ahmad A. Tarhini, Aik Choon Tan, Samuel S. Coleman

Advanced age is associated with changes in alveolar macrophages and their responses to the stress of traumatic injury

Journal of Leukocyte Biology(2022)10.1002/jlb.3hi0620-399rr

N/A

0.442DataRank · unranked

18 citations

Holly J. Hulsebus, Kevin M. Najarro, Juliet E. Mullen, Hyunmin Kim, Aik Choon Tan +3 more

Association of Glucagon‐Like Peptide‐1 Receptor Agonists With Cancer Risk in Older Adults With Type 2 Diabetes

Obesity(2025)10.1002/oby.24366

N/A

0.383DataRank · unranked

10 citations

Hao Dai, Huilin Tang, William T. Donahoo, Thomas J. George, Ramon C. Sun +9 more

Novel Human-Derived RET Fusion NSCLC Cell Lines Have Heterogeneous Responses to RET Inhibitors and Differential Regulation of Downstream Signaling

Molecular Pharmacology(2021)10.1124/molpharm.120.000207

N/A

0.360DataRank · unranked

10 citations

Anh T. Le, Adriana Estrada‐Bernal, Andrea E. Doak, Minjae Yoo, Sarah E. Ferrara +6 more

A Bioinformatics Tool for Identifying Intratumoral Microbes from the ORIEN Dataset

Cancer Research Communications(2024)10.1158/2767-9764.crc-23-0213

N/A

0.312DataRank · unranked

7 citations

Anjun Ma, Yingjie Li, Megan E. McNutt, Shiqi Zhang, Jiangjiang Zhu +27 more

Leptomeningeal Metastasis from Adrenocortical Carcinoma: A Case Report

Journal of the Endocrine Society(2020)10.1210/jendso/bvaa017

N/A

0.292DataRank · unranked

6 citations

Adwitiya Kar, Andrew Goodspeed, Nikita Pozdeyev, Hilary Somerset, Christopher D. Raeburn +5 more

NuKit: A deep learning platform for fast nucleus segmentation of histopathological images

Journal of Bioinformatics and Computational Biology(2023)10.1142/s0219720023500026

N/A

0.269DataRank · unranked

5 citations

Christine H. Chung, Aik Choon Tan, Ching-Nung Lin

Obesity promotes conserved inflammatory and metabolic transcriptional programs in colon tumors: evidence from mouse models and the ColoCare Study Patient Cohort

American Journal of Clinical Nutrition(2025)10.1016/j.ajcnut.2025.09.031

N/A

0.241DataRank · unranked

4 citations

Tengda Lin, Victoria M. Bandera, Babak Mirminachi, Saratchandra Singh Khumukcham, Biljana Gigic +28 more

A bioinformatics tool for identifying intratumoral microbes from the ORIEN dataset

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.24.541982

N/A

0.208DataRank · unranked

3 citations

Anjun Ma, Megan E. McNutt, Rebecca Hoyd, Caroline E. Wheeler, Lary A. Robinson +24 more

The tumor microbiome reacts to hypoxia and can influence response to radiation treatment in colorectal cancer

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.09.01.555936

N/A

0.206DataRank · unranked

2 citations

Rebecca Hoyd, McKenzie Kreamer, Caroline E. Wheeler, Dennis J. Grencewicz, Fouad Choueiry +27 more

Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer

Cancer Research Communications(2025)10.1158/2767-9764.crc-25-0177

N/A

0.170DataRank · unranked

2 citations

Rebecca Hoyd, Ayse S. Yilmaz, Jiangjiang Zhu, YunZhou Liu, Malvenderjit S. Jagjit Singh +31 more

Differences in Co-Expression of T Cell Co-Inhibitory and Co-Stimulatory Molecules with PD-1 Across Different Human Cancers

Journal of Oncology Research and Therapy(2024)10.29011/2574-710x.10224

N/A

0.104DataRank · unranked

1 citations

Dale J. Hedges, Aik Choon Tan, Paulo C. Rodrı́guez, Vineeth Sukrithan, Aakrosh Ratan +10 more

The tumor microbiome as a predictor of outcomes in patients with metastatic melanoma treated with immune checkpoint inhibitors

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.24.542123

N/A

0DataRank · unranked

5 citations

Samuel S. Coleman, Rebecca Hoyd, Louis Denko, Carlos H.F. Chan, Michelle L. Churchman +19 more

Response to high dose ipilimumab plus temozolomide after progression on standard or low dose ipilimumab in advanced melanoma: a retrospective analysis

