William F. DeGrado

Also affiliated with Tohoku University, University of San Francisco

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 54 papers. Top paper: “Constructing ion channels from water-soluble α-helical barrels”.

Constructing ion channels from water-soluble α-helical barrels

Nature Chemistry(2021)10.1038/s41557-021-00688-0

N/A

2.7DataRank · unranked

123 citations

Ai Niitsu, Huong T. Kratochvil, Eric J. M. Lang, Jason T. Sengel, William Dawson +11 more

A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi

Nature Communications(2023)10.1038/s41467-023-37573-y

N/A

0.628DataRank · unranked

65 citations

Patrícia Alves de Castro, Rafael Wesley Bastos, Camila Figueiredo Pinzan, Pedro Filho Noronha Souza, Suzanne Ackloo +11 more

Cleavage of talin by calpain promotes platelet-mediated fibrin clot contraction

Blood Advances(2021)10.1182/bloodadvances.2021004582

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0.614DataRank · unranked

18 citations

Kathleen S. Molnar, Nicholas J. Agard, Rustem I. Litvinov, Oleg V. Kim, James A. Wells +4 more

De novo design of drug-binding proteins with predictable binding energy and specificity

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.23.573178

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0.208DataRank · unranked

3 citations

Xuxu Gou, Sophia K. Tan, Samuel I. Mann, Hyunjun Yang, Xiaofang Zhong +9 more

EMBER multi-dimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.01.526692

N/A

0.104DataRank · unranked

1 citations

Peng Yuan, Yibing Wu, Marie Shi, Christoffer D. Caro, Atsushi Tengeiji +5 more

Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.06.19.162248

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0DataRank · unranked

2 citations

William F. DeGrado, Gregory A. Voth, Laura C. Watkins

Platform to Discover Protease-Activated Antibiotics and Application to Siderophore-Antibiotic Conjugates

ChemRxiv(2020)10.26434/chemrxiv.12809603

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0DataRank · unranked

2 citations

Bobo Dang, Beatrice Ary, Quinn Edmondson, Charles S. Craik, William F. DeGrado +2 more

Elucidation of the molecular interactions that enable stable assembly and structural diversity in multicomponent immune receptors

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.12.22.424036

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0DataRank · unranked

0 citations

Matthew J. Chalkley, Sophia K. Tan, Michael Grabe, William F. DeGrado, Lam‐Kiu Fong

De novo metalloprotein design

Nature Reviews Chemistry(2021)10.1038/s41570-021-00339-5

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0DataRank · unranked

132 citations

Samuel I. Mann, William F. DeGrado, Matthew J. Chalkley

Inclusion of the C-Terminal Domain in the β-Sheet Core of Heparin-Fibrillized Three-Repeat Tau Protein Revealed by Solid-State Nuclear Magnetic Resonance Spectroscopy

Journal of the American Chemical Society(2021)10.1021/jacs.1c03314

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0DataRank · unranked

52 citations

Harrison K. Wang, Haifan Wu, Pu Duan, Jia Jin, William F. DeGrado +2 more

Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndrome

Acta Neuropathologica Communications(2021)10.1186/s40478-021-01298-0

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0DataRank · unranked

26 citations

Peng Yuan, Brianna M. Rivera, Wilder Schaaf, Mihovil Mladinov, V. P. Prasher +4 more

Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity

Biochemistry(2021)10.1021/acs.biochem.1c00437

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0DataRank · unranked

23 citations

Marley L. Samways, Athina Konstantinidi, Chunlong Ma, Yanmei Hu, Hannah E. Bruce Macdonald +5 more

Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models

Journal of Clinical Investigation(2021)10.1172/jci138140

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0DataRank · unranked

15 citations

Uyen Ngo, Xin-Zi Tang, Xin Ren, Wenli Qiu, Xiaozhu Huang +6 more

Visualization of Platelet Integrins via Two-Photon Microscopy Using Anti-transmembrane Domain Peptides Containing a Blue Fluorescent Amino Acid

Biochemistry(2021)10.1021/acs.biochem.1c00238

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0DataRank · unranked

13 citations

Ismail A. Ahmed, Marco Mravic, Hyunil Jo, Oleg V. Kim, Rustem I. Litvinov +5 more

Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of α-Helix As Oxyanion-Binding Site

Journal of the American Chemical Society(2021)10.1021/jacs.0c10053

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0DataRank · unranked

12 citations

Alastair G. McEwen, Sophia K. Tan, Pierre Poussin‐Courmontagne, J.‐L. Schmitt, Catherine Birck +3 more

Spiers Memorial Lecture: Analysis and de novo design of membrane-interactive peptides

Faraday Discussions(2021)10.1039/d1fd00061f

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0DataRank · unranked

11 citations

Robert W. Newberry, Bruk Mensa, Marco Mravic, William F. DeGrado, Huong T. Kratochvil

Brilacidin, a COVID-19 Drug Candidate, demonstrates broad-spectrum antiviral activity against human coronaviruses OC43, 229E and NL63 through targeting both the virus and the host cell

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.11.04.467344

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0DataRank · unranked

2 citations

Hyunil Jo, William F. DeGrado, Jun Wang, Yanmei Hu

Emergence of distinct and heterogeneous strains of amyloid beta as Alzheimer’s disease progresses in Down syndrome

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.07.30.454527

N/A

0DataRank · unranked

0 citations

Peng Yuan, Brianna M. Rivera, Wilder Schaaf, Mihovil Mladinov, V. P. Prasher +4 more

Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2114486119

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0DataRank · unranked

89 citations

Haifan Wu, Dibyendu Mondal, Annalise Bond, Erika Castillo, Jia Jin +7 more

Brilacidin, a COVID‐19 drug candidate, demonstrates broad‐spectrum antiviral activity against human coronaviruses OC43, 229E, and NL63 through targeting both the virus and the host cell

Journal of Medical Virology(2022)10.1002/jmv.27616

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0DataRank · unranked

49 citations

Hyunil Jo, William F. DeGrado, Jun Wang, Yanmei Hu

The CD3ζ adaptor structure determines functional differences between human and mouse CD16 Fc receptor signaling

The Journal of Experimental Medicine(2022)10.1084/jem.20220022

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0DataRank · unranked

36 citations

Lam‐Kiu Fong, Kenichi Ishiyama, William F. DeGrado, Lewis L. Lanier, Oscar A. Aguilar

Covalent labeling of a chromatin reader domain using proximity-reactive cyclic peptides

Chemical Science(2022)10.1039/d2sc00555g

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0DataRank · unranked

28 citations

Hyunjun Yang, Gloria Ortiz, Michael J. Trnka, Nektaria Petronikolou, Alma L. Burlingame +3 more

Quaternary structure independent folding of voltage-gated ion channel pore domain subunits

Nature Structural & Molecular Biology(2022)10.1038/s41594-022-00775-x

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0DataRank · unranked

8 citations

Marco Lolicato, David Shaya, Ahmed Rohaim, Felix Findeisen, Lam‐Kiu Fong +9 more

Stacked binding of a small molecule PET tracer to Alzheimer’s tau paired helical filaments

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.30.510175

N/A

0DataRank · unranked

8 citations

Matthew J. Chalkley, Sophia K. Tan, Eric Tse, Joanne Lee, Stanley B. Prusiner +4 more

A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.28.509882

N/A

0DataRank · unranked

5 citations

Patrícia Alves de Castro, Rafael Wesley Bastos, Camila Figueiredo Pinzan, Pedro Filho Noronha Souza, Suzanne Ackloo +8 more

Transient Water Wires Mediate Selective Proton Transport in Designed Channel Proteins

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.03.28.485852

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0DataRank · unranked

2 citations

Laura C. Watkins, Marco Mravic, Noah H. Somberg, Jessica L. Thomaston, John M. Nicoludis +5 more

Stacked binding of a PET ligand to Alzheimer’s tau paired helical filaments

Nature Communications(2023)10.1038/s41467-023-38537-y

N/A

0DataRank · unranked

66 citations

Matthew J. Chalkley, Sophia K. Tan, Eric Tse, Joanne Lee, Stanley B. Prusiner +4 more

