Katherine A. Donovan

Also affiliated with Dana-Farber Cancer Institute

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 60 papers. Top paper: “Proteolysis-targeting chimeras with reduced off-targets”.

Proteolysis-targeting chimeras with reduced off-targets

Nature Chemistry(2023)10.1038/s41557-023-01379-8

N/A

3.6DataRank · unranked

123 citations

Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K. Tiwari, Katherine A. Donovan +11 more

Cereblon covalent modulation through structure-based design of histidine targeting chemical probes

RSC Chemical Biology(2022)10.1039/d2cb00078d

N/A

0.646DataRank · unranked

73 citations

Geoffrey P. Dann, Jianwei Che, Katherine A. Donovan, Silas Ferrao, Scott B. Ficarro +11 more

Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry

Journal of the American Chemical Society(2023)10.1021/jacs.3c06622

N/A

0.637DataRank · unranked

69 citations

Inchul You, Yen-Der Li, Sean T. Toenjes, Katherine A. Donovan, Pooreum Seo +11 more

Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2

Angewandte Chemie International Edition(2021)10.1002/anie.202101328

N/A

0.612DataRank · unranked

58 citations

Jie Jiang, Qibiao Wu, Nathaniel J. Henning, Katherine A. Donovan, Hong Yue +7 more

Machine Learning Modeling of Protein-Intrinsic Features Predicts Tractability of Targeted Protein Degradation

Genomics Proteomics & Bioinformatics(2022)10.1016/j.gpb.2022.11.008

N/A

0.593DataRank · unranked

51 citations

Shourya S. Roy Burman, Jiaye Chen, Katherine A. Donovan, Yang Cao, Chelsea Shu +9 more

Unveiling the hidden interactome of CRBN molecular glues

Nature Communications(2025)10.1038/s41467-025-62099-w

N/A

0.590DataRank · unranked

50 citations

Rebecca J. Metivier, Shourya S. Roy Burman, Jonathan W. Bushman, Hojong Yoon, Ryan J. Lumpkin +13 more

Proteomics-Based Identification of DUB Substrates Using Selective Inhibitors

Cell chemical biology(2020)10.1016/j.chembiol.2020.09.005

N/A

0.564DataRank · unranked

42 citations

Katherine A. Donovan, Nathan J. Schauer, Xiaoxi Liu, Wanyi Hu, Anthony C. Varca +3 more

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways

Cell Reports(2023)10.1016/j.celrep.2023.112496

N/A

0.489DataRank · unranked

25 citations

Xuezhen Ge, Moritz Hunkeler, Katherine A. Donovan, W Michelle, Cyrus Y. Jin +4 more

Polymerization of ZBTB transcription factors regulates chromatin occupancy

Molecular Cell(2024)10.1016/j.molcel.2024.06.010

N/A

0.449DataRank · unranked

19 citations

Jiho Park, Jared Brown, Moritz Hunkeler, Shourya S. Roy Burman, Katherine A. Donovan +6 more

Machine learning modeling of protein-intrinsic features predicts tractability of targeted protein degradation

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.09.27.462040

N/A

0.430DataRank · unranked

5 citations

Shourya S. Roy Burman, Jiaye Chen, Katherine A. Donovan, Yang Cao, Boning Zhang +7 more

Development of potent and selective degraders of PI5P4Kγ

European Journal of Medicinal Chemistry(2022)10.1016/j.ejmech.2022.115027

N/A

0.373DataRank · unranked

11 citations

Eric S. Wang, Theresa Manz, Jie Jiang, Katherine A. Donovan, Xianmixinuer Abulaiti +5 more

Discovery of Potent Degraders of the Dengue Virus Envelope Protein

Advanced Science(2024)10.1002/advs.202405829

N/A

0.373DataRank · unranked

11 citations

Han‐Yuan Liu, Zhixiang He, Antara Chakravarty, Ryan P. Golden, Zixuan Jiang +13 more

HDAC6/aggresome processing pathway importance for inflammasome formation is context-dependent

Journal of Biological Chemistry(2024)10.1016/j.jbc.2024.105638

N/A

0.345DataRank · unranked

9 citations

Shihua Shi, Adeline Unterreiner, Ronan Kapétanovic, Sucheta Ghosh, Jacint Sanchez +9 more

Discovery of electrophilic degraders that exploit SNAr chemistry

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.09.25.615094

N/A

0.292DataRank · unranked

6 citations

Woong Sub Byun, Zuzanna Kozicka, Brendan G. Dwyer, Katherine A. Donovan, Zixuan Jiang +9 more

