Jeffrey L. Brodsky

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

3in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 3 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 54 papers. Top paper: “A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation”.

A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation

Science(2019)10.1126/science.aau9263

N/A

4.7DataRank · unranked

159 citations

Smriti Parashar, Muhammad Zahoor, Patrick G. Needham, Muriel Mari, Ming Zhu +7 more

ADD66, a Gene Involved in the Endoplasmic Reticulum-associated Degradation of α-1-Antitrypsin-Z in Yeast, Facilitates Proteasome Activity and Assembly

Molecular Biology of the Cell(2007)10.1091/mbc.e07-01-0034

N/A

1.2DataRank · unranked

34 citations

Kristina B. Kruse, Béla Z. Schmidt, David H. Perlmutter, Ardythe A. McCracken, Jeffrey L. Brodsky +1 more

Complementary computational and experimental evaluation of missense variants in the ROMK potassium channel

PLoS Computational Biology(2020)10.1371/journal.pcbi.1007749

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0DataRank · unranked

11 citations

Nga H. Nguyen, İvet Bahar, Jeffrey L. Brodsky, Luca Ponzoni

Regulation of CFTR Biogenesis by the Proteostatic Network and Pharmacological Modulators

International Journal of Molecular Sciences(2020)10.3390/ijms21020452

N/A

0DataRank · unranked

42 citations

Jeffrey L. Brodsky, Samuel K. Estabrooks

The Capture of a Disabled Proteasome Identifies Erg25 as a Substrate for Endoplasmic Reticulum Associated Degradation

Molecular & Cellular Proteomics(2020)10.1074/mcp.ra120.002050

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0DataRank · unranked

5 citations

Xuemei Zeng, Pamela S. Cantrell, Richard Cattley, Zikri Hasanbasri, Megan E. Yates +4 more

Ubiquitination of disease-causing CFTR variants in a microsome-based assay

Analytical Biochemistry(2020)10.1016/j.ab.2020.113829

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0DataRank · unranked

4 citations

Jeffrey L. Brodsky, Samuel K. Estabrooks

Identification of an Allosteric Small-Molecule Inhibitor Selective for the Inducible Form of Heat Shock Protein 70

UNC Libraries(2020)10.17615/edp0-j378

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0DataRank · unranked

0 citations

David B. Darr, Philip F. Hughes, Jeffrey L. Brodsky, Jamie L. Jordan, David A. Carlson +11 more

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations

UNC Libraries(2020)10.17615/cqba-1865

N/A

0DataRank · unranked

0 citations

Garry R. Cutting, Zhiwei Cai, Scott A. Houck, Veit, Gudio, David N. Sheppard +13 more

ER-Phagy, ER Homeostasis, and ER Quality Control: Implications for Disease

Trends in Biochemical Sciences(2021)10.1016/j.tibs.2020.12.013

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0DataRank · unranked

166 citations

Fulvio Reggiori, Jeffrey L. Brodsky, Susan Ferro-Novick

The Targeting of Native Proteins to the Endoplasmic Reticulum-Associated Degradation (ERAD) Pathway: An Expanding Repertoire of Regulated Substrates

Biomolecules(2021)10.3390/biom11081185

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0DataRank · unranked

38 citations

Jeffrey L. Brodsky, Deepa Kumari

Unique integrated stress response sensors regulate cancer cell susceptibility when Hsp70 activity is compromised

eLife(2021)10.7554/elife.64977

N/A

0DataRank · unranked

28 citations

Megan E. Yates, Mark E. Schurdak, Steffi Oesterreich, Adrian V. Lee, Peter Wipf +2 more

Improved correction of F508del-CFTR biogenesis with a folding facilitator and an inhibitor of protein ubiquitination

Bioorganic & Medicinal Chemistry Letters(2021)10.1016/j.bmcl.2021.128243

N/A

0DataRank · unranked

14 citations

R. Aldrin Denny, Disha Joshi, Clare Hill, Mads Larsen, Annette Chiang +5 more

Heat Shock Protein 70 as a Sex-Skewed Regulator of α-Synucleinopathy

Neurotherapeutics(2021)10.1007/s13311-021-01114-6

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0DataRank · unranked

11 citations

Rachel N. Clark, Patrick G. Needham, Kristin M. Miner, Anuj S. Jamenis, Elizabeth A. Eckhoff +7 more

Substrate ubiquitination retains misfolded membrane proteins in the endoplasmic reticulum for degradation

