Leah C. Kottyan

Cincinnati Children's Hospital Medical Center

Also affiliated with University of Cincinnati Medical Center

Biochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 7%percentile

0.111Author DataRank

Indexed papers

2in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 2 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

After the Infection: A Survey of Pathogens and Non-communicable Human Disease

medRxiv(2023)10.1101/2023.09.14.23295428

Top 72%

0.111DataRank

Top 72%1 citations

Daniel Schnell, Sreeja Parameswaran, Kevin Ernst, Shannon K. O’Connor, Nathan Salomonis +5 more

Papers

Driven by 63 papers — median percentile 28. Top paper: “Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations”.

Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations

Nature Medicine(2024)10.1038/s41591-024-02796-z

N/A

4.8DataRank · unranked

196 citations

Leah C. Kottyan, Christopher Kachulis, Noura S. Abul‐Husn, Joshua Arias, Gillian M. Belbin +73 more

Returning integrated genomic risk and clinical recommendations: The eMERGE study

Genetics in Medicine(2023)10.1016/j.gim.2023.100006

N/A

2.6DataRank · unranked

121 citations

Aimee Allworth, Harris T. Bland, Pedro J. Caraballo, Rex L. Chisholm, Ellen Wright Clayton +95 more

Global discovery of lupus genetic risk variant allelic enhancer activity

Nature Communications(2021)10.1038/s41467-021-21854-5

N/A

1.7DataRank · unranked

84 citations

Xiaoting Chen, Carmy Forney, Omer Donmez, Daniel Miller, Sreeja Parameswaran +11 more

Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets

Nature Communications(2023)10.1038/s41467-023-41442-z

N/A

1.2DataRank · unranked

62 citations

Michael McGregor, Mehdi Bouhaddou, Benjamin J. Polacco, Eun‐Young Kim, Thông Nguyen +50 more

Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus

Annals of the Rheumatic Diseases(2020)10.1136/annrheumdis-2020-219209

N/A

0.781DataRank · unranked

182 citations

Kwangwoo Kim, Hiroyuki Suetsugu, So‐Young Bang, Leilei Wen, Masaru Koido +82 more

Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure

Nature Communications(2022)10.1038/s41467-022-34216-6

N/A

0.754DataRank · unranked

151 citations

Noah L. Tsao, Pankhuri Singhal, Chang Liu, Ha My T. Vy, Ishan Paranjpe +38 more

Filaggrin loss-of-function variants are associated with atopic dermatitis phenotypes in a diverse, early-life prospective cohort

JCI Insight(2024)10.1172/jci.insight.178258

N/A

0.655DataRank · unranked

22 citations

Latha Satish, Jocelyn M. Biagini, Hassan Chaı̈b, Wan Chi Chang, Phillip J. Dexheimer +17 more

Multiancestral polygenic risk score for pediatric asthma

Journal of Allergy and Clinical Immunology(2022)10.1016/j.jaci.2022.03.035

N/A

0.593DataRank · unranked

51 citations

Michael Lape, Edyta Małolepsza, Stanley B. DeVore, Matthew T. Weirauch, Ozan Dikilitas +19 more

Therapeutic Targeting of Follicular T Cells with Chimeric Antigen Receptor-Expressing Natural Killer Cells

Cell Reports Medicine(2020)10.1016/j.xcrm.2020.100003

N/A

0.590DataRank · unranked

50 citations

Stacey Cranert, Kelly M. Rangel, Ayad Ali, Ivayla E. Gyurova, Arthur T. de la Cruz-Lynch +7 more

Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants

Science(2025)10.1126/science.adp4753

N/A

0.587DataRank · unranked

49 citations

Amin Abedini, Eunji Ha, Ziyuan Ma, Xin Sheng, Bernhard Dumoulin +94 more

Genome-wide admixture and association analysis identifies African ancestry–specific risk loci of eosinophilic esophagitis in African Americans

Journal of Allergy and Clinical Immunology(2022)10.1016/j.jaci.2022.09.040

N/A

0.489DataRank · unranked

25 citations

Julie M. Caldwell, Leah C. Kottyan, Mirna Chehade, Evan S. Dellon, Marc E. Rothenberg +15 more

