Kenneth A. Jacobson

Also affiliated with National Institute of Diabetes and Digestive and Kidney Diseases

Biochemistry, Genetics and Molecular BiologyChemistryNeuroscience

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 169 papers. Top paper: “Exploration of Alternative Scaffolds for P2Y14 Receptor Antagonists Containing a Biaryl Core”.

Exploration of Alternative Scaffolds for P2Y14 Receptor Antagonists Containing a Biaryl Core

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.0c00745

N/A

1.2DataRank · unranked

35 citations

Jinha Yu, Zhiwei Wen, Veronica Salmaso, Tadeusz Karcz, Ngan B. Phung +9 more

UDP-glucose and P2Y14 receptor amplify allergen-induced airway eosinophilia

Journal of Clinical Investigation(2021)10.1172/jci140709

N/A

0.624DataRank · unranked

63 citations

Gregory S. Whitehead, Keiko Nakano, Hideki Nakano, Sara A. Grimm, Jason G. Williams +4 more

Structure of the human dopamine transporter and mechanisms of inhibition

Nature(2024)10.1038/s41586-024-07739-9

N/A

0.606DataRank · unranked

56 citations

Vikas Navratna, Dilip K. Tosh, Audrey Chinn, Md Fulbabu Sk, Emad Tajkhorshid +3 more

Lack of adipocyte purinergic P2Y 6 receptor greatly improves whole body glucose homeostasis

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.2006578117

N/A

0.578DataRank · unranked

46 citations

Sai P. Pydi, Kiran S. Toti, Bernard Robaye, Marco Idzko, Oksana Gavrilova +3 more

Uncovering the Mechanisms of Adenosine Receptor-Mediated Pain Control: Focus on the A3 Receptor Subtype

International Journal of Molecular Sciences(2021)10.3390/ijms22157952

N/A

0.520DataRank · unranked

31 citations

Federica Cherchi, Elena Lucarini, Carla Ghelardini, Felicita Pedata, Kenneth A. Jacobson +4 more

Species dependence of A3 adenosine receptor pharmacology and function

Purinergic Signalling(2022)10.1007/s11302-022-09910-1

N/A

0.515DataRank · unranked

30 citations

John A. Auchampach, Kenneth A. Jacobson, Zhan‐Guo Gao

Purinergic Signaling: Impact of GPCR Structures on Rational Drug Design

ChemMedChem(2020)10.1002/cmdc.202000465

N/A

0.505DataRank · unranked

28 citations

Kenneth A. Jacobson, Veronica Salmaso

GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A2A Adenosine Receptor

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c00462

N/A

0.500DataRank · unranked

27 citations

Daejin Park, Gyudong Kim, Yoonji Lee, Xiyan Hou, Dnyandev B. Jarhad +12 more

Fragment-based design of selective GPCR ligands guided by free energy simulations

Chemical Communications(2021)10.1039/d1cc03202j

N/A

0.464DataRank · unranked

21 citations

Duc Duy Vo, Zhan‐Guo Gao, Jan Kihlberg, Kenneth A. Jacobson, Jens Carlsson +1 more

Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A3 Adenosine Receptor Homology Models and Structural Network Analysis Can Predict This Boundary

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c00239

N/A

0.464DataRank · unranked

21 citations

Xiyan Hou, Jin Hee Lee, Akshata Nayak, Varughese Alexander, Pankaz K. Sharma +7 more

Structure activity relationship of 3-nitro-2-(trifluoromethyl)-2H-chromene derivatives as P2Y6 receptor antagonists

Bioorganic & Medicinal Chemistry Letters(2021)10.1016/j.bmcl.2021.128008

N/A

0.449DataRank · unranked

19 citations

Shanu Jain, Varun Gopinatth, Ngan B. Phung, Zhan‐Guo Gao, Kenneth A. Jacobson +1 more