Research Square(2023)10.21203/rs.3.rs-2997157/v1

N/A

0DataRank · unranked

1 citations

Muhammad Zaki Hidayatullah Fadlullah, Magdalena Kovacsovics-Bankowski, Berit Gibson, Umang Swami, Alyssa Erickson‐Wayman +14 more

Data from Exogenous Thyroid Hormone Is Associated with Shortened Survival and Upregulation of High-Risk Gene Expression Profiles in Steroid Receptor–Positive Breast Cancers

(2023)10.1158/1078-0432.c.6529971

N/A

0DataRank · unranked

0 citations

Susan M. Edgerton, Hiba Salem, Hyunmin Kim, Aik Choon Tan, Jessica Finlay-Schultz +7 more

Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures

Nature Communications(2020)10.1038/s41467-020-16212-w

N/A

0DataRank · unranked

143 citations

Nara Yoon, Viktoriya Marusyk, Arda Durmaz, Andrew Dhawan, Daria Miroshnychenko +13 more

Supplementary Tables and Figures from Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma

Figshare(2023)10.1158/1535-7163.22521675.v1

N/A

0DataRank · unranked

0 citations

Jennifer D. Hintzsche, Stacey M. Bagby, Verónica Espinoza, Christophe Langouët-Astrié, Carol M. Amato +6 more

Data from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma

(2023)10.1158/2767-9764.c.6630455

N/A

0DataRank · unranked

0 citations

Robbert J.C. Slebos, Leenil C. Noel, Feifei Song, Maria I. Poole, Dirk S. Hoening +8 more

The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer

Cancer Research Communications(2024)10.1158/2767-9764.crc-23-0367

N/A

0DataRank · unranked

24 citations

Rebecca Hoyd, McKenzie Kreamer, Caroline E. Wheeler, Dennis J. Grencewicz, Fouad Choueiry +27 more

Phase II trial of pembrolizumab, ipilimumab, and aspirin in melanoma: clinical outcomes and translational predictors of response

BJC Reports(2024)10.1038/s44276-024-00057-7

N/A

0DataRank · unranked

19 citations

Saya Jacob, Muhammad Zaki Hidayatullah Fadlullah, Chaorong Wu, Clinton Wu, Laura A. Huppert +16 more

The classification of melanocytic gene signatures

Pigment Cell & Melanoma Research(2024)10.1111/pcmr.13189

N/A

0DataRank · unranked

11 citations

Samuel S. Coleman, Robert L. Judson‐Torres, Aik Choon Tan, Min Hu

Exploring the Landscape of Immune Checkpoint Inhibitor-Induced Adverse Events Through Big Data Mining of Pan-Cancer Clinical Trials

The Oncologist(2024)10.1093/oncolo/oyae012

N/A

0DataRank · unranked

5 citations

Ching-Nung Lin, Samuel S. Coleman, Arabella Young, Abdul Rafeh Naqash, Siwen Hu‐Lieskovan +2 more

SASH1 S519N Variant Links Skin Hyperpigmentation and Premature Hair Graying to Dysfunction of Melanocyte Lineage

Journal of Investigative Dermatology(2024)10.1016/j.jid.2024.04.027

N/A

0DataRank · unranked

5 citations

Christopher M. Clements, Nabanita Mukherjee, Theresa Pacheco, Samantha X. Shellman, Morkos A. Henen +13 more

An Epigenomic fingerprint of human cancers by landscape interrogation of super enhancers at the constituent level

PLoS Computational Biology(2024)10.1371/journal.pcbi.1011873

N/A

0DataRank · unranked

0 citations

Nancy Gillis, Chang Jiang, Anthony McCofie, Timothy I. Shaw, Aik Choon Tan +5 more

A microRNA-regulated transcriptional state defines intratumoral CD8+ T cells that respond to immunotherapy

Cell Reports(2025)10.1016/j.celrep.2025.115301

N/A

0DataRank · unranked

11 citations

Ben Battistone, Kaylyn M. Bauer, Allison M. Weis, Cindy Barba, Muhammad Zaki Hidayatullah Fadlullah +19 more

Downregulated ALDH2 Contributes to Tumor Progression and Targeted Therapy Resistance in Human Metastatic Melanoma Cells

Cells(2025)10.3390/cells14120913

N/A

0DataRank · unranked

4 citations

Takeshi Yamauchi, Karenna Sandoval, Kira Villarreal, Man Wai Charlotte Kwong, Emily J. Swanson +3 more

Dramatic Responses to High-Dose Ipilimumab Plus Temozolomide After Progression on Standard- or Low-Dose Ipilimumab in Advanced Melanoma