Transient water wires mediate selective proton transport in designed channel proteins

Nature Chemistry(2023)10.1038/s41557-023-01210-4

N/A

0DataRank · unranked

65 citations

Laura C. Watkins, Marco Mravic, Jessica L. Thomaston, John M. Nicoludis, Noah H. Somberg +5 more

Hexamethylene amiloride binds the SARS‐CoV‐2 envelope protein at the protein–lipid interface

Protein Science(2023)10.1002/pro.4755

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0DataRank · unranked

13 citations

João Medeiros‐Silva, Hyunil Jo, Jun Wang, William F. DeGrado, Mei Hong +1 more

Zfp106 binds to G-quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.05.531055

N/A

0DataRank · unranked

0 citations

Haifan Wu, Bobo Dang, Huong T. Kratochvil, William F. DeGrado, Brian L. Black +1 more

Patterning and folding of intestinal villi by active mesenchymal dewetting

Cell(2024)10.1016/j.cell.2024.04.039

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0DataRank · unranked

88 citations

Teemu J. Häkkinen, Hikaru Miyazaki, Vasudha Srivastava, Emilie Barruet, Christopher S. McGinnis +14 more

De novo design of drug-binding proteins with predictable binding energy and specificity

Science(2024)10.1126/science.adl5364

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0DataRank · unranked

69 citations

Xuxu Gou, Sophia K. Tan, Samuel I. Mann, Hyunjun Yang, Xiaofang Zhong +9 more

De novo-designed transmembrane proteins bind and regulate a cytokine receptor

Nature Chemical Biology(2024)10.1038/s41589-024-01562-z

N/A

0DataRank · unranked

27 citations

Li He, Huong T. Kratochvil, Hailin Hu, Sarah E. Nick, Weiya Bai +6 more

Zfp106 binds to G-quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2220020121

N/A

0DataRank · unranked

12 citations

Sally Salomonsson, Haifan Wu, Bobo Dang, Huong T. Kratochvil, Claire D. Clelland +3 more

IL-13 and IL-17A activate β1 integrin through an NF-kB/Rho kinase/PIP5K1γ pathway to enhance force transmission in airway smooth muscle

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2401251121

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0DataRank · unranked

14 citations

Ying Shi, Prescott G. Woodruff, Kevan M. Shokat, William F. DeGrado, Hyunil Jo +3 more

SuFEx Chemistry Enables Covalent Assembly of a 280-kDa 18-Subunit Pore-Forming Complex

Journal of the American Chemical Society(2024)10.1021/jacs.4c07920

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0DataRank · unranked

13 citations

Sophia K. Tan, Pratik Raj Singh, Floriana Capuano, Alistair J. Scott, Richard Hambley +6 more

An enhanced broad-spectrum peptide inhibits Omicron variants in vivo

Cell Reports Medicine(2024)10.1016/j.xcrm.2024.101418

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0DataRank · unranked

11 citations

Kaiming Tang, Guilin Chen, Yubin Xie, Nicholas F. Polizzi, William F. DeGrado +3 more

De novo design of peptides that bind specific conformers of α-synuclein

Chemical Science(2024)10.1039/d3sc06245g

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0DataRank · unranked

11 citations

Hyunjun Yang, Sophia K. Tan, Henry S. Pan, Rose Yang, Junyi Xu +5 more

De novo design of porphyrin-containing proteins as efficient and stereoselective catalysts

Science(2025)10.1126/science.adt7268

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0DataRank · unranked

43 citations

Wei Huang, Miao Qi, Thomas H. Tugwell, Turki M. Alturaifi, Yuda Chen +7 more

ProBASS—a language model with sequence and structural features for predicting the effect of mutations on binding affinity

Bioinformatics(2025)10.1093/bioinformatics/btaf270

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0DataRank · unranked

10 citations

Yibing Wu, William F. DeGrado, Julia M. Shifman, Sagara N.S. Gurusinghe

High-throughput discovery of fluoroprobes that recognize amyloid fibril polymorphs

Nature Chemistry(2025)10.1038/s41557-025-01889-7

N/A

0DataRank · unranked

7 citations

Hyunjun Yang, Wyatt C. Powell, Annemarie F. Charvat, Abby Oehler, Julia P. G. Jones +13 more

