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Synthesis and biological evaluation of carboxamide and quinoline derivatives as P2X7R antagonists

Bioorganic Chemistry(2023)10.1016/j.bioorg.2023.106796Source: DataRank Database

Synthesis and biological evaluation of carboxamide and quinoline derivatives as P2X7R antagonists is a research paper published in Bioorganic Chemistry (2023). On theSindex it has a DataRank of 0.345. It has been cited 9 times.

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0.345DataRank · unranked

Scored on demand from live citation data

Open Access9 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 1.51)OA: greenTopics (39)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.345

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

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Authors (5)

Zahid Hussain ORCID,Bilal Ahmad Khan ORCID,Kenneth A. Jacobson ORCID,Jamshed Iqbal ORCID,Qasim Shah ORCID

Live enrichment

PubMed:37683539 PMC:PMC10544280 OpenAlex:https://openalex.org/W4386365926

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: ZIADK031127

Higher Education Commision, Pakistan

Grant: 20–15846/NRPU/R&D/HEC/2021

Higher Education Commision, Pakistan

Grant: 20–15846/NRPU/R&amp;D/HEC/2021

NIDDK NIH HHS

Grant: R01 DK031127

Deutscher Akademischer Austauschdienst

FWCI

1.51

Citation Percentile

0.8%

Citation Trend

2024

2025

2026

greenLicense: https://www.elsevier.com/legal/tdmrep-license

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10544280/pdf/nihms-1930433.pdf

publisherhttps://api.elsevier.com/content/article/PII:S0045206823004571?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0045206823004571?httpAccept=text/plain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/10544280

Fields of Study

Adenosine and Purinergic SignalingClick Chemistry and ApplicationsSynthesis and Biological EvaluationHumansApoptosisAstrocytomaHydroxyquinolinesQuinolinesReceptors, Purinergic P2X7Purinergic P2X Receptor Antagonists

MeSH Terms

AstrocytomaHumansHydroxyquinolinesQuinolinesApoptosisReceptors, Purinergic P2X7Purinergic P2X Receptor Antagonists

Keywords

ChemistryViability assayCell cultureFlow cytometryTransfectionQuinolineApoptosisCarboxamideIC50HEK 293 cellsCytotoxicityMTT assayMolecular biologyReceptorStereochemistryIn vitroBiochemistryBiologyStructure activity relationshipCell deathP2X receptorsCalcium Mobilization

Sustainable Development Goals

SDG 0: Good health and well-being

Synthesis and biological evaluation of carboxamide and quinoline derivatives as P2X7R antagonists

FAIR Checklist

DataRank Breakdown

Authors (5)

Funding (5 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)