Proteomics‐Based Discovery of First‐in‐Class Chemical Probes for Programmed Cell Death Protein 2 (PDCD2)

Angewandte Chemie International Edition(2023)10.1002/anie.202308292

N/A

0.269DataRank · unranked

5 citations

Woong Sub Byun, Wenchao Lu, Xijun Zhu, Katherine A. Donovan, Brendan G. Dwyer +8 more

Targeted degradation of the oncogenic phosphatase SHP2

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.06.02.446786

N/A

0.269DataRank · unranked

5 citations

Katherine A. Donovan, T.C.M. Seegar, Julia M. Rogers, Munhyung Bae, Ryan J. Lumpkin +6 more

Development and utility of a PAK1-selective degrader

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.05.12.491715

N/A

0.165DataRank · unranked

2 citations

Sofiia Karchugina, Brian J. Groendyke, Sean T. Toenjes, John M. Hatcher, Katherine A. Donovan +7 more

Development of Degraders and 2-pyridinecarboxyaldehyde (2-PCA) as a recruitment Ligand for FBXO22

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.19.671158

N/A

0.104DataRank · unranked

1 citations

Zhe Zhuang, Woong Sub Byun, Zuzanna Kozicka, Kheewoong Baek, Jianing Zhong +7 more

SMAC mimetics induce human macrophages to phagocytose live cancer cells

Immunotherapy Advances(2024)10.1093/immadv/ltaf026

N/A

0.104DataRank · unranked

1 citations

Marc Hulsman, Philipp Leyendecker, Eugena Chang, Katherine A. Donovan, Fabian Strobel +6 more

Covalent Stapling of the Cereblon Sensor Loop Histidine Using Sulfur-Heterocycle Exchange

ACS Medicinal Chemistry Letters(2023)10.1021/acsmedchemlett.3c00371

N/A

0DataRank · unranked

23 citations

Radosław P. Nowak, Katherine A. Donovan, Scott B. Ficarro, Huang Huang, Hu Liu +6 more

The human E3 ligase RNF185 is a regulator of the SARS-CoV-2 envelope protein

iScience(2023)10.1016/j.isci.2023.106601

N/A

0DataRank · unranked

10 citations

Hojong Yoon, Paul M.C. Park, J. J. Patten, Jesse Pellman, Jeannie Carreiro +12 more

Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader

Angewandte Chemie International Edition(2023)10.1002/anie.202302364

N/A

0DataRank · unranked

8 citations

Jie Jiang, Eric S. Wang, Qixiang Geng, Sean T. Toenjes, Katherine A. Donovan +9 more

Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.14.528208

N/A

0DataRank · unranked

45 citations

W Michelle, Muhammad Murtaza Hassan, Moritz Hunkeler, Mingxing Teng, Kedar Puvar +23 more

HDAC6/aggresome processing pathway importance for inflammasome formation is context dependent

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.08.15.553363

N/A

0DataRank · unranked

2 citations

Adeline Unterreiner, Ronan Kapétanovic, Selma Aslani, Yuan Xiong, Katherine A. Donovan +5 more

Proteomics‐Based Discovery of First‐in‐Class Chemical Probes for Programmed Cell Death Protein 2 (PDCD2)

Angewandte Chemie(2023)10.1002/ange.202308292

N/A

0DataRank · unranked

0 citations

Woong Sub Byun, Wenchao Lu, Xijun Zhu, Katherine A. Donovan, Brendan G. Dwyer +8 more

Template-assisted covalent modification underlies activity of covalent molecular glues

Nature Chemical Biology(2024)10.1038/s41589-024-01668-4

N/A

0DataRank · unranked

93 citations

W Michelle, Muhammad Murtaza Hassan, Moritz Hunkeler, Mingxing Teng, Kedar Puvar +30 more

Continuous evolution of compact protein degradation tags regulated by selective molecular glues

Science(2024)10.1126/science.adk4422

N/A

0DataRank · unranked

78 citations

Stephan J. DeCarlo, Shourya S. Roy Burman, Vedagopuram Sreekanth, Andrew T. Nelson, Moritz Hunkeler +10 more

Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library

Journal of the American Chemical Society(2024)10.1021/jacs.4c06127

N/A

0DataRank · unranked

45 citations

Zixuan Jiang, Kheewoong Baek, Inchul You, Qixiang Geng, Katherine A. Donovan +11 more

Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism

Nature Communications(2024)10.1038/s41467-024-49161-9

N/A

0DataRank · unranked

24 citations

Zhengnian Li, Theresia Reindl, Zhixiang He, Xueer Qiu, Ryan P. Golden +7 more

Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation

Science Signaling(2024)10.1126/scisignal.adf2670

N/A

0DataRank · unranked

13 citations

Inchul You, Grace E. Perry, Aurelien Dugourd, Katherine A. Donovan, Claire Crafter +11 more