Cell Reports(2021)10.1016/j.celrep.2021.109717

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0DataRank · unranked

13 citations

Christopher J. Guerriero, Jeffrey L. Brodsky, Zhihao Sun

Synthesis and evaluation of bifunctional PTP4A3 phosphatase inhibitors activating the ER stress pathway

Bioorganic & Medicinal Chemistry Letters(2021)10.1016/j.bmcl.2021.128167

N/A

0DataRank · unranked

7 citations

Sara Sannino, Duncan J. Hart, Elizabeth R. Sharlow, John S. Lazo, Jeffrey L. Brodsky +2 more

TorsinA folding and N-linked glycosylation are sensitive to redox homeostasis

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research(2021)10.1016/j.bbamcr.2021.119073

N/A

0DataRank · unranked

2 citations

Katie Niemeyer, Christian Fercher, Ana L. Diez Tissera, Noushin Jaberolansar, Yohaann Jafrani +7 more

Emerging links between endoplasmic reticulum stress responses and acute kidney injury

American Journal of Physiology-Cell Physiology(2022)10.1152/ajpcell.00370.2022

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0DataRank · unranked

22 citations

Jeffrey L. Brodsky, Teresa M. Buck, Aidan W. Porter

The molecular chaperone GRP170 protects against ER stress and acute kidney injury in mice

JCI Insight(2022)10.1172/jci.insight.151869

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0DataRank · unranked

24 citations

Diep Nguyen, Dennis R. Clayton, Wily G. Ruiz, Stephanie M. Mutchler, Evan C. Ray +10 more

A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities

Cell chemical biology(2022)10.1016/j.chembiol.2022.06.006

N/A

0DataRank · unranked

13 citations

Shuhei Taguwa, Luke A. Gilbert, Arielle Shkedi, Sara Sannino, Christopher J. Guerriero +7 more

A positive genetic selection for transmembrane domain mutations in HRD1 underscores the importance of Hrd1 complex integrity during ERAD

Current Genetics(2022)10.1007/s00294-022-01227-1

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0DataRank · unranked

6 citations

Sylvia Wigge, Yuki Takano, Tomoyuki Kawarasaki, Takumi Kamura, Jeffrey L. Brodsky +1 more

Proteasome activity modulates amyloid toxicity

FEMS Yeast Research(2022)10.1093/femsyr/foac004

N/A

0DataRank · unranked

2 citations

Liz Curran, Francisco Moreno, Alicia Goossens, Nicki L. Aubuchon‐Endsley, Michael A. McMurray +7 more

The Molecular Chaperone, GRP170, Protects Against Acute Kidney Injury and ER Stress in Mice

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.r4334

N/A

0DataRank · unranked

0 citations

Aidan W. Porter, Wily G. Ruiz, Dennis R. Clayton, Stephanie M. Mutchler, Evan C. Ray +9 more

Elucidating the Quality Control Pathway of KCC2, a Critical Synchronizer of Neuronal Development

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.r3942

N/A

0DataRank · unranked

0 citations

Ishika Singh, Karen A. Hartnett-Scott, Elias Aizenman, Jeffrey L. Brodsky, Morgan Kok

The degradation of misfolded proteins in the ER

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.0i136

N/A

0DataRank · unranked

0 citations

Jeffrey L. Brodsky

Fundamental and translational research in Cystic Fibrosis – why we still need it

Journal of Cystic Fibrosis(2022)10.1016/j.jcf.2022.12.010

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0DataRank · unranked

0 citations

Jeffrey L. Brodsky, Nicoletta Pedemonte, Carlos M. Farinha

The Essential Functions of Molecular Chaperones and Folding Enzymes in Maintaining Endoplasmic Reticulum Homeostasis

Journal of Molecular Biology(2023)10.1016/j.jmb.2023.168418

N/A

0DataRank · unranked

56 citations

Teresa M. Buck, Jeffrey L. Brodsky, Linda M. Hendershot

Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress

Molecular Cancer Research(2023)10.1158/1541-7786.mcr-22-0843

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0DataRank · unranked

14 citations

Allison M. Manuel, Chaowei Shang, Stacy G. Wendell, Peter Wipf, Jeffrey L. Brodsky +1 more

Differential regulation of MAP2 by phosphorylation events in proline‐rich versus C‐terminal domains