De Novo Design of Proteins That Bind Naphthalenediimides, Powerful Photooxidants with Tunable Photophysical Properties

Journal of the American Chemical Society(2025)10.1021/jacs.4c18151

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0DataRank · unranked

13 citations

Zhi Lin, Sophia K. Tan, Jiaqi Zhu, Zachary X. W. Widel, Ian Bakanas +8 more

De Novo Design, Directed Evolution and Computational Study of Heme-Binding Helical Bundle Protein Catalysts for Biocatalytic Enantioselective Ge–H Insertion

Journal of the American Chemical Society(2025)10.1021/jacs.5c13909

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0DataRank · unranked

4 citations

Gessica M. Adornato, Maggie Horst, Turki M. Alturaifi, Kai-Peng Hou, Peng Liu +3 more

Design of a light and Ca 2+ switchable organic–peptide hybrid

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2411316122

N/A

0DataRank · unranked

2 citations

Young Hyun No, Nam Hyeong Kim, Do Hyun Bae, Yibing Wu, Suhyeon Kim +11 more

Hydroxy-substituted electron deficient Pd porphyrin cofactors illuminate ultrafast proton transfer reactions

Journal of Inorganic Biochemistry(2025)10.1016/j.jinorgbio.2025.113116

N/A

0DataRank · unranked

1 citations

Rui Liu, Jarrett P. Mansergh, Minting Ouyang, Lindsay R. Pederson, Ian Bakanas +3 more

De novo designed bright, hyperstable rhodamine binders for fluorescence microscopy

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.06.24.661379

N/A

0DataRank · unranked

4 citations

Klaus Yserentant, Kibeom Hong, Y. P. Kuang, Arghya Bhowmick, Arthur Charles‐Orszag +10 more

Antimicrobial Activity of Brilacidin against E. coli

ACS Infectious Diseases(2025)10.1021/acsinfecdis.5c00023

N/A

0DataRank · unranked

0 citations

Mohammad Sharifian Gh., Bruk Mensa, Gabriella L. Howell, William F. DeGrado, Hai‐Lung Dai +1 more

Platform for the synthesis and evaluation of verrucarol-based ribosome inhibitors

ChemRxiv(2025)10.26434/chemrxiv-2025-7n89p

N/A

0DataRank · unranked

0 citations

Tushar Raskar, Eugene D. Toth, Jiakai Zhang, Andrew K. Ecker, Seul Ki Yeon +5 more

A defined structural unit enables de novo design of small-molecule–binding proteins

Science(2020)10.1126/science.abb8330

N/A

0DataRank · unranked

152 citations

William F. DeGrado, Nicholas F. Polizzi

De novo design of semisynthetic protein nanopores

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.09.08.674823

N/A

0DataRank · unranked

0 citations

A. Katherine Hatstat, Alistair J. Scott, Sophia K. Tan, Richard Hambley, William Dawson +9 more

De novoprotein design, a retrospective

Quarterly Reviews of Biophysics(2020)10.1017/s0033583519000131

N/A

0DataRank · unranked

250 citations

William F. DeGrado, Ivan V. Korendovych

Deep mutational scanning reveals the structural basis for α-synuclein activity

Nature Chemical Biology(2020)10.1038/s41589-020-0480-6

N/A

0DataRank · unranked

100 citations

Jaime T. Leong, Eric D. Chow, Martin Kampmann, William F. DeGrado, Robert W. Newberry

Prion biology: implications for Alzheimer's disease therapeutics

The Lancet Neurology(2020)10.1016/s1474-4422(20)30274-x

N/A

0DataRank · unranked

20 citations

William F. DeGrado, Stanley B. Prusiner, Carlo Condello

Platform to Discover Protease-Activated Antibiotics and Application to Siderophore-Antibiotic Conjugates

ChemRxiv(2020)10.26434/chemrxiv.12809603.v2

N/A

0DataRank · unranked

3 citations

Bobo Dang, Beatrice Ary, Quinn Edmondson, Charles S. Craik, William F. DeGrado +2 more