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Substrate stiffness dictates unique doxorubicin-induced senescence-associated secretory phenotypes and transcriptomic signatures in human pulmonary fibroblasts

GeroScience(2025)10.1007/s11357-025-01507-xSource: DataRank Database

Substrate stiffness dictates unique doxorubicin-induced senescence-associated secretory phenotypes and transcriptomic signatures in human pulmonary fibroblasts is a research paper published in GeroScience (2025). On theSindex it has a DataRank of 0.409. It has been cited 11 times, with 11 citing works in its 1-hop citation network.

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0.409DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access11 citations · 11 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE282384

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (16 grants)OA: greenTopics (31)IDs (PubMed, PMC)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 91%Citation Network 9%

Base Score Contribution

0.373

From this paper's citation signal

Citation Network Contribution

0.0362

From 4 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 11 citers.

Substrate Stiffness and Viscoelasticity Influence Fibroblast Senescence
Journal of Biomedical Materials Research Part A20261 citations44 referencesContributes 0.016
Substrate stiffness dictates unique paths towards proliferative arrest in WI-38 cells
GeroScience20251 citations63 referencesContributes 0.011
The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy
Molecular Cancer202534 citations327 referencesContributes 0.011
A tough job: ion channels, transporters, and pumps during organ fibrosis
American Journal of Physiology-Cell Physiology20252 citations219 referencesContributes 0.005
Spatial Mass Spectrometry-Based Proteomic Analysis of Normal-Appearing Glomeruli from Young and Old Adults
Kidney36020250 citations43 referencesContributes 0.000

Authors (18)

Jacob Rose ORCID,Joanna Bons ORCID,Guo Li ORCID,Taylor R. Valentino ORCID,Fei Wu ORCID

Live enrichment

PubMed:39826027 PMC:PMC12181613

National Institutes of Health

Grant: R01DK128435

National Institutes of Health

Grant: S10 OD028654

National Institutes of Health

Grant: S10 OD016281

Huiying Memorial Foundation

Grant: Huiying Memorial Foundation

Canadian Institutes of Health Research

Grant: PJT-186165

University of Southern California and Buck Institute Nathan Shock Center

Grant: P30 AG068345

T32 NIH fellowship

Grant: NIA T32 AG000266

NIA NIH HHS

Grant: U01 AG060906

NIA NIH HHS

Grant: T32 AG000266

National Institutes of Health

Grant: 1R01DK128435-01A1

The B Cell Insulin Receptor in Health and in Insulin Resistance

National Institutes of Health

Grant: 5T32AG000266-03

TRAINING IN BASIC AGING RESEARCH

Canadian Institutes of Health Research

Grant: unidentified

unidentified

National Institutes of Health

Grant: 1S10OD028654-01

Orbitrap Fusion Lumos ETD with FAIMS Pro

National Institutes of Health

Grant: 1S10OD016281-01

TripleTOF 5600 High Resolution Mass Spectrometer

National Institutes of Health

Grant: 3P30AG068345-02S1

The University of Southern California and Buck Institute Nathan Shock Center

Buck Institute for Research on Aging

greenLicense: Springer Nature TDM

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12181613/pdf/11357_2025_Article_1507.pdf

publisherhttps://link.springer.com/content/pdf/10.1007/s11357-025-01507-x.pdf

publisherhttps://link.springer.com/article/10.1007/s11357-025-01507-x/fulltext.html

https://doi.org/10.1007/s11357-025-01507-x

https://doi.org/10.1101/2024.11.18.623471

Fields of Study

0301 basic medicine03 medical and health sciences

MeSH Terms

LungCells, CulturedFibroblastsAnimalsHumansMicePulmonary FibrosisDoxorubicinBleomycinMechanotransduction, CellularTranscriptomeCellular SenescenceSenescence-Associated Secretory Phenotype

Keywords

Senescent CellsTissue StiffnessSenescence-associated Secretory PhenotypePulmonary FibrosisFibroblastsMechanotransduction, CellularArticleMiceBleomycinDoxorubicinHumansAnimalsTranscriptomeLungCellular SenescenceCells, Cultured