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Hyperactivation of RAB5 disrupts the endosomal Rab cascade leading to endolysosomal dysregulation in Down syndrome: A necessary role for increased APP gene dose

Alzheimer s & Dementia(2025)10.1002/alz.70046Source: DataRank Database

Hyperactivation of RAB5 disrupts the endosomal Rab cascade leading to endolysosomal dysregulation in Down syndrome: A necessary role for increased APP gene dose is a research paper published in Alzheimer s & Dementia (2025). On theSindex it has a DataRank of 0. It has been cited 9 times.

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Open Access9 citations

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Enrichment:Funding (8 grants)Impact (FWCI 5.55)OA: hybridTopics (96)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

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Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (4)

Xinxin Zuo,Ann Becker ORCID,William C. Mobley ORCID,Xu‐Qiao Chen ORCID

Live enrichment

PubMed:40339170 PMC:PMC12058456 OpenAlex:https://openalex.org/W4410152720

National Institutes of Health

Grant: R01AG061151

National Institutes of Health

Grant: R01AG055523

National Institutes of Health

Grant: R01AG070154

the Cure Alzheimer's Fund

Grant: UCSD2019-2544

DH Chen Foundation

Grant: R-86U55A

National Institutes of Health

Grant: 5R01AG055523-02

Treating with Gamma-Secretase Modulators to Prevent Neurodegeneration in Mouse Models of Down Syndrome and Alzheimer Disease

National Institutes of Health

Grant: 1R01AG070154-01

Multiplexed Single Nucleus RNA and ATAC-seq Sequencing and Cortical Organoids: Transformative Insights into Down Syndrome

National Institutes of Health

Grant: 5R01AG061151-04

Antisense Oligonucleotides targeting APP to prevent neurodegeneration in models of Down Syndrome and Alzheimer's disease

FWCI

5.55

Citation Percentile

1.0%

Citation Trend

2025

2026

hybridLicense: cc-by

journalhttps://doi.org/10.1002/alz.70046

publisherhttps://doi.org/10.1002/alz.70046

publisherhttps://alz-journals.onlinelibrary.wiley.com/doi/pdf/10.1002/alz.70046

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40339170

repositoryhttps://escholarship.org/uc/item/2c0443fx

Fields of Study

Cellular transport and secretionLysosomal Storage Disorders ResearchCalcium signaling and nucleotide metabolism03 medical and health sciences0302 clinical medicinerab5 GTP-Binding ProteinsHumansAmyloid beta-Protein PrecursorAnimalsEndosomesLysosomesDown SyndromeMicerab GTP-Binding ProteinsBrainGene DosageGuanine Nucleotide Exchange FactorsDisease Models, AnimalFemaleMaleAlzheimer DiseaseNeurons

MeSH Terms

Alzheimer DiseaseAnimalsBrainDisease Models, AnimalDown SyndromeFemaleHumansLysosomesMaleNeuronsEndosomesAmyloid beta-Protein PrecursorGene DosageGuanine Nucleotide Exchange Factorsrab GTP-Binding Proteinsrab5 GTP-Binding ProteinsMice

Keywords

EndosomeRabGuanine nucleotide exchange factorCell biologyGTPaseSmall GTPaseBiologyAmyloid precursor proteinHyperactivationChemistrySignal transductionInternal medicineAlzheimer's diseaseIntracellularMedicineCathepsinAPPDown syndromeRab5GefDp16 MouseEndosomal Rab CascadeMaleAgingIntellectual and Developmental Disabilities (IDD)1.1 Normal biological development and functioningBiological PsychologyClinical SciencesGene DosageEndosomesNeurodegenerativeAmyloid beta-Protein PrecursorMiceAlzheimer DiseaseAcquired Cognitive ImpairmentPsychology2.1 Biological and endogenous factorsHumansAnimalsGuanine Nucleotide Exchange Factorsrab5 GTP-Binding ProteinsNeuronsBiomedical and Clinical SciencesAnimalNeurosciencesAlzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)BrainBrain DisordersDisease Models, AnimalGeriatricsrab GTP-Binding ProteinsNeurologicalDisease ModelsDementiaFemaleLysosomesResearch Article

Sustainable Development Goals

SDG 0: Good health and well-being