Update on the genetics of allergic diseases

Journal of Allergy and Clinical Immunology(2025)10.1016/j.jaci.2025.03.012

N/A

0.477DataRank · unranked

23 citations

Sreeja Parameswaran, Ronald Allan M. Panganiban, Gregory Constantine, Matthew T. Weirauch, Leah C. Kottyan +1 more

Quantifying factors that affect polygenic risk score performance across diverse ancestries and age groups for body mass index

medRxiv(2022)10.1101/2022.05.27.22275647

N/A

0.417DataRank · unranked

5 citations

Brenda Xiao, Ozan Dikilitas, Robert R. Freimuth, Marguerite R. Irvin, Gail P. Jarvik +14 more

Advances and ongoing challenges in eosinophilic gastrointestinal disorders presented at the CEGIR/TIGERs Symposium at the 2024 American Academy of Allergy, Asthma & Immunology meeting

Journal of Allergy and Clinical Immunology(2024)10.1016/j.jaci.2024.07.022

N/A

0.406DataRank · unranked

14 citations

J. Pablo Abonia, Edsel M. Abud, Seema S. Aceves, Steven J. Ackerman, Melinda Braskett +22 more

CASCADE: high-throughput characterization of regulatory complex binding altered by non-coding variants

Cell Genomics(2022)10.1016/j.xgen.2022.100098

N/A

0.406DataRank · unranked

14 citations

Heather Hook, Rose Zhao, Jessica L. Keenan, Ashley Penvose, Yemi Osayame +7 more

Genome-wide meta-analysis identifies novel risk loci for uterine fibroids within and across multiple ancestry groups

Nature Communications(2025)10.1038/s41467-025-57483-5

N/A

0.385DataRank · unranked

12 citations

Ariel Williams, Hannah Noh, Elizabeth A. Jasper, Sarah H. Jones, James Jaworski +18 more

Selection, optimization, and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse populations

medRxiv(2023)10.1101/2023.05.25.23290535

N/A

0.330DataRank · unranked

8 citations

Leah C. Kottyan, Christopher Kachulis, Noura S. Abul‐Husn, Josh Arias, Gillian M. Belbin +71 more

Risk factors affecting polygenic score performance across diverse cohorts

eLife(2023)10.7554/elife.88149

N/A

0.312DataRank · unranked

7 citations

Scott Dudek, Krzysztof Kiryluk, Theresa L. Walunas, Iftikhar J. Kullo, Wei‐Qi Wei +16 more

Expanding the genetic landscape of endometriosis: Integrative -omics analyses implicate key genes and pathways in a multi-ancestry study of over one million women

medRxiv(2024)10.1101/2024.11.26.24316723

N/A

0.312DataRank · unranked

7 citations

Jagyashila Das, Lannawill Caruth, Ananya Rajagopalan, Alexis T. Akerele, Ben Brumpton +33 more

Breakthroughs in understanding and treating eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERs Symposium at the 2022 American Academy of Allergy, Asthma & Immunology Meeting

Journal of Allergy and Clinical Immunology(2023)10.1016/j.jaci.2023.08.021

N/A

0.312DataRank · unranked

7 citations

Benjamin L. Wright, Dan Atkins, Seema S. Aceves, Steven J. Ackerman, Amal Assa’ad +26 more

Macrophage epigenetic memories of early life injury drive neonatal nociceptive priming

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.13.528015

N/A

0.241DataRank · unranked

4 citations

Adewale Oluwaseun Fadaka, Anna M. Warshak, Aditi Paranjpe, Benjamin Weinhaus, Luis F. Queme +10 more

maxATAC: genome-scale transcription-factor binding prediction from ATAC-seq with deep neural networks

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.01.28.478235

N/A

0.208DataRank · unranked

3 citations

Faiz W. Rizvi, Balaji Iyer, Xiaoting Chen, Michael Kotliar, Anthony T. Bejjani +10 more

Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity

eLife(2024)10.7554/elife.101578

N/A

0.176DataRank · unranked

2 citations

Sreeja Parameswaran, Matthew J. Beucler, Lee Edsall, Andrew VonHandorf, Audrey Crowther +19 more

B‐Cell Repertoire of Children With Atopic Dermatitis Exhibits Altered IgE Maturation Associated With Allergic Food Sensitization

Allergy(2025)10.1111/all.70150

N/A

0.165DataRank · unranked

2 citations

Carolina Moore, Onyekachi Nwogu, John Kroner, Wan‐Chi Chang, Jeffrey Burkle +14 more

