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WRN rescues replication forks compromised by a BRCA2 deficiency: Predictions for how inhibition of a helicase that suppresses premature aging tilts the balance to fork demise and chromosomal instability in cancer

BioEssays(2022)10.1002/bies.202200057Source: DataRank Database

WRN rescues replication forks compromised by a BRCA2 deficiency: Predictions for how inhibition of a helicase that suppresses premature aging tilts the balance to fork demise and chromosomal instability in cancer is a research paper published in BioEssays (2022). On theSindex it has a DataRank of 0. It has been cited 9 times.

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Open Access9 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (2 grants)Impact (FWCI 0.67)OA: greenTopics (36)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (2)

Robert M. Brosh ORCID,Arindam Datta ORCID

Live enrichment

PubMed:35751457 PMC:PMC9527950 OpenAlex:https://openalex.org/W4283518783

National Institute on Aging

Grant: AG000741

Intramural NIH HHS

Grant: ZIA AG000741

FWCI

0.67

Citation Percentile

0.7%

Citation Trend

2022

2023

2024

2025

2026

greenLicense: http://onlinelibrary.wiley.com/termsAndConditions#vor

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9527950

publisherhttps://onlinelibrary.wiley.com/doi/pdf/10.1002/bies.202200057

publisherhttps://onlinelibrary.wiley.com/doi/full-xml/10.1002/bies.202200057

journalhttps://doi.org/10.1002/bies.202200057

Fields of Study

DNA Repair MechanismsPlant Genetic and Mutation StudiesCRISPR and Genetic Engineering

MeSH Terms

Werner Syndrome HelicaseDNA ReplicationDNA HelicasesExodeoxyribonucleasesHumansNeoplasmsWerner SyndromeAging, PrematureBRCA2 ProteinChromosomal Instability

Keywords

Genome instabilityTelomereBiologyHelicasePremature agingWerner syndromeDNA replicationChromosome instabilityGeneticsDNA repairCell biologyDNA damageDNAGeneChromosomeAgingCancerGenomic instabilityBRCA2Genetic diseaseSynthetic LethalityWrnReplication Stress

Sustainable Development Goals

SDG 0: Good health and well-being