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An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors of CYP3A4

Bioorganic & Medicinal Chemistry(2020)10.1016/j.bmc.2020.115349Source: DataRank Database

An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors of CYP3A4 is a research paper published in Bioorganic & Medicinal Chemistry (2020). On theSindex it has a DataRank of 0. It has been cited 18 times.

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0DataRank · unranked

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Open Access18 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 2.08)OA: greenTopics (57)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (2)

Irina F. Sevrioukova ORCID,Eric R. Samuels ORCID

Live enrichment

PubMed:32044230 PMC:PMC7179874 OpenAlex:https://openalex.org/W3003506636

NIGMS NIH HHS

Grant: P41 GM103393

NIEHS NIH HHS

Grant: R01 ES025767

National Institutes of Health

Grant: 5R01ES025767-08

Toxicological importance of CYP3A4 catalysis and inhibition

National Institutes of Health

Grant: 8P41GM103393-33

A Synchroton Radiation Structural Biology Resource

National Institutes of Health

FWCI

2.08

Citation Percentile

0.9%

Citation Trend

2020

2021

2022

2023

2024

2025

greenLicense: Elsevier TDM

repositoryhttps://www.osti.gov/biblio/1693997

publisherhttps://api.elsevier.com/content/article/PII:S0968089620301401?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0968089620301401?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.bmc.2020.115349

Fields of Study

Pharmacogenetics and Drug MetabolismHIV/AIDS drug development and treatmentDrug Transport and Resistance Mechanisms0301 basic medicine03 medical and health sciences0303 health sciencesCytochrome P-450 CYP3ACytochrome P-450 CYP3A InhibitorsDose-Response Relationship, DrugHumansHydrophobic and Hydrophilic InteractionsMolecular StructureRitonavirStructure-Activity Relationship

MeSH Terms

Dose-Response Relationship, DrugHumansStructure-Activity RelationshipMolecular StructureRitonavirCytochrome P-450 CYP3AHydrophobic and Hydrophilic InteractionsCytochrome P-450 CYP3A Inhibitors

Keywords

ChemistryCYP3A4Indole testSide chainStereochemistryRitonavirLigand (biochemistry)NaphthaleneCytochrome P450PharmacologyBiochemistryEnzymeReceptorHuman immunodeficiency virus (HIV)Organic chemistryCrystal structureLigand bindingInhibitor DesignStructure-activity RelationsMedicinal & Biomolecular ChemistryDose-Response RelationshipMedicinal and Biomolecular ChemistryStructure-Activity RelationshipCytochrome P-450 CYP3AHumansDose-Response Relationship, DrugMolecular StructurePharmacology and Pharmaceutical Sciences5.1 PharmaceuticalsBiochemistry and cell biologyChemical SciencesCytochrome P-450 CYP3A InhibitorsDevelopment of treatments and therapeutic interventionsDrugHydrophobic and Hydrophilic Interactions

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being