Thomas C. Irving

MedicineBiochemistry, Genetics and Molecular BiologyPhysics and Astronomy

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 3%percentile

1.1Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

A round-robin approach provides a detailed assessment of biomolecular small-angle scattering data reproducibility and yields consensus curves for benchmarking

Acta Crystallographica Section D Structural Biology(2022)10.1107/s2059798322009184

Top 18%

1.1DataRank

Top 18%34 citations

Patrice Vachette, Jan C. Bierma, Clément Blanchet, Emre Brookes, Srinivas Chakravarthy +41 more

Papers

Driven by 55 papers — median percentile 82. Top paper: “A round-robin approach provides a detailed assessment of biomolecular small-angle scattering data reproducibility and yields consensus curves for benchmarking”.

A round-robin approach provides a detailed assessment of biomolecular small-angle scattering data reproducibility and yields consensus curves for benchmarking

Acta Crystallographica Section D Structural Biology(2022)10.1107/s2059798322009184

Top 18%

1.1DataRank

Top 18%34 citations

Patrice Vachette, Jan C. Bierma, Clément Blanchet, Emre Brookes, Srinivas Chakravarthy +41 more

Nanometer-scale structure differences in the myofilament lattice spacing of two cockroach leg muscles correspond to their different functions

Journal of Experimental Biology(2020)10.1242/jeb.212829

N/A

0.585DataRank · unranked

15 citations

Weikang Ma, Thomas C. Irving, Simon Sponberg, Travis Tune

Danicamtiv Increases Myosin Recruitment and Alters Cross-Bridge Cycling in Cardiac Muscle

Circulation Research(2023)10.1161/circresaha.123.322629

N/A

0.584DataRank · unranked

48 citations

Saffie Mohran, Kyrah L. Turner, Weikang Ma, Amy Martinson, Galina Flint +16 more

The structural OFF and ON states of myosin can be decoupled from the biochemical super- and disordered-relaxed states

PNAS Nexus(2024)10.1093/pnasnexus/pgae039

N/A

0.574DataRank · unranked

45 citations

Taejeong Song, Chengqian Gao, Henry Gong, Sakthivel Sadayappan, David A. Kass +3 more

Dependence of thick filament structure in relaxed mammalian skeletal muscle on temperature and interfilament spacing

The Journal of General Physiology(2021)10.1085/jgp.202012713

N/A

0.571DataRank · unranked

44 citations

Luca Fusi, Marco Linari, Massimo Reconditi, Gabriella Piazzesi, Thomas C. Irving +5 more

The myosin II coiled-coil domain atomic structure in its native environment

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2024151118

N/A

0.550DataRank · unranked

38 citations

Wen Ma, Zhongjun Hu, Nadia Daneshparvar, Dianne W. Taylor, J. Andrew McCammon +4 more

Molecular basis of force-pCa relation in MYL2 cardiomyopathy mice: Role of the super-relaxed state of myosin

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2110328119

N/A

0.550DataRank · unranked

38 citations

Katarzyna Kaźmierczak, Jingsheng Liang, Weikang Ma, Thomas C. Irving, Danuta Szczesna‐Cordary +1 more

Myosin-binding protein C regulates the sarcomere lattice and stabilizes the OFF states of myosin heads

Nature Communications(2024)10.1038/s41467-024-46957-7

N/A

0.524DataRank · unranked

32 citations

Nichlas M. Engels, Michel N. Kuehn, Devin Nissen, Rachel Sadler, Weikang Ma +4 more

Super-relaxed myosins contribute to respiratory muscle hibernation in mechanically ventilated patients

Science Translational Medicine(2024)10.1126/scitranslmed.adg3894

N/A

0.505DataRank · unranked

28 citations

Zhonghua Shi, Wout J. Claassen, Pleuni E. Hooijman, Christopher T. A. Lewis, Jesper L. Andersen +23 more

Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility

Journal of Molecular and Cellular Cardiology(2021)10.1016/j.yjmcc.2021.03.009

N/A

0.494DataRank · unranked

26 citations

Mohit Kumar, James W. McNamara, Diederik W.D. Kuster, Mayandi Sivaguru, Rohit Singh +20 more

Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure With Pulmonary Hypertension

Circulation(2023)10.1161/circulationaha.123.064717

N/A

0.483DataRank · unranked

24 citations

Mohammed Aslam, Axel J. Fenwick, Weikang Ma, Henry Gong, Gregory N. Milburn +11 more

EMD-57033 Augments the Contractility in Porcine Myocardium by Promoting the Activation of Myosin in Thick Filaments

