Michael J. Eck

Also affiliated with Dana-Farber Cancer Institute

MedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 45 papers. Top paper: “Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors”.

Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors

Nature Communications(2022)10.1038/s41467-022-30258-y

N/A

2.0DataRank · unranked

88 citations

Ciric To, David E. Heppner, Jaimin K. Rana, Anna M. Schmoker, Jaebong Jang +7 more

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

Science(2004)10.1126/science.1099314

N/A

1.4DataRank · unranked

9384 citations

Pasi A. Jänne, Jeffrey C. Lee, Sean Tracy, Heidi Greulich, Anthony Philippakis +13 more

Design of a “Two-in-One” Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c00848

N/A

1.3DataRank · unranked

45 citations

David E. Heppner, Ciric To, Marcel Günther, Bo Hee Shin, Jaimin K. Rana +13 more

Cryo-EM structure of a RAS/RAF recruitment complex

Nature Communications(2023)10.1038/s41467-023-40299-6

N/A

0.578DataRank · unranked

46 citations

Shaun Rawson, Anna M. Schmoker, Byeong-Won Kim, Se-hee Oh, Kangkang Song +3 more

PH domain-mediated autoinhibition and oncogenic activation of Akt

eLife(2022)10.7554/elife.80148

N/A

0.515DataRank · unranked

30 citations

Thibault Viennet, Eunyoung Park, Nam Chu, Antonieta L. Salguero, Michael J. Eck +3 more

Cryo-EM structures of CRAF/MEK1/14-3-3 complexes in autoinhibited and open-monomer states reveal features of RAF regulation

Nature Communications(2025)10.1038/s41467-025-63227-2

N/A

0.457DataRank · unranked

14 citations

Kayla Boxer, Byung Hak Ha, Emre Tkacik, Talya S. Levitz, Shaun Rawson +5 more

Oncogenic K-Ras suppresses global miRNA function

Molecular Cell(2023)10.1016/j.molcel.2023.06.008

N/A

0.442DataRank · unranked

18 citations

Tyler S. Beyett, Zhengyi Chen, Xiaoyi Li, Gaspare La Rocca, William Gazlay +5 more

Characterization and inhibitor sensitivity of ARAF, BRAF, and CRAF kinases

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110800

N/A

0.327DataRank · unranked

7 citations

Dong Man Jang, Kayla Boxer, Byung Hak Ha, Michael J. Eck, Emre Tkacik

Allosteric inhibition of JAK2 with lysine-reactive compounds that bind the pseudokinase domain

European Journal of Medicinal Chemistry(2025)10.1016/j.ejmech.2025.118274

N/A

0.245DataRank · unranked

4 citations

Maurício T. Tavares, John M. Hatcher, Hyelim Kang, Tomás A. C. Kresina, Sayan Chakraborty +9 more

ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.3c01891

N/A

0.241DataRank · unranked

4 citations

Wenchao Lu, Tyler S. Beyett, Scott B. Ficarro, Jie Jiang, Jason Tse +8 more

Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

ChemRxiv(2023)10.26434/chemrxiv-2023-cs3xn-v2

N/A

0.208DataRank · unranked

3 citations

Blessing C. Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D. Pham, Ilse K. Schaeffner +15 more

PH Domain-Mediated Autoinhibition and Oncogenic Activation of Akt

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.05.25.493453

N/A

0.104DataRank · unranked

1 citations

Thibault Viennet, Eunyoung Park, Nam Chu, Antonieta L. Salguero, Michael J. Eck +3 more

An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer

Nature Cancer(2022)10.1038/s43018-022-00351-8

N/A

0DataRank · unranked

163 citations

Tyler S. Beyett, Jaebong Jang, William W. Feng, Magda Bahcall, Heidi M. Haikala +21 more

A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non–Small Cell Lung Cancer

Cancer Research(2022)10.1158/0008-5472.can-21-2693

N/A

0DataRank · unranked

36 citations

Jaebong Jang, Tyler S. Beyett, Yoonji Eum, Heidi M. Haikala, Alyssa Verano +13 more

Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC

Bioorganic & Medicinal Chemistry Letters(2022)10.1016/j.bmcl.2022.128718

N/A

0DataRank · unranked

23 citations

David E. Heppner, Tyler S. Beyett, Ciric To, Seth C. Azevedo, Jaebong Jang +11 more

Structural analysis of the macrocyclic inhibitor BI-4020 binding to EGFR kinase

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.08.27.505540

N/A

0DataRank · unranked

5 citations

Jaimin K. Rana, Ilse K. Schaeffner, David E. Heppner, Michael J. Eck, Tyler S. Beyett

Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448)

ChemRxiv(2022)10.26434/chemrxiv-2022-5m8h5-v2

N/A

0DataRank · unranked

3 citations

Tyler S. Beyett, Tatiana Shaurova, Calvin Pham, Florian Wittlinger, Ilse K. Schaeffner +6 more

Cryo-EM structure of a RAS/RAF recruitment complex

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.07.14.500081

N/A

0DataRank · unranked

2 citations

Shaun Rawson, Anna M. Schmoker, Byeong-Won Kim, Se-hee Oh, Kangkang Song +3 more

Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448)

ChemRxiv(2022)10.26434/chemrxiv-2022-5m8h5

N/A

0DataRank · unranked

0 citations

Tyler S. Beyett, Tatiana Shaurova, Calvin Pham, Florian Wittlinger, Ilse K. Schaeffner +6 more

Structure and RAF family kinase isoform selectivity of type II RAF inhibitors tovorafenib and naporafenib

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.104634

N/A

0DataRank · unranked

70 citations

Kunhua Li, Gonzalo L. González‐Del Pino, Byung Hak Ha, Javier Viñals, Eunyoung Park +3 more

Crystal Structure of the FERM Domain of Focal Adhesion Kinase

UNC Libraries(2021)10.17615/5rx4-h922

N/A

0DataRank · unranked

0 citations

Derek F. Ceccarelli, Michael D. Schaller, Michael J. Eck, Kyu Song Hyun, Florence Poy

A structural perspective on targeting the RTK/Ras/MAP kinase pathway in cancer

Protein Science(2021)10.1002/pro.4125

N/A

0DataRank · unranked

33 citations

Michael J. Eck, David E. Heppner

Structural elements that enable specificity for mutant EGFR kinase domains with next-generation small-molecule inhibitors

Methods in enzymology on CD-ROM/Methods in enzymology(2023)10.1016/bs.mie.2023.03.013

N/A

0DataRank · unranked

8 citations

Florian Wittlinger, Tyler S. Beyett, Michael J. Eck, Stefan Laufer, David E. Heppner +1 more

Development of Mutant-Selective Allosteric EGFR Inhibitors for Drug-Resistant Lung Cancer

Journal of Pharmacology and Experimental Therapeutics(2023)10.1124/jpet.122.162040

N/A

0DataRank · unranked

1 citations

Ciric To, David E. Heppner, Thomas W. Gero, Nathanael S. Gray, David A. Scott +3 more

A Constitutive EGFR Kinase Dimer to Study Inhibitor Pharmacology

Molecular Pharmacology(2023)10.1124/molpharm.123.000768

N/A

0DataRank · unranked

2 citations

Ilse K. Schaeffner, David E. Heppner, Ciric To, Pasi A. Jänne, Tyler S. Beyett +2 more

Examining molecular factors of inactive versus active bivalent EGFR inhibitors: A missing link in fragment-based drug design.

ChemRxiv(2023)10.26434/chemrxiv-2023-cs3xn

N/A

0DataRank · unranked

3 citations

Blessing C. Ogboo, Calvin D. Pham, Ilse K. Schaeffner, Surbhi P. Chitnis, Tahereh Damghani +12 more

Structural Basis for the Autoinhibition of Focal Adhesion Kinase

UNC Libraries(2020)10.17615/cgk9-3v51

N/A

0DataRank · unranked

0 citations

Michael J. Eck, Yiqun Li, Derek F. Ceccarelli, Michael D. Schaller, Xinming Cai +1 more

The origin of potency and mutant-selective inhibition by bivalent ATP-allosteric EGFR inhibitors

ChemRxiv(2023)10.26434/chemrxiv-2023-zzfc3

N/A

0DataRank · unranked

2 citations

Surbhi P. Chitnis, Calvin D Pham, Tahereh Damghani, Ilse K. Schaeffner, Matthew Q. Deng +13 more

Structural elements that enable specificity for mutant EGFR kinase domains with next-generation small-molecule inhibitors.

