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Cardiac decompensation and promiscuous prenylation of small GTPases in cardiomyocytes in response to local mevalonate pathway disruption†

The Journal of Pathology(2021)10.1002/path.5837Source: DataRank Database

Cardiac decompensation and promiscuous prenylation of small GTPases in cardiomyocytes in response to local mevalonate pathway disruption† is a research paper published in The Journal of Pathology (2021). On theSindex it has a DataRank of 0. It has been cited 5 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access5 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (2 grants)Impact (FWCI 0.30)OA: bronzeTopics (42)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (3)

Richard J. Auchus ORCID,Matthew J. Brody ORCID,Kobina Essandoh ORCID

Live enrichment

PubMed:34783037 PMC:PMC8825694 OpenAlex:https://openalex.org/W3211601393

NHLBI NIH HHS

Grant: R00 HL136695

American Heart Association

Grant: 827440

FWCI

0.30

Citation Percentile

0.5%

Citation Trend

2022

2023

2024

2025

bronze

journalhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/path.5837

publisherhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/path.5837

journalhttps://doi.org/10.1002/path.5837

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34783037

repositoryhttps://hdl.handle.net/2027.42/171869

Fields of Study

Plant biochemistry and biosynthesisAntioxidant Activity and Oxidative StressComputational Drug Discovery MethodsHeart FailureHumansMevalonic AcidMonomeric GTP-Binding ProteinsMyocytes, CardiacPrenylationProtein Prenylation

MeSH Terms

Heart FailureHumansMevalonic AcidProtein PrenylationMonomeric GTP-Binding ProteinsMyocytes, CardiacPrenylation

Keywords

FarnesyltransferasePrenylationMevalonate pathwayRHEBSmall GTPaseFarnesyltransferase inhibitorPI3K/AKT/mTOR pathwayGeranylgeranylationCell biologyGTPaseAutophagySignal transductionBiologyBiochemistryChemistryEnzymeBiosynthesisApoptosismTORC1RasSmall GtpasesFarnesyl Diphosphate SynthaseFarnesylationstatinsCaax Motif

Sustainable Development Goals

SDG 0: Good health and well-being