Macrophage and adipocyte <scp>IGF</scp>1 maintain adipose tissue homeostasis during metabolic stresses is a research paper published in Obesity (2016). On theSindex it has a DataRank of 2.8. It has been cited 74 times, with 74 citing works in its 1-hop citation network.
ObjectiveInsulin‐like growth factor‐1 (IGF1) regulates differentiation and growth of tissues and reduces stress and injury. IGF1 also in a tissue‐specific manner modulates the differentiation and lipid storage capacity of adipocytes in vitro, but its roles in adipose tissue development and response to stress are not known.MethodsTo study IGF1 in vivo, the cellular sources of adipose tissue Igf1 expression were identified and mice were generated with targeted deletion in adipocytes and macrophages. The effects of adipocyte and macrophage deficiency of IGF1 on adipose tissue development and the response to chronic (high‐fat feeding) and acute (cold challenge) stress were studied.ResultsThe expression of Igf1 by adipose tissue was derived from multiple cell types including adipocytes and macrophages. In lean animals, adipocytes were the primary source of IGF1, but in obesity expression by adipocytes was reduced and by macrophages increased, so as to maintain overall adipose tissue Igf1 expression. Genetic deletion studies revealed that adipocyte‐derived IGF1 regulated perigonadal but not subcutaneous adipose tissue mass during high‐fat feeding and the development of obesity. Conversely, macrophage‐derived IGF1 acutely modulated perigonadal adipose tissue mass during thermogenic challenges.ConclusionsLocal IGF1 is not required in lean adipose tissue development but is required to maintain homeostasis during both chronic and acute metabolic stresses.
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Base Score Contribution
0.648
From this paper's citation signal
Citation Network Contribution
2.1
From 63 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 23% comes from its base citations and 77% from the citation network (63 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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