ChemRxiv(2023)10.26434/chemrxiv-2023-v522v

N/A

0DataRank · unranked

0 citations

Florian Wittlinger, Tyler S. Beyett, Michael J. Eck, Stefan Laufer, David E. Heppner +1 more

Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

Research Square(2023)10.21203/rs.3.rs-3286949/v1

N/A

0DataRank · unranked

0 citations

Florian Wittlinger, Blessing C. Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin Pham +15 more

Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

Communications Chemistry(2024)10.1038/s42004-024-01108-3

N/A

0DataRank · unranked

24 citations

Blessing C. Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D. Pham, Ilse K. Schaeffner +15 more

Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality

ACS Central Science(2024)10.1021/acscentsci.3c01245

N/A

0DataRank · unranked

15 citations

Jie Jiang, Scott B. Ficarro, Tyler S. Beyett, Ciric To, Isidoro Tavares +9 more

Structural Analysis of the Macrocyclic Inhibitor BI‐4020 Binding to EGFR Kinase

ChemMedChem(2024)10.1002/cmdc.202300343

N/A

0DataRank · unranked

10 citations

Jaimin K. Rana, Ilse K. Schaeffner, David E. Heppner, Michael J. Eck, Tyler S. Beyett

Tilting the Scales toward EGFR Mutant Selectivity: Expanding the Scope of Bivalent “Type V” Kinase Inhibitors

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.4c02311

N/A

0DataRank · unranked

8 citations

Surbhi P. Chitnis, Calvin D. Pham, Tahereh Damghani, Kishan B. Patel, Mareike Möllers +17 more

Biochemical analysis of EGFR exon20 insertion variants insASV and insSVD and their inhibitor sensitivity

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2417144121

N/A

0DataRank · unranked

5 citations

Tyler S. Beyett, Jie Jiang, Jaimin K. Rana, Ilse K. Schaeffner, J. A. da S. Santana +3 more

Molecular Design of a “Two-in-One” Orthosteric-Allosteric Chimeric Mutant Selective EGFR Inhibitor

(2020)10.26434/chemrxiv.13416452.v1

N/A

0DataRank · unranked

0 citations

David E. Heppner, Ciric To, Marcel C. Guenther, Bo Hee Shin, Jaimin K Rana +6 more

Molecular Design of a “Two-in-One” Orthosteric-Allosteric Chimeric Mutant Selective EGFR Inhibitor

ChemRxiv(2020)10.26434/chemrxiv.13416452

N/A

0DataRank · unranked

1 citations

david heppner, Ciric To, Marcel C. Guenther, Bo Hee Shin, Jaimin K Rana +6 more

Mutant‐Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug‐Resistant Mutations

Angewandte Chemie(2020)10.1002/ange.202003500

N/A

0DataRank · unranked

15 citations

Ciric To, Dries J.H. De Clercq, Eunyoung Park, Charles M. Ponthier, Bo Hee Shin +7 more

Structure–Activity Relationships of Inactive‐Conformation Binding EGFR Inhibitors: Linking the ATP and Allosteric Pockets

Archiv der Pharmazie(2025)10.1002/ardp.70027

N/A

0DataRank · unranked

5 citations

Florian Wittlinger, Mareike Möllers, Tyler J. Hartman, Marcel Günther, Michael J. Eck +3 more

Mutant‐Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug‐Resistant Mutations

Angewandte Chemie International Edition(2020)10.1002/anie.202003500

N/A

0DataRank · unranked

140 citations

Ciric To, Dries J.H. De Clercq, Eunyoung Park, Charles M. Ponthier, Bo Hee Shin +7 more

Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity

Nature Cell Biology(2025)10.1038/s41556-024-01555-z

N/A

0DataRank · unranked

3 citations

Tevis Vitale, M. Ravichandran, Katherine Zhang, Jonathan M. Palozzi, Christopher F. Bennett +11 more

Characterization and inhibitor sensitivity of ARAF, BRAF, and CRAF complexes

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.14.670349

N/A

0DataRank · unranked

1 citations

Dong Man Jang, Kayla Boxer, Byung Hak Ha, Michael J. Eck, Emre Tkacik

RAF isoform selectivity of MEK inhibitors and rational design of a covalent ARAF-MEK inhibitor

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.64898/2025.12.15.693503

N/A

0DataRank · unranked

1 citations

Jie Jiang, Javier Vinals Camallonga, Dimitris Gazgalis, Thomas W. Gero, Maurício T. Tavares +13 more

Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c01041

N/A

0DataRank · unranked

31 citations

Tyler S. Beyett, William W. Feng, Andreas Krämer, Janik Weckesser, Ilse K. Schaeffner +6 more

Structure-activity relationships of inactive-conformation binding EGFR inhibitors: Linking the ATP and allosteric pockets

ChemRxiv(2025)10.26434/chemrxiv-2025-2cdjb

N/A

0DataRank · unranked

0 citations

Florian Wittlinger, Mareike Möllers, Tyler J. Hartman, Marcel Günther, Michael J. Eck +3 more