Ernest Hamel

Also affiliated with Government of the United States of America, Frederick National Laboratory for Cancer Research, National Cancer Institute

ChemistryMedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 35 papers. Top paper: “Novel indole-pyrazole hybrids as potential tubulin-targeting agents; Synthesis, antiproliferative evaluation, and molecular modeling studies”.

Novel indole-pyrazole hybrids as potential tubulin-targeting agents; Synthesis, antiproliferative evaluation, and molecular modeling studies

Journal of Molecular Structure(2023)10.1016/j.molstruc.2023.135477

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1.1DataRank · unranked

33 citations

Sezen Güntekin Ergün, Deniz Kahraman, Abdurrahman Olğaç, Ernest Hamel, Rengül Çetin-Atalay +2 more

Identification of pyrrolo[3′,4’:3,4]cyclohepta[1,2-d][1,2]oxazoles as promising new candidates for the treatment of lymphomas

European Journal of Medicinal Chemistry(2023)10.1016/j.ejmech.2023.115372

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0.529DataRank · unranked

33 citations

Virginia Spanò, Roberta Rocca, Roberta Bivacqua, Gianmarco Gualtieri, Maria Valeria Raimondi +11 more

Synthesis and biological activity of A-nor-paclitaxel analogues

Bioorganic & Medicinal Chemistry(1997)10.1016/s0968-0896(97)00035-7

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0.406DataRank · unranked

14 citations

David G.I. Kingston, Ernest Hamel, Chii M. Lin, Byron H. Long, Craig A. Fairchild +3 more

Design and Synthesis of 2-(3-Benzo[ b ]thienyl)-6,7-methylenedioxyquinolin-4-one Analogues as Potent Antitumor Agents that Inhibit Tubulin Assembly

UNC Libraries(2020)10.17615/gcyb-rb98

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0.104DataRank · unranked

1 citations

Susan L. Morris‐Natschke, Ernest Hamel, Yu‐Hsun Chang, Kuo‐Hsiung Lee, Li‐Jiau Huang +4 more

The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity

Bioorganic & Medicinal Chemistry(2020)10.1016/j.bmc.2020.115887

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0DataRank · unranked

7 citations

Tasdique M. Quadery, Ernest Hamel, Lerin R. Luckett‐Chastain, Michael A. Ihnat, Susan L. Mooberry +2 more

Optimization of 4-( N -Cycloamino)phenylquinazolines as a Novel Class of Tubulin-Polymerization Inhibitors Targeting the Colchicine Site

Figshare(2020)10.17615/6211-vz21

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0DataRank · unranked

2 citations

Keduo Qian, Xiaofeng Wang, Kuo‐Hsiung Lee, Sheng-Biao Wang, Dongqing Zhu +11 more

Development of a Novel Class of Tubulin Inhibitor from Desmosdumotin B with a Hydroxylated Bicyclic B-Ring

UNC Libraries(2020)10.17615/0rre-bf18

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0DataRank · unranked

0 citations

Emika Ohkoshi, Kuo‐Hsiung Lee, Masuo Goto, Akifumi Oda, Kyoko Nakagawa‐Goto +1 more

Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors

UNC Libraries(2020)10.17615/yex1-7e37

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0DataRank · unranked

0 citations

Kuo Hsiung Lee, Dong Qing Zhu, Sheng Biao Wang, Kan Yen Hsieh, Masuo Goto +7 more

Triethylated chromones with substituted naphthalenes as tubulin inhibitors

UNC Libraries(2020)10.17615/93h2-tb06

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0DataRank · unranked

0 citations

Yukako Taniguchi, Ernest Hamel, Masuo Goto, Kyoko Nakagawa‐Goto, Akifumi Oda +3 more

Antitumor Agents. 284. New Desmosdumotin B Analogues with Bicyclic B-Ring as Cytotoxic and Antitubulin Agents

Figshare(2020)10.17615/95ba-nx37

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0DataRank · unranked

0 citations

Masuo Goto, Kyoko Nakagawa‐Goto, Emika Ohkoshi, Kuo‐Hsiung Lee, Takashi Kozaka +6 more

