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Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls

Acta Pharmaceutica Sinica B(2021)10.1016/j.apsb.2021.09.023Source: DataRank Database

Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls is a research paper published in Acta Pharmaceutica Sinica B (2021). On theSindex it has a DataRank of 0. It has been cited 143 times.

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Open Access143 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (8 grants)Impact (FWCI 13.31)OA: goldTopics (65)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Olamide B. Adelusi ORCID,Jephte Y. Akakpo ORCID,Nga Nguyen ORCID,Giselle Sánchez-Guerrero ORCID,David S. Umbaugh ORCID

Live enrichment

PubMed:35024303 PMC:PMC8727921 OpenAlex:https://openalex.org/W3204215704

National Institutes of Health

Grant: F31 DK120194-01

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: R01 DK070195

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: R01 DK102142

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: R01 DK125465

NIGMS NIH HHS

Grant: P30 GM118247

NIDDK NIH HHS

Grant: F31 DK120194

NIGMS NIH HHS

Grant: P20 GM103549

National Institute of General Medical Sciences

FWCI

13.31

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

goldLicense: cc-by-nc-nd

journalhttps://doi.org/10.1016/j.apsb.2021.09.023

publisherhttps://doi.org/10.1016/j.apsb.2021.09.023

publisherhttps://api.elsevier.com/content/article/PII:S2211383521003828?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2211383521003828?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/35024303

Fields of Study

Drug-Induced Hepatotoxicity and ProtectionCannabis and Cannabinoid ResearchLiver Disease and Transplantation

Keywords

AcetaminophenMedicineIntensive care medicineDrugLiver injuryAntipyreticAutophagyPsychological interventionPharmacologyAnalgesicBioinformaticsBiologyPsychiatryMitochondriaApoptosisDrug metabolisminnate immunityNRF2Ros, Reactive Oxygen SpeciesJnk, C-jun N-terminal KinaseAmpk, Amp-activated Protein KinaseMda, MalondialdehydeNf-κb, Nuclear Factor ΚbFerroptosisAcetaminophen HepatotoxicityGsh, GlutathioneDmso, DimethylsulfoxidePufas, Polyunsaturated Fatty AcidsNac, N-acetylcysteineNqo1, Nad(p)h:quinone Oxidoreductase 1Keap1, Kelch-like Ech-associated Protein 1Mnsod, Manganese Superoxide DismutaseAre, Antioxidant Response ElementHne, 4-HydroxynonenalNrf2, Nuclear Factor Erythroid 2-Related Factor 2Gssg, Glutathione DisulfideMcp-1, Monocyte Chemoattractant Protein-1Hmgb1, High Mobility Group Box Protein 1Tunel, Terminal Deoxynucleotidyl Transferase Dutp Nick End LabelingMtorc1, Mammalian Target Of Rapamycin Complex 1Apap, AcetaminophenAif, Apoptosis-inducing FactorMpt, Mitochondrial Permeability TransitionTlr, Toll Like ReceptorDamps, Damage-associated Molecular PatternsLpo, Lipid PeroxidationNapqi, N-acetyl-p-benzoquinone ImineBso, Buthionine SulfoximineGpx4, Glutathione Peroxidase 4Lamp, Lysosomal-associated Membrane ProteinLc3, Light Chain 3Gclc, Glutamate–cysteine Ligase Catalytic SubunitGclm, Glutamate–cysteine Ligase Modifier SubunitUgt, Udp-glucuronosyltransferasesCyp, Cytochrome P450 EnzymesEndog, Endonuclease GAtg, Autophagy-related GenesCad, Caspase-activated DnaseFsp1, Ferroptosis Suppressing Protein 1Looh, Lipid HydroperoxidesMap Kinase, Mitogen Activated Protein KinaseSmac/diablo, Second Mitochondria-derived Activator Of Caspase/direct Inhibitor Of Apoptosis-binding Protein With Low Pi

Sustainable Development Goals

SDG 0: Good health and well-being