The FASEB Journal(2023)10.1096/fj.202300486r

N/A

0DataRank · unranked

7 citations

Patrick G. Needham, O. A. Andrews, H. Tristan, Melanie Grubisha, Jeffrey L. Brodsky +3 more

The cellular pathways that maintain the quality control and transport of diverse potassium channels

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms(2023)10.1016/j.bbagrm.2023.194908

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0DataRank · unranked

5 citations

Jeffrey L. Brodsky, Nga H. Nguyen

Lhs1 dependent ERAD is determined by transmembrane domain context

Biochemical Journal(2023)10.1042/bcj20230075

N/A

0DataRank · unranked

5 citations

Abigail M. Keith, Emma M. Perrault, Hannah E. Vorndran, Alexa S. Jordahl, Megan E. Yates +12 more

Genome mining yields putative disease-associated ROMK variants with distinct defects

PLoS Genetics(2023)10.1371/journal.pgen.1011051

N/A

0DataRank · unranked

5 citations

Srikant Sarangi, Erin M. McChesney, Shaohu Sheng, Jacob D. Durrant, Aidan W. Porter +4 more

The generation of detergent-insoluble clipped fragments from an ERAD substrate in mammalian cells

Scientific Reports(2023)10.1038/s41598-023-48769-z

N/A

0DataRank · unranked

1 citations

Jeffrey L. Brodsky, Grant J. Daskivich

FITM2 deficiency results in ER lipid accumulation, ER stress, reduced apolipoprotein B lipidation, and VLDL triglyceride secretion in vitro and in mouse liver

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.05.570183

N/A

0DataRank · unranked

4 citations

Cyrus Nikain, Jaime Amengual, Maxwell La Forest, Yong Yu, Meng C. Wang +11 more

Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum functions

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.19.563191

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0DataRank · unranked

3 citations

Chris Melendez-Suchi, Maria Sukhoplyasova, Ashley R. Flory, Mary Carson Irvine, Anuradha Iyer +6 more

Genome mining yields new disease-associated ROMK variants with distinct defects

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.05.539609

N/A

0DataRank · unranked

2 citations

Srikant Sarangi, Erin M. McChesney, Shaohu Sheng, Aidan W. Porter, Thomas R. Kleyman +3 more

FITM2 deficiency results in ER lipid accumulation, ER stress, and reduced apolipoprotein B lipidation and VLDL triglyceride secretion in vitro and in mouse liver

Molecular Metabolism(2024)10.1016/j.molmet.2024.102048

N/A

0DataRank · unranked

12 citations

Cyrus Nikain, Konstantinos Fortounas, Jaume Amengual, Özlem Tufanlı, Maxwell La Forest +13 more

Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum function

Molecular Biology of the Cell(2024)10.1091/mbc.e24-01-0012

N/A

0DataRank · unranked

10 citations

Chris Melendez-Suchi, Hannah E. Vorndran, Maria Sukhoplyasova, Ashley R. Flory, Mary Carson Irvine +6 more

Excess dietary sodium restores electrolyte and water homeostasis caused by loss of the endoplasmic reticulum molecular chaperone, GRP170, in the mouse nephron

American Journal of Physiology-Renal Physiology(2024)10.1152/ajprenal.00192.2024

N/A

0DataRank · unranked

6 citations

Hannah E. Vorndran, Allison L. Marciszyn, Stephanie M. Mutchler, Arohan R. Subramanya, Thomas R. Kleyman +4 more

The expression system influences stability, maturation efficiency, and oligomeric properties of the potassium-chloride co-transporter KCC2

Neurochemistry International(2024)10.1016/j.neuint.2024.105695

N/A

0DataRank · unranked

8 citations

Karen A. Hartnett-Scott, Cassandra Happe, Matthew L. MacDonald, Elias Aizenman, Jeffrey L. Brodsky +1 more

Optimization of the fluorogen-activating protein tag for quantitative protein trafficking and colocalization studies in S. cerevisiae

Molecular Biology of the Cell(2024)10.1091/mbc.e24-04-0174

N/A

0DataRank · unranked

4 citations

Natalie Hager, Ceara K. McAtee, Elif Filiztekin, Chaowei Shang, Justina A. Warnick +6 more

Identification of polycystin 2 missense mutants targeted for endoplasmic reticulum-associated degradation

American Journal of Physiology-Cell Physiology(2024)10.1152/ajpcell.00776.2024

N/A

0DataRank · unranked

4 citations

Marcelo D. Carattino, Katherine G. Sharp, Luke J. Kantz, Nikolay Gresko, Michael J. Caplan +2 more