N-Aryl-6-methoxy-1,2,3,4-tetrahydroquinolines: A novel class of antitumor agents targeting the colchicine site on tubulin

UNC Libraries(2020)10.17615/xzv2-mc56

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0DataRank · unranked

0 citations

Keduo Qian, Lan Xie, Susan L. Morris‐Natschke, Kuo‐Hsiung Lee, Sheng-Biao Wang +4 more

Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents

UNC Libraries(2020)10.17615/fza6-dq15

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0DataRank · unranked

0 citations

Ernest Hamel, Chin Yu Lai, Kyoko Nakagawa‐Goto, Kuo Hsiung Lee, Takashi Kozaka +3 more

Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure–activity relationship, in vitro and in vivo evaluation as antitumor agents

Bioorganic & Medicinal Chemistry Letters(2021)10.1016/j.bmcl.2021.127923

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0DataRank · unranked

24 citations

Tasdique M. Quadery, Ruoli Bai, Lerin R. Luckett‐Chastain, Ernest Hamel, Michael A. Ihnat +2 more

Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer

Bioorganic & Medicinal Chemistry(2021)10.1016/j.bmc.2021.116061

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0DataRank · unranked

9 citations

Arpit Doshi, Lerin R. Luckett‐Chastain, Michael A. Ihnat, Ernest Hamel, Susan L. Mooberry +2 more

Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas

European Journal of Medicinal Chemistry(2022)10.1016/j.ejmech.2022.114744

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0DataRank · unranked

45 citations

Virginia Spanò, Roberta Rocca, Roberta Bivacqua, Anne‐Catherine Abel, Annalisa Maruca +14 more

Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c01457

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0DataRank · unranked

23 citations

Jianchao Wu, Ruoli Bai, Michele D’Ambrosio, Marianna Nalli, Antonio Coluccia +15 more

Pyrrolo[2′,3′:3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.0c01315

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0DataRank · unranked

54 citations

Roberta Rocca, Marilia Barreca, Daniele Giallombardo, Alessandra Montalbano, Anna Carbone +11 more

Design, Synthesis and Biological Investigation of 2-Anilino Triazolopyrimidines as Tubulin Polymerization Inhibitors with Anticancer Activities

Pharmaceuticals(2022)10.3390/ph15081031

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0DataRank · unranked

15 citations

Paola Oliva, Filippo Prencipe, Stefano Manfredini, Federica Budassi, Andrea Brancale +9 more

The interaction of spongistatin 1 with tubulin

Archives of Biochemistry and Biophysics(2022)10.1016/j.abb.2022.109296

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0DataRank · unranked

4 citations

Amos B. Smith, George R. Pettit, Ernest Hamel, Ruoli Bai

2‐Difluoromethoxy‐Substituted Estratriene Sulfamates: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Steroid Sulfatase Inhibition

ChemMedChem(2022)10.1002/cmdc.202200408

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0DataRank · unranked

2 citations

Hannah Asiki, Wojciech Gruchot, Paul Foster, Havreen K. Sahota, Ruoli Bai +4 more

Synthesis and biological evaluation of structurally diverse 6-aryl-3-aroyl-indole analogues as inhibitors of tubulin polymerization

European Journal of Medicinal Chemistry(2023)10.1016/j.ejmech.2023.115794

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0DataRank · unranked

17 citations

Yuling Deng, J. WARD, Rebecca Vairin, Ruoli Bai, Hashini Wanniarachchi +9 more

4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c01424

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0DataRank · unranked

15 citations

Michela Puxeddu, Laura Di Magno, Michele D’Ambrosio, Anastasia Parisi, Marianna Nalli +22 more

Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site

Bioorganic & Medicinal Chemistry(2023)10.1016/j.bmc.2023.117217

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0DataRank · unranked

7 citations

Krishna Kaku, Andrew J. Robles, Ernest Hamel, Susan L. Mooberry, Aleem Gangjee +1 more

Structure Guided Design, Synthesis, and Biological Evaluation of Oxetane-Containing Indole Analogues

Bioorganic & Medicinal Chemistry(2023)10.1016/j.bmc.2023.117400

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0DataRank · unranked

3 citations

Rebecca Vairin, J. WARD, Ricardo Francis, Jenny M. VanNatta, Ruoli Bai +6 more

Data from The Synergistic Combination of the Farnesyl Transferase Inhibitor Lonafarnib and Paclitaxel Enhances Tubulin Acetylation and Requires a Functional Tubulin Deacetylase

