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Disease variants of human Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2)

Archives of Biochemistry and Biophysics(2021)10.1016/j.abb.2021.108852Source: DataRank Database

Disease variants of human Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) is a research paper published in Archives of Biochemistry and Biophysics (2021). On theSindex it has a DataRank of 0. It has been cited 15 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access15 citations

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Linked data & code

omim brenda refseq uniprot pdb doi

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 0.89)OA: greenTopics (43)IDs (PubMed, PMC, OpenAlex)Annotations (6)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Javier Seravalli ORCID,Xinwen Liang ORCID,John J. Tanner ORCID,Donald Becker ORCID,Sagar M. Patel ORCID

Live enrichment

PubMed:33771508 PMC:PMC8120637 OpenAlex:https://openalex.org/W3137720997

National Institutes of Health

Grant: R01GM065546

National Institutes of Health

Grant: R01GM132640

National Institutes of Health

Grant: 5R01GM065546-14

Substrate Channeling and Communication in Proline Metabolic Enzymes

National Institutes of Health

Grant: 2R01GM132640-03

Investigating the Proline Cycle as a Potential Cancer Therapy Target

National Institute of General Medical Sciences

FWCI

0.89

Citation Percentile

0.7%

Citation Trend

2021

2022

2023

2024

2025

2026

greenLicense: Elsevier TDM

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8120637

publisherhttps://api.elsevier.com/content/article/PII:S0003986121001028?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0003986121001028?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.abb.2021.108852

Fields of Study

RNA regulation and diseaseRNA and protein synthesis mechanismsEnzyme Structure and Function0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

delta-1-Pyrroline-5-Carboxylate ReductaseDiseaseEnzyme StabilityHumansKineticsMutationPyrroline Carboxylate ReductasesTemperatureProtein Structure, Secondary

Keywords

NAD+ kinaseReductaseBiochemistryEnzymeBiologyProlineThermostabilityMicrocephalyChemistryMolecular biologyAmino acidGeneticsCircular dichroismsteady-state kineticsProtein ThermostabilityΔ(1)-pyrroline-5-carboxylate ReductaseProline BiosynthesisProduct Inhibition KineticsSubstrate-binding OrderKineticsdelta-1-Pyrroline-5-Carboxylate ReductaseEnzyme StabilityMutationTemperatureHumansDiseasePyrroline Carboxylate ReductasesProtein Structure, Secondary

Sustainable Development Goals

SDG 2: 2. Zero hunger

Disease variants of human Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2)

FAIR Checklist

Authors (5)

Funding (5 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)