International Journal of Molecular Sciences(2022)10.3390/ijms232314517

N/A

0.416DataRank · unranked

15 citations

Wenjing Qian, Shengyao Yuan, Thomas C. Irving, Weikang Ma, Vivek Jani

Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited in response to inotropic interventions

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2314914121

N/A

0.406DataRank · unranked

14 citations

Carlos del Rio, Lin Qi, Momčilo Prodanović, Srboljub M. Mijailovich, Christopher Zambataro +6 more

Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in Drosophila

Molecular Biology of the Cell(2021)10.1091/mbc.e21-02-0088

N/A

0.373DataRank · unranked

11 citations

Karen H. Hsu, Joy T. Puthawala, Meera Viswanathan, Amy K. Loya, Thomas C. Irving +4 more

Annotating the x-ray diffraction pattern of vertebrate striated muscle

Biophysical Journal(2025)10.1016/j.bpj.2025.09.019

N/A

0.360DataRank · unranked

10 citations

Debabrata Dutta, Weikang Ma, Andrey K. Tsaturyan, Thomas C. Irving, Raúl Padrón +2 more

Unlocking the Role of sMyBP-C: A Key Player in Skeletal Muscle Development and Growth

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.23.563591

N/A

0.330DataRank · unranked

8 citations

James W. McNamara, Akhil Baby, Weikang Ma, Maicon Landim-Vieira, Sankar Natesan +5 more

The structural and functional effects of myosin regulatory light chain phosphorylation are amplified by increases in sarcomere length and [Ca2+]

The Journal of Physiology(2024)10.1113/jp286802

N/A

0.269DataRank · unranked

5 citations

Blake J. Vander Top, Kristina B. Kooiker, Saffie Mohran, Christian Mandrycky, Timothy S. McMillen +5 more

Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure with Pulmonary Hypertension

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.09.531988

N/A

0.104DataRank · unranked

1 citations

Mohammed Aslam, Axel J. Fenwick, Weikang Ma, Henry Gong, Gregory N. Milburn +11 more

Structural OFF/ON transitions of myosin in relaxed porcine myocardium predict calcium-activated force

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2207615120

N/A

0DataRank · unranked

60 citations

Timothy S. McMillen, Matthew C. Childers, Henry Gong, Michael Regnier, Thomas C. Irving +1 more

Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2221244120

N/A

0DataRank · unranked

27 citations

Weikang Ma, Taejeong Song, Hosna Rastegarpouyani, Henry Gong, Isabella Leite Coscarella +12 more

The structural and functional integrities of porcine myocardium are mostly preserved by cryopreservation

The Journal of General Physiology(2023)10.1085/jgp.202313345

N/A

0DataRank · unranked

17 citations

Kyoung Hwan Lee, Christine Delligatti, Michael Davis, Yahan Zheng, Henry Gong +4 more

Disruption of Z-Disc Function Promotes Mechanical Dysfunction in Human Myocardium: Evidence for a Dual Myofilament Modulatory Role by Alpha-Actinin 2

International Journal of Molecular Sciences(2023)10.3390/ijms241914572

N/A

0DataRank · unranked

11 citations

Jeffrey Schmeckpeper, Maicon Landim-Vieira, Isabella Leite Coscarella, Xuan Fang, Weikang Ma +12 more

Using Multiscale Simulations as a Tool to Interpret Equatorial X-ray Fiber Diffraction Patterns from Skeletal Muscle

International Journal of Molecular Sciences(2023)10.3390/ijms24108474

N/A

0DataRank · unranked

5 citations

Yiwei Wang, Srboljub M. Mijailovich, Thomas C. Irving, Momčilo Prodanović

Danicamtiv increases myosin recruitment and alters the chemomechanical cross bridge cycle in cardiac muscle

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.01.31.526380

N/A

0DataRank · unranked

5 citations

Saffie Mohran, Kyrah L. Turner, Weikang Ma, Galina Flint, Lin Qi +16 more

The distinctive mechanical and structural signatures of residual force enhancement in myofibers

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.19.529125

N/A

0DataRank · unranked

5 citations

Michel N. Kuehn, Bradley M. Palmer, Devin Nissen, Dhruv Mishra, Venus Joumaa +6 more

Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited via inotropic effectors

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.10.536292

N/A

0DataRank · unranked

4 citations

Carlos del Rio, Lin Qi, Momčilo Prodanović, Srboljub M. Mijailovich, Christopher Zambataro +6 more