Design and in vivo activity of A3 adenosine receptor agonist prodrugs

Purinergic Signalling(2020)10.1007/s11302-020-09715-0

N/A

0.449DataRank · unranked

19 citations

Shanu Jain, Zhoumou Chen, Dilip K. Tosh, Yanling Ma, Maren C. Podszun +4 more

Novel cyanothiouracil and cyanothiocytosine derivatives as concentration-dependent selective inhibitors of U87MG glioblastomas: Adenosine receptor binding and potent PDE4 inhibition

European Journal of Medicinal Chemistry(2020)10.1016/j.ejmech.2020.113125

N/A

0.434DataRank · unranked

17 citations

Sevde Nur Biltekin, Leyla Yurttaş, Barkın Berk, Yağmur Özhan, Hande Si̇pahi̇ +4 more

A2B adenosine receptor signaling and regulation

Purinergic Signalling(2024)10.1007/s11302-024-10025-y

N/A

0.416DataRank · unranked

15 citations

Mansour Haddad, Kenneth A. Jacobson, Zhan-Guo Gao

Analgesic candidate adenosine A3 receptors are expressed by perineuronal peripheral macrophages in human dorsal root ganglion and spinal cord microglia

Pain(2024)10.1097/j.pain.0000000000003242

N/A

0.385DataRank · unranked

12 citations

Ellen S. Staedtler, Diana M. King, Dragan Maric, Jahandar Jahanipour, Andre Ghetti +4 more

Effects of Purinergic Receptor Deletion or Pharmacologic Modulation on Pulmonary Inflammation in Mice

ACS Pharmacology & Translational Science(2022)10.1021/acsptsci.2c00128

N/A

0.373DataRank · unranked

11 citations

Tadeusz Karcz, Dilip K. Tosh, Kwan‐Young Jung, Zhiwei Wen, Ryan G. Campbell +5 more

A3 adenosine receptor agonists containing dopamine moieties for enhanced interspecies affinity

European Journal of Medicinal Chemistry(2021)10.1016/j.ejmech.2021.113983

N/A

0.360DataRank · unranked

10 citations

Veronica Salmaso, Ryan G. Campbell, Harsha Rao, Amelia Bitant, Eline Pottie +7 more

Synthesis and biological evaluation of carboxamide and quinoline derivatives as P2X7R antagonists

Bioorganic Chemistry(2023)10.1016/j.bioorg.2023.106796

N/A

0.345DataRank · unranked

9 citations

Zahid Hussain, Bilal Ahmad Khan, Kenneth A. Jacobson, Jamshed Iqbal, Qasim Shah

A2A adenosine receptor agonists, antagonists, inverse agonists and partial agonists

International review of neurobiology(2023)10.1016/bs.irn.2023.08.001

N/A

0.312DataRank · unranked

7 citations

R. Rama Suresh, Paola Oliva, Kenneth A. Jacobson

Covalently Binding Adenosine A3 Receptor Agonist ICBM Irreversibly Reduces Voltage-Gated Ca2+ Currents in Dorsal Root Ganglion Neurons

Purinergic Signalling(2023)10.1007/s11302-023-09929-y

N/A

0.295DataRank · unranked

4 citations

Martina Venturini, Giada Magni, Mirko Scortichini, Kenneth A. Jacobson, Anna Maria Pugliese +2 more

A2B adenosine receptor activation and modulation by protein kinase C

iScience(2023)10.1016/j.isci.2023.107178

N/A

0.292DataRank · unranked

6 citations

Ian M. Levitan, Asuka Inoue, Qiang Wei, Kenneth A. Jacobson, Zhan‐Guo Gao

In vivo phenotypic validation of adenosine receptor-dependent activity of non-adenosine drugs

Purinergic Signalling(2023)10.1007/s11302-023-09924-3

N/A

0.208DataRank · unranked

3 citations

Oksana Gavrilova, Naili Liu, Sarah A. Lewicki, Marc L. Reitman, Kenneth A. Jacobson +1 more

Dual N6/C7-Substituted 7-Deazapurine and Tricyclic Ribonucleosides with Affinity for G Protein-Coupled Receptors

