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Rational Design of CDK12/13 and BRD4 Molecular Glue Degraders

Angewandte Chemie International Edition(2025)10.1002/anie.202508427Source: DataRank Database

Rational Design of CDK12/13 and BRD4 Molecular Glue Degraders is a research paper published in Angewandte Chemie International Edition (2025). On theSindex it has a DataRank of 0. It has been cited 16 times.

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Open Access16 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (19 grants)Impact (FWCI 6.10)OA: bronzeTopics (44)IDs (PubMed, PMC, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (12)

Woong Sub Byun ORCID,Zuzanna Kozicka ORCID,Katherine A. Donovan ORCID,Brendan G. Dwyer ORCID,Abby M. Thornhill

Live enrichment

PubMed:40626960 PMC:PMC12831537 OpenAlex:https://openalex.org/W4412110902

National Institutes of Health

Grant: R01CA262188

National Institutes of Health

Grant: R01CA2144608

National Institutes of Health

Grant: R01CA218278

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Grant: SNF 310030_301206

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Grant: 310030_214852

Swiss National Science Foundation

Grant: 301206

NIH High End Instrumentation

Grant: 1S10OD028697-01

500 MHz NMR Spectrometer System with High Sensitivity Cryoprobe and Automated Sample Changer for Biochemical Research

ESR Marie Curie-Skłodowska fellowship

Grant: UbiCODE 765445

Swiss National Science Foundation

Grant: 214852

Reading out bHLH transcription factors on chromatin

Swiss National Science Foundation

Grant: 310030

European Union's H2020 Research Program

Grant: 884331

Accessing Nucleosomal DNA

Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education

Grant: RS-2024-00410290

NIH HHS

Grant: S10 OD028697

National Institutes of Health

Grant: 5R01CA218278-03

Degrading therapeutically important kinases using small molecules

National Institutes of Health

Grant: 5R01CA262188-03

Development of a generalizable chemo-proteomics screening platform for small molecule degraders applied to HDACs

European Research Council

Stanford Chemical and Systems Biology and Stanford Cancer Institute

European Research Council

Stanford Chemical and Systems Biology and Stanford Cancer Institute

FWCI

6.10

Citation Percentile

1.0%

Citation Trend

2025

2026

bronzeLicense: Wiley Online Library User Agreement

journalhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.202508427

publisherhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.202508427

publisherhttps://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202508427

journalhttps://doi.org/10.1002/anie.202508427

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40626960

Fields of Study

Protein Degradation and InhibitorsHistone Deacetylase Inhibitors ResearchUbiquitin and proteasome pathwaysMedicineChemistryCell Cycle ProteinsHumansTranscription FactorsCyclin-Dependent KinasesDrug DesignProteolysisProtein Kinase InhibitorsMolecular StructureBromodomain Containing ProteinsDNA-Binding Proteins

MeSH Terms

Bromodomain Containing ProteinsDNA-Binding ProteinsHumansTranscription FactorsDrug DesignMolecular StructureCell Cycle ProteinsCyclin-Dependent KinasesProtein Kinase InhibitorsProteolysis

Keywords

GLUEComputer scienceEngineeringMechanical engineeringTargeted Protein DegradationMolecular GlueBromodomain‐containing Protein 4Cyclin‐dependent Kinase 12/13DNA-Binding ProteinsBromodomain Containing ProteinsMolecular StructureDrug DesignProteolysisHumansCell Cycle ProteinsProtein Kinase InhibitorsArticleCyclin-Dependent KinasesTranscription Factors