Current Oncology(2025)10.3390/curroncol32030144

N/A

0DataRank · unranked

2 citations

Muhammad Zaki Hidayatullah Fadlullah, Magdalena Kovacsovics-Bankowski, Berit Gibson, Umang Swami, Alyssa Erickson‐Wayman +14 more

Plasma cell-free DNA methylation-based prognosis in metastatic castrate-resistant prostate cancer

npj Precision Oncology(2025)10.1038/s41698-025-01232-w

N/A

0DataRank · unranked

1 citations

Yijun Tian, Manishkumar S. Patel, Kapil Avasthi, Claire Hanson, Matt Larsen +11 more

A real-world cohort study of immune-related adverse events in patients receiving immune checkpoint inhibitors

medRxiv(2025)10.1101/2025.01.24.25321082

N/A

0DataRank · unranked

2 citations

Yi Guo, Aik Choon Tan, Lili Zhao, Xu Shi, Yong Chen +7 more

Obesity promotes conserved inflammatory and metabolic transcriptional programs in mouse and human colon tumors

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.06.19.660576

N/A

0DataRank · unranked

0 citations

Tengda Lin, Victoria M. Bandera, Babak Mirminachi, Saratchandra Singh Khumukcham, Biljana Gigic +28 more

RNA splicing is required for timely completion of abscission and is modulated by the abscission checkpoint

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.11.09.687034

N/A

0DataRank · unranked

0 citations

Jessica N. Vincent-Mueller, Douglas R. Mackay, Christopher C. Jensen, Chris Stubben, Li Li +4 more

Investigating the influence of baseline medications on immune checkpoint inhibitor treatment outcomes for cancer patients 3706

The Journal of Immunology(2025)10.1093/jimmun/vkaf283.1474

N/A

0DataRank · unranked

0 citations

Zaki F. Wilmot, Zoe Quandt, Aik Choon Tan, Samantha Liang, Enjun Yang +3 more

Data from Exogenous Thyroid Hormone Is Associated with Shortened Survival and Upregulation of High-Risk Gene Expression Profiles in Steroid Receptor–Positive Breast Cancers

(2023)10.1158/1078-0432.c.6529971.v1

N/A

0DataRank · unranked

0 citations

Susan M. Edgerton, Hiba Salem, Hyunmin Kim, Aik Choon Tan, Jessica Finlay-Schultz +7 more

Exogenous Thyroid Hormone Is Associated with Shortened Survival and Upregulation of High-Risk Gene Expression Profiles in Steroid Receptor–Positive Breast Cancers

Clinical Cancer Research(2020)10.1158/1078-0432.ccr-20-2647

N/A

0DataRank · unranked

16 citations

Susan M. Edgerton, Hiba Salem, Hyunmin Kim, Aik Choon Tan, Jessica Finlay-Schultz +7 more

Studying Immunotherapy Resistance in a Melanoma Autologous Humanized Mouse Xenograft

Molecular Cancer Research(2020)10.1158/1541-7786.mcr-20-0686

N/A

0DataRank · unranked

8 citations

Nathaniel Alzofon, Stephen B. Keysar, Tugs-Saikhan Chimed, Julie Reisinger, Loni Perrenoud +16 more

The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p

UNC Libraries(2020)10.17615/dnrn-cx42

N/A

0DataRank · unranked

0 citations

Heide L. Ford, Austin E. Gillen, Carol A. Sartorius, Michelle A. Guney, Aik Choon Tan +7 more

MERTK receptor tyrosine kinase is a therapeutic target in melanoma

UNC Libraries(2020)10.17615/7cf0-0a25

N/A

0DataRank · unranked

0 citations

John J. Tentler, H. Shelton Earp, Stephen V. Frye, Amanda Winges, Weihe Zhang +20 more

Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2000915118

N/A

0DataRank · unranked

194 citations

Dinoop Ravindran Menon, Douglas G. Osborne, C. Preston Neff, Nicholas E. Powers, Fabia Gamboni +17 more

Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma

Molecular Cancer Therapeutics(2021)10.1158/1535-7163.mct-20-1126

N/A

0DataRank · unranked

38 citations

Jennifer D. Hintzsche, Stacey M. Bagby, Veronica L. Espinoza, Christophe Langouët-Astrié, Carol M. Amato +6 more

TIMEx: tumor-immune microenvironment deconvolution web-portal for bulk transcriptomics using pan-cancer scRNA-seq signatures

Bioinformatics(2021)10.1093/bioinformatics/btab244

N/A

0DataRank · unranked

21 citations

Kyubum Lee, John H. Lockhart, Scott D Cukras, Rodrigo Carvajal, Amer A. Beg +5 more

Neoadjuvant endocrine therapy expands stromal populations that predict poor prognosis in estrogen receptor‐positive breast cancer