ACS Medicinal Chemistry Letters(2023)10.1021/acsmedchemlett.3c00427

N/A

0.165DataRank · unranked

2 citations

Federica Matteucci, Kristof Van Hecke, Guy Caljon, Kenneth A. Jacobson, Serge Van Calenbergh +1 more

Geoffrey Burnstock – An accidental pharmacologist

Biochemical Pharmacology(2020)10.1016/j.bcp.2020.114300

N/A

0.165DataRank · unranked

2 citations

Kenneth A. Jacobson, Michael Williams, Francesco Di Virgilio

Tribute to Prof. Geoffrey Burnstock: transition of purinergicsignaling to drug discovery

Purinergic Signalling(2020)10.1007/s11302-020-09717-y

N/A

0.165DataRank · unranked

2 citations

Kenneth A. Jacobson

Editorial: Small molecules and biologics for future purinergic therapeutics

Purinergic Signalling(2023)10.1007/s11302-023-09964-9

N/A

0.104DataRank · unranked

1 citations

Daniela Salvemini, Kenneth A. Jacobson

Membrane Mimetic-Dependence of GPCR Energy Landscapes

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.16.562552

N/A

0.104DataRank · unranked

1 citations

Arka Prabha Ray, Edward Lyman, Zhan‐Guo Gao, Kenneth A. Jacobson, Matthew T. Eddy +1 more

UDP-glucose and MRS2905 agonist-bound states of the purinergic P2Y14 receptor

Communications Biology(2025)10.1038/s42003-025-09174-6

N/A

0.104DataRank · unranked

1 citations

Joseph N. Kousouros, Zhan-Guo Gao, Matteo Pavan, Paola Oliva, Asmita Pramanik +6 more

Pilot-Scale Screening of Clinically Approved Drugs to Identify Uridine Insertion/Deletion RNA Editing Inhibitors in Trypanosoma brucei

ACS Infectious Diseases(2024)10.1021/acsinfecdis.4c00394

N/A

0.104DataRank · unranked

1 citations

Arezou Kamelshahroudi, Vanessa Pitsitikas, Kenneth A. Jacobson, Reza Salavati, Mojtaba Rostamighadi

The Role of Amino Acids in Extracellular Loops of the Human P2Y 1 Receptor in Surface Expression and Activation Processes

UNC Libraries(2020)10.17615/trtx-es56

N/A

0.104DataRank · unranked

1 citations

Stefano Moro, T. Kendall Harden, Robert A. Nicholas, Kenneth A. Jacobson, Carsten Hoffmann

Editorial: Geoffrey Burnstock - An Accidental Pharmacologist

Biochemical Pharmacology(2021)10.1016/j.bcp.2021.114421

N/A

0.104DataRank · unranked

1 citations

Kenneth A. Jacobson, Michael Williams, Francesco Di Virgilio

A2B adenosine receptor-triggered intracellular calcium mobilization: Cell type-dependent involvement of Gi, Gq, Gs proteins and protein kinase C

Research Square(2024)10.21203/rs.3.rs-5442142/v1

N/A

0.104DataRank · unranked

1 citations

Ray R. Gao, Clayton K. Meyer, Kenneth A. Jacobson, Zhan-Guo Gao

Enhanced Potency of Nucleotide−Dendrimer Conjugates as Agonists of the P2Y 14 Receptor: Multivalent Effect in G Protein-Coupled Receptor Recognition

Figshare(2020)10.17615/wtck-5m29

N/A

0DataRank · unranked

1 citations

Kenneth A. Jacobson, Rhonda L. Carter, Andrei A. Ivanov, Arijit Das, T. Kendall Harden +1 more

Adenosine-Related Mechanisms in Non-Adenosine Receptor Drugs

Preprints.org(2020)10.20944/preprints202004.0115.v1

N/A

0DataRank · unranked

8 citations

Marc L. Reitman, Kenneth A. Jacobson

Transient anchorage of cross-linked glycosyl-phosphatidylinositol–anchored proteins depends on cholesterol, Src family kinases, caveolin, and phosphoinositides

