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A positive genetic selection for transmembrane domain mutations in HRD1 underscores the importance of Hrd1 complex integrity during ERAD

Current Genetics(2022)10.1007/s00294-022-01227-1Source: DataRank Database

A positive genetic selection for transmembrane domain mutations in HRD1 underscores the importance of Hrd1 complex integrity during ERAD is a research paper published in Current Genetics (2022). On theSindex it has a DataRank of 0. It has been cited 6 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access6 citations

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uniprot doi

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (8 grants)Impact (FWCI 0.65)OA: bronzeTopics (40)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Sylvia Wigge,Yuki Takano ORCID,Tomoyuki Kawarasaki,Takumi Kamura ORCID,Jeffrey L. Brodsky ORCID

Live enrichment

PubMed:35041076 PMC:PMC9036396 OpenAlex:https://openalex.org/W4205687150

Japan Society for the Promotion of Science

Grant: 15K18503

Japan Society for the Promotion of Science

Grant: 19H02923

Japan Society for the Promotion of Science

Grant: 18K19306

National Institutes of Health

Grant: GM131732

NIGMS NIH HHS

Grant: R35 GM131732

National Institutes of Health

Grant: 5R35GM131732-04

ER and post-ER quality control of integral membrane proteins

Toyoaki Scholarship Foundation

Toray Science Foundation

FWCI

0.65

Citation Percentile

0.6%

Influential Citations

Citation Trend

2022

2023

2024

2025

bronzeLicense: Springer Nature TDM

journalhttps://link.springer.com/content/pdf/10.1007/s00294-022-01227-1.pdf

GREENhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036396

publisherhttps://link.springer.com/content/pdf/10.1007/s00294-022-01227-1.pdf

publisherhttps://link.springer.com/article/10.1007/s00294-022-01227-1

journalhttps://doi.org/10.1007/s00294-022-01227-1

Fields of Study

Endoplasmic Reticulum Stress and DiseaseCellular transport and secretionPancreatic function and diabetesMedicineBiology0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

Endoplasmic ReticulumMembrane ProteinsMutationSelection, GeneticUbiquitin-Protein LigasesEndoplasmic Reticulum-Associated Degradation

Keywords

Endoplasmic-reticulum-associated protein degradationBiologyUbiquitin ligaseSec61Transmembrane proteinEndoplasmic reticulumTransmembrane domainCell biologyMutantIntegral membrane proteinUbiquitinMembrane proteinGeneticsUnfolded protein responseGeneTransloconDegradationUbiquitinationProteasomeE3 ubiquitin ligaseEr Quality ControlUbiquitin-Protein LigasesMutationMembrane ProteinsEndoplasmic Reticulum-Associated DegradationSelection, Genetic

Sustainable Development Goals

SDG 0: Life in Land

A positive genetic selection for transmembrane domain mutations in HRD1 underscores the importance of Hrd1 complex integrity during ERAD

FAIR Checklist

Authors (6)

Funding (8 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)