Myosin-binding protein C forms C-links and stabilizes OFF states of myosin

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.09.10.556972

N/A

0DataRank · unranked

1 citations

Nichlas M. Engels, Michel N. Kuehn, Devin Nissen, Rachel Sadler, Weikang Ma +4 more

Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.19.563160

N/A

0DataRank · unranked

0 citations

Michel N. Kuehn, Seong-won Han, Weikang Ma, Thomas C. Irving, Brent A. Momb +5 more

Titin-based force regulates cardiac myofilament structures mediating length-dependent activation

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.11.09.566413

N/A

0DataRank · unranked

0 citations

Michel N. Kuehn, Nichlas M. Engels, Devin Nissen, Johanna K. Freundt, Weikang Ma +3 more

The distinctive mechanical and structural signatures of residual force enhancement in myofibers

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2413883121

N/A

0DataRank · unranked

16 citations

Michel N. Kuehn, Bradley M. Palmer, Devin Nissen, Dhruv Mishra, Venus Joumaa +6 more

Calcium has a direct effect on thick filament activation in porcine myocardium

The Journal of General Physiology(2024)10.1085/jgp.202413545

N/A

0DataRank · unranked

9 citations

Timothy S. McMillen, Christian Mandrycky, An-Yue Tu, Kristina B. Kooiker, Wenjing Qian +7 more

Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure

Communications Biology(2024)10.1038/s42003-024-06265-8

N/A

0DataRank · unranked

4 citations

Michel N. Kuehn, Seong-won Han, Weikang Ma, Thomas C. Irving, Brent A. Momb +5 more

Mechanisms of a novel regulatory light chain–dependent cardiac myosin inhibitor

The Journal of General Physiology(2024)10.1085/jgp.202313503

N/A

0DataRank · unranked

3 citations

Qing-Fen Gan, Ming Yu, Na Sa, Saffie Mohran, Yuanhua Cheng +11 more

Mavacamten facilitates myosin head ON ‐to‐ OFF transitions and shortens thin filament length in relaxed mouse skeletal muscle

Physiological Reports(2025)10.14814/phy2.70606

N/A

0DataRank · unranked

3 citations

Nichlas M. Engels, Devin Nissen, Johanna K. Freundt, Weikang Ma, Samantha P. Harris +4 more

Myosin modulator Aficamten inhibits force in cardiac muscle by altering myosin’s biochemical activity without changing thick filament structure

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.05.14.654110

N/A

0DataRank · unranked

3 citations

Kristina B. Kooiker, Ateeqa Naim, Matvey Pilagov, Anthony Asencio, Kyrah L. Turner +13 more

Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy

ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)(2025)10.1101/2025.05.08.652664

N/A

0DataRank · unranked

0 citations

Marica Dente, Weikang Ma, Beatrice Scellini, Nicoletta Piroddi, Marina Scardigli +12 more

The myosin interacting-heads motif present in live tarantula muscle explains tetanic and posttetanic phosphorylation mechanisms

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.1921312117

N/A

0DataRank · unranked

48 citations

Weikang Ma, Sebastian Duno-Miranda, Natalia A. Koubassova, Kyoung Hwan Lee, Antonio Pinto +6 more

Comparison of Predicted X-Ray Fiber Diffraction Patterns from All-Atom and Coarse-Grained Actin Filament Models Under Nonuniform Strain

International Journal of Molecular Sciences(2025)10.3390/ijms27010280

N/A

0DataRank · unranked

0 citations

Andjela Kafedziski, Thomas C. Irving, Srboljub M. Mijailovich, Momčilo Prodanović

Triggering typical nemaline myopathy with compound heterozygous nebulin mutations reveals myofilament structural changes as pathomechanism

Nature Communications(2020)10.1038/s41467-020-16526-9

N/A

0DataRank · unranked

19 citations

Weikang Ma, Frank Li, Yaeren Hernandez, Justin Kolb, Balázs Kiss +11 more

In vivo x-ray diffraction and simultaneous EMG reveal the time course of myofilament lattice dilation and filament stretch

Journal of Experimental Biology(2020)10.1242/jeb.224188

N/A

0DataRank · unranked

12 citations

Anthony Asencio, J. Cass, Weikang Ma, Thomas C. Irving, T. L. Daniel +1 more

Myosin dynamics during relaxation in mouse soleus muscle and modulation by 2′‐deoxy‐ATP

The Journal of Physiology(2020)10.1113/jp280402

N/A

0DataRank · unranked

37 citations

Matthew C. Childers, Jason D. Murray, Farid Moussavi‐Harami, Henry Gong, Robert S. Weiss +4 more