UNC Libraries(2020)10.17615/x15x-nc79

N/A

0DataRank · unranked

1 citations

Sharon L. Milgram, William R. Thelin, Bing Yang, Yun Chen, Kenneth A. Jacobson

Analysis of lateral redistribution of a monoclonal antibody complex plasma membrane glycoprotein which occurs during cell locomotion

UNC Libraries(2020)10.17615/m01m-wf22

N/A

0DataRank · unranked

1 citations

Bruce F. Holifield, Akira Ishihara, Kenneth A. Jacobson

Diffusion of injected macromolecules within the cytoplasm of living cells.

UNC Libraries(2020)10.17615/as6t-0r16

N/A

0DataRank · unranked

0 citations

E. S. Wu, John Wojcieszyn, Kenneth A. Jacobson, Robert Schlegel

Correction to Accelerating the Throughput of Affinity Mass Spectrometry-Based Ligand Screening toward a G Protein-Coupled Receptor

Analytical Chemistry(2020)10.1021/acs.analchem.0c00754

N/A

0DataRank · unranked

0 citations

Shanshan Qin, Bingjie Zhang, Antao Dai, Xiaoqing Cai, Mengna Ma +7 more

Defects in lysosomal maturation facilitate the activation of innate sensors in systemic lupus erythematosus

UNC Libraries(2020)10.17615/0eds-1n25

N/A

0DataRank · unranked

0 citations

M. Joseph Costello, Andrew J. Monteith, Eric L. Scott, Sunah Kang, Barbara J. Vilen +3 more

Spatiotemporal relationships between the cell shape and the actomyosin cortex of periodically protruding cells

UNC Libraries(2020)10.17615/seeb-6431

N/A

0DataRank · unranked

0 citations

Wolfgang Losert, Kenneth A. Jacobson, Meghan Driscoll, Maryna Kapustina

Ligand and structure-based methodologies for the prediction of the activity of G protein-coupled receptor ligands

UNC Libraries(2020)10.17615/bka0-qh43

N/A

0DataRank · unranked

0 citations

Kenneth A. Jacobson, Stefano Costanzi, T. Kendall Harden, Irina G. Tikhonova

Molecular recognition in the P2Y14 receptor: Probing the structurally permissive terminal sugar moiety of uridine-5′-diphosphoglucose

UNC Libraries(2020)10.17615/gcez-6m23

N/A

0DataRank · unranked

0 citations

Hyojin Ko, Jan Hajduch, Andrei A. Ivanov, Artem Melman, Arijit Das +8 more

Gleevec, an Abl Family Inhibitor, Produces a Profound Change in Cell Shape and Migration

UNC Libraries(2020)10.17615/wkw8-4a17

N/A

0DataRank · unranked

0 citations

Xavier Trepat, George A. Truskey, Zaozao Chen, Kenneth A. Jacobson, Shawn M. Gomez +8 more

RhoA Regulates Calcium-Independent Periodic Contractions of the Cell Cortex

UNC Libraries(2020)10.17615/etdb-xw34

N/A

0DataRank · unranked

0 citations

Maryna Kapustina, Andrew J. Monteith, Nancy Costigliola, Timothy C. Elston, Kenneth A. Jacobson +2 more

UDP-glucose promotes neutrophil recruitment in the lung

UNC Libraries(2020)10.17615/qb3w-2y38

N/A

0DataRank · unranked

0 citations

Juliana I. Sesma, Scott H. Donaldson, Alessandra Livraghi-Butrico, Hong Dang, Clarissa D. Weitzer +4 more

Direct interaction with filamins modulates the stability and plasma membrane expression of CFTR

UNC Libraries(2020)10.17615/jcwp-sf52

N/A

0DataRank · unranked

0 citations

Yun Chen, Martina Gentzsch, Cameron O. Scarlett, Kenneth A. Jacobson, Sharon L. Milgram +5 more

