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Indazole to 2‐Cyanoindole Scaffold Progression for Mycobacterial Lipoamide Dehydrogenase Inhibitors Achieves Extended Target Residence Time and Improved Antibacterial Activity

Angewandte Chemie International Edition(2024)10.1002/anie.202407276Source: DataRank Database

Indazole to 2‐Cyanoindole Scaffold Progression for Mycobacterial Lipoamide Dehydrogenase Inhibitors Achieves Extended Target Residence Time and Improved Antibacterial Activity is a research paper published in Angewandte Chemie International Edition (2024). On theSindex it has a DataRank of 0. It has been cited 4 times.

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Open Access4 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (3 grants)Impact (FWCI 0.86)OA: greenTopics (41)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (12)

John D. Ginn,Tomasz Kochańczyk ORCID,Nancy Arango,Xiuju Jiang ORCID,David J. Huggins ORCID

Live enrichment

PubMed:38997232 PMC:PMC11887847 OpenAlex:https://openalex.org/W4400598821

Division of Intramural Research

Grant: AI175342

National Cancer Institute

Grant: P30CA008748

NIAID NIH HHS

Grant: R01 AI175342

FWCI

0.86

Citation Percentile

0.7%

Citation Trend

2024

2025

greenLicense: http://onlinelibrary.wiley.com/termsAndConditions#vor

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11887847/pdf/nihms-2048815.pdf

publisherhttps://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202407276

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/11887847

journalhttps://doi.org/10.1002/anie.202407276

Fields of Study

Biochemical Acid Research StudiesBiochemical and Molecular ResearchPharmacogenetics and Drug MetabolismIndolesMycobacterium tuberculosisDihydrolipoamide DehydrogenaseIndazolesEnzyme InhibitorsAnimalsMicrobial Sensitivity TestsMiceAnti-Bacterial AgentsAntitubercular AgentsStructure-Activity RelationshipMolecular StructureHumans

MeSH Terms

AnimalsAnti-Bacterial AgentsAntitubercular AgentsEnzyme InhibitorsHumansIndazolesIndolesDihydrolipoamide DehydrogenaseMicrobial Sensitivity TestsMycobacterium tuberculosisStructure-Activity RelationshipMolecular StructureMice

Keywords

ChemistryMycobacterium tuberculosisEnzymePharmacologyBiochemistryTuberculosisBiologyMedicineMycobacteriaLipoamide DehydrogenaseTight Binding InhibitorOn-target Residence Time

Sustainable Development Goals

SDG 0: Good health and well-being