(2023)10.1158/0008-5472.c.6494576

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0DataRank · unranked

0 citations

Jun Zhou, Aurora O’Brate, Ernest Hamel, Jason W.H. Wong, Michael C. Nivens +5 more

Data from The Synergistic Combination of the Farnesyl Transferase Inhibitor Lonafarnib and Paclitaxel Enhances Tubulin Acetylation and Requires a Functional Tubulin Deacetylase

(2023)10.1158/0008-5472.c.6494576.v1

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0DataRank · unranked

0 citations

Jun Zhou, Aurora O’Brate, Ernest Hamel, Jason W.H. Wong, Michael C. Nivens +5 more

Design, Synthesis and Biological Evaluation of 2-Phenyl Indole Analogues of OXi8006 as Colchicine Site Inhibitors of Tubulin Polymerization and Vascular Disrupting Agents

Bioorganic & Medicinal Chemistry(2024)10.1016/j.bmc.2024.117981

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0DataRank · unranked

5 citations

C. Tamminga, Zhe Shi, Christian Borchardt, Jayaram Jambulapati, Ruoli Bai +7 more

Drug-linker constructs bearing unique dual-mechanism tubulin binding payloads tethered through cleavable and non-cleavable linkers

Tetrahedron(2024)10.1016/j.tet.2024.134350

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0DataRank · unranked

3 citations

Jennifer M. VanNatta, Deboprosad Mondal, Chen-Ming Lin, Yuling Deng, Ruoli Bai +4 more

Synthesis and structure-activity relationship of boronic acid bioisosteres of combretastatin A-4 as anticancer agents

Bioorganic & Medicinal Chemistry(2024)10.1016/j.bmc.2024.117999

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0DataRank · unranked

3 citations

Michael Edler, Ernest Hamel, Asa R Britton-Jenkins, Omar Gillan, Susan L. Mooberry +3 more

Targeting tumor-associated hypoxia with bioreductively activatable prodrug conjugates derived from dihydronaphthalene, benzosuberene, and indole-based inhibitors of tubulin polymerization

RSC Medicinal Chemistry(2025)10.1039/d5md00564g

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0DataRank · unranked

2 citations

Rajsekhar Guddneppanavar, Blake A. Winn, Matthew T. MacDonough, Clinton S. George, Yifan Wang +11 more

Microwave-assisted synthesis of tubulin assembly inhibitors as anticancer agents by aryl ring reversal and conjunctive approach

RSC Medicinal Chemistry(2025)10.1039/d5md00406c

N/A

0DataRank · unranked

2 citations

Michela Puxeddu, Claudia Colla, Antonio Coluccia, Martina Santelli, Pietro Sciò +8 more

Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents

Pharmaceutics(2022)10.3390/pharmaceutics14061191

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0DataRank · unranked

19 citations

Romeo Romagnoli, Barbara Cacciari, Stefano Manfredini, Chiara Padroni, Andrea Brancale +9 more

Diaryl disulfides and thiosulfonates as combretastatin A-4 analogues: Synthesis, cytotoxicity and antitubulin activity

Bioorganic Chemistry(2020)10.1016/j.bioorg.2020.104017

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0DataRank · unranked

16 citations

Ruoli Bai, Ernest Hamel, Estela Mariana Guimarães Lourenço, Euzébio Guimarães Barbosa, Adilson Beatriz +3 more

Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia

Journal of Natural Products(2020)10.1021/acs.jnatprod.9b00773

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0DataRank · unranked

25 citations

Laxman Devkota, Bunnarack Kuch, Matthew T. MacDonough, Tracy E. Strecker, Yifan Wang +11 more

A brain-penetrant microtubule-targeting agent that disrupts hallmarks of glioma tumorigenesis

Neuro-Oncology Advances(2020)10.1093/noajnl/vdaa165

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0DataRank · unranked

24 citations

Philippe Diaz, Patrick J. Cimino, Erik Jung, Cong Xu, Ernest Hamel +9 more