The Super-Relaxed State and Length Dependent Activation in Porcine Myocardium

Circulation Research(2021)10.1161/circresaha.120.318647

N/A

0DataRank · unranked

82 citations

Marcus Henze, Robert L. Anderson, Henry Gong, Fiona L. Wong, Carlos del Rio +2 more

Two Classes of Myosin Inhibitors, Para-nitroblebbistatin and Mavacamten, Stabilize β-Cardiac Myosin in Different Structural and Functional States

Journal of Molecular Biology(2021)10.1016/j.jmb.2021.167295

N/A

0DataRank · unranked

49 citations

Weikang Ma, Srinivas Chakravarthy, Ariana C. Combs, Na Sa, Stephen J. Langer +3 more

Pathogenic variants in TNNC2 cause congenital myopathy due to an impaired force response to calcium

Journal of Clinical Investigation(2021)10.1172/jci145700

N/A

0DataRank · unranked

24 citations

Sandra Donkervoort, Josine M. de Winter, Stefan Conijn, Leon P. L. Begthel, Benno Küsters +20 more

Relaxed tarantula skeletal muscle has two ATP energy-saving mechanisms

The Journal of General Physiology(2021)10.1085/jgp.202012780

N/A

0DataRank · unranked

13 citations

Sebastian Duno-Miranda, Thomas C. Irving, Roger Craig, Raúl Padrón, Weikang Ma

The stoic tooth root: how the mineral and extracellular matrix counterbalance to keep aged dentin stable

Acta Biomaterialia(2021)10.1016/j.actbio.2021.10.051

N/A

0DataRank · unranked

8 citations

Yvette Alania, Ariene A. Leme‐Kraus, Robert Free, Derk Joester, Weikang Ma +3 more

A mechanism for sarcomere breathing: volume change and advective flow within the myofilament lattice

Biophysical Journal(2021)10.1016/j.bpj.2021.08.006

N/A

0DataRank · unranked

0 citations

Chelsea Williams, Thomas C. Irving, Eric Lauga, Sage Malingen, Thomas L. Daniel +2 more

Myofibril orientation as a metric for characterizing heart disease

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.09.24.461697

N/A

0DataRank · unranked

0 citations

Henry Gong, Vivek Jani, Maicon Landim-Vieira, Maria Papadaki, José R. Pinto +4 more

Small Angle X-ray Diffraction as a Tool for Structural Characterization of Muscle Disease

International Journal of Molecular Sciences(2022)10.3390/ijms23063052

N/A

0DataRank · unranked

71 citations

Thomas C. Irving, Weikang Ma

Cardiac myosin filaments are directly regulated by calcium

The Journal of General Physiology(2022)10.1085/jgp.202213213

N/A

0DataRank · unranked

48 citations

Suman Nag, Henry Gong, Lin Qi, Thomas C. Irving, Weikang Ma

Myofibril orientation as a metric for characterizing heart disease

Biophysical Journal(2022)10.1016/j.bpj.2022.01.009

N/A

0DataRank · unranked

37 citations

Henry Gong, Vivek Jani, Kyoung Hwan Lee, Maicon Landim-Vieira, Maria Papadaki +5 more

Thick filament activation is different in fast‐ and slow‐twitch skeletal muscle

The Journal of Physiology(2022)10.1113/jp283574

N/A

0DataRank · unranked

21 citations

Weikang Ma, Michael Regnier, Thomas C. Irving, Henry Gong

MgADP Promotes Myosin Head Movement toward Actin at Low [Ca2+] to Increase Force Production and Ca2+-Sensitivity of Contraction in Permeabilized Porcine Myocardial Strips

International Journal of Molecular Sciences(2022)10.3390/ijms232315084

N/A

0DataRank · unranked

4 citations

Weikang Ma, Kyrah L. Turner, Jing Zhao, Henry Gong, Mindy Thompson +4 more

Cardiac myosin filaments are directly regulated by calcium

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.02.19.481172

N/A

0DataRank · unranked

4 citations

Henry Gong, Lin Qi, Suman Nag, Thomas C. Irving, Weikang Ma

Thick Filament Activation Is Different in Fast and Slow-Twitch Skeletal Muscle

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.07.09.499423

N/A

0DataRank · unranked

0 citations

Weikang Ma, Michael Regnier, Thomas C. Irving, Henry Gong

Thomas C. Irving

Indexed papers

Top data-sharing exemplar

Papers