Modeling capping protein FRAP and CALI experiments reveals in vivo regulation of actin dynamics

UNC Libraries(2020)10.17615/k8gy-n846

N/A

0DataRank · unranked

0 citations

Maryna Kapustina, Leslie M. Loew, Timothy C. Elston, Kenneth A. Jacobson, Eric A. Vitriol

Quantification of recombinant and platelet P2Y1 receptors utilizing a [125I]-labeled high-affinity antagonist 2-iodo-N6-methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′-bisphosphate ([125I]MRS2500)

UNC Libraries(2020)10.17615/wkxc-5d94

N/A

0DataRank · unranked

0 citations

Garth G. Brown, Christian Gachet, Sonia de Castro, Philippe Ohlmann, T. Kendall Harden +1 more

Synthesis and P2Y receptor activity of nucleoside 5′-phosphonate derivatives

UNC Libraries(2020)10.17615/3bdc-7914

N/A

0DataRank · unranked

0 citations

T. Kendall Harden, Serge Van Calenbergh, Bhalchandra V. Joshi, Hyojin Ko, Liesbet Cosyn +2 more

Low Copy Numbers of DC-SIGN in Cell Membrane Microdomains: Implications for Structure and Function: Quantification of DC-SIGN Copy Numbers in Microdomains

UNC Libraries(2020)10.17615/mqav-tj16

N/A

0DataRank · unranked

0 citations

Kenneth A. Jacobson, Aaron K. Neumann, Aravinda M. de Silva, Xiang Wang, Michelle S. Itano +2 more

Pyrimidine Ribonucleotides with Enhanced Selectivity as P2Y 6 Receptor Agonists: Novel 4-Alkyloxyimino, (S)-Methanocarba, and 5′-Triphosphate γ-Ester Modifications †

UNC Libraries(2020)10.17615/9vwt-ya70

N/A

0DataRank · unranked

0 citations

Barkın Berk, Kenneth A. Jacobson, Рамачандран Баласубраманиан, Dilip K. Tosh, Hiroshi Maruoka +6 more

Local Photorelease of Caged Thymosin β4 in Locomoting Keratocytes Causes Cell Turning

UNC Libraries(2020)10.17615/84w1-em20

N/A

0DataRank · unranked

0 citations

David Jones, Gerard Marriott, Zenon Rajfur, Kenneth A. Jacobson, Partha Pratim Roy +1 more

Molecular Modeling of the Human P2Y2 Receptor and Design of a Selective Agonist, 2′-Amino-2′-deoxy-2-thio-UTP

UNC Libraries(2020)10.17615/9mzk-sp93

N/A

0DataRank · unranked

0 citations

Stefano Costanzi, Andrei A. Ivanov, Ingrid Fricks, Serge Van Calenbergh, Kenneth A. Jacobson +5 more

Chromophore-assisted laser inactivation in cell biology

UNC Libraries(2020)10.17615/ds80-2451

N/A

0DataRank · unranked

0 citations

Kenneth A. Jacobson, Zenon Rajfur, Klaus M. Hahn, Eric A. Vitriol

Development of Selective High Affinity Antagonists, Agonists, and Radioligands for the P2Y1 Receptor

UNC Libraries(2020)10.17615/drbc-s553

N/A

0DataRank · unranked

0 citations

T. Harden, Kenneth A. Jacobson, Stefano Costanzi, Dayle Houston

Molecular dynamics simulation of the P2Y14 receptor. Ligand docking and identification of a putative binding site of the distal hexose moiety

UNC Libraries(2020)10.17615/m7gg-5z22

N/A

0DataRank · unranked

0 citations

Andrei A. Ivanov, Kenneth A. Jacobson, T. Kendall Harden, Ingrid Fricks

Phosphorylation of paxillin by p38MAPK is involved in the neurite extension of PC-12 cells

