🏆 Finalist — NIH Data Sharing Index (“S-Index”) Challenge

Carleigh A. O’Brien

University of Pennsylvania

ORCID: 0000-0003-4549-0640
NeuroscienceImmunology and MicrobiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile
0Author DataRank

Indexed papers

0in pilot corpus
datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 14 papers. Top paper: “Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism”.

Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism

Neuron(2024)10.1016/j.neuron.2024.07.015
N/A
0.584DataRank · unranked
48 citations

Sean Harvey, Kaja Bajc, Tony Z Zhang, Danielle A Jeffrey, Alexander Z Zhang +16 more

Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi–Goutières syndrome neuropathology

eLife(2025)10.7554/elife.102900
N/A
0.104DataRank · unranked
1 citations

Genevieve Uy, V Sai Chaluvadi, Freddy S Purnell, Bilal Elfayoumi, Leila Byerly +17 more

ICOS-deficient and ICOS YF mutant mice fail to control Toxoplasma gondii infection of the brain

PLoS ONE(2020)10.1371/journal.pone.0228251
N/A
0DataRank · unranked
9 citations

Tajie H. Harris, Carleigh A. O’Brien

Gasdermin-D-dependent IL-1 α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.01.22.915652
N/A
0DataRank · unranked
0 citations

Katherine M. Still, David M. Johanson, Jeremy Thompson, Carleigh A. O’Brien, John R. Lukens +2 more

Engineering an inhibitor-resistant human CSF1R variant for microglia replacement

The Journal of Experimental Medicine(2022)10.1084/jem.20220857
N/A
0DataRank · unranked
95 citations

Sonia I Lombroso, Graham C. Peet, Jonathan Hasselmann, Christina Tu, Dave E. Marzan +17 more

Microglial STAT1-sufficiency is required for resistance to toxoplasmic encephalitis

PLoS Pathogens(2022)10.1371/journal.ppat.1010637
N/A
0DataRank · unranked
23 citations

Michael A. Kovacs, Ish Sethi, Isaac W. Babcock, Katherine M. Still, Samantha J. Batista +6 more

Microglia in antiviral immunity of the brain and spinal cord

Seminars in Immunology(2022)10.1016/j.smim.2022.101650
N/A
0DataRank · unranked
18 citations

F. Chris Bennett, Mariko L. Bennett, Carleigh A. O’Brien

Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling

PLoS Pathogens(2020)10.1371/journal.ppat.1009027
N/A
0DataRank · unranked
46 citations

Samantha J. Batista, Carleigh A. O’Brien, Oyebola O. Oyesola, Simon P. Früh, Lauren M. Webb +8 more

Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1+ microglia

Immunity(2025)10.1016/j.immuni.2025.04.006
N/A
0DataRank · unranked
54 citations

Carleigh A. O’Brien, Mónica Vara‐Pérez, Myrthe Mampay, Lynn van Olst, Liam Barry-Carroll +20 more

Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease

Immunity(2025)10.1016/j.immuni.2025.03.019
N/A
0DataRank · unranked
23 citations

Carleigh A. O’Brien, Madison Sangster, Fazeela Yaqoob, Yuanchao Zhang, Brian Temsamrit +25 more

Microglia depletion improves hippocampal circuit function after mild traumatic brain injury in male mice

Brain Behavior and Immunity(2025)10.1016/j.bbi.2025.106178
N/A
0DataRank · unranked
5 citations

Anthony Farrugia, Ian A Diaz Nieves, Carleigh A. O’Brien, F. Chris Bennett, Akiva S. Cohen +1 more

Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells

Molecular Therapy(2025)10.1016/j.ymthe.2025.10.050
N/A
0DataRank · unranked
2 citations

Emily I. Church, Ryan N. Anderson, Carleigh A. O’Brien, Yixuan Zhu, Asif A. Dar +25 more

Neonatal microglia replacement in mice modulates seizure severity in adulthood

Molecular Therapy(2025)10.1016/j.ymthe.2025.08.039
N/A
0DataRank · unranked
2 citations

Samuelle A S Delcy, Sangeeta Shukla, Eli M Levitt, Akiva S. Cohen, Mariko L. Bennett +2 more

Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection

Nature Communications(2020)10.1038/s41467-020-17491-z
N/A
0DataRank · unranked
114 citations

Katherine M. Still, David M. Johanson, Jeremy Thompson, Carleigh A. O’Brien, John R. Lukens +2 more