After the Infection: A Survey of Pathogens and Non-communicable Human Disease

medRxiv(2023)10.1101/2023.09.14.23295428

Top 72%

0.111DataRank

Top 72%1 citations

Daniel Schnell, Sreeja Parameswaran, Kevin Ernst, Shannon K. O’Connor, Nathan Salomonis +5 more

Genome-wide epigenetic profiling and transcriptome analysis in pediatric Obstructive Sleep Apnea: A focus on Black female children

Heliyon(2024)10.1016/j.heliyon.2024.e40830

N/A

0.104DataRank · unranked

1 citations

Sreeja Parameswaran, Omer A. Donmez, Carmy Forney, Hope Rowden, Charles A. Moore +7 more

Enhancing genetic association power in endometriosis through unsupervised clustering of clinical subtypes identified from electronic health records

Research Square(2024)10.21203/rs.3.rs-5004325/v1

N/A

0DataRank · unranked

1 citations

Lindsay Guare, Leigh Ann Humphrey, Margaret Rush, Meredith Pollie, James Jaworski +13 more

A survey of pathogenic involvement in non-communicable human diseases

Communications Medicine(2025)10.1038/s43856-025-00956-x

N/A

0DataRank · unranked

6 citations

Dan Schnell, Sreeja Parameswaran, Kevin Ernst, Shannon K. O’Connor, Nathan Salomonis +5 more

GDF10 promotes rodent cardiomyocyte maturation during the postnatal period

Journal of Molecular and Cellular Cardiology(2025)10.1016/j.yjmcc.2025.01.010

N/A

0DataRank · unranked

3 citations

Maria L Spaeth, Marissa Granitto, Brittany A. Gonzalez, Matthew T. Weirauch, Leah C. Kottyan +2 more

Genome‐wide cross‐trait analysis of heterogeneous outcomes in early life atopic dermatitis

Pediatric Allergy and Immunology(2025)10.1111/pai.70253

N/A

0DataRank · unranked

1 citations

Hua He, Daniel Spagna, Seth Jenkins, Brittany Grashel, Wan Chi Chang +9 more

Multi-trait Analysis of GWAS Expands Eosinophilic Esophagitis Genetic Susceptibility and Polygenic Risk Scores

Research Square(2025)10.21203/rs.3.rs-6630283/v1

N/A

0DataRank · unranked

1 citations

Bahram Namjou, Netali Ben-Baruch Morgenstern, Mark Rochman, Xiaoting Chen, G. A. Osswald +12 more

Risk factors affecting polygenic score performance across diverse cohorts

eLife(2025)10.7554/elife.88149.3

N/A

0DataRank · unranked

0 citations

Scott Dudek, Krzysztof Kiryluk, Theresa L. Walunas, Iftikhar Kullo, Wei‐Qi Wei +16 more

Genome-wide discovery of multiple sclerosis genetic risk variant allelic regulatory activity

G3 Genes Genomes Genetics(2025)10.1093/g3journal/jkaf192

N/A

0DataRank · unranked

0 citations

Lois Parks, Molly Shook, Carmy Forney, Xiaoting Chen, Lee Edsall +8 more

Massively parallel analysis of genotype-dependent enhancer activity among atopic dermatitis genetic risk variants

Journal of Allergy and Clinical Immunology(2025)10.1016/j.jaci.2025.07.032

N/A

0DataRank · unranked

0 citations

Xiaoming Lu, Xiaoting Chen, Lee Edsall, Marissa Granitto, Samuel J. Virolainen +14 more

Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity

eLife(2025)10.7554/elife.101578.2

N/A

0DataRank · unranked

0 citations

Sreeja Parameswaran, Matthew J. Beucler, Lee Edsall, Andrew VonHandorf, Audrey Crowther +19 more

Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity

eLife(2025)10.7554/elife.101578.3

N/A

0DataRank · unranked

0 citations

Sreeja Parameswaran, Matthew J. Beucler, Lee Edsall, Andrew VonHandorf, Audrey Crowther +19 more

Expanding the genetic landscape of endometriosis: Integrative -omics analyses implicate key genes and pathways in a multi-ancestry study of over one million women

