Novel differentially expressed genes and multiple biological pathways for Alzheimer's disease identified in brain tissue from African American donors is a dataset published in Alzheimer s & Dementia (2025). On theSindex it has a DataRank of 0.172, placing it in the top 66.9% of the data-sharing corpus. It has been cited 2 times, with 2 citing works in its 1-hop citation network. Its calibrated FAIR score is 50/100.
Ranks in the top 67% for downstream scientific impact
DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Full FAIR picture · advisory
The headline score is computed from the scored criteria — the fact-shaped checks (a repository, an accession, a licence) that two independent models agree on. The advisory criteria below are real FAIR guidance but rest on judgment calls that models read differently, so they inform without moving the number.
“RNA sequencing data are available at the National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS; https://www.niagads.org ).”
The only identifier given is a web URL (https://www.niagads.org) which is not a persistent identifier scheme (no DOI, Handle, ARK, or repository accession). [majority verdict 'partial' (4/5 passes agreed)]
RDA-F1-01D — FAIR Data Maturity Model: 'Data is identified by a persistent identifier' (priorit · RDA-F1-02D — FAIR Data Maturity Model: 'Data is identified by a globally unique identifier' · FsF-F1-02D — F-UJI/FAIRsFAIR: 'Data is assigned a persistent identifier'
“RNA sequencing data are available at the National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS; https://www.niagads.org ).”
NIAGADS is a named data repository (a curated archive for Alzheimer's genetics data). [majority verdict 'yes' (3/5 passes agreed)]
RDA-F4-01M — FAIR Data Maturity Model: metadata is offered so it can be harvested and indexed ( · NIH DMS Policy Element 4 (NOT-OD-21-014) — name the repository where data will be archived · NSTC Desirable Characteristics of Data Repositories (2022) — 'Long-Term Sustainability', 'Reten
“RNA sequencing data are available at the National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS; https://www.niagads.org ).”
The dataset identifier/link appears only in the body text (data availability statement), not as a reference-list entry. [majority verdict 'partial' (3/5 passes agreed)]
FORCE11 Joint Declaration of Data Citation Principles (2014) — data should be cited as a first- · RDA-F3-01M — metadata clearly and explicitly includes the identifier of the data it describes · FsF-F3-01M — F-UJI: 'Metadata includes the identifier of the data it describes'
Advisory · not in the published score
“RNA sequencing data are available at the National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS; https://www.niagads.org ).”
The statement points to a repository (NIAGADS) but carries no accession, DOI, or persistent link to a specific record, so it does not qualify as a repository record per Colavizza category 3. [majority verdict 'partial' (4/5 passes agreed)]
Colavizza, Hrynaszkiewicz, Staden, Whitaker & McGillivray (2020), 'The citation advantage of li · Springer Nature research data policy — Data Availability Statements: standard statement templat · RDA-F3-01M — metadata clearly and explicitly includes the identifier of the data it describes
“We generated transcriptome‐wide bulk pre‐frontal cortex (PFC) gene expression data from 125 AA donors with neuropathologically determined AD and 82 AA controls.”
The dataset content is described in a single running‑prose sentence, not as an itemised inventory (section, table, or list of files/variables). [majority verdict 'partial' (4/5 passes agreed)]
RDA-F2-01M — 'Rich metadata is provided to allow discovery' (priority Essential) · FsF-F2-01M — F-UJI: 'Metadata includes descriptive core elements to support data findability' · FsF-R1-01MD — F-UJI: 'Metadata specifies the content of the data'
“RNA sequencing data are available at the National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS; https://www.niagads.org ).”
The data availability statement gives a repository URL with no stated precondition, implying unconditional availability. [majority verdict 'yes' (4/5 passes agreed)]
RDA-A1.1-01D — 'Data is accessible through a free access protocol' · FsF-A1-01M — F-UJI: 'Metadata contains access level and access conditions of the data' · NSTC Desirable Characteristics of Data Repositories (2022) — 'Free and Easy Access'
Advisory · not in the published score
The paper does not label the access level of the data itself; only the article is labeled open access via CC BY-NC-ND, but that license applies to the article, not the data. [majority verdict 'no' (3/5 passes agreed)]
FsF-A1-01M — F-UJI: 'Metadata contains access level and access conditions of the data' · RDA-A1-01M — metadata contains information to enable the user to get access to the data · COAR Controlled Vocabularies — Access Rights v1.0 (open / embargoed / restricted / metadata-onl
The paper names no gatekeeper for the sensitive human data; the DAS merely states 'available at NIAGADS' without specifying a Data Access Committee, IRB, or any other institutional gatekeeper. [majority verdict 'no' (3/5 passes agreed)]
NIH Genomic Data Sharing Policy (NOT-OD-14-124) — controlled-access via a Data Access Committee · RDA-A1.2-01D — 'Data is accessible through an access protocol that supports authentication and · NIH DMS Policy Element 5 (NOT-OD-21-014) — Access, Distribution, or Reuse Considerations (conse
The paper says nothing about when the data become available or how long they persist; no retention or timing commitment is made.
