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SOS1 inhibition suppresses the emergence of osimertinib resistance to generate a durable response in EGFR -mutant lung cancer

Science Signaling(2025)10.1126/scisignal.aea2788Source: DataRank Database

SOS1 inhibition suppresses the emergence of osimertinib resistance to generate a durable response in EGFR -mutant lung cancer is a research paper published in Science Signaling (2025). On theSindex it has a DataRank of 0. It has been cited 3 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access3 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (3 grants)Impact (FWCI 2.19)OA: greenTopics (42)IDs (PubMed, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

Patricia L. Theard ORCID,Jacob M. Hughes ORCID,Bridget A. Finniff ORCID,Marco H. Hofmann ORCID,Kaja Kostyrko ORCID

Live enrichment

PubMed:41289356 OpenAlex:https://openalex.org/W4416655751

National Institutes of Health

Grant: R01 CA255232

National Institutes of Health

Grant: R21 CA267515

NCI NIH HHS

Grant: T32 CA009476

FWCI

2.19

Citation Percentile

0.9%

Citation Trend

2025

2026

green

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC13021283/

publisherhttps://www.science.org/doi/pdf/10.1126/scisignal.aea2788

journalhttps://doi.org/10.1126/scisignal.aea2788

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41289356

Fields of Study

Lung Cancer Treatments and MutationsPI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase SignalingMedicineAniline CompoundsAcrylamidesHumansLung NeoplasmsErbB ReceptorsAnimalsDrug Resistance, NeoplasmSOS1 ProteinMiceCarcinoma, Non-Small-Cell LungMutationXenograft Model Antitumor AssaysCell Line, TumorIndolesPyrimidines

MeSH Terms

AcrylamidesAniline CompoundsAnimalsCarcinoma, Non-Small-Cell LungHumansIndolesLung NeoplasmsMutationPyrimidinesDrug Resistance, NeoplasmSOS1 ProteinXenograft Model Antitumor AssaysCell Line, TumorMiceErbB Receptors

Keywords

OsimertinibLung cancerCarcinogenesisCell growthCancer cellCellTyrosine kinaseSignal transduction