Research Square(2025)10.21203/rs.3.rs-8116602/v1

N/A

0DataRank · unranked

0 citations

Lindsay Guare, Jagyashila Das, Lannawill Caruth, Ananya Rajagopalan, Alexis T. Akerele +31 more

Immune pathways and perinatal environmental exposures contribute to epigenetic gestational age prediction and acceleration

10.1101/2025.06.13.659090

N/A

0DataRank · unranked

0 citations

Ian M. Loveless, Mingming Pan, Xiaoyu Liang, Audrey Urquhart, Jennifer Straughen +10 more

The genetic etiology of eosinophilic esophagitis

Journal of Allergy and Clinical Immunology(2020)10.1016/j.jaci.2019.11.013

N/A

0DataRank · unranked

93 citations

Sreeja Parameswaran, Matthew T. Weirauch, Marc E. Rothenberg, Lisa J. Martin, Leah C. Kottyan

Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming

Cell Reports(2020)10.1016/j.celrep.2020.107604

N/A

0DataRank · unranked

55 citations

Leah C. Kottyan, Harinder Singh, Chandrashekhar Pasare, Margaret M. McDaniel

Very early onset eosinophilic esophagitis is common, responds to standard therapy, and demonstrates enrichment for CAPN14 genetic variants

Journal of Allergy and Clinical Immunology(2020)10.1016/j.jaci.2020.10.017

N/A

0DataRank · unranked

45 citations

Lisa J. Martin, Tetsuo Shoda, Margaret H. Collins, Michael P. Trimarchi, Hua He +4 more

Comprehensive Review of Steroid-Sensitive Nephrotic Syndrome Genetic Risk Loci and Transcriptional Regulation as a Possible Mechanistic Link to Disease Risk

Kidney International Reports(2020)10.1016/j.ekir.2020.09.048

N/A

0DataRank · unranked

5 citations

Sreeja Parameswaran, Amy Eapen, Xiaoting Chen, John B. Harley, Prasad Devarajan +3 more

Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis

UNC Libraries(2020)10.17615/kgg2-9t07

N/A

0DataRank · unranked

1 citations

Heidi Sucharew, Glenn T. Furuta, Kari C. Nadeau, John B. Harley, Russell J. Hopp +21 more

Genome-wide discovery of SLE genetic risk variant allelic enhancer activity

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.01.20.906701

N/A

0DataRank · unranked

4 citations

Xiaoting Chen, Carmy Forney, Omer Donmez, Daniel Miller, Sreeja Parameswaran +11 more

Meta-analysis of 208,370 East Asians identifies 113 genomic loci and yields new non-immune cell relevant biological insights for systemic lupus erythematosus

medRxiv(2020)10.1101/2020.08.22.20178939

N/A

0DataRank · unranked

1 citations

Kwangwoo Kim, Hiroyuki Suetsugu, So‐Young Bang, Leilei Wen, Masaru Koido +81 more

Epstein-Barr virus nuclear antigen 2 (EBNA2) extensively rewires the human chromatin landscape at autoimmune risk loci

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.04.15.043612

N/A

0DataRank · unranked

0 citations

Sreeja Parameswaran, Omer Donmez, Daniel Miller, Carmy Forney, Michael Lape +11 more

IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility

Cell Reports(2021)10.1016/j.celrep.2021.108891

N/A

0DataRank · unranked

95 citations

Yajing Gao, Igor Dozmorov, Venkat S. Malladi, Irene Saha, Margaret M. McDaniel +11 more

Runx1 shapes the chromatin landscape via a cascade of direct and indirect targets

PLoS Genetics(2021)10.1371/journal.pgen.1009574

N/A

0DataRank · unranked

30 citations

Daniel Brissette, Sreeja Parameswaran, Mario Pujato, Rebekah Karns, Leah C. Kottyan +3 more

Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease

UNC Libraries(2021)10.17615/vk4g-5457

N/A

0DataRank · unranked

0 citations

Mark Rochman, David M. Fleischer, Phillip J. Dexheimer, Matthew T. Weirauch, Andrew Rupert +24 more

Epstein–Barr virus nuclear antigen 2 extensively rewires the human chromatin landscape at autoimmune risk loci

Genome Research(2021)10.1101/gr.264705.120

N/A

0DataRank · unranked

56 citations

Sreeja Parameswaran, Omer A. Donmez, Daniel Miller, Carmy Forney, Michael Lape +11 more