Characterization of hyperactive mutations in the renal potassium channel ROMK uncovers unique effects on channel biogenesis and ion conductance

Molecular Biology of the Cell(2024)10.1091/mbc.e23-12-0494

N/A

0DataRank · unranked

3 citations

Shaohu Sheng, Anupam Banerjee, Christopher J. Guerriero, Jingxin Chen, Xueqi Wang +7 more

Assays to measure small molecule Hsp70 agonist activity in vitro and in vivo

Analytical Biochemistry(2024)10.1016/j.ab.2024.115712

N/A

0DataRank · unranked

3 citations

Clara Woods, Amanda M. Gleixner, Sara Sannino, Marilyn Ngo, Michael D. McDaniels +5 more

The biogenesis of potassium transporters: implications of disease-associated mutations

Critical Reviews in Biochemistry and Molecular Biology(2024)10.1080/10409238.2024.2369986

N/A

0DataRank · unranked

2 citations

Jeffrey L. Brodsky, Morgan Kok

Defining a small-molecule stimulator of the human Hsp70-disaggregase system with selectivity for DnaJB proteins

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.01.11.575109

N/A

0DataRank · unranked

3 citations

Ryan R. Cupo, J. Bevan, Mikhaila Rice, Shuli Mao, Erica L. Gorenberg +6 more

Excess dietary sodium partially restores salt and water homeostasis caused by loss of the endoplasmic reticulum molecular chaperone, GRP170, in the mouse nephron

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.01.13.575426

N/A

0DataRank · unranked

1 citations

Hannah E. Vorndran, Allison L. Marciszyn, Stephanie M. Mutchler, Arohan R. Subramanya, Thomas R. Kleyman +4 more

Optimization of the fluorogen-activating protein tag for quantitative protein trafficking and co-localization studies in S. cerevisiae

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.04.20.590399

N/A

0DataRank · unranked

0 citations

Natalie Hager, Ceara K. McAtee, Elif Filiztekin, Chaowei Shang, Justina A. Warnick +6 more

In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma

Oncotarget(2025)10.18632/oncotarget.28764

N/A

0DataRank · unranked

3 citations

Yue Pan, Jacqueline Morales, Matthew J. Watson, David V. Allegakoen, Alex G. Lee +6 more

Reconstitution of CFTR ubiquitination identifies lysine-420 as a regulator of cell surface residence and current

Biochemistry and Biophysics Reports(2025)10.1016/j.bbrep.2025.102393

N/A

0DataRank · unranked

1 citations

Xuemei Zeng, Jeong S. Hong, Disha Joshi, Zhengrong Yang, Fan Jiang +4 more

Regulated degradation of KCC2, a potassium-chloride co-transporter required for synaptic transmission and neurodevelopment

Channels(2025)10.1080/19336950.2025.2607247

N/A

0DataRank · unranked

1 citations

Elias Aizenman, Christopher J. Guerriero, Jeffrey L. Brodsky, Morgan Kok

Inefficient maturation of disease-linked mutant forms of the KCC2 potassium-chloride cotransporter correlates with predicted pathogenicity

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.108399

N/A

0DataRank · unranked

2 citations

Ishika Singh, Elias Aizenman, Jeffrey L. Brodsky, Morgan Kok

Aicardi-Goutières Syndrome Associated ADAR G1007R mutation dominantly induces neuroinflammation in mouse brain

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.21.649787

N/A

0DataRank · unranked

0 citations

Jiajun Liu, Chaowei Shang, Christopher J. Guerriero, Clayton A. Wiley, Richard A. Steinman +6 more

Protein Disulfide Isomerases promote the Endoplasmic Reticulum Associated Degradation of diverse substrates using different mechanisms

The FASEB Journal(2012)10.1096/fasebj.26.1_supplement.954.5

N/A

0DataRank · unranked

0 citations

Liang Guo, Edward A. Fisher, Jeffrey L. Brodsky, Sarah Grubb

Direct involvement of Hsp70 ATP hydrolysis in Ubr1-dependent quality control

Molecular Biology of the Cell(2020)10.1091/mbc.e20-08-0541

N/A

0DataRank · unranked

18 citations

Nidhi Vashistha, Jarrod W. Heck, Xin Tang, Peter Wipf, Jeffrey L. Brodsky +2 more