Molecular Carcinogenesis(2021)10.1002/mc.23377

N/A

0DataRank · unranked

6 citations

Mengyu Xie, Etana Kopin, Amy Han, Kiran Paul, Jaime Hagen +8 more

88 Evidence of enhanced immune activation within the tumor microenvironment and the circulation of female patients with high-risk melanoma compared to males

Regular and Young Investigator Award Abstracts(2021)10.1136/jitc-2021-sitc2021.088

N/A

0DataRank · unranked

1 citations

Aik Choon Tan, Issam El Naqa, Sandra Lee, F. Stephen Hodi, Lisa H. Butterfield +9 more

87 Enhanced immunogenicity within the tumor microenvironment and the circulation of high-risk melanoma patients with unknown primary compared to those whose primary melanoma is known

Journal for ImmunoTherapy of Cancer(2021)10.1136/jitc-2021-sitc2021.087

N/A

0DataRank · unranked

0 citations

Aik Choon Tan, Issam El Naqa, Sandra Lee, F. Stephen Hodi, Lisa H. Butterfield +8 more

ΔNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer

Nature Communications(2022)10.1038/s41467-022-28202-1

N/A

0DataRank · unranked

22 citations

Sarah J. Wu, Bethanie L. Gore, Hussein A. Abbas, Kyubum Lee, Rahul Checker +7 more

EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma

Cancer Research Communications(2023)10.1158/2767-9764.crc-22-0443

N/A

0DataRank · unranked

14 citations

Robbert J.C. Slebos, Leenil C. Noel, Feifei Song, Maria I. Poole, Dirk S. Hoening +8 more

Real-world pan-cancer landscape of frameshift mutations and their role in predicting responses to immune checkpoint inhibitors in cancers with low tumor mutational burden

Journal for ImmunoTherapy of Cancer(2023)10.1136/jitc-2023-007440

N/A

0DataRank · unranked

14 citations

Charalampos S. Floudas, Asaf Maoz, Abdul Rafeh Naqash, Carter Norton, Aik Choon Tan +12 more

Grading of lung adenocarcinomas with simultaneous segmentation by artificial intelligence (GLASS-AI)

npj Precision Oncology(2023)10.1038/s41698-023-00419-3

N/A

0DataRank · unranked

12 citations

Hayley D. Ackerman, Kyubum Lee, Mahmoud A. Abdalah, Andrew John Davis, Nicole Hackel +10 more

H3K4me3 remodeling induced acquired resistance through O-GlcNAc transferase

Drug Resistance Updates(2023)10.1016/j.drup.2023.100993

N/A

0DataRank · unranked

10 citations

Heinz Hammerlindl, Grégory Gimenez, Sabrina Hammerlindl, Elmar Zuegner, Joachim Torrano +15 more

PATH-SURVEYOR: pathway level survival enquiry for immuno-oncology and drug repurposing

BMC Bioinformatics(2023)10.1186/s12859-023-05393-y

N/A

0DataRank · unranked

9 citations

Darwin Chang, Gabrielle Nobles, Mingxiang Teng, Aik Choon Tan, Xuefeng Wang +9 more

Immune landscape in molecular subtypes of human papillomavirus‐negative head and neck cancer

Molecular Carcinogenesis(2023)10.1002/mc.23640

N/A

0DataRank · unranked

4 citations

Ritu Chaudhary, Robbert J.C. Slebos, Kyubum Lee, Feifei Song, Maria I. Poole +7 more

BCL2L11 Induction Mediates Sensitivity to Src and MEK1/2 Inhibition in Thyroid Cancer

Cancers(2023)10.3390/cancers15020378

N/A

0DataRank · unranked

13 citations

Veronica L. Espinoza, Katelyn J. Hoff, Laura A. Pike, Vibha Sharma, Marie‐Claude Hofmann +4 more

Thyroid hormone enhances estrogen-mediated proliferation and cell cycle regulatory pathways in steroid receptor-positive breast Cancer

Cell Cycle(2023)10.1080/15384101.2023.2249702

N/A

0DataRank · unranked

7 citations

Susan M. Edgerton, Hyunmin Kim, Aik Choon Tan, Bryan R. Haugen, Bolin Liu +2 more

Deciphering the Tumor–Immune–Microbe Interactions in HPV-Negative Head and Neck Cancer

Genes(2023)10.3390/genes14081599

N/A

0DataRank · unranked

5 citations

Samuel S. Coleman, Muhammad Zaki Hidayatullah Fadlullah, Daniel Spakowicz, Christine H. Chung, Aik Choon Tan +1 more