1502 Genetic predisposition to lupus across ancestries has >300 separable genetic contributions: what we know today

Abstracts(2021)10.1136/lupus-2021-lupus21century.85

N/A

0DataRank · unranked

2 citations

Leah C. Kottyan, Matthew T. Weirauch, Kenneth M. Kaufman, John B. Harley, Viktoryia Laurynenka

Gene–environment interactions and their impact on human health

Genes and Immunity(2022)10.1038/s41435-022-00192-6

N/A

0DataRank · unranked

298 citations

Andrew VonHandorf, Kenyatta C. M. F. Viel, Matthew T. Weirauch, Leah C. Kottyan, Samuel J. Virolainen

Epigenetic and transcriptional dysregulation in CD4+ T cells in patients with atopic dermatitis

PLoS Genetics(2022)10.1371/journal.pgen.1009973

N/A

0DataRank · unranked

15 citations

Sreeja Parameswaran, Carmy Forney, Lee Edsall, Daniel Miller, Rebekah Karns +14 more

High-resolution promoter interaction analysis implicates genes involved in the activation of Type 3 Innate Lymphoid Cells in autoimmune disease risk

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.10.19.512842

N/A

0DataRank · unranked

5 citations

Helen Ray-Jones, Nora Lakes, Rachel A. Brown, Tareian Cazares, Owen Clay +30 more

maxATAC: Genome-scale transcription-factor binding prediction from ATAC-seq with deep neural networks

PLoS Computational Biology(2023)10.1371/journal.pcbi.1010863

N/A

0DataRank · unranked

41 citations

Faiz W. Rizvi, Balaji Iyer, Xiaoting Chen, Michael Kotliar, Anthony T. Bejjani +10 more

Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells

Cell Reports(2023)10.1016/j.celrep.2023.113180

N/A

0DataRank · unranked

30 citations

Kathrynne A. Warrick, Andrew VonHandorf, Charles N. Vallez, Kiana Kawarizadeh, Irene Saha +6 more

A functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth

BMC Medicine(2023)10.1186/s12916-023-02973-w

N/A

0DataRank · unranked

1 citations

Robert M. Rossi, Xiaoting Chen, Jing Chen, Jilian Runyon, Mehak Chawla +11 more

Aryl Hydrocarbon Receptor Suppresses Eosinophilic Esophagitis Responses through OVOL1 and SPINK7

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.17.541192

N/A

0DataRank · unranked

3 citations

Andrea M. Klingler, Mark Rochman, Misu Paul, Julie M. Caldwell, Michael Brusilovsky +9 more

Macrophage memories of early-life injury drive neonatal nociceptive priming

Cell Reports(2024)10.1016/j.celrep.2024.114129

N/A

0DataRank · unranked

21 citations

Adewale Oluwaseun Fadaka, Anna M. Warshak, Aditi Paranjpe, Benjamin Weinhaus, Luis F. Queme +10 more

Systematic identification of genotype-dependent enhancer variants in eosinophilic esophagitis

The American Journal of Human Genetics(2024)10.1016/j.ajhg.2023.12.008

N/A

0DataRank · unranked

16 citations

Xiaoming Lu, Xiaoting Chen, Sreeja Parameswaran, Lee Edsall, Michael P. Trimarchi +10 more

Accessible chromatin maps of inflammatory bowel disease intestine nominate cell-type mediators of genetic disease risk

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.02.09.579678

N/A

0DataRank · unranked

4 citations

Zi Yang, Elizabeth Angerman, Erin Bonkowski, Ingrid Jurickova, Xiaoting Chen +11 more

Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.04.12.588762

N/A

0DataRank · unranked

2 citations

Sreeja Parameswaran, Matthew J. Beucler, Lee Edsall, Andrew VonHandorf, Audrey Crowther +19 more

Enhancing Genetic Association Power in Endometriosis through Unsupervised Clustering of Clinical Subtypes Identified from Electronic Health Records

medRxiv(2024)10.1101/2024.04.22.24306092

N/A

0DataRank · unranked

2 citations

Leigh Ann Humphrey, Margaret Rush, Meredith Pollie, Yuan Luo, Chunhua Weng +12 more

Leah C. Kottyan

Indexed papers

Top data-sharing exemplar

Papers