NIH DMS Plan Element 4 (NOT-OD-21-014) — Data Preservation, Access, and Associated Timelines · NSTC Desirable Characteristics (2022), Organizational Infrastructure: 'Retention Policy' · RDA-A2-01M — 'Metadata is guaranteed to remain available after data is no longer available'
The paper does not name any file format for the released RNA-seq data (e.g., FASTQ, BAM, counts matrix).
FsF-R1.3-02D — F-UJI: 'Data is available in a file format recommended by the target research co · RDA-R1.3-02D — data is expressed in a machine-understandable community standard · RDA-I1-01D — data uses a knowledge representation expressed in a standardised format
Advisory · not in the published score
No community data/metadata standard (e.g., MIAME, MINSEQE, FAIRsharing-registered checklist) is named for the data; the paper only uses GO terms for analysis, not as a standard for the data itself. [majority verdict 'no' (2/5 passes agreed)]
RDA-R1.3-01M — 'Metadata complies with a community standard' (priority Essential) · RDA-R1.3-01D — 'Data complies with a community standard' · RDA-I2-01M — '(Meta)data use vocabularies that follow FAIR principles'
“We examined the Genotype‐Tissue Expression (GTEx) Portal ( https://www.gtexportal.org/ accessed April 02, 2025)”
The paper provides a URL for the GTEx Portal, an external resource used for comparison; this is a qualified reference to a resource other than the study's own dataset. [majority verdict 'yes' (3/5 passes agreed)]
RDA-I3-01M — '(meta)data include references to other (meta)data' · RDA-I3-03M — 'metadata includes qualified references to other metadata' · FsF-I3-01M — F-UJI: 'Metadata includes links between the data and its related entities'
No license or reuse terms are stated for the data; the CC BY-NC-ND license applies only to the article.
RDA-R1.1-01M — 'Metadata includes information about the licence under which the data can be reu · RDA-R1.1-02M — 'Metadata refers to a standard reuse licence' · RDA-R1.1-03M — 'Metadata refers to a machine-understandable reuse licence'
Neither a version token nor a date is given for the dataset; the data are referred to without any snapshot identifier.
DataCite Metadata Schema 4.6 — the 'Version' property · RDA-R1.2-01M — provenance information (which version was used is provenance) · NSTC Desirable Characteristics of Data Repositories (2022) — 'Provenance', 'Retention Policy'
The paper does not mention any code availability; no locator (URL, DOI, or repository) for the study's own code is provided.
NIH DMS Policy Element 2 (NOT-OD-21-014) — 'Related Tools, Software and/or Code' · FAIR4RS Principles v1.0 (Chue Hong et al., 2022; RDA/FORCE11/ReSA) — FAIR Principles for Resear · FORCE11 Software Citation Principles (Smith, Katz & Niemeyer, 2016, PeerJ CS 2:e86)
“This study was supported by National Institute of Health grants R01‐AG048927, U01‐AG058654, U54‐AG052427, U19‐AG068753, U01‐AG062602, P30‐AG072978, U01‐081230, P01‐AG003949, P30‐AG062677, P30‐AG062421; P30‐AG 066507, P30‐AG066511, P30‐AG 072972, P30‐AG066468, R01‐AG072474, RF1‐AG066107, U24‐AG056270, P01‐AG003949, RF1‐AG082339, RF1‐NS118584, P30‐AG072946; P01‐AG003991, P30‐AG066444, P01‐AG026276, P30‐AG066462, P30‐AG072958, and P30‐AG072978, and by Florida Department of Health awards 8AZ06 and 20A22.”
Multiple NIH grant numbers and a state award number are explicitly listed in the acknowledgments. [majority verdict 'yes' (4/5 passes agreed)]
DataCite Metadata Schema 4.6 — 'FundingReference' property (funderName, funderIdentifier, award · Crossref Funder Registry — canonical funder identifiers for funding metadata · RDA-F2-01M — rich metadata provided to allow discovery (funding is part of the descriptive reco
Advisory · not in the published score
“RNA was extracted from the PFC tissue using the Maxwell RSC simplyRNA Tissue Kit from Promega according to the manufacturer's instructions.”