UNC Libraries(2020)10.17615/mjmt-1j07

N/A

0DataRank · unranked

0 citations

Kenneth A. Jacobson, Cai Huang, Michael D. Schaller, Christoph H. Borchers

Polyamidoamine (PAMAM) Dendrimer Conjugates of “Clickable” Agonists of the A 3 Adenosine Receptor and Coactivation of the P2Y 14 Receptor by a Tethered Nucleotide

UNC Libraries(2020)10.17615/wk9d-zk24

N/A

0DataRank · unranked

0 citations

Zhan Gao, Matthew O. Barrett, Kenneth A. Jacobson, T. Kendall Harden, Ingrid Fricks +5 more

Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5′-triphosphate analogues at the human P2Y2 and P2Y4 receptors

UNC Libraries(2020)10.17615/2w5x-0707

N/A

0DataRank · unranked

0 citations

Zhan‐Guo Gao, T. Kendall Harden, Andrei A. Ivanov, Stefano Costanzi, Kenneth A. Jacobson +3 more

Adenosine A3 agonists reverse neuropathic pain via T cell–mediated production of IL-10

Journal of Clinical Investigation(2021)10.1172/jci139299

N/A

0DataRank · unranked

69 citations

Silvia Squillace, Filomena Lauro, Luigino Antonio Giancotti, Elisabetta Coppi, Federica Cherchi +12 more

Optical control of adenosine A3 receptor function in psoriasis

Pharmacological Research(2021)10.1016/j.phrs.2021.105731

N/A

0DataRank · unranked

25 citations

Ingrid Filgaira, Ernest G. Nolen, Gisela Cabré, Jordi Hernando, Dilip K. Tosh +4 more

A2A Adenosine Receptor Antagonists in Neurodegenerative Diseases

Current Medicinal Chemistry(2021)10.2174/0929867328666211129122550

N/A

0DataRank · unranked

39 citations

Pier Andrea Borea, Katia Varani, Fabrizio Vincenzi, Kenneth A. Jacobson, Stefania Gessi +1 more

Adipocyte P2Y14 receptors play a key role in regulating whole-body glucose and lipid homeostasis

JCI Insight(2021)10.1172/jci.insight.146577

N/A

0DataRank · unranked

29 citations

Sai P. Pydi, Kwan‐Young Jung, Mirko Scortichini, Efrat L. Kesner, Tadeusz Karcz +5 more

Adenosine Kinase Expression Determines DNA Methylation in Cancer Cell Lines

ACS Pharmacology & Translational Science(2021)10.1021/acsptsci.1c00008

N/A

0DataRank · unranked

19 citations

Denise Fedele, Hoda Gebril, Enmar Alharfoush, Kiran S. Toti, Kenneth A. Jacobson +2 more

Structure–Activity Relationship of Heterocyclic P2Y14 Receptor Antagonists: Removal of the Zwitterionic Character with Piperidine Bioisosteres

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c00164

N/A

0DataRank · unranked

20 citations

Veronica Salmaso, Zhiwei Wen, John M. Bennett, Ngan B. Phung, David I. Lieberman +8 more

Synthesis and evaluation of adenosine derivatives as A1, A2A, A2B and A3 adenosine receptor ligands containing boron clusters as phenyl isosteres and selective A3 agonists

European Journal of Medicinal Chemistry(2021)10.1016/j.ejmech.2021.113607

N/A

0DataRank · unranked

15 citations

Adam Mieczkowski, Aleksandra Kierozalska, Dijana Saftić, Konrad Głąbała, Tomasz Przygodzki +8 more

Expanding the repertoire of methanocarba nucleosides from purinergic signaling to diverse targets

RSC Medicinal Chemistry(2021)10.1039/d1md00167a

N/A

0DataRank · unranked

14 citations

Veronica Salmaso, R. Rama Suresh, Dilip K. Tosh, Kenneth A. Jacobson

Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonists

Purinergic Signalling(2021)10.1007/s11302-021-09823-5

N/A

0DataRank · unranked

12 citations

R. Rama Suresh, Kenneth A. Jacobson, Zhan‐Guo Gao

Structure-activity relationships of pyrimidine nucleotides containing a 5′-α,β-methylene diphosphonate at the P2Y6 receptor