Unveiling the hidden interactome of CRBN molecular glues with chemoproteomics

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.09.11.612438

N/A

0DataRank · unranked

20 citations

Rebecca J. Metivier, Shourya S. Roy Burman, Jonathan W. Bushman, Hojong Yoon, Ryan J. Lumpkin +9 more

Discovery of Potent Degraders of the Dengue Virus Envelope Protein

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.06.01.596987

N/A

0DataRank · unranked

6 citations

Han‐Yuan Liu, Zhixiang He, Antara Chakravarty, Ryan P. Golden, Zixuan Jiang +13 more

A Kinetic Scout Approach Accelerates Targeted Protein Degrader Development

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.09.17.612508

N/A

0DataRank · unranked

1 citations

Gillian E. Gadbois, Hai‐Tsang Huang, Jiewei Jiang, Logan H. Sigua, Emily R. Smith +9 more

Rational Design of CDK12/13 and BRD4 Molecular Glue Degraders

Angewandte Chemie International Edition(2025)10.1002/anie.202508427

N/A

0DataRank · unranked

16 citations

Woong Sub Byun, Zuzanna Kozicka, Katherine A. Donovan, Brendan G. Dwyer, Abby M. Thornhill +7 more

Development of Potent and Selective CK1α Molecular Glue Degraders

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.4c02415

N/A

0DataRank · unranked

14 citations

Zixuan Jiang, Woong Sub Byun, Katherine A. Donovan, Zhe Zhuang, Fen Jiang +9 more

Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation

Molecular Cell(2025)10.1016/j.molcel.2025.07.019

N/A

0DataRank · unranked

13 citations

Jiho Park, Radosław P. Nowak, Shourya S. Roy Burman, Jesse Pellman, Charles Zou +23 more

Discovery of BRD9 Molecular Glue Degraders That Spare Cardiomyocytes

Journal of the American Chemical Society(2025)10.1021/jacs.5c09857

N/A

0DataRank · unranked

13 citations

Zhe Zhuang, Anna P. Hnatiuk, Cyrus Y. Jin, Zixuan Jiang, Kheewoong Baek +6 more

Development of FBXO22 Degraders and the Recruitment Ligand 2-Pyridinecarboxyaldehyde (2-PCA)

Journal of the American Chemical Society(2025)10.1021/jacs.5c14141

N/A

0DataRank · unranked

7 citations

Zhe Zhuang, Woong Sub Byun, Zuzanna Kozicka, Kheewoong Baek, Jianing Zhong +7 more

Dual CARM1-and IKZF3-targeting: A novel approach to multiple myeloma therapy

Molecular Therapy Oncology(2025)10.1016/j.omton.2025.200952

N/A

0DataRank · unranked

0 citations

Swati Garg, Basudev Chowdhury, Martin Sattler, Dana Sanchez, Chengcheng Meng +13 more

Niclosamide: CRL4 AMBRA1 mediated degradation of cyclin D1 following mitochondrial membrane depolarization

RSC Medicinal Chemistry(2025)10.1039/d5md00054h

N/A

0DataRank · unranked

0 citations

Jessica A. Gasser, Mikołaj Słabicki, Katherine A. Donovan, Eric S. Fischer, Benjamin L. Ebert +3 more

Development of CDK2 and CDK5 Dual Degrader TMX‐2172

Angewandte Chemie International Edition(2020)10.1002/anie.202004087

N/A

0DataRank · unranked

78 citations

Jie Jiang, Zhixiang He, Nicholas Kwiatkowski, Katherine A. Donovan, Caitlin E. Mills +7 more

Rational Design of CDK12/13 and BRD4 Molecular Glue Degraders

Angewandte Chemie(2025)10.1002/ange.202508427

N/A

0DataRank · unranked

0 citations

Woong Sub Byun, Zuzanna Kozicka, Katherine A. Donovan, Brendan G. Dwyer, Abby M. Thornhill +7 more

Development of CDK2 and CDK5 Dual Degrader TMX‐2172

Angewandte Chemie(2020)10.1002/ange.202004087

N/A

0DataRank · unranked

5 citations

Jie Jiang, Zhixiang He, Nicholas Kwiatkowski, Katherine A. Donovan, Caitlin E. Mills +7 more

INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors

Cancer Discovery(2021)10.1158/2159-8290.cd-20-1726

N/A

0DataRank · unranked

166 citations

Baishan Jiang, Jiaye Guo, Hong Shao, Isabella Del Priore, Qing Chang +20 more

Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c01832

N/A

0DataRank · unranked

57 citations

Wenchao Lu, Katherine A. Donovan, Jialin Sun, Noah M. Krupnick, Radosław P. Nowak +7 more

Targeting oncoproteins with a positive selection assay for protein degraders

Science Advances(2021)10.1126/sciadv.abd6263

N/A

0DataRank · unranked

47 citations

Leslie Duplaquet, Benjamin L. Lampson, Adam C. Wang, Amin H. Sabet, Mette Ishoey +21 more

A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders

European Journal of Medicinal Chemistry(2021)10.1016/j.ejmech.2021.113435

N/A

0DataRank · unranked

35 citations

Evangelos Papadopoulos, Jon Dempersmier, Zifu Wang, Radosław P. Nowak, Katherine A. Donovan +13 more

Structure-Guided Design of a “Bump-and-Hole” Bromodomain-Based Degradation Tag

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c00958

N/A

0DataRank · unranked

27 citations

Yuan Xiong, Nadia Kirmani, Joann Kalabathula, Katherine A. Donovan, Nicholas A. Eleuteri +3 more

Exploring Ligand-Directed N-Acyl-N-alkylsulfonamide-Based Acylation Chemistry for Potential Targeted Degrader Development

ACS Medicinal Chemistry Letters(2021)10.1021/acsmedchemlett.1c00285

N/A

0DataRank · unranked

15 citations

Jie Jiang, Scott B. Ficarro, Hyuk‐Soo Seo, Jae Hyun Bae, Katherine A. Donovan +6 more

Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2

Angewandte Chemie(2021)10.1002/ange.202101328

N/A

0DataRank · unranked

6 citations

Jie Jiang, Qibiao Wu, Nathaniel J. Henning, Katherine A. Donovan, Hong Yue +7 more

Synthesis and structure-activity relationships of targeted protein degraders for the understudied kinase NEK9

Current Research in Chemical Biology(2021)10.1016/j.crchbi.2021.100008

N/A

0DataRank · unranked

3 citations

Gillian E. Gadbois, Andrew J. Tao, Benjamin Fram, Jie Jiang, Bridget Boyle +10 more

Proteolysis Targeting Chimeras With Reduced Off-targets

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.11.18.468552

N/A

0DataRank · unranked

14 citations

Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K. Tiwari, Katherine A. Donovan +11 more

Exploring the target scope of KEAP1 E3 ligase-based PROTACs

Cell chemical biology(2022)10.1016/j.chembiol.2022.08.003

N/A

0DataRank · unranked

90 citations

Jie Jiang, Nathaniel J. Henning, Nozhat Safaee, Eriko Koide, Radosław P. Nowak +14 more

Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells

Journal of Clinical Investigation(2022)10.1172/jci153514

N/A

0DataRank · unranked

67 citations

Adam S. Sperling, Mikołaj Słabicki, Jessica A. Gasser, Marie McConkey, Katherine A. Donovan +24 more

Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells

Cell chemical biology(2022)10.1016/j.chembiol.2022.06.007

N/A

0DataRank · unranked

45 citations

Altantsetseg Buyanbat, Kai Yan, Ozge Karayel, Seth Goldman, Davide Seruggia +12 more

Development and Utility of a PAK1-Selective Degrader

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c00756

N/A

0DataRank · unranked

31 citations

Sofiia Karchugina, Brian J. Groendyke, Sean T. Toenjes, John M. Hatcher, Katherine A. Donovan +7 more

Multi-omic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.10.11.511726

N/A

0DataRank · unranked

2 citations

Inchul You, Grace E. Perry, Aurelien Dugourd, Katherine A. Donovan, Claire Crafter +11 more

UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability

Molecular Cell(2023)10.1016/j.molcel.2023.06.028

N/A

0DataRank · unranked

73 citations

Jacob D. Aguirre, Yen-Der Li, Jared Brown, Vivian Focht, Lukas Kater +30 more

Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.2c01864

N/A

0DataRank · unranked

42 citations

Baishan Jiang, Hellen Kim, Matthew J. Berberich, Jianwei Che, Katherine A. Donovan +13 more

Development of a covalent cereblon-based PROTAC employing a fluorosulfate warhead

RSC Chemical Biology(2023)10.1039/d3cb00103b

N/A

0DataRank · unranked

42 citations

Leah Ragosta, Fidel Huerta, Hu Liu, Scott B. Ficarro, Justin T. Cruite +7 more