The paper names specific instruments, kits, and software (Maxwell RSC simplyRNA Tissue Kit, Agilent 2100 Bioanalyzer, STAR, RSEM, etc.) used to produce the data. [majority verdict 'yes' (4/5 passes agreed)]
RDA-R1.2-01M — 'Metadata includes provenance information according to community- specific standa · FsF-R1.2-01M — F-UJI: 'Metadata includes provenance information about data creation or generati · W3C PROV-O (W3C Recommendation, 2013) — the entity/activity/agent model of provenance
No README, data dictionary, codebook, or schema file is named as accompanying the data; variable definitions are not provided in the article either.
RDA-R1-01M — '(Meta)data are richly described with a plurality of accurate and relevant attribu · FsF-R1-01MD — F-UJI: 'Metadata specifies the content of the data' · NIH DMS Policy Element 3 (NOT-OD-21-014) — Standards (documentation and metadata to accompany t
Calibrated FAIR score — a parallel quality metric, independent of the DataRank citation score. See the full evaluation →
Base Score Contribution
0.165
From this paper's citation signal
Citation Network Contribution
7.27 × 10⁻³
From 1 citing papers with measurable signal
Ranked by each citer's contribution to N(p) — log1p(Cq) divided by its reference count — out of 2 citers.
National Institutes of Health
Grant: P01‐AG026276
NIH HHS
Grant: P30-AG072978
National Institutes of Health
Grant: P30‐AG 066507
National Institutes of Health
Grant: P30‐AG062421
National Institutes of Health
Grant: P30‐AG072958
NIH HHS
Grant: R01-AG072474
National Institutes of Health
Grant: U01‐AG058654
NIH HHS
Grant: P01-AG026276
NIA NIH HHS
Grant: P30 AG066462
NIH HHS
Grant: P30-AG 072972
NIH HHS
Grant: P30-AG062421
NIH HHS
Grant: P30-AG066462
NIH HHS
Grant: P30-AG066468
National Institutes of Health
Grant: P30‐AG066468
NIA NIH HHS
Grant: RF1 AG082339
National Institutes of Health
Grant: U01‐081230
National Institutes of Health
Grant: U01‐AG062602
NIA NIH HHS
Grant: P01 AG003991
NIA NIH HHS
Grant: P01 AG026276
NIH HHS
Grant: P01-AG003949
NIA NIH HHS
Grant: P30 AG062421
NIA NIH HHS
Grant: P30 AG072972
NIH HHS
Grant: P30-AG062677
NIH HHS
Grant: P30-AG066444
NIH HHS
Grant: P30-AG066511
National Institutes of Health
Grant: P30‐AG 072972
National Institutes of Health
Grant: P30‐AG072978
NIH HHS
Grant: R01-AG048927
National Institutes of Health
Grant: R01‐AG048927
National Institutes of Health
Grant: RF1‐AG082339
NIH HHS
Grant: U01-AG058654
NIH HHS
Grant: U01-AG062602
NIH HHS
Grant: U19-AG068753
NIA NIH HHS
Grant: P30 AG066507
NIH HHS
Grant: P30-AG072958
National Institutes of Health
Grant: P30‐AG066444
NIH HHS
Grant: RF1-AG066107
NIH HHS
Grant: RF1-AG082339
NIH HHS
Grant: RF1-NS118584
Florida Department of Health
Grant: 8AZ06
NIA NIH HHS
Grant: P30 AG066444
NIH HHS
Grant: P30-AG072946
National Institutes of Health
Grant: R01‐AG072474
NIH HHS
Grant: U24-AG056270
Florida Department of Health
Grant: 20A22
NIH HHS
Grant: P01-AG003991
NIA NIH HHS
Grant: P30 AG072978
National Institutes of Health
Grant: P30‐AG066462
National Institutes of Health
Grant: RF1‐AG066107
National Institutes of Health
Grant: RF1‐NS118584
NIH HHS
Grant: U01-081230
National Institutes of Health
Grant: U19‐AG068753
NIH HHS
Grant: P30-AG 066507
National Institutes of Health
Grant: P30‐AG062677
National Institutes of Health
Grant: U24‐AG056270
National Institutes of Health
Grant: U54‐AG052427
National Institutes of Health
Grant: P01‐AG003949
National Institutes of Health
Grant: P01‐AG003991
National Institutes of Health
Grant: P30‐AG066511
National Institutes of Health
Grant: P30‐AG072946
NINDS NIH HHS
Grant: R01 NS122854
NIH HHS
Grant: U54-AG052427
FWCI
1.32
Citation Percentile
0.8%
Citation Trend
Fields of Study
MeSH Terms
Keywords