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Ablation of TNF-RI/RII Expression in Alzheimer's Disease Mice Leads to an Unexpected Enhancement of Pathology

The American Journal of Pathology(2011)10.1016/j.ajpath.2011.07.001Source: DataRank Database

Ablation of TNF-RI/RII Expression in Alzheimer's Disease Mice Leads to an Unexpected Enhancement of Pathology is a research paper published in The American Journal of Pathology (2011). On theSindex it has a DataRank of 4.3. It has been cited 98 times, with 97 citing works in its 1-hop citation network.

N/A

4.3DataRank · unranked

Scored on demand from live citation data

98 citations · 97 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (6 grants)Impact (FWCI 3.69)OA: bronzeTopics (76)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (0/2)

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 16%Citation Network 84%

Base Score Contribution

0.689

From this paper's citation signal

Citation Network Contribution

3.6

From 90 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 97 citers.

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Brain Behavior and Immunity2013129 citations27 referencesContributes 0.180
Peripheral administration of an anti-TNF-α receptor fusion protein counteracts the amyloid induced elevation of hippocampal TNF-α levels and memory deficits in mice
Neurochemistry International201470 citations33 referencesContributes 0.129
The effect of chronic periodontitis on serum levels of tumor necrosis factor-alpha in Alzheimer disease.
PubMed201444 citations32 referencesContributes 0.119
Deficiency of Inflammatory Response to Acute Trauma Exposure as a Neuroimmune Mechanism Driving the Development of Chronic PTSD: Another Paradigmatic Shift for the Conceptualization of Stress-Related Disorders?
American Journal of Psychiatry202020 citations26 referencesContributes 0.117
Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer’s disease-related pathology
Proceedings of the National Academy of Sciences2013252 citations49 referencesContributes 0.113

Authors (7)

Michael A. Mastrangelo,Diala Habib,Wade C. Narrow,Sara A. Knowlden ORCID,Terry W. Wright ORCID

Live enrichment

PubMed:21835156 OpenAlex:https://openalex.org/W10297594

National Institutes of Health

Grant: F31-AG038063

National Institutes of Health

Grant: R01-AG023593

National Institutes of Health

Grant: R01-AG026328

NIA NIH HHS

Grant: R01 AG023593

NIA NIH HHS

Grant: R01 AG026328

NIA NIH HHS

Grant: F31 AG038063

FWCI

3.69

Citation Percentile

0.9%

Citation Trend

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bronzeLicense: http://www.elsevier.com/open-access/userlicense/1.0/

journalhttp://ajp.amjpathol.org/article/S0002944011006377/pdf

publisherhttp://ajp.amjpathol.org/article/S0002944011006377/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0002944011006377?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0002944011006377?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.ajpath.2011.07.001

Fields of Study

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsImmune Response and InflammationAdaptor Proteins, Signal TransducingAgingAlzheimer DiseaseAmyloidAmyloid beta-Protein PrecursorAnimalsBrainCA1 Region, HippocampalCA3 Region, HippocampalCalcium-Binding ProteinsCrosses, GeneticFemaleHumansLipopolysaccharide ReceptorsLong-Term PotentiationMaleMiceMice, KnockoutMicrofilament ProteinsMicrogliaPhagocytosisReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IISynapsesTransgenesTumor Necrosis Factor-alphatau Proteins

MeSH Terms

AgingAlzheimer DiseaseAmyloidAnimalsBrainCalcium-Binding ProteinsCrosses, GeneticFemaleHumansMaleMicrofilament ProteinsPhagocytosisSynapsesTumor Necrosis Factor-alphaAmyloid beta-Protein Precursortau ProteinsMicrogliaLong-Term PotentiationMice, KnockoutLipopolysaccharide ReceptorsTransgenesReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIAdaptor Proteins, Signal TransducingMiceCA1 Region, HippocampalCA3 Region, Hippocampal

Keywords

NeuroinflammationMicrogliaTumor necrosis factor alphaPathogenesisCytokineReceptorAlzheimer's diseaseBiologyGenetically modified mouseImmunologyNeuroscienceInflammationMedicineTransgenePathologyInternal medicineDiseaseGeneticsGene

Sustainable Development Goals

SDG 0: Good health and well-being