Jacob M. Hughes

MedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 9 papers. Top paper: “SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma”.

SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

Cancer Research(2024)10.1158/0008-5472.can-23-3256

N/A

0.396DataRank · unranked

13 citations

Nancy E. Sealover, Bridget A. Finniff, Jacob M. Hughes, Erin Sheffels, Daniel Gerlach +11 more

SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2313137120

N/A

0DataRank · unranked

29 citations

Heidi M. Vieira, Chaitra Rao, Jacob M. Hughes, Zaria Beckley, Dianna H. Huisman +9 more

In situ modeling of acquired resistance to RTK/RAS-pathway-targeted therapies

iScience(2023)10.1016/j.isci.2023.108711

N/A

0DataRank · unranked

15 citations

Patricia L. Theard, Jacob M. Hughes, Amanda J. Linke, Brianna R. Daley, Robert L. Kortum +1 more

SOS1 inhibition enhances the efficacy of and delays resistance to G12C inhibitors in lung adenocarcinoma

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.07.570642

N/A

0DataRank · unranked

6 citations

Nancy E. Sealover, Erin Sheffels, Jacob M. Hughes, Daniel Gerlach, Marco H. Hofmann +8 more

In situ modeling of acquired resistance to RTK/RAS pathway targeted therapies

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.01.27.525958

N/A

0DataRank · unranked

2 citations

Patricia T. Theard, Amanda J. Linke, Jacob M. Hughes, Brianna R. Daley, Robert L. Kortum +1 more

Protocol for modeling acquired resistance to targeted therapeutics in adherent and suspension cancer cell lines via in situ resistance assay

STAR Protocols(2024)10.1016/j.xpro.2024.103361

N/A

0DataRank · unranked

6 citations

Jacob M. Hughes, Patricia L. Theard, Deepan Chatterjee, Amanda J. Linke, Bridget A. Finniff +4 more

Wild-type RAS signaling is an essential therapeutic target in RAS -mutated cancers

Science Signaling(2025)10.1126/scisignal.adx5186

N/A

0DataRank · unranked

4 citations

Bridget A. Finniff, Jacob M. Hughes, Erin Sheffels, Hyun Lee, Joseph P. LaMorte +7 more

SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.12.06.519395

N/A

0DataRank · unranked

3 citations

Heidi M. Vieira, Chaitra Rao, Jacob M. Hughes, Zaria Beckley, Dianna H. Huisman +9 more

SOS1 inhibition suppresses the emergence of osimertinib resistance to generate a durable response in EGFR -mutant lung cancer

Science Signaling(2025)10.1126/scisignal.aea2788

N/A

0DataRank · unranked

3 citations

Patricia L. Theard, Jacob M. Hughes, Bridget A. Finniff, Marco H. Hofmann, Kaja Kostyrko +6 more