Bioorganic & Medicinal Chemistry Letters(2021)10.1016/j.bmcl.2021.128137

N/A

0DataRank · unranked

11 citations

Mirko Scortichini, Clemens Dobelmann, Shanu Jain, Varun Gopinatth, Kiran S. Toti +4 more

Purinergic GPCR transmembrane residues involved in ligand recognition and dimerization

Methods in cell biology(2021)10.1016/bs.mcb.2021.06.001

N/A

0DataRank · unranked

5 citations

Shanu Jain, Kenneth A. Jacobson, Veronica Salmaso

Spinal A 3 adenosine receptor activation acutely restores morphine antinociception in opioid tolerant male rats

Journal of Neuroscience Research(2021)10.1002/jnr.24869

N/A

0DataRank · unranked

7 citations

Cynthia Xu, Churmy Y. Fan, Rebecca Dalgarno, Yuta Kohro, Sydney Sparanese +6 more

Adenosine A1 receptor is dispensable for hepatocyte glucose metabolism and insulin sensitivity

Biochemical Pharmacology(2021)10.1016/j.bcp.2021.114739

N/A

0DataRank · unranked

6 citations

Luiz F. Barella, Jürgen Wess, Marc L. Reitman, Kenneth A. Jacobson, Shanu Jain

Convergent synthesis of 2-thioether-substituted ( N )-methanocarba-adenosines as purine receptor agonists

RSC Advances(2021)10.1039/d1ra05096f

N/A

0DataRank · unranked

4 citations

Russell B. Poe, Baorui Lin, Kexin Lv, Ryan G. Campbell, Zhan‐Guo Gao +4 more

Discovery of Highly Potent Adenosine A1 Receptor Agonists: Targeting Positron Emission Tomography Probes

ACS Chemical Neuroscience(2021)10.1021/acschemneuro.1c00397

N/A

0DataRank · unranked

4 citations

Abolghasem Bakhoda, Zhan‐Guo Gao, Joseph M. Ramsey, Yang Li, Kelly A. O’Conor +12 more

Human P2Y 14 Receptor Agonists: Truncation of the Hexose Moiety of Uridine-5′-Diphosphoglucose and Its Replacement with Alkyl and Aryl Groups

Figshare(2021)10.17615/gnkz-fx16

N/A

0DataRank · unranked

1 citations

Lauren E. Burianek, Kenneth A. Jacobson, T. Kendall Harden, M. Barrett, Hyojin Ko +1 more

4-Alkyloxyimino-cytosine nucleotides: tethering approaches to molecular probes for the P2Y6 receptor

UNC Libraries(2021)10.17615/83yv-nm15

N/A

0DataRank · unranked

0 citations

Kyle A. Brown, Eszter Kozma, Lucia Squarcialupi, P. Suresh Jayasekara, Hiroshi Maruoka +5 more

International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update

Pharmacological Reviews(2022)10.1124/pharmrev.121.000445

N/A

0DataRank · unranked

154 citations

Kenneth A. Jacobson, Christa E. Müller, Bruce N. Cronstein, Rodrigo A. Cunha, Adriaan P. IJzerman

Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice

Acta Neuropathologica Communications(2022)10.1186/s40478-022-01315-w

N/A

0DataRank · unranked

46 citations

Rajasekaran Mahalingam, Silvia Squillace, Kenneth A. Jacobson, Dilip K. Tosh, Shruti Dharmaraj +5 more

Structure–Activity Relationship of 3-Methylcytidine-5′-α,β-methylenediphosphates as CD73 Inhibitors

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.1c01852

N/A

0DataRank · unranked

18 citations

Riham M. Idris, Susanne Moschütz, Antje Keim, Veronica Salmaso, Clemens Dobelmann +11 more

Synthesis and pharmacological characterization of multiply substituted 2H-chromene derivatives as P2Y6 receptor antagonists

Bioorganic & Medicinal Chemistry Letters(2022)10.1016/j.bmcl.2022.128981

N/A

0DataRank · unranked

18 citations

Qasim Shah, Sarah A. Lewicki, Asmita Pramanik, Varun Gopinatth, Julie Pelletier +4 more

Structure–Activity Relationship and Neuroprotective Activity of 1,5-Dihydro-2H-naphtho[1,2-b][1,4]diazepine-2,4(3H)-diones as P2X4 Receptor Antagonists

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c01197

N/A

0DataRank · unranked

15 citations

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Cells(2020)10.3390/cells9051200

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Journal of Pharmacology and Experimental Therapeutics(2020)10.1124/jpet.120.000004

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Bioorganic & Medicinal Chemistry Letters(2020)10.1016/j.bmcl.2020.127599

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PLoS ONE(2020)10.1371/journal.pone.0243986

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7 citations

Cuiying Xiao, Allison S. Mogul, Ankita Sahoo, Kenneth A. Jacobson, Ramón A. Piñol +3 more

Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration

UNC Libraries(2020)10.17615/xwha-nk97

N/A

0DataRank · unranked

6 citations

Zenon Rajfur, Nima Yousefi, Kenneth A. Jacobson, Zaozao Chen, Mark H. Ginsberg +1 more

Structure−Activity Relationship of Uridine 5‘ - Diphosphoglucose Analogues as Agonists of the Human P2Y 14 Receptor

UNC Libraries(2020)10.17615/xb5c-w853

N/A

0DataRank · unranked

5 citations

Kenneth A. Jacobson, Hyojin Ko, Andrei A. Ivanov, T. Kendall Harden, Ingrid Fricks

Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists

UNC Libraries(2020)10.17615/savq-8g88

N/A

0DataRank · unranked

4 citations

Sonia de Castro, Mario Grifantini, Serge Van Calenbergh, T. Kendall Harden, Hyojin Ko +8 more

Actin-Myosin Viscoelastic Flow in the Keratocyte Lamellipod

UNC Libraries(2020)10.17615/d8p4-fg54

N/A

0DataRank · unranked

2 citations

Kenneth A. Jacobson, Alex Mogilner, Maxime F. Fournier, Alexander B. Verkhovsky, Boris Rubinstein

Human P2Y 6 Receptor: Molecular Modeling Leads to the Rational Design of a Novel Agonist Based on a Unique Conformational Preference

Figshare(2020)10.17615/c3bm-j883

N/A

0DataRank · unranked

2 citations

Kenneth A. Jacobson, Víctor E. Márquez, Bhalchandra V. Joshi, Liaman Mamedova, Stefano Costanzi +3 more

Human P2Y 1 Receptor: Molecular Modeling and Site-Directed Mutagenesis as Tools To Identify Agonist and Antagonist Recognition Sites

UNC Libraries(2020)10.17615/wq9x-z036

N/A

0DataRank · unranked

2 citations

Emidio Camaioni, Stefano Moro, José L. Boyer, Kenneth A. Jacobson, Danping Guo +1 more

Functionalized Congeners of P2Y 1 Receptor Antagonists: 2-Alkynyl ( N )-Methanocarba 2′-Deoxyadenosine 3′,5′-Bisphosphate Analogues and Conjugation to a Polyamidoamine (PAMAM) Dendrimer Carrier

UNC Libraries(2020)10.17615/ked8-2s69

N/A

0DataRank · unranked

1 citations

Stefano Costanzi, S. Michael Kilbey, T. Kendall Harden, Béatrice Hechler, Garth G. Brown +5 more

[ 32 P]2-iodo- N 6 -methyl-( N )-methanocarba-2′-deoxyadenosine-3′,5′-bisphosphate ([ 32 P]MRS2500), a novel radioligand for quantification of native P2Y 1 receptors

UNC Libraries(2020)10.17615/44e8-xn58

N/A

0DataRank · unranked

1 citations

Dayle Houston, T. Kendall Harden, M. Ohno, Kenneth A